Downtown Clayton
St. Louis
Visit Downtown Clayton
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
CA $34
per adult
100% of travellers recommend
StL's Signature "Sights and Bites" - Private Tour in St. Louis
CA $246
per adult
Lemp Haunted Neighborhood Walking Tour
CA $35
per adult
84% of travellers recommend
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
The price is CA $128 per night from Aug 30 to Aug 31
CA $128
CA $149 total
Aug 30 - Aug 31
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (3,367 reviews)
"Great property and lovely staff and great location!"
Reviewed on Aug 11, 2026
Le Méridien St. Louis Clayton
7730 Bonhomme Ave St. Louis MO
The price is CA $212 per night from Aug 16 to Aug 17
CA $212
CA $250 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.8/10 Excellent! (756 reviews)
"Would have liked juice or flavored waters in the to go items in lobby. Something without caffeine or artificial sugars."
Reviewed on Aug 10, 2026
AC Hotel St. Louis Clayton
227 South Central Ave St. Louis MO
The price is CA $165 per night from Aug 16 to Aug 17
CA $165
CA $192 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
9.2/10 Wonderful! (359 reviews)
"I felt safe and relaxed; absolutely loved that I could have breakfast and dinner there."
Reviewed on Aug 11, 2026
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
The price is CA $187 per night from Sep 4 to Sep 5
CA $187
CA $220 total
Sep 4 - Sep 5
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (4,229 reviews)
"Excelente lugar! Muy buena atención"
Reviewed on Aug 11, 2026
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
The price is CA $139 per night from Sep 8 to Sep 9
CA $139
CA $204 total
Sep 8 - Sep 9
includes taxes & fees
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
The price is CA $155 per night from Aug 28 to Aug 29
CA $155
CA $181 total
Aug 28 - Aug 29
includes taxes & fees
Book a stay at this business-friendly hotel in St. Louis. Enjoy an outdoor pool, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check Downtown Clayton hotel availability
Where to stay in Downtown Clayton
Find the best Downtown Clayton areas and neighborhoods for the activities you enjoy most.
Downtown St. Louis
Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.
Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Photo by Terry Eaves
Open Photo by Terry Eaves
Downtown West
If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.
Central West End
The ample dining options and lush forests are just a few popular features of the neighborhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.
Creve Coeur
Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.
