Photo by RVLuckyorWhat

Find hotels in Upstate South Carolina, SC from CA $93
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Check prices for these dates
Our top choices for Upstate South Carolina hotels

Carolina Inn Anderson Clemson Area
Carolina Inn Anderson Clemson AreaAnderson
8.0 out of 10, Very good, (4 reviews)
The price is CA $77
CA $85 total
includes taxes & fees
Jun 11 - Jun 12

Deluxe Inn
Deluxe InnMauldin
9.6 out of 10, Exceptional, (4 reviews)
The price is CA $84
CA $93 total
includes taxes & fees
Jun 11 - Jun 12

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123Downtown
8.0 out of 10, Very good, (711 reviews)
The price is CA $118
CA $139 total
includes taxes & fees
Jun 14 - Jun 15

Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference CenterClemson
8.2 out of 10, Very good, (1,001 reviews)
The price is CA $133
CA $147 total
includes taxes & fees
Jun 14 - Jun 15

Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,010 reviews)
The price is CA $152
CA $189 total
includes taxes & fees
Jun 28 - Jun 29

The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (859 reviews)
The price is CA $208
CA $231 total
includes taxes & fees
Jun 11 - Jun 12

Inn @ Clemson
Inn @ ClemsonClemson
8.0 out of 10, Very good, (1,007 reviews)
The price is CA $102
CA $113 total
includes taxes & fees
Jun 11 - Jun 12

Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHGSimpsonville
9.4 out of 10, Exceptional, (536 reviews)
The price is CA $181
CA $200 total
includes taxes & fees
Jun 20 - Jun 21

Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (729 reviews)
The price is CA $113
CA $123 total
includes taxes & fees
Jun 28 - Jun 29

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
8.6 out of 10, Excellent, (248 reviews)
The price is CA $111
CA $122 total
includes taxes & fees
Jun 29 - Jun 30

Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (235 reviews)
The price is CA $167
CA $184 total
includes taxes & fees
Jun 18 - Jun 19

Carolina Camp Cedar
Carolina Camp CedarPickens
10.0 out of 10, Exceptional, (3 reviews)
The price is CA $222
CA $362 total
includes taxes & fees
Jun 11 - Jun 12

Inn on the Square, an Ascend Collection Hotel
Inn on the Square, an Ascend Collection HotelUptown Greenwood
9.2 out of 10, Wonderful, (744 reviews)
The price is CA $162
CA $180 total
includes taxes & fees
Jun 28 - Jun 29

Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
9.2 out of 10, Wonderful, (1,506 reviews)
The price is CA $114
CA $125 total
includes taxes & fees
Jun 14 - Jun 15

Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (463 reviews)
The price is CA $194
CA $211 total
includes taxes & fees
Jun 11 - Jun 12

Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,004 reviews)
The price is CA $194
CA $215 total
includes taxes & fees
Jul 1 - Jul 2

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (624 reviews)
The price is CA $153
CA $170 total
includes taxes & fees
Jul 4 - Jul 5

Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (845 reviews)
The price is CA $142
CA $156 total
includes taxes & fees
Jun 18 - Jun 19

Hampton Inn & Suites Clinton - I-26
Hampton Inn & Suites Clinton - I-26Clinton
9.0 out of 10, Wonderful, (744 reviews)
The price is CA $167
CA $187 total
includes taxes & fees
Jul 7 - Jul 8

The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown ClemsonClemson
9.8 out of 10, Exceptional, (813 reviews)
The price is CA $195
CA $217 total
includes taxes & fees
Jun 16 - Jun 17
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Upstate South Carolina
Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (78 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Learn more about Upstate South Carolina
Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

Photo by Ryan Watts
Open Photo by Ryan Watts
More cheap stays in Upstate South Carolina

Sleep Inn Spartanburg Southwest
501 South Blackstock Rd Spartanburg SC
The price is CA $86 per night from Jul 10 to Jul 11
CA $86
CA $96 total
Jul 10 - Jul 11
includes taxes & fees
6/10 (614 reviews)
Hotels in Upstate South Carolina with star rating

4 Star Hotels
36 properties
Explore a world of travel with Expedia
- Anglewood Hotels
- Hotels near BMW Performance Center
- Hotels near Converse College
- Cross Anchor Hotels
- Spartanburg County Hotels
- Duncan Hotels
- Aparthotels in Enoree
- B&B in Enoree
- Cheap Hotels in Enoree
- Enoree Hotels
- Aparthotels in Fingerville
- Fingerville Hotels
- Five Forks Hotels
- Cheap Hotels in Fountain Inn
- Fountain Inn Hotels
- Motels in Fountain Inn
- Gray Court Hotels
- Hotels near Greenville-Spartanburg Intl.
- Hotels near Heritage Park
- Lyman Hotels
- Moore Hotels
- Farmstay in Pauline
- B&B in Pauline
- Pauline Hotels
- B&B in Reidville
- Guest Houses in Reidville
- Reidville Hotels
- Farmstay in Roebuck
- Luxury Hotels in Roebuck
- Roebuck Hotels
- Simpsonville Hotels
- Southern Shops Hotels
- Hotels near Spartanburg Downtown Memorial
- Spartanburg Historic District Hotels
- Spartanburg Hotels
- Hotels near Spartanburg Regional Hospital
- Hotels near Spartanburg Station
- Hotels near Tyger River Park
- Una Hotels
- Hotels near WestGate Mall
- Hotels near Wofford College
- B&B in Woodruff
- Cheap Hotels in Woodruff
- Woodruff Hotels
- Motels in Woodruff
- Flights to Cross Anchor
- Flights to Roebuck
- Flights to Woodruff
- Flights from Pauline
- Flights from Gray Court
- Flights from Cross Anchor
- Flights from Moore
- Flights from Roebuck
- Flights from Fountain Inn
- Flights from Aiken (AIK) to Spartanburg (SPA)
- Flights from Atlanta (ATL) to Spartanburg (SPA)
- Flights from Asheville (AVL) to Spartanburg (SPA)
- Flights from Bradford (BFD) to Spartanburg (SPA)
- Flights from Battle Creek (BTL) to Spartanburg (SPA)
- Flights from Bowling Green (BWG) to Spartanburg (SPA)
- Flights from North Myrtle Beach (CRE) to Spartanburg (SPA)
- Flights from Charleston (CRW) to Spartanburg (SPA)
- Flights from Washington (DCA) to Spartanburg (SPA)
- Flights from Elmira (ELM) to Spartanburg (SPA)
- Flights from Fayetteville (FAY) to Spartanburg (SPA)
- Flights from Frederick (FDK) to Spartanburg (SPA)
- Flights from Greenville (GSP) to Spartanburg (SPA)
- Flights from New Haven (HVN) to Spartanburg (SPA)
- Flights from Niagara Falls (IAG) to Spartanburg (SPA)
- Flights from Kinston (ISO) to Spartanburg (SPA)
- Flights from Manville (JVI) to Spartanburg (SPA)
- Flights from Macon (MCN) to Spartanburg (SPA)
- Flights from Miami (MIA) to Spartanburg (SPA)
- Flights from Muscle Shoals (MSL) to Spartanburg (SPA)
- Flights from Minneapolis (MSP) to Spartanburg (SPA)
- Flights from Milan (MXP) to Spartanburg (SPA)
- Flights from Jacksonville (OAJ) to Spartanburg (SPA)
- Flights from Oakland (OAK) to Spartanburg (SPA)
- Flights from Owensboro (OWB) to Spartanburg (SPA)
- Flights from Portland (PDX) to Spartanburg (SPA)
- Flights from Philadelphia (PHL) to Spartanburg (SPA)
- Flights from Seattle (SEA) to Spartanburg (SPA)
- Flights from Syracuse (SYR) to Spartanburg (SPA)
- Flights from Teterboro (TEB) to Spartanburg (SPA)
- Flights from Tampa (TPA) to Spartanburg (SPA)
- Flights from Tri-Cities (TRI) to Spartanburg (SPA)
- Flights from Trenton (TTN) to Spartanburg (SPA)
- Flights from Tupelo (TUP) to Spartanburg (SPA)
- Flights from Tokyo (TYO) to Spartanburg (SPA)
- Flights from Valdosta (VLD) to Spartanburg (SPA)
- Flights from Halifax (YHZ) to Spartanburg (SPA)
- Flights from Montreal (YUL) to Spartanburg (SPA)
- Flights from Vancouver (YVR) to Spartanburg (SPA)
- Flights from Toronto (YYZ) to Spartanburg (SPA)






































































































































