Southern Indiana Vacation Packages

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Your Southern Indiana Vacation

Make planning your next big adventure a breeze with a Southern Indiana vacation package. Whether it's nature, history or something else that draws you here, our packages will help you discover it all. A trip to Southern Indiana wouldn't be complete without exploring some of its leading cities, starting with Louisville. A couple of the most popular attractions here include KFC Yum Centre and Kentucky Kingdom. Evansville is another favourite with Southern Indiana travellers. Visitors to this destination enjoy Ford Centre and Bally's Evansville Casino. When you're ready to stop daydreaming and start doing, Expedia will help turn your Southern Indiana vacation into a reality.

Top Southern Indiana Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Cottonwood Airport & Expo Hotel Louisville

Cottonwood Airport & Expo Hotel Louisville

3.5 out of 5
Shively
Price was CA $1,108, price is now CA $967 per person
CA $967
per person
Apr 16 - Apr 20
found 21 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Louisville (SDF)
8.6/10 Excellent! (986 reviews)
The room was clean and staff were very friendly and helpful, but i do wish the restaurant and bar were open in the evenings.

Reviewed on Jan 5, 2026

Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
Downtown Louisville
Price was CA $1,933, price is now CA $1,576 per person
CA $1,576
per person
May 18 - May 21
found 17 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Louisville (SDF)
9/10 Wonderful! (1,002 reviews)
Awesome downtown location! Oliver and Hermina were extremely helpfu. Clean and nice rooms! Will definitely stay again!

Reviewed on Mar 10, 2026

5 Bd/3 Ba-Near Expo/UL/Fair/YUM/Zoo

5 Bd/3 Ba-Near Expo/UL/Fair/YUM/Zoo

3 out of 5
Price was CA $2,149, price is now CA $1,832 per person
CA $1,832
per person
Apr 16 - Apr 20
found 21 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Louisville (SDF)
No reviews
Holiday Inn Louisville Downtown by IHG

Holiday Inn Louisville Downtown by IHG

3 out of 5
Downtown Louisville
Price was CA $1,208, price is now CA $1,066 per person
CA $1,066
per person
Apr 16 - Apr 20
found 21 hours ago
Roundtrip non-stop flight included
Calgary (YYC) to Louisville (SDF)
8/10 Very Good! (797 reviews)
having the restaurants on 4th street nearby was a real plus. excellent value for $ for the room. Also, a lot to see and do in Louisville. a great trip and holiday inn was terrific.

Reviewed on Mar 6, 2026

21c Museum Hotel Louisville

21c Museum Hotel Louisville

4.5 out of 5
Downtown Louisville
Price was CA $1,618, price is now CA $1,448 per person
CA $1,448
per person
May 18 - May 21
found 17 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Louisville (SDF)
9.4/10 Exceptional! (1,005 reviews)
Lovely hotel. Would stay there again.

Reviewed on Mar 5, 2026

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Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
Louisville Science Center which includes outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

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Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
The price is CA $80 per night from Apr 12 to Apr 13
CA $80
CA $91 total
Apr 12 - Apr 13
includes taxes & fees
7/10 Good! (2,830 reviews)
Staff is always nice hotel looks great. Pool looks amazing and it’s really clean.

Reviewed on Mar 12, 2026

Radisson Hotel Louisville North
Fairfield Inn By Marriott Evansville East

Fairfield Inn By Marriott Evansville East

3 out of 5
7879 Eagle Crest Blvd Evansville IN
Fully refundableReserve now, pay when you stay
The price is CA $114 per night from Mar 15 to Mar 16
CA $114
CA $132 total
Mar 15 - Mar 16
includes taxes & fees
8.8/10 Excellent! (472 reviews)
Clean room and friendly staff. Older building but well maintained. Breakfast is the same pre-packaged eggs and meats as other hotel chains. It would be nice to see some fresh options available

Reviewed on Mar 4, 2026

Fairfield Inn By Marriott Evansville East
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Fully refundable
The price is CA $77 per night from Apr 12 to Apr 13
CA $77
CA $88 total
Apr 12 - Apr 13
includes taxes & fees
Derby Hotel & Suites
See all 1,627 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Family Vacations

Discover the most popular places to visit in Southern Indiana

Panorama Ohio River waterway riverboats and bridges leading to heart of downtown Louisville KY

KFC Yum Center

4.5/5(4 reviews)

Catch an event at KFC Yum Center during your trip to Louisville. Stroll along the riverfront or attend a sporting event in the area.

KFC Yum Center
Louisville Slugger Museum featuring interior views

Louisville Slugger Museum

4.5/5(18 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Holiday World and Splashin\' Safari featuring a waterpark as well as a small group of people

Holiday World and Splashin' Safari

Every day is a holiday at this fun-filled combination theme park and water park, where visitors of all ages can explore roller coasters, raft rides and wave pools.

Holiday World and Splashin' Safari

Frequently asked questions

Can I cancel my flight booking to Southern Indiana due to COVID-19?
Our handy Customer Service Portal is your one-stop shop for almost every travel question, including about flight changes and cancellations due to COVID-19. For more peace of mind, look over the terms and conditions of your fare before reserving a seat.
What's the best way to find cheap flights to Southern Indiana that have flexible change policies?
At Expedia, we've been channeling our inner yoga master to get you the most flexible fares around town. Simply check the "No change fee" box right underneath the "Flexible change policies" heading to find your perfect flight to Southern Indiana.
What are some of the general tips for travelers to Southern Indiana during the COVID-19 outbreak?
If it's your first time traveling during the COVID-19 pandemic, you'll notice a raft of new standards and rules in place. Take note of these tips and make your escape to Southern Indiana a smooth one:
  • Find out if any travel restrictions apply to your origin and destination before locking in a flight. Also check if there are any requirements you'll have to follow on arrival, such as proof of a negative COVID-19 test.
  • Keep your face mask on during airport screening. A TSA officer will require you to lower your mask temporarily for ID purposes.
  • To reduce the possibility of cross-contamination, position your boarding pass on the scanner yourself and then hold it up for inspection. Do not hand your boarding pass directly to a TSA employee.
  • One container of liquid hand sanitizer is now allowed in your carry-on luggage. It must be no larger than 12 oz (350 ml), and you'll have to remove it from your bag for scanning.
  • To reduce handling during the screening process, put items such as your belt, phone and wallet into your carry-on instead of the bins.
  • If you're planning to take food on board, place it in a clear plastic bag and then into a scanning bin. This reduces the likelihood that a TSA officer will need to handle your food container or carry-on bag for closer inspection.

Which airlines fly to Southern Indiana?
Let Delta take you there. This leading carrier schedules 121 flights per month to Evansville Regional Airport (EVV), a Southern Indiana gateway.
How can I find cheap tickets to Southern Indiana?
Start searching as early as possible, fly in or out of nearby airports, use miles or points — there's no shortage of ways! One more is to use Expedia's "flexible dates" function. Find your Southern Indiana flight, then compare the prices for nearby dates. In the last seven days, the best price for a flight to Southern Indiana was .
How much is a flight to Southern Indiana?
There were a lot of cheap fares up for grabs in the last seven days, with the price of a return ticket to Southern Indiana varying between and . Many lucky vacationers purchased one-way flights from () for as low as .
What are the most popular airports to fly into in Southern Indiana?
Jet into Evansville Regional Airport (EVV) and experience all that Southern Indiana has to offer. As the region's primary entry point, roughly 381 flights land here every month.
When is the cheapest time to fly to Southern Indiana?
If you'd prefer to spend your vacation cash on having fun in Southern Indiana rather than on getting there, leave early in the week. The most economical day to travel is normally Tuesday, with Monday a close second. With many people traveling over the weekend, Saturday often has the costliest fares.
How much is a plane ticket to Southern Indiana?
Seats to Southern Indiana ranged from to in the last seven days. Usually, the sooner you make a reservation, the bigger the bargain.
Which airlines with flights to Southern Indiana employ COVID-19 cleanliness policies?
In response to the current pandemic, the majority of airlines have rolled out additional steps and actions to help everybody get back in the air. Here's what these carriers are doing:
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.
  • United Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.