Title: Book The Best Hotels in Pamplico, SC for 2025 from CA $85 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Pamplico](https://expedia.ca/Pamplico-Vacation-Rentals.d3000353197.Travel-Guide-VacationRentals)[Things to do in Pamplico](https://expedia.ca/Things-To-Do-In-Pamplico.d3000353197.Travel-Guide-Activities)[Pamplico Car Rentals](https://expedia.ca/Car-Rentals-In-Pamplico.d3000353197.Car-Rental-Guide)[Pamplico Vacation Packages](https://expedia.ca/Pamplico.d3000353197.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Pamplico, SC from CA $85 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Pamplico Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2025-10-11&d1=2025-10-11&endDate=2025-10-13&d2=2025-10-13&travelerType=family_friendly) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2025-10-11&d1=2025-10-11&endDate=2025-10-13&d2=2025-10-13&amenities=PETS) Pool [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2025-10-11&d1=2025-10-11&endDate=2025-10-13&d2=2025-10-13&amenities=POOL) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Pamplico%2C+South+Carolina%2C+United+States+of+America®ionId=3000353197&latLong=33.995995%2C-79.570061&adults=2&startDate=2025-10-11&d1=2025-10-11&endDate=2025-10-13&d2=2025-10-13&amenities=HOT_TUB) ## Check prices for these dates Tonight [Sep 27 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-09-27&endDate=2025-09-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-09-28&endDate=2025-09-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=3000353197&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 135 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Lobby](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/0da1bc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/25ba1b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/6fee16b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/2000000/1210000/1202800/1202776/079e4bcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Executive Inn Latta 8.2/10 Very good (901) "Pet friendly home away from home!" CA $136 CA $148 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Executive-Inn.h1202776.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/8f02222f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/f75cb7bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite](https://images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/bf604151.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at the Crossroads Lake City 9.4/10 Exceptional (779) "Fantastic restaurant on site, clean rooms and friendly staff. Very nice hotel." CA $174 CA $195 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/22e67acb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/0ea8f0b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/83187168.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence 9.2/10 Wonderful (1089) "The staff at check in was very friendly and cheerful. Property is convenient to restaurants and is clean and quiet. Love the gnome decorations!" CA $146 CA $163 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/5abcf1ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/b2e2f539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/bf29fa04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/22000000/21760000/21758600/21758593/1aa3f791.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staybridge Suites Florence - Civic Center by IHG Florence 9.4/10 Exceptional (898) "Great bacon" CA $188 CA $211 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-Staybridge-Suites-Florence-Civic-Center.h21758593.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/51d8f371.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC Florence 9.0/10 Wonderful (2153) "Great stay" CA $124 CA $139 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/a45dedcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/9afe242f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/7c55894f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/3000000/2480000/2478700/2478624/dad4ec3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn Marriott Florence Florence 8.8/10 Excellent (427) "The staff and the breakfast was amazing!!" CA $144 CA $161 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Florence-Hotels-Residence-Inn-Marriott-Florence.h2478624.Hotel-Information) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/1b5fb4c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/bac50e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/d1f8ba02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/11800/11724/d2976b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Florence Near Civic Center Florence 6.8/10 (1002) "The stay was nice" CA $95 CA $106 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-Florence-Near-Civic-Center.h11724.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/484ca695.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/824b9567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/38be55ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/80000/74500/74404/f63ba12c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Florence Florence 8.0/10 Very good (1684) "Great location " CA $144 CA $162 total includes taxes & fees Sep 29 - Sep 30 [](https://www.expedia.ca/Florence-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Florence.h74404.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/36a85f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/16ca8b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/22eb9cd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2400000/2393000/2392993/a2c60bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Florence-North-I-95 Florence 9.0/10 Wonderful (746) "Enjoyed our stay" CA $159 CA $178 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Florence-Hotels-Hampton-Inn-Suites-Florence-North-I-95.h2392993.Hotel-Information) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/dc8d999b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/024086db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/258371f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn & Suites Florence Civic Center Florence 7.8/10 Good (1241) "The staff makes this place my go to for overnight stays in Florence. The hotel is clean and freshly renovated. You can’t beat the price/value of this hotel. " CA $120 CA $135 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/b5687a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/ebea43b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence Florence 8.8/10 Excellent (2370) "This is a really nice hotel. Thought the room was like perfect quite honestly and I would definitely stay here again" CA $91 CA $102 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20300/20253/f3055d4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20300/20253/1ae2912b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20300/20253/44ec11f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/20300/20253/97f34681.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Florence Inn and Suites Florence 6.4/10 (317) "We had a good experience here. Staff very helpful " CA $69 CA $78 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Florence-Hotels-Florence-Inn-And-Suites.h20253.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/90000/84600/84519/a86309c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/90000/84600/84519/719d7bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/1000000/90000/84600/84519/67e23cb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free cribs/infant beds, free rollaway beds](https://images.trvl-media.com/lodging/1000000/90000/84600/84519/44d17659.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Florence Florence 7.8/10 Good (675) " Wry nice place to stay" CA $141 CA $158 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-Courtyard-By-Marriott-Florence.h84519.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/b1bbd639.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/65e0bac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/dab62d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/099eb7f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Florence/I-95 North Florence 6.8/10 (1009) "Clean room Nice staff Good area Plenty of food places to eat Air conditioning worked great Nice place" CA $90 CA $101 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/455/af3985b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/500/455/be7cdd34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/500/455/5074ad24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn Florence 7.6/10 Good (1008) "Nice staff, clean rooms, easy access." CA $110 CA $123 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5dc20640.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/7942388a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/5a5d3612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/18000000/17040000/17036000/17035960/90789704.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Florence I-20 Florence 9.0/10 Wonderful (509) "Great rest stop" CA $155 CA $174 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Florence-Hotels-Fairfield-Inn-Suites-By-Marriott-Florence-I-20.h17035960.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/90a03799.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/b467d613.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/5961e0c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/980000/975000/974962/0d9737a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Florence Florence 8.6/10 Excellent (938) "Great place to stay. " CA $150 CA $168 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Florence-Hotels-SpringHill-Suites-By-Marriott-Florence.h974962.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/94573105.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/bdf580c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG Florence 8.6/10 Excellent (1013) "Great accommodations. Staff was very friendly. Breakfast was hot and delicious." CA $170 CA $190 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/530000/528200/528148/098e0775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/530000/528200/528148/078b0644.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/530000/528200/528148/18421e39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/530000/528200/528148/87bb3ed5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Florence SC I-95 North / Hwy 76 Florence 5.2/10 (342) "Nice hotel" CA $82 CA $92 total includes taxes & fees Sep 28 - Sep 29 [](https://www.expedia.ca/Florence-Hotels-Travelodge-By-Wyndham-Florence.h528148.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/0724af0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/92c4b04d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/e765049f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/77000000/76030000/76026200/76026194/a0ec666e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Florence Florence 8.4/10 Very good (195) "Great hotel" CA $153 CA $172 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Florence-Hotels-Aloft-Florence.h76026194.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-11&endDate=2025-10-12®ionId=3000353197&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Hotels.d3000353197.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPamplico-Hotels.d3000353197.Travel-Guide-Hotels) ## More cheap stays in Pamplico ![Park Inn by Radisson Florence, SC](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Park Inn by Radisson Florence, SC 1729 Mandeville Road, Florence, SC CA $124 CA $139 total Sep 28 - Sep 29 includes taxes & fees 9/10 Wonderful! (2,146 reviews) [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Howard Johnson by Wyndham Florence 2038 W Lucas Street, I-95 Exit 164, Florence, SC CA $91 CA $102 total Sep 28 - Sep 29 includes taxes & fees 8.6/10 Excellent! (2,374 reviews) [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Quality Inn & Suites Florence Civic Center](https://images.trvl-media.com/lodging/1000000/20000/11600/11535/74f401dc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn & Suites Florence Civic Center 150 Dunbarton Dr, Florence, SC CA $120 CA $135 total Oct 26 - Oct 27 includes taxes & fees 7.6/10 Good! (1,240 reviews) [](https://expedia.ca/Florence-Hotels-Quality-Inn-And-Suites-Civic.h11535.Hotel-Information) ![Days Inn by Wyndham Florence/I-95 North](https://images.trvl-media.com/lodging/1000000/20000/15500/15497/b1bbd639_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Florence/I-95 North 2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC CA $90 CA $101 total Sep 30 - Oct 1 includes taxes & fees 6.6/10 (1,008 reviews) [](https://expedia.ca/Florence-Hotels-Days-Inn-By-Wyndham-FlorenceI-95-North.h15497.Hotel-Information) ![Comfort Inn & Suites](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Comfort Inn & Suites 527 Woody Jones Blvd, Florence, SC CA $146 CA $163 total Sep 29 - Sep 30 includes taxes & fees 9/10 Wonderful! (1,086 reviews) [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Best Western Inn](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Inn 1808 W Lucas Street, Florence, SC CA $110 CA $123 total Sep 28 - Sep 29 includes taxes & fees 7.6/10 Good! (1,006 reviews) [](https://expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ## Recent reviews of Pamplico hotels ![Comfort Inn & Suites](//images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites 5/5 Excellent "We have stayed at this facility several times on our way to family. It could use some upgrading but overall it is a good place to stay. Little things like ac thermostat wiggled on the wall and jumped numbers when trying to adjust. TV remote had no back, just taped and batteries kept falling out. But...beds are super comfortable and it has the hottest water we have ever had ! " A verified traveller stayed at Comfort Inn & Suites Posted 5 days ago [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![TownePlace Suites by Marriott Florence](//images.trvl-media.com/lodging/11000000/10630000/10620800/10620701/4140d9d6_y.jpg) ### TownePlace Suites by Marriott Florence 5/5 Excellent "Cleaniness" A verified traveller from COLUMBIA stayed at TownePlace Suites by Marriott Florence Posted 6 days ago [](https://expedia.ca/Florence-Hotels-TownePlace-Suites-By-Marriott-Florence.h10620701.Hotel-Information) ![Howard Johnson by Wyndham Florence](//images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 5/5 Excellent Great stop over "We stayed one night on our way back to PA from FL. We checked in late (after 10pm) and left early (before 8am) but the rooms were clean and spacious. The water pressure in the shower was great. Front desk staff were friendly. I didn’t eat breakfast but my kids did before we left so that was nice. Price was right and would stay again if in the area. " A verified traveller stayed at Howard Johnson by Wyndham Florence Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Comfort Suites Florence I-95](//images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/d963a865_y.jpg) ### Comfort Suites Florence I-95 5/5 Excellent "The people at the desk were very friendly and the room was clean. The only thing we noticed was that the refrigerator still had stuff in it from someone’s previous stay in the room and the microwave could use a little more cleaning." A verified traveller stayed at Comfort Suites Florence I-95 Posted 6 days ago [](https://expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) ![Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG](//images.trvl-media.com/lodging/1000000/970000/970000/969975/9fdaeb31_y.jpg) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG 5/5 Excellent "Okay " A verified traveller stayed at Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG Posted 7 days ago [](https://expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Park Inn by Radisson Florence, SC](//images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4_y.jpg) ### Park Inn by Radisson Florence, SC 5/5 Excellent Short stay on I-95 Trip "Excellent stay at this property. Every employee was welcoming and helpful. My special requests were accomodated. The room was comfortable and quiet. Breakfast was good. " A verified traveller stayed at Park Inn by Radisson Florence, SC Posted 7 days ago [](https://expedia.ca/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Hyatt Place Florence Downtown](//images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321_y.jpg) ### Hyatt Place Florence Downtown 5/5 Excellent "Stayed here for my birthday and it was perfect! Great location and amenities. They did have an unexpected surcharge of about $30 but they did offer a $15 bar credit. " A verified traveller stayed at Hyatt Place Florence Downtown Posted 8 days ago [](https://expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![The Inn at the Crossroads](//images.trvl-media.com/lodging/10000000/9150000/9142300/9142228/06692e76_y.jpg) ### The Inn at the Crossroads 5/5 Excellent "It was clean and well kept" A verified traveller stayed at The Inn at the Crossroads Posted 9 days ago [](https://expedia.ca/Florence-Hotels-The-Inn-At-The-Crossroads.h9142228.Hotel-Information) ![Tru by Hilton Florence I-95](//images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d_y.jpg) ### Tru by Hilton Florence I-95 5/5 Excellent "Great clean place to stay!" A verified traveller stayed at Tru by Hilton Florence I-95 Posted 10 days ago [](https://expedia.ca/Florence-Hotels-Tru-By-Hilton-Florence-I-95.h27041849.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [5 Star Hotels in Florence](https://www.expedia.ca/5Star-Florence-Hotels.s50-0-d1221.Travel-Guide-Filter-Hotels) - [Aynor Hotels](https://www.expedia.ca/Aynor-Hotels.d3000353082.Travel-Guide-Hotels) - [Coward Hotels](https://www.expedia.ca/Coward-Hotels.d3000353109.Travel-Guide-Hotels) - [Darlington Hotels](https://www.expedia.ca/Darlington-Hotels.d7558.Travel-Guide-Hotels) - [Hotels near Darlington Raceway](https://www.expedia.ca/Darlington-Raceway-Hotels.0-l6144924-0.Travel-Guide-Filter-Hotels) - [Darlington County Hotels](https://www.expedia.ca/Destinations-In-Darlington-County.d553248635976432334.Hotel-Destinations) - [Cheap Hotels in Florence County](https://www.expedia.ca/Destinations-In-Florence-County-Cheap-Hotels.0-0-d553248635976432658-tCheapHotels.Hotel-Filter-Destinations) - 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[Turbeville Hotels](https://www.expedia.ca/Turbeville-Hotels.d167716.Travel-Guide-Hotels) - [Flights to Florence](https://www.expedia.ca/Cheap-Flights-To-Florence.d1221.Travel-Guide-Flights) - [Flights to Marion](https://www.expedia.ca/Cheap-Flights-To-Marion.d8689.Travel-Guide-Flights) - [Flights to Florence County](https://www.expedia.ca/Destinations-In-Florence-County.d553248635976432658.Flight-Destinations) - [Flights from Florence Regional](https://www.expedia.ca/lp/airports/flo/flights-from-florence-regional-airport) - [Flights from Coward](https://www.expedia.ca/lp/flights/3000353109/flights-from-coward) - [Flights from Johnsonville](https://www.expedia.ca/lp/flights/3000455987/flights-from-johnsonville) - [Flights from Butte (BTM) to Florence (FLO)](https://www.expedia.ca/lp/flights/btm/flo/butte-to-florence) - [Flights from London (LGW) to Florence (FLO)](https://www.expedia.ca/lp/flights/lgw/flo/london-to-florence) - [Flights from Edmonton (YEG) to Florence (FLO)](https://www.expedia.ca/lp/flights/yeg/flo/edmonton-to-florence) - 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