Title: Visit Santiago del Estero Province: Best of Santiago del Estero Province Tourism | Expedia Travel Guide - Expedia.ca [Santiago del Estero Province Hotels](https://expedia.ca/Destinations-In-Santiago-Del-Estero-Province.d6232466.Hotel-Destinations)[Vacation Rentals in Santiago del Estero Province](https://expedia.ca/Destinations-In-Santiago-Del-Estero-Province.d6232466.Vacation-Rental-Destinations)[Santiago del Estero Province Flights](https://expedia.ca/Destinations-In-Santiago-Del-Estero-Province.d6232466.Flight-Destinations)[Santiago del Estero Province Car Rentals](https://expedia.ca/Destinations-In-Santiago-Del-Estero-Province.d6232466.Car-Rental-Destinations)[Santiago del Estero Province Vacations](https://expedia.ca/Santiago-Del-Estero-Province.d6232466.Destination-Travel-Guides) # Santiago del Estero Province ## Argentina ![Santiago del Estero which includes a luxury hotel or resort, a hotel and a pool](https://images.trvl-media.com/place/6232466/e3d9f8aa-6f4c-4448-a776-2a7bb13d0d1c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santiago del Estero which includes a luxury hotel or resort, a hotel and a pool](https://images.trvl-media.com/place/6232466/e3d9f8aa-6f4c-4448-a776-2a7bb13d0d1c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Santiago del Estero which includes a luxury hotel or resort, a pool and mist or fog](https://images.trvl-media.com/place/6232466/ecfb55b6-862d-4c7a-ac28-7ea3393e6853.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) #### Experience thermal baths, fishing tours and intriguing towns in this area steeped in anthropological history and wild parklands. Venture into South American history at Santiago del Estero, an expanse of colonial Spanish townships and natural playgrounds. The region stretches across 52,500 square miles (136,000 square kilometers) of northern Argentina. Come here to enjoy a laid-back atmosphere, architectural heritage and fishing estuaries. Make your base in the province's main township, which shares the name Santiago del Estero. This town was founded in 1553 after a visit by Spanish conquistador Diego de Rojas. Admire its Cathedral Basilica, which has a gorgeous façade towering over the main plaza. Stroll across the Plaza Libertad or enjoy the peaceful ambiance of Aguirre Park, which is decorated with stone fountains and eucalyptus trees. Learn about the province's history at the Bicentenary Cultural Center, where you'll see pre-Columbian ceramics, prehistoric fossils and a collection of Argentinean paintings. Delve into Santiago del Estero's religious heritage at the Museum of Sacred Art, which exhibits clothing of Franciscan monks, among other 16th-century relics. Visit Termas de Rio Hondo, a lakeside town built around the thermal pools of the Hondo River. Relax in these medicinal waters before enjoying a massage. Afterward, see 6,000-year-old human relics and animal fossils dating back 5 million years at the Municipal Museum of Rincon de Atacama. Travel to the Quiroga Dike, a temperate lake just a short drive from Santiago del Estero, to fish and enjoy Argentina's dynamic natural landscape. Dorado fishing trips along the Salado and Dulce rivers are also very popular in spring and summer. Santiago del Estero is accessible via its main town's airport. Get around using a rented car or use inexpensive buses. Expect warm weather the province's subtropical location keeps temperatures high year-round. A large portion of the Santiago del Estero province is covered by the Copo National Park, which spans 282,300 acres (114,200 hectares) of the Dry Chacho Region. Hike though extraordinary grasslands and look for rare wildlife including the giant armadillo and the skunk pig. ### Popular cities in Santiago del Estero Province [Termas de Rio Hondo Known for Natural parks, Nature and Museums ](https://expedia.ca/Termas-De-Rio-Hondo.dx6159820) Escape to Termas de Rio Hondo! Enjoy its parks and museums. [Explore city](https://expedia.ca/Termas-De-Rio-Hondo.dx6159820)[Find hotels](https://expedia.ca/Termas-De-Rio-Hondo-Hotels.d6159820.Travel-Guide-Hotels) [Santiago del Estero Known for Spas, Business and Culture ](https://expedia.ca/Santiago-Del-Estero.dx3107) Learn about the colonial culture of the country’s oldest city, founded by Spanish colonists and still going strong after almost five centuries. [Explore city](https://expedia.ca/Santiago-Del-Estero.dx3107)[Find hotels](https://expedia.ca/Santiago-Del-Estero-Hotels.d3107.Travel-Guide-Hotels) [San Pedro ](https://expedia.ca/San-Pedro.dx553248635924012661) Plan your trip to San Pedro and take advantage of the sights and activities in the area. [Explore city](https://expedia.ca/San-Pedro.dx553248635924012661)[Find hotels](https://expedia.ca/San-Pedro-Hotels.d553248635924012661.Travel-Guide-Hotels) [La Banda ](https://expedia.ca/La-Banda.dx6348181) Head to Casa de Gobierno and Plaza Libertad—just two of the sights around La Banda. [Explore city](https://expedia.ca/La-Banda.dx6348181)[Find hotels](https://expedia.ca/La-Banda-Hotels.d6348181.Travel-Guide-Hotels) [Colonia Dora ](https://expedia.ca/Colonia-Dora.dx3000429743) Venture to Centro Cultural Monseñor Jorge Gottau—just one of the sights to explore around Colonia Dora. [Explore city](https://expedia.ca/Colonia-Dora.dx3000429743)[Find hotels](https://expedia.ca/Colonia-Dora-Hotels.d3000429743.Travel-Guide-Hotels) [Quimilí ](https://expedia.ca/Quimili.dx553248635964996810) During your stay in Quimilí, you can discover things to see and do in the local area. [Explore city](https://expedia.ca/Quimili.dx553248635964996810)[Find hotels](https://expedia.ca/Quimili-Hotels.d553248635964996810.Travel-Guide-Hotels) ## Cities in Santiago del Estero Province ![Government House. Santiago del Estero. Argentina.](https://images.trvl-media.com/place/3107/5597c51f-4875-4ad5-801c-9eebf927b11d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Santiago del Estero Learn about the colonial culture of the country’s oldest city, founded by Spanish colonists and still going strong after almost five centuries. ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 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