Our top choices for Upstate South Carolina hotels

Carolina Inn Anderson Clemson Area

Anderson

Trevor

CA $84 total

includes taxes & fees

May 20 - May 21

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Lauren

CA $168 total

includes taxes & fees

May 24 - May 25

Quality Inn Seneca Clemson Area US-123

Downtown

Cheryl

CA $143 total

includes taxes & fees

Jun 9 - Jun 10

Hampton Inn Gaffney

Gaffney

Theresa

CA $125 total

includes taxes & fees

May 31 - Jun 1

Premium bedding, in-room safe, individually furnished, laptop workspace

Carolina Camp Cedar

Pickens

Katlynn

CA $354 total

includes taxes & fees

Jun 2 - Jun 3

Lakeside Lodge Clemson

Seneca

Valarie Tina

CA $186 total

includes taxes & fees

May 21 - May 22

Deluxe Inn

Mauldin

CA $95 total

includes taxes & fees

May 20 - May 21

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

Sarah

CA $195 total

includes taxes & fees

May 24 - May 25

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

James

CA $179 total

includes taxes & fees

May 24 - May 25

Tru by Hilton Seneca Clemson

Seneca

Sydney

CA $172 total

includes taxes & fees

Jun 1 - Jun 2

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Charles

CA $138 total

includes taxes & fees

May 31 - Jun 1

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

CA $127 total

includes taxes & fees

May 31 - Jun 1

Inn on the Square, an Ascend Collection Hotel

Uptown Greenwood

Frederick

CA $177 total

includes taxes & fees

May 31 - Jun 1

Hampton Inn Easley

Easley

Jenine

CA $186 total

includes taxes & fees

Jun 7 - Jun 8

Urban Boutique Hotel, BW Signature Collection

Greenville

Jane

CA $100 total

includes taxes & fees

May 24 - May 25

Standard Room, 1 King Bed, Non Smoking, Jetted Tub

Best Western Seneca-Clemson

Seneca

Judith

CA $148 total

includes taxes & fees

May 25 - May 26

The Abernathy of Clemson

Clemson

William

CA $201 total

includes taxes & fees

May 21 - May 22

Best Western Spartanburg Northwest

Spartanburg

Ashvani

CA $135 total

includes taxes & fees

Jun 2 - Jun 3

Aloft by Marriott Greenville Downtown

Greenville Downtown

Tamara

CA $209 total

includes taxes & fees

Jun 14 - Jun 15

Clemson University's James F. Martin Inn

Clemson

Sara

CA $227 total

includes taxes & fees

May 21 - May 22

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great spot"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Arrived after office closing, getting pack with key was no problem. The gate code was not on packet, had to call emergency number to get it and got quite the attitude with whom answered."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place, clean and quiet."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

Wooded Cottage - 3 Mi to Clemson University

Clemson

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

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Stay near popular Upstate South Carolina attractions

Clemson University

4.8/5 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Woodspring Suites Greenville Airport

6/10 Okay

"Room was clean and spacious. All kitchen utensils must be supplied by customer. Laundry room was large with multiple washer and dryer’s. Staff were helpful and friendly. Now here are my complaints, fire alarm went off 3 times in the middle of the night. Other rooms were very loud during the middle of the night. I had multiple rooms playing loud music all through the night. Hotel is worth the price but some of the customers made it hard me to enjoy."

Drury Inn & Suites Greenville

10/10 Excellent

"The staff was very nice. Ty assisted with all my questions and more. Site was very clean and our room was comfortable. I would stay at this site again. Hot breakfast and the time was good for me. I hate getting up at 5:30 am for breakfast. Everything was great; however, I did not care for the grits at all. I like mine creamy. Great place to stay and a lot of places near walking distance as well."

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent

"Things were like the shuttle drivers were awesome Jimmy, Ella chris and Martha Peyton at the front desk was awesome during the bartender amazing. Very friendly staff the real only problem was is the pool was cold but other than that everything there was great."

Hotel Hartness

10/10 Excellent

"We loved the property! Lush, green hiking trails with ponds and a farm, right behind the hotel. The hotel staff were all very friendly and helpful. The hotel was meticulously maintained. One evening, I witnessed a hotel employee doing an inspection of the pool and even ran his hand over every Adirondack chair around the pool area. I quizzed him, of course. He was checking to make sure every screwhead was flush so as not to snag a guest's clothing. His name was Patrick and I saw him all over the property, working hard and ensuring all was well. Amazing place, the gardens were fabulous with fragrant gardenia bushes everywhere. Restaurant had delicious food. It was a wonderful experience!"

Mint House Greenville Downtown by Kasa

8/10 Good

"The ad for this property undersold what we got. This was a large apartment with a full kitchen, huge bathroom and separate laundry room. We were not expecting how nice it was. Great location, only a block of the river. Great food options. Downtown a very short walk. Riverwalk one block away. This was a great place to stay. We would stay again without hesitation. Note there was a separate damage deposit that was a little suspect because it wasn't mentioned in the Expedia reservation. I went through with it and received the deposit refund within a week of checking out. Turned out fine, even though it was a little odd. Last thing-pay for parking onsite. It is worth the convenience."