South America Luxury Vacations

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Flight and Luxury hotel deals in South America

Price found within the past 48 hours. Click for updated prices.
Ananda Hotel Boutique

Ananda Hotel Boutique

Cartagena Walled City
CA $1,256
per person
Nov 1 - Nov 5
found 6 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Cartagena (CTG)
9.2/10 Wonderful! (465 reviews)
Perfect location/hotel, I can’t find anything to complain about my stay there. I would definitely recommend and stay there again.

Reviewed on Aug 1, 2026

Country Club Lima Hotel - The Leading Hotels of the World

Country Club Lima Hotel - The Leading Hotels of the World

San Isidro
CA $2,042
per person
Oct 14 - Oct 21
just found
Roundtrip non-stop flight included
Toronto (YYZ) to Lima (LIM)
9.4/10 Exceptional! (697 reviews)
Regal Pacific Buenos Aires

Regal Pacific Buenos Aires

Microcentro
CA $1,958
per person
Sep 15 - Sep 22
found 9 hours ago
Roundtrip non-stop flight included
San Salvador (SAL) to Buenos Aires (EZE)
8.8/10 Excellent! (1,006 reviews)
Buena relación precio servicio

Reviewed on Aug 8, 2026

InterContinental Cartagena De Indias by IHG

InterContinental Cartagena De Indias by IHG

Bocagrande
CA $1,363
per person
Oct 14 - Oct 20
found 22 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Cartagena (CTG)
9.4/10 Exceptional! (1,685 reviews)
I had a great and luxurious stay here

Reviewed on Aug 12, 2026

Faena Hotel Buenos Aires

Faena Hotel Buenos Aires

Puerto Madero
CA $2,878
per person
Sep 15 - Sep 22
found 9 hours ago
Roundtrip non-stop flight included
San Salvador (SAL) to Buenos Aires (EZE)
8.8/10 Excellent! (542 reviews)
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5* Luxury holidays in South America

Price found within the past 48 hours. Click for updated prices.
The Westin Lima Hotel & Convention Center

The Westin Lima Hotel & Convention Center

San Isidro
CA $1,842
per person
Oct 14 - Oct 21
just found
Roundtrip non-stop flight included
Toronto (YYZ) to Lima (LIM)
9.6/10 Exceptional! (584 reviews)
Country Club Lima Hotel - The Leading Hotels of the World

Country Club Lima Hotel - The Leading Hotels of the World

San Isidro
CA $2,042
per person
Oct 14 - Oct 21
just found
Roundtrip non-stop flight included
Toronto (YYZ) to Lima (LIM)
9.4/10 Exceptional! (697 reviews)
Faena Hotel Buenos Aires

Faena Hotel Buenos Aires

Puerto Madero
CA $2,878
per person
Sep 15 - Sep 22
found 9 hours ago
Roundtrip non-stop flight included
San Salvador (SAL) to Buenos Aires (EZE)
8.8/10 Excellent! (542 reviews)
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3 Night Luxury holidays in South America

Price found within the past 48 hours. Click for updated prices.
Hotel Boutique Casa del Coliseo

Hotel Boutique Casa del Coliseo

Cartagena Walled City
CA $628
per person
Sep 22 - Sep 25
found 1 day ago
Roundtrip non-stop flight included
Bogotá (BOG) to Cartagena (CTG)
9.4/10 Exceptional! (323 reviews)
Ananda Hotel Boutique

Ananda Hotel Boutique

Cartagena Walled City
CA $733
per person
Sep 22 - Sep 25
found 1 day ago
Roundtrip non-stop flight included
Bogotá (BOG) to Cartagena (CTG)
9.2/10 Wonderful! (465 reviews)
Perfect location/hotel, I can’t find anything to complain about my stay there. I would definitely recommend and stay there again.

Reviewed on Aug 1, 2026

Charleston Santa Teresa Cartagena

Charleston Santa Teresa Cartagena

Cartagena Walled City
CA $891
per person
Sep 22 - Sep 25
found 1 day ago
Roundtrip flight included
Bogotá (BOG) to Cartagena (CTG)
9.4/10 Exceptional! (874 reviews)
Excelente hotel, la mejor atención .

Reviewed on Aug 8, 2026

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4 Night Luxury holidays in South America

Price found within the past 48 hours. Click for updated prices.
Ananda Hotel Boutique

Ananda Hotel Boutique

Cartagena Walled City
CA $1,256
per person
Nov 1 - Nov 5
found 6 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Cartagena (CTG)
9.2/10 Wonderful! (465 reviews)
Perfect location/hotel, I can’t find anything to complain about my stay there. I would definitely recommend and stay there again.

Reviewed on Aug 1, 2026

Hotel Boutique Casa del Coliseo

Hotel Boutique Casa del Coliseo

Cartagena Walled City
CA $1,575
per person
Sep 23 - Sep 27
found 24 hours ago
Roundtrip flight included
Toronto (YYZ) to Cartagena (CTG)
9.4/10 Exceptional! (323 reviews)
The Charlee Hotel

The Charlee Hotel

El Poblado
CA $1,292
per person
Sep 15 - Sep 19
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Medellín (MDE)
8.8/10 Excellent! (1,008 reviews)
Wonderful Stay & Exceptional Service ⭐️⭐️⭐️⭐️⭐️ My group and I had a wonderful stay at The Charlee Hotel. The hotel has a great atmosphere, and what truly elevated our experience was the exceptional service from the entire team — warm, professional, attentive, and genuinely welcoming. A special thank you to Anderson at reception, who looked after me beautifully from the moment I arrived. I was waiting for my group of 14 friends whose flight had been delayed, and Anderson was incredibly kind, helpful, and attentive throughout. His service was exceptional. Santiago was equally outstanding. When our group of 15 departed with around 30 suitcases, he went above and beyond to help the driver load everything into the van, all while maintaining a wonderful smile and positive attitude. Truly first-class service. A big thank you as well to the evening security team, who looked after us while we waited outside for transportation and helped keep unwanted street vendors and solicitors at bay. We really appreciated their care and professionalism. The only minor improvements would be adding sun loungers around the pool and speeding up the egg service at breakfast, which could sometimes take 15–20 minutes. Overall, a fantastic experience. Thank you to the entire Charlee team — especially Anderson, Santiago, and the evening security staff — for making our stay so memorable

Reviewed on Aug 12, 2026

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Plan the perfect luxury South America vacation with Expedia

What are some benefits when booking luxury South America vacations?

When you book a luxury South America vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax.

How can I find all-inclusive luxury vacations in South America?

If you're looking for something luxurious in South America, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together.

Can I book a cheap luxury vacation?

While luxury vacations tend to be on the more costly end of the spectrum, ranging from CA $628, there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to 33. After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first.

Are there luxury spa vacations?

Yes, luxury spa vacations are available and quite popular in South America. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search.

What should I look for in a luxury family vacation in South America?

When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout South America.

Can I book last-minute luxury vacations?

Yes, last-minute bookings are often available in South America. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces.

What can help me find the best luxury vacation deals in South America?

You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of South America or travelling to more obscure destinations altogether can often lead to lower prices.

Can I book a luxury vacation that is fully refundable?

Yes, fully refundable reservations are sometimes available on luxury vacation packages in South America. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking.

Why should I book my luxury vacation with Expedia?

When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings.

Luxury Hotels in South America

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls

Rodovia Br 469 Km 32 Foz do Iguaçu PR
CA $996
CA $1,153 total
Aug 17 - Aug 18
includes taxes & fees
Book a stay at this luxury hotel in Foz do Iguaçu. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff and the property ...
10/10 Exceptional! (1,014 reviews)
"Excellent in every respect, this hotel exceeds all your expectations."

Reviewed on Aug 12, 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Hotel Club Frances

Hotel Club Frances

Rodríguez Peña 1832 Buenos Aires Capital Federal
CA $312
CA $316 total
Sep 11 - Sep 12
Book a stay at this luxury hotel in Buenos Aires. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (674 reviews)
"Great location for a business trip"

Reviewed on Jul 9, 2026

Hotel Club Frances
Palacio del Inka, A Luxury Collection Hotel by Marriott

Palacio del Inka, A Luxury Collection Hotel by Marriott

Plazoleta Santo Domingo No 259 Cusco Cusco
CA $437
CA $538 total
Sep 1 - Sep 2
Book a stay at this luxury hotel in Cusco. Enjoy a full-service spa, room service, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,005 reviews)
"The rooms, location, amenities, and service were all top-notch. Would stay here every time!"

Reviewed on Aug 11, 2026

Palacio del Inka, A Luxury Collection Hotel by Marriott
See all 126,872 properties in South America
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.