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Our top choices for Upstate South Carolina hotels

1. Comfort Suites At WestGate Mall

Spartanburg

Kristina

CA $149 total

includes taxes & fees

Sep 1 - Sep 2

2. Tru by Hilton Spartanburg

Spartanburg

Jeremy

CA $165 total

includes taxes & fees

Aug 13 - Aug 14

3. Best Western Spartanburg I-26

Spartanburg

Francisco

CA $131 total

includes taxes & fees

Aug 10 - Aug 11

4. Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

Carole

CA $123 total

includes taxes & fees

Aug 16 - Aug 17

5. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG

Simpsonville

Alicia

CA $168 total

includes taxes & fees

Aug 14 - Aug 15

6. Clarion Greenville Airport Inn

Greenville

Mohamed Ayman

CA $108 total

includes taxes & fees

Sep 1 - Sep 2

7. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Sidney

CA $162 total

includes taxes & fees

Aug 9 - Aug 10

8. Hampton Inn & Suites Greenville/Spartanburg I-85, SC

Duncan

Kathy

CA $171 total

includes taxes & fees

Aug 20 - Aug 21

9. Spartanburg Marriott

Spartanburg

Katherine

CA $184 total

includes taxes & fees

Aug 16 - Aug 17

10. Four Points by Sheraton Spartanburg

Spartanburg

Susan

CA $185 total

includes taxes & fees

Aug 16 - Aug 17

11. Courtyard by Marriott Greenville Mauldin

Greenville

sarah

CA $168 total

includes taxes & fees

Aug 9 - Aug 10

3 restaurants; breakfast and dinner served

12. AC Hotel by Marriott Spartanburg

Spartanburg

shannon

CA $232 total

includes taxes & fees

Aug 16 - Aug 17

13. Hampton Inn Greer Greenville, SC

Greer

Teresa

CA $212 total

includes taxes & fees

Aug 9 - Aug 10

14. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Kelley

CA $141 total

includes taxes & fees

Aug 13 - Aug 14

15. Holiday Inn Express I-26 & Us 29 At Westgate Mall by IHG

Spartanburg

Skylyn

CA $171 total

includes taxes & fees

Aug 9 - Aug 10

16. Hilton Garden Inn Spartanburg

Spartanburg

Stan

CA $184 total

includes taxes & fees

Aug 9 - Aug 10

17. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Angela

CA $155 total

includes taxes & fees

Aug 16 - Aug 17

18. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall

Spartanburg

Chris

CA $171 total

includes taxes & fees

Aug 23 - Aug 24

19. Greenville Marriott

Greenville

John

CA $167 total

includes taxes & fees

Aug 14 - Aug 15

20. Comfort Suites Greenville Airport

Greenville

Chandler

CA $157 total

includes taxes & fees

Aug 23 - Aug 24

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Vacation Rentals in Upstate South Carolina

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area

Mint House Greenville Downtown by Kasa

Greenville Downtown

"We had a great time, very close to eating and shopping. The amenities were very helpful and we felt the area was very safe. We had an issue with getting a ticket even though we paid for parking but it was taken care of within an hour!"

Aparthotel

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Aparthotel

Coffee/tea maker, full-size fridge, microwave, oven

stayAPT Suites Greenville-Haywood Mall

Greenville

"All the staff from front desk to housekeeping were excellent, friendly and helpful. If looking for rooms with a feel like home StayApt is what you are looking for. I recommend reserving here great place if you want to cook your own meals"

Apartment

Landing Apartments Greer - Sugar Creek

Greer

"The apartment was clean. Excellent value for stay. Amenities were great. Will book again!"

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

4 Seasons of Fun! Walhalla Home w/ Spacious Yard!

Walhalla

"Check-in and out was seamless. The rental operators were easily reachable and responsive. The house was well appointed and very comfortable. The house has been nicely renovated and the kitchen was amazing. The master bathroom was beautiful and the shower was enviable. The location was at once pleasantly remote, and yet very close to everything we wanted to explore. It happened to rain the whole holiday weekend we visited, but the comfortableness house made it so that wasn’t a loss at all....

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Venture to sights like Martin Farm and Discovery Island Water Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

A multi-tiered waterfall cascading over rocks in a forested area.

Top Upstate South Carolina Hotel Reviews

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

10/10 Excellent

"I had a wonderful experience. Especially the house keeping staff! They went above and beyond to help me! I truly enjoyed the experience!! 10/10"

Lakeside Lodge Clemson

10/10 Excellent

"Well I'm not sure about all the other so-called subpar reviews on here but I've stayed at many a place over the years and I certainly would ranked this very nice. We had a maintenance issue which really turned out to be not true issue at all, it's more like how the plumbing is arranged for the hot water stands for cold and cold as hot but the maintenance man came right up check it without any problem. There was no noise during the night and there were no bugs to speak of whatsoever. The accommodation for comfortable the bed was very comfortable, the water pressure was acceptable, and they were plenty of utensils and fairly good stock kitchen. The only thing I would make changes to is the television was out of date and was not a smart TV, I went also add a ceiling fan to the room due to the vaulted ceiling. The restaurant could use a little help but the food selection which was mediocre at best. While edible it was not worth the price charged. I believe that that's a separate issue from the hotel itself."