Title: Book The Best Hotels in Upstate South Carolina, SC for 2026 from CA $96 - Fully Refundable Options - Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx553248635975748552)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d553248635975748552.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d553248635975748552.Destination-Travel-Guides) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Watts ![](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Upstate South Carolina Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&amenities=HOT_TUB) Spa [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&amenities=SPA_ON_SITE) Pool [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&amenities=POOL) Resort [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&lodging=HOTEL_RESORT) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&lodging=CABIN) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&lodging=APART_HOTEL) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&travelerType=family_friendly) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&lodging=APARTMENT) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&amenities=WATER_PARK) Farm [](https://www.expedia.ca/Hotel-Search?destination=Upstate+South+Carolina%2C+South+Carolina%2C+United+States+of+America®ionId=553248635975748552&latLong=34.711583%2C-82.278231&adults=2&startDate=2026-02-07&d1=2026-02-07&endDate=2026-02-09&d2=2026-02-09&lodging=AGRITOURISM) ## Check prices for these dates Tonight [Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 25 - Jan 26](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-01-25&endDate=2026-01-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Upstate South Carolina hotels ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/c321176c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/2b6111ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/726f3d0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1220000/1213000/1212931/b23b9566.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn on the Square, an Ascend Collection Hotel [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) Uptown Greenwood 9.2/10 Wonderful (712 reviews) "It was a very clean and beautiful lace to stay. We were there for our honeymoon " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $153 CA $169 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Greenwood-Hotels-Inn-On-The-Square.h1212931.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/16000000/15620000/15615900/15615872/2e727bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15620000/15615900/15615872/db9e84e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/16000000/15620000/15615900/15615872/33e3af91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15620000/15615900/15615872/afe44e2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Greenwood Mall by IHG [](https://www.expedia.ca/Greenwood-Hotels-Holiday-Inn-Express-Suites-Greenwood-Mall.h15615872.Hotel-Information) Greenwood 9.0/10 Wonderful (489 reviews) "Very clean room and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark CA $207 CA $230 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Greenwood-Hotels-Holiday-Inn-Express-Suites-Greenwood-Mall.h15615872.Hotel-Information) ![Free breakfast](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/353a96bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/120fd9b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/14b9a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Two queen beds nonsmoking](https://images.trvl-media.com/lodging/2000000/1460000/1453500/1453465/e06b0f6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Easley [](https://www.expedia.ca/Easley-Hotels-Hampton-Inn-Easley.h1453465.Hotel-Information) Easley 9.2/10 Wonderful (688 reviews) "Clean room and convenient location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gable CA $179 CA $198 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Easley-Hotels-Hampton-Inn-Easley.h1453465.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/a5fc35a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/d789a59c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/95b4cb26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26900/26875/7e082995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clinton - Laurens I-26 [](https://www.expedia.ca/Clinton-Hotels-Quality-Inn-Clinton.h26875.Hotel-Information) Clinton 7.4/10 Good (522 reviews) "Super clean and quiet and staff was extremely nice and friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $86 CA $101 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Clinton-Hotels-Quality-Inn-Clinton.h26875.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/d257793d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/f1cbacdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/34438b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds](https://images.trvl-media.com/lodging/1000000/90000/84700/84636/01f08951.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn @ Clemson [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) Clemson 8.2/10 Very good (1,005 reviews) "Love this hotel. It’s a little home away from home for me ❤️❤️❤️" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stacey [](https://www.expedia.ca/Anderson-Hotels-Inn-Clemson.h84636.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/83732283.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/b202edd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/590fd43d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/ac7a917f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Seneca Clemson [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) Seneca 9.2/10 Wonderful (804 reviews) "Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy CA $134 CA $147 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/dfd5de25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/7cd027cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/26c9fcbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/8ef1c109.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Greenville Airport [](https://www.expedia.ca/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) Greenville 8.4/10 Very good (329 reviews) "everything was perfect " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Makiya CA $108 CA $119 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/db449d90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/91e6d418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/589bd84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/6abd26aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Lodge Clemson [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) Seneca 9.0/10 Wonderful (1,006 reviews) "Great place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gene CA $149 CA $185 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Hallway](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/4d00561c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/893b2bfc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/cb83efe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception hall](https://images.trvl-media.com/lodging/20000000/19520000/19511400/19511329/959a330b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Patrick Square [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) Clemson 9.8/10 Exceptional (792 reviews) "Clean room, great location, wonderful staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce CA $204 CA $227 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Anderson-Hotels-The-Inn-At-Patrick-Square.h19511329.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/31000000/30470000/30468900/30468866/375f8e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/31000000/30470000/30468900/30468866/a8a35598.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/31000000/30470000/30468900/30468866/e9483147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/31000000/30470000/30468900/30468866/cb13a9b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home2 Suites by Hilton Duncan [](https://www.expedia.ca/Duncan-Hotels-Home2-Suites-By-Hilton-Duncan.h30468866.Hotel-Information) Duncan 9.4/10 Exceptional (285 reviews) "The lady that greeted us was excellent and exceptional " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Manuel CA $162 CA $179 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Duncan-Hotels-Home2-Suites-By-Hilton-Duncan.h30468866.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/d93f55e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/56ecee45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/2f127f57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68980000/68975500/68975422/799eeb33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Greer Greenville, SC [](https://www.expedia.ca/Greer-Hotels-Hampton-Inn-Greer-Greenville.h68975422.Hotel-Information) Greer 9.6/10 Exceptional (428 reviews) "Parking garage for hotel guests, location was great, hotel was clean, staff was great. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tyler CA $177 CA $193 total includes taxes & fees Feb 20 - Feb 21 [](https://www.expedia.ca/Greer-Hotels-Hampton-Inn-Greer-Greenville.h68975422.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/f08daaa9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/d8583276.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/7636779c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28100/28087/c9a89e89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Points by Sheraton Spartanburg [](https://www.expedia.ca/Spartanburg-Hotels-Four-Points-By-Sheraton-Spartanburg.h28087.Hotel-Information) Spartanburg 9.4/10 Exceptional (448 reviews) "Friendly staff, clean rooms, excellent food! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $163 CA $181 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Spartanburg-Hotels-Four-Points-By-Sheraton-Spartanburg.h28087.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/8f736b3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/52f82f37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/aca2d330.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Seneca-Clemson Area [](https://www.expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) Seneca 9.2/10 Wonderful (673 reviews) "Everything was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debby CA $169 CA $186 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/f6f7c8c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/16b3def6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/81c4f249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Seneca Clemson Area US-123 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) Downtown 8.0/10 Very good (672 reviews) "Our stay was very nice. Clean room. The outside was clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gayle CA $107 CA $126 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Golf](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/ad943919.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/63d829f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/199642a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool, open 10:00 AM to 9:00 PM, free cabanas](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/8fa71ed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson University's James F. Martin Inn [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) Clemson 9.6/10 Exceptional (965 reviews) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mindi CA $204 CA $227 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/a5d6b89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) Clemson 9.6/10 Exceptional (561 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $188 CA $209 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/76f56d99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/2a4dd9e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/ffe59c14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/6bd999f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Greenville Airport [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) Greenville 9.2/10 Wonderful (1,011 reviews) "Hotel was perfect for my birthday weekend. Loved my room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $136 CA $153 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/b0e15e12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Double Beds, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/f2d60448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/10000/3300/3223/8238721d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites Greenville Golf Resort & Conference Center [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) Greenville 9.0/10 Wonderful (1,039 reviews) "Great stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kurt CA $145 CA $159 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/ff716430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/w6000h3996x0y0-b212d0d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible (Mobility Accessible, Communications)](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/5d59466d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2558700/2558616/78b30d8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Clemson by IHG [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Suites-Clemson.h2558616.Hotel-Information) Clemson 8.8/10 Excellent (956 reviews) "Staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) barry CA $169 CA $187 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Suites-Clemson.h2558616.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency)](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/4f8e319f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/26b1d839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/330446c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Clemson - University Area [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Clemson 8.2/10 Very good (1,001 reviews) "Clean room. Friendly staff. Convenient location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anita CA $130 CA $145 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-07&endDate=2026-02-08®ionId=553248635975748552&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Vacation Rentals in Upstate South Carolina Cottage ![Signature Cottage, 2 Bedrooms | Living room](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/a4df93b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/b86441f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/9cd5859a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Cottage, 2 Bedrooms | Private kitchen](https://images.trvl-media.com/lodging/90000000/89510000/89502700/89502605/w775h924x3y0-5b08ac43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Clemson 9.8/10 Exceptional (9 reviews) "We enjoyed our stay, it was the perfect size for our family of four. " [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House.h89502605.Hotel-Information) Aparthotel ![Apartment, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/c1ffc683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch TV with digital channels](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/f6834f04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/6a920723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/b51157db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Place Apartments by Landing [](https://www.expedia.ca/Greenville-Hotels-Barsala-At-The-American-Spinning-Mill-Apartments.h111130227.Hotel-Information) Greenville 7.6/10 Good (45 reviews) "The facility is beautiful, but there is no visibility of staff. We had several mechanical issues with dishwasher, washing machine and the Internet. We were able to resolve the Internet issue. But the dishwasher was never fixed during the four nights we stayed and our clothes. Locked in the washer. We could not get anyone to come and fix so we had to leave our items there. It’s been two weeks and I still haven’t heard back from anyone to retrieve my belongings." [](https://www.expedia.ca/Greenville-Hotels-Barsala-At-The-American-Spinning-Mill-Apartments.h111130227.Hotel-Information) Cottage ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/ce6330d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/925daccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/6f31060d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98550000/98548800/98548744/f306db0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Updated Greenville Home w/ Backyard! [](https://www.expedia.ca/Greenville-Hotels-Updated-Greenville-Home-W-Backyard.h98548744.Hotel-Information) Greenville 10/10 Exceptional (2 reviews) [](https://www.expedia.ca/Greenville-Hotels-Updated-Greenville-Home-W-Backyard.h98548744.Hotel-Information) Cabin ![View from property](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/d7c06df6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/2da98b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/53271cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 1 Queen Bed (View) | Private kitchen](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/60991646.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Seneca 9.8/10 Exceptional (55 reviews) "Excellent stay." [](https://www.expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) Aparthotel ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/61217476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/cc01b08f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/2d11b158.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/70000000/69720000/69716800/69716747/002ffe20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Greenville-Haywood Mall [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Greenville 9.2/10 Wonderful (200 reviews) "Great place!" [](https://www.expedia.ca/Greenville-Hotels-StayAPT-Suites-Greenville-Haywood-Mall.h69716747.Hotel-Information) Mobile Home ![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/e62d89db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/44e61f9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/6f5c7f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | Living room](https://images.trvl-media.com/lodging/10000000/9130000/9126600/9126575/1853a44e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Carolina Landing RV Resort - Caravan Park [](https://www.expedia.ca/Anderson-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information) Fair Play 7.6/10 Good (47 reviews) "Lake " [](https://www.expedia.ca/Anderson-Hotels-Carolina-Landing-RV-Resort-Caravan-Park.h9126575.Hotel-Information) Aparthotel ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/346fcb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/87440d66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/fa38c3ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vista Wedge Cottage | Private kitchen](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/9304eefe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Station by Compo Hotels [](https://www.expedia.ca/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) Travelers Rest 10/10 Exceptional (16 reviews) "great place perfect for more privacy vs. a standard hotel" [](https://www.expedia.ca/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) Cottage ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/784635bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/6c10521c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/1767b060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103710000/103707900/103707807/09b84ce7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Waterfront Seneca Cabin \~ 4 Mi to Boat Launch! [](https://www.expedia.ca/Seneca-Hotels-Waterfront-Seneca-Cabin-4-Mi-To-Boat-Launch.h103707807.Hotel-Information) Seneca 10/10 Exceptional (1 review) "Beautiful and quaint cabin! Highly recommend, great view of the lake." [](https://www.expedia.ca/Seneca-Hotels-Waterfront-Seneca-Cabin-4-Mi-To-Boat-Launch.h103707807.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/101000000/100430000/100424100/100424061/ac11bf1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/101000000/100430000/100424100/100424061/5adbdf79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/101000000/100430000/100424100/100424061/aef9f750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/101000000/100430000/100424100/100424061/4147e96a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Access & Boat Slip: Greenwood Cottage! [](https://www.expedia.ca/Greenwood-Hotels-Greenwood-Cottage-W-Lake-Access-Boat-Slip.h100424061.Hotel-Information) Greenwood 10/10 Exceptional (1 review) "Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. " [](https://www.expedia.ca/Greenwood-Hotels-Greenwood-Cottage-W-Lake-Access-Boat-Slip.h100424061.Hotel-Information) Cottage ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94970000/94965700/94965665/b9728109.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94970000/94965700/94965665/91d5d964.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94970000/94965700/94965665/8108d915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94970000/94965700/94965665/8b275f49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Claires Cottage \~ 4 Mi to Downtown Greenville! [](https://www.expedia.ca/Greenville-Hotels-Charming-Cottage-4-Mi-To-Downtown-Greenville.h94965665.Hotel-Information) Greenville 10/10 Exceptional (1 review) "Great trip. The small cottage was perfect for my wife and I and the owner was very responsive." [](https://www.expedia.ca/Greenville-Hotels-Charming-Cottage-4-Mi-To-Downtown-Greenville.h94965665.Hotel-Information) Apartment ![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958000/94957904/869da7ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958000/94957904/a735e279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958000/94957904/456ccd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958000/94957904/5314fa58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Designer Retreat w/ Pool, Golf + Beach Access! [](https://www.expedia.ca/Salem-Hotels-Designer-Retreat-W-Pool.h94957904.Hotel-Information) Salem 10/10 Exceptional (1 review) "Property is in a great community, and it was very clean and beautifully decorated." [](https://www.expedia.ca/Salem-Hotels-Designer-Retreat-W-Pool.h94957904.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/d0930e15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/b0d329c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/85b2b418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537500/93537410/97641e90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stunning Lakefront Retreat w/ Dock Access! [](https://www.expedia.ca/Greenwood-Hotels-Stunning-Lakefront-Retreat-W-Dock-Access.h93537410.Hotel-Information) Greenwood 10/10 Exceptional (1 review) [](https://www.expedia.ca/Greenwood-Hotels-Stunning-Lakefront-Retreat-W-Dock-Access.h93537410.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/114000000/113190000/113184500/113184450/309d8bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/114000000/113190000/113184500/113184450/34ff4e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/114000000/113190000/113184500/113184450/86d9c4f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/114000000/113190000/113184500/113184450/ebe19f88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deck, Grill & Dock Access: Lake Keowee Retreat! [](https://www.expedia.ca/Seneca-Hotels-Deck.h113184450.Hotel-Information) Seneca 10/10 Exceptional (1 review) "The best, perfect " [](https://www.expedia.ca/Seneca-Hotels-Deck.h113184450.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98553800/98553702/89d76ac5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98553800/98553702/506b693f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98553800/98553702/1b10d271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/99000000/98560000/98553800/98553702/3e1d7748.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Waterfront Lake Hartwell Vacation Rental w/ Dock! [](https://www.expedia.ca/Townville-Hotels-Waterfront-Lake-Hartwell-Vacation-Rental-W-Dock.h98553702.Hotel-Information) Townville 10/10 Exceptional (1 review) [](https://www.expedia.ca/Townville-Hotels-Waterfront-Lake-Hartwell-Vacation-Rental-W-Dock.h98553702.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/cbc428e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/7bea9b1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/9bd47812.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/116000000/115590000/115584200/115584157/1ede9ee1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stay at Jos Taylor Retreat: 9 Mi to Greenville! [](https://www.expedia.ca/Taylors-Hotels-Stay-At-Jos-Taylor-Retreat-9-Mi-To-Greenville.h115584157.Hotel-Information) Taylors 10/10 Exceptional (1 review) "This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer." [](https://www.expedia.ca/Taylors-Hotels-Stay-At-Jos-Taylor-Retreat-9-Mi-To-Greenville.h115584157.Hotel-Information) [See all vacation rentals](https://expedia.ca/Hotel-Search?startDate=2026-02-21&endDate=2026-02-24®ionId=553248635975748552&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels) ## Learn more about Upstate South Carolina Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina. [See all hotels in Upstate South Carolina](https://www.expedia.ca/Hotel-Search?startDate=2026-02-07&endDate=2026-02-08&adults=2®ionId=553248635975748552) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) Photo by Ryan Watts ### Stay near popular Upstate South Carolina attractions [](https://expedia.ca/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) !["Clemson University is an American public, coeducational, land-grant and sea-grant research university located in Clemson, South Carolina, United States.More clemson images:"](https://images.trvl-media.com/place/6127431/81e51bd8-6dfc-4739-9fb0-b15a1329fa3d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Clemson University Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6127431) [](https://expedia.ca/Falls-Park-On-The-Reedy-Hotels.0-l6082697-0.Travel-Guide-Filter-Hotels) ![Falls Park in the middle of downtown! Beautiful place to relax, set up a hammock, play in the water and listen to the falls. ](https://images.trvl-media.com/place/1388/9768cca7-241b-46cc-9044-0389ae1e8a0a.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Falls Park on the Reedy Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6082697) [](https://expedia.ca/Fred-W-Symmes-Chapel-Hotels.0-l553248621532656718-0.Travel-Guide-Filter-Hotels) ![At the foot of the Cross lies my peace... A popular place for weddings in the small open-sided chapel atop the mountain at the YMCA camp. To sit in the pews and look out on the world is a great side of peace. #cross #peace #mountains #SC #relaxing #beautifulday #outdoors #traveljunkie #ktphoenixphotography](https://images.trvl-media.com/place/553248621532656718/82a12a54-2b7c-457d-b071-556ed8fd587d.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Fred W. Symmes Chapel You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532656718) [](https://expedia.ca/Bob-Jones-University-Hotels.0-l6169875-0.Travel-Guide-Filter-Hotels) ![Dorm Life.](https://images.trvl-media.com/place/1388/bd027402-c909-400b-8af6-0628685e12ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bob Jones University Enjoy the collegiate vibe when you visit Bob Jones University, during your travels in Greenville. Attend a sporting event or visit the shops in this family-friendly area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6169875) [](https://expedia.ca/Devils-Fork-State-Park-Hotels.0-l6232058-0.Travel-Guide-Filter-Hotels) ![Lake Jocassee, the gorgeous blue heart of the Jocassee Gorges, is actually a man-made lake. It was created when the Jocassee Dam was built in 1973. ... flooding the town. Attakulla Lodge, an old hotel, is still standing at the bottom of Lake Jocassee, under 300 feet of water. You can dive here and see a gas station and the cemetery.](https://images.trvl-media.com/place/63870/71aee099-eb31-409e-9ea6-19284ef31cff.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Devils Fork State Park You can take time to visit Devils Fork State Park during your travels to Salem. Wander the lakeside or discover the area's mountain views. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6232058) [](https://expedia.ca/Bon-Secours-Wellness-Arena-Hotels.0-l6082715-0.Travel-Guide-Filter-Hotels) #### Bon Secours Wellness Arena Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the acclaimed theater scene in this family-friendly area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6082715) ## More cheap stays in Upstate South Carolina ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/ce467f24_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Anderson 1007 George Smith Mill Rd Anderson SC CA $86 CA $96 total Feb 2 - Feb 3 includes taxes & fees 7.8/10 Good! (1,005 reviews) [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd](https://images.trvl-media.com/lodging/1000000/210000/202200/202137/b07dd898_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd 1024 Woodruff Rd Greenville SC CA $94 CA $104 total Feb 8 - Feb 9 includes taxes & fees 8.2/10 Very Good! (1,001 reviews) [](https://expedia.ca/Greenville-Hotels-Microtel-Inn-Suites-By-Wyndham-Greenville-Woodruff-Rd.h202137.Hotel-Information) ![ECHO Suites Extended Stay by Wyndham Spartanburg](https://images.trvl-media.com/lodging/106000000/105490000/105488100/105488071/ab517c5d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### ECHO Suites Extended Stay by Wyndham Spartanburg 490 W Blackstock Road Spartanburg SC CA $102 CA $116 total Feb 1 - Feb 2 includes taxes & fees 8/10 Very Good! (329 reviews) [](https://expedia.ca/Spartanburg-Hotels-Echo-Suites-Spartanburg-Opening-June-2024.h105488071.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](https://images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Greenville I-385 Inn & Suites 831 Congaree Rd Greenville SC CA $106 CA $117 total Feb 1 - Feb 2 includes taxes & fees 9/10 Wonderful! (1,429 reviews) [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Seneca Clemson Area US-123 226 Hi Tech Rd Seneca SC CA $107 CA $126 total Feb 1 - Feb 2 includes taxes & fees 7.8/10 Good! (670 reviews) [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Best Western Plus Clemson Hotel & Conference Center 1310 Tiger Blvd Clemson SC CA $130 CA $144 total Jan 27 - Jan 28 includes taxes & fees 8.2/10 Very Good! (1,000 reviews) [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ## Hotels in Upstate South Carolina with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 11 properties [](https://expedia.ca/4Star-Upstate-South-Carolina-Hotels.s40-0-d553248635975748552.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 210 properties [](https://expedia.ca/3Star-Upstate-South-Carolina-Hotels.s30-0-d553248635975748552.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 317 properties [](https://expedia.ca/2Star-Upstate-South-Carolina-Hotels.s20-0-d553248635975748552.Travel-Guide-Filter-Hotels) ## Recent reviews of Upstate South Carolina hotels ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](https://images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 5/5 Excellent "Everything was up to par " A verified traveller stayed at Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG Posted 2 days ago [](https://expedia.ca/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Hyatt Regency Greenville](https://images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 5/5 Excellent ":Perfect " A verified traveller stayed at Hyatt Regency Greenville Posted 3 days ago [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Hyatt Place Greenville/Haywood](https://images.trvl-media.com/lodging/1000000/70000/64600/64570/9a71f6a4_y.jpg) ### Hyatt Place Greenville/Haywood 5/5 Excellent "Friendly staff and comfortable room " A verified traveller stayed at Hyatt Place Greenville/Haywood Posted 3 days ago [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleHaywood.h64570.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45_y.jpg) ### The Shepherd Hotel Downtown Clemson 5/5 Excellent "Would definitely stay here again. Was an amazing hotel." A verified traveller from Cottage Grove stayed at The Shepherd Hotel Downtown Clemson Posted 3 days ago [](https://expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Embassy Suites by Hilton Greenville Downtown Riverplace](https://images.trvl-media.com/lodging/16000000/15060000/15052000/15051911/b5c8aa89_y.jpg) ### Embassy Suites by Hilton Greenville Downtown Riverplace 5/5 Excellent "Breakfast was fresh. Place was clean and had a nice stay. " A verified traveller stayed at Embassy Suites by Hilton Greenville Downtown Riverplace Posted 4 days ago [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-By-Hilton-Greenville-Downtown-Riverplace.h15051911.Hotel-Information) ![Aloft Greenville Downtown](https://images.trvl-media.com/lodging/12000000/11960000/11959000/11958914/d91c1d51_y.jpg) ### Aloft Greenville Downtown 5/5 Excellent "The room was amazing, the amenities were top notch, I've just gotta find a reason to come back!" A verified traveller stayed at Aloft Greenville Downtown Posted 4 days ago [](https://expedia.ca/Greenville-Hotels-Aloft-Greenville-Downtown.h11958914.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 5/5 Excellent "Rooms are clean. Staff was very pleasant. " A verified traveller stayed at Best Western Plus Clemson Hotel & Conference Center Posted 5 days ago [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hampton Inn & Suites Greenville-Downtown-RiverPlace](https://images.trvl-media.com/lodging/2000000/1470000/1460400/1460359/d9184989_y.jpg) ### Hampton Inn & Suites Greenville-Downtown-RiverPlace 5/5 Excellent "On site covered parking, especially if it is valet" A verified traveller stayed at Hampton Inn & Suites Greenville-Downtown-RiverPlace Posted 5 days ago [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Downtown-RiverPlace.h1460359.Hotel-Information) ![AC Hotel By Marriott Greenville](https://images.trvl-media.com/lodging/59000000/58290000/58282600/58282504/575c54cb_y.jpg) ### AC Hotel By Marriott Greenville 5/5 Excellent "Super clean and very elegant room with balcony" A verified traveller stayed at AC Hotel By Marriott Greenville Posted 6 days ago [](https://expedia.ca/Greenville-Spartanburg-Hotels-AC-Hotel-By-Marriott-Greenville.h58282504.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Anglewood Hotels ](https://www.expedia.ca/Anglewood-Hotels.d553248635975857985.Travel-Guide-Hotels) - [Hotels near BMW Performance Center ](https://www.expedia.ca/BMW-Performance-Center-Hotels.0-l6217409-0.Travel-Guide-Filter-Hotels) - [Hotels near Converse College ](https://www.expedia.ca/Converse-College-Hotels.0-l6144852-0.Travel-Guide-Filter-Hotels) - [Cross Anchor Hotels ](https://www.expedia.ca/Cross-Anchor-Hotels.d553248635519281641.Travel-Guide-Hotels) - [Spartanburg County Hotels ](https://www.expedia.ca/Destinations-In-Spartanburg-County.d553248635976433422.Hotel-Destinations) - [Duncan Hotels ](https://www.expedia.ca/Duncan-Hotels.d6761.Travel-Guide-Hotels) - [Aparthotels in Enoree ](https://www.expedia.ca/Enoree-Apart-Hotels.d3000353124-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Enoree ](https://www.expedia.ca/Enoree-Bed-And-Breakfast.d3000353124-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Enoree ](https://www.expedia.ca/Enoree-Hotels-Cheap-Hotels.0-0-d3000353124-tCheapHotels.Travel-Guide-Filter-Hotels) - 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