Title: The 10 Best Hotels Near Sanctuary of Guadalupe, Piedras Negras from CA $104 | Expedia.ca [Piedras Negras Travel Guide](https://expedia.ca/Piedras-Negras.dx6052600)[Vacation Rentals in Piedras Negras](https://expedia.ca/Piedras-Negras-Vacation-Rentals.d6052600.Travel-Guide-VacationRentals)[Sanctuary of Guadalupe Car Rentals](https://expedia.ca/Car-Rentals-In-Sanctuary-Of-Guadalupe.d6276699.Car-Rental-Guide)[Sanctuary of Guadalupe Vacations](https://expedia.ca/Sanctuary-Of-Guadalupe-Piedras-Negras.d6276699.Vacation-Attraction) ![Sanctuary of Our Lady of Guadalupe in Guadalajara - Jalisco, Mexico](https://images.trvl-media.com/place/6276699/ac123695-417f-4f46-992b-709a96a66321.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6276699/ac123695-417f-4f46-992b-709a96a66321.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Apr 5 - Apr 6](https://www.expedia.ca/Hotel-Search?regionId=6276699&startDate=2026-04-05&endDate=2026-04-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 6 - Apr 7](https://www.expedia.ca/Hotel-Search?regionId=6276699&startDate=2026-04-06&endDate=2026-04-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=6276699&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 17 - Apr 19](https://www.expedia.ca/Hotel-Search?regionId=6276699&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Sanctuary of Guadalupe hotels ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/b331987e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/c50920ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/06527b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/50e27a3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Autel Rio Inn Luxury Inns [](https://www.expedia.ca/Piedras-Negras-Hotels-Autel-Rio-Inn-Luxury-Inns.h15490085.Hotel-Information) 0.3 km from Sanctuary of Guadalupe 8.0/10 Very good (278 reviews) "Located a block from downtown shopping that is easy to walk and not be bothered with traffic. It provides shade and entertainment plus free breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roberto CA $109 CA $130 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Piedras-Negras-Hotels-Autel-Rio-Inn-Luxury-Inns.h15490085.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/424db3e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/d0af41c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/078de1de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/3a53d6b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Piedras Negras [](https://www.expedia.ca/Piedras-Negras-Hotels-Days-Inn-By-Wyndham-Piedras-Negras.h35812618.Hotel-Information) 1.4 km from Sanctuary of Guadalupe 8.4/10 Very good (423 reviews) "Everything for our stay was great! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rosa CA $116 CA $139 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Piedras-Negras-Hotels-Days-Inn-By-Wyndham-Piedras-Negras.h35812618.Hotel-Information) ![Standard Room](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/bcc73c39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/6edec5f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/0a3f746b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/1e60a0d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Yolotl Sleep Experience [](https://www.expedia.ca/Piedras-Negras-Hotels-Yolotl-Sleep-Experience.h98435861.Hotel-Information) 1.3 km from Sanctuary of Guadalupe 7.4/10 Good (58 reviews) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose CA $87 CA $104 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Piedras-Negras-Hotels-Yolotl-Sleep-Experience.h98435861.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/cbdbc155.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/e21fc0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/08a921af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/f5d8e75f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Piedras Negras by IHG [](https://www.expedia.ca/Piedras-Negras-Hotels-Holiday-Inn-Express-Piedras-Negras.h687851.Hotel-Information) 3.2 km from Sanctuary of Guadalupe 9.0/10 Wonderful (397 reviews) "Breakfast was delicious, the room was clean, ac worked great, and staff was very friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda CA $158 CA $176 total includes taxes & fees Apr 10 - Apr 11 [](https://www.expedia.ca/Piedras-Negras-Hotels-Holiday-Inn-Express-Piedras-Negras.h687851.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/de26f15b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/538a9cf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/0f62cb12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/c62cf005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### QUINTA SAN CARLOS INN [](https://www.expedia.ca/Piedras-Negras-Hotels-QUINTA-SAN-CARLOS-INN.h41980680.Hotel-Information) 3.2 km from Sanctuary of Guadalupe 9.0/10 Wonderful (4 reviews) "muy buen lugar para descansar " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Emmanuel Alejandro CA $111 CA $133 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Piedras-Negras-Hotels-QUINTA-SAN-CARLOS-INN.h41980680.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/7ed133af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/0f23b784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/8b3424ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/1ecfb893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Piedras Negras [](https://www.expedia.ca/Piedras-Negras-Hotels-Quality-Inn-Piedras-Negras.h78138.Hotel-Information) 3.8 km from Sanctuary of Guadalupe 8.6/10 Excellent (537 reviews) "Clean room, comfortable beds, safe and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martha CA $126 CA $140 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Piedras-Negras-Hotels-Quality-Inn-Piedras-Negras.h78138.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/e2db00af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/a15d6725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/87e7ea2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/46afe873.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn by Hilton Piedras Negras [](https://www.expedia.ca/Piedras-Negras-Hotels-Hampton-Inn-By-Hilton-Piedras-Negras.h15431578.Hotel-Information) 4.8 km from Sanctuary of Guadalupe 9.4/10 Exceptional (959 reviews) "great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) RODRIGO CA $171 CA $190 total includes taxes & fees Apr 11 - Apr 12 [](https://www.expedia.ca/Piedras-Negras-Hotels-Hampton-Inn-By-Hilton-Piedras-Negras.h15431578.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/e42eea97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/db6c7230.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/602379a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 Queen Bed with Sofa bed](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/ffa761b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City Express by Marriott Piedras Negras [](https://www.expedia.ca/Piedras-Negras-Hotels-City-Express-Piedras-Negras.h15380105.Hotel-Information) 4 km from Sanctuary of Guadalupe 8.6/10 Excellent (808 reviews) "Nearby shopping centers. The family was great and felt welcoming. Pet friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Betsy CA $127 CA $141 total includes taxes & fees Apr 26 - Apr 27 [](https://www.expedia.ca/Piedras-Negras-Hotels-City-Express-Piedras-Negras.h15380105.Hotel-Information) ![Standard Room](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/22fdeb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/b1bf2382.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/3af0637a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/45000000/44050000/44044000/44043969/4f6a82c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Herederos Hotel Piedras Negras [](https://www.expedia.ca/Piedras-Negras-Hotels-Hotel-Herederos.h44043969.Hotel-Information) 3.9 km from Sanctuary of Guadalupe 7.2/10 Good (1,000 reviews) "It was a peaceful stay and the complementary breakfast was outstanding 100/100" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Angela CA $109 CA $130 total includes taxes & fees Apr 8 - Apr 9 [](https://www.expedia.ca/Piedras-Negras-Hotels-Hotel-Herederos.h44043969.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-19&endDate=2026-04-20®ionId=6276699&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels close to Sanctuary of Guadalupe | Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | ----------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/b331987e.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Autel Rio Inn Luxury Inns | 3.0 star property | 8.0Very good278 reviews | View | | | | | | | ![Outdoor pool](https://images.trvl-media.com/lodging/36000000/35820000/35812700/35812618/424db3e0.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Days Inn by Wyndham Piedras Negras | 3.0 star property | 8.4Very good423 reviews | View | | | | | | | ![Standard Room](https://images.trvl-media.com/lodging/99000000/98440000/98435900/98435861/bcc73c39.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Yolotl Sleep Experience | 2.0 star property | 7.4Good58 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/cbdbc155.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Holiday Inn Express Piedras Negras by IHG | 3.0 star property | 9.0Wonderful397 reviews | View | | | | | | | ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/42000000/41990000/41980700/41980680/de26f15b.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)QUINTA SAN CARLOS INN | 2.5 star property | 9.0Wonderful4 reviews | View | | | | | | ## Top Sanctuary of Guadalupe Hotel Reviews ![Holiday Inn Express Piedras Negras by IHG](https://images.trvl-media.com/lodging/1000000/690000/687900/687851/cbdbc155_y.jpg) ### Holiday Inn Express Piedras Negras by IHG 10/10 Excellent "great services" [](https://expedia.ca/Piedras-Negras-Hotels-Holiday-Inn-Express-Piedras-Negras.h687851.Hotel-Information) ![Hampton Inn by Hilton Piedras Negras](https://images.trvl-media.com/lodging/16000000/15440000/15431600/15431578/e2db00af_y.jpg) ### Hampton Inn by Hilton Piedras Negras 10/10 Excellent "El desayuno estaba excelente , el servicio , muy muy limpio tranquilo y en un lugar donde puedes salir a comprar fácilmente ! Definitivamente regresaría gracias " [](https://expedia.ca/Piedras-Negras-Hotels-Hampton-Inn-By-Hilton-Piedras-Negras.h15431578.Hotel-Information) ![Autel Rio Inn Luxury Inns](https://images.trvl-media.com/lodging/16000000/15500000/15490100/15490085/b331987e_y.jpg) ### Autel Rio Inn Luxury Inns 10/10 Excellent "Located a block from downtown shopping that is easy to walk and not be bothered with traffic. It provides shade and entertainment plus free breakfast!" [](https://expedia.ca/Piedras-Negras-Hotels-Autel-Rio-Inn-Luxury-Inns.h15490085.Hotel-Information) ![City Express by Marriott Piedras Negras](https://images.trvl-media.com/lodging/16000000/15390000/15380200/15380105/e42eea97_y.jpg) ### City Express by Marriott Piedras Negras 6/10 Okay "This is not a luxury hotel, but I am not on vacation. I am traveling from point A to point B and need a clean, safe place to spend the night. This hotel meets those needs. My only complaint is that there was no hot water in the shower - there was only cold and less cold. Don't understand why that was the case since there was hot water from the bathroom sink." [](https://expedia.ca/Piedras-Negras-Hotels-City-Express-Piedras-Negras.h15380105.Hotel-Information) ![Quality Inn Piedras Negras](https://images.trvl-media.com/lodging/1000000/80000/78200/78138/7ed133af_y.jpg) ### Quality Inn Piedras Negras 10/10 Excellent "Everything was excellent " [](https://expedia.ca/Piedras-Negras-Hotels-Quality-Inn-Piedras-Negras.h78138.Hotel-Information) ![Spacious 3-bedroom house in serene Piedras Negras with AC and pool](https://images.trvl-media.com/lodging/122000000/121280000/121277000/121276963/3da7031d_y.jpg) ### Spacious 3-bedroom house in serene Piedras Negras with AC and pool 10/10 Excellent "our host was very responsive " [](https://expedia.ca/Piedras-Negras-Hotels-Spacious-3-Bedroom-House-In-Serene-Piedras-Negras-With-AC-And-Pool.h121276963.Hotel-Information) ## Hotels near other Sanctuary of Guadalupe attractions ### Gran Plaza 4.2/5 (302 reviews) Learn about the local history of Piedras Negras when you spend time at Gran Plaza. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6276692) ### Museo de la Frontera Norte You can spend time exploring the galleries in Museo de la Frontera Norte during your travels in Piedras Negras. You can enjoy the restaurants while in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=956848376843145216) ### Eagle Pass International Bridge I Eagle Pass International Bridge I is just one of the places to see in Eagle Pass, so why not enjoy the other things to explore during your travels? Check out the casinos and top-notch restaurants in this relaxing area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=951034639462883328) ### Piedras Negras River Walk After visiting Piedras Negras River Walk, make a plan to see the other sights and activities in Piedras Negras. You can enjoy the restaurants while in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=956848816743837696) ### Eagle Pass Golf Course 3.8/5 (236 reviews) Enjoy a round of golf in Eagle Pass at Eagle Pass Golf Course. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6277120) ### Fort Duncan Museum 3.9/5 (216 reviews) You can spend time studying the exhibits at Fort Duncan Museum during your travels in Eagle Pass. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6303588) ### City of Eagle Pass Art And Culture Center Enjoy an outing to City of Eagle Pass Art And Culture Center during your stay in Eagle Pass. Check out the casinos and top-notch restaurants in this relaxing area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=1001622594174431232) ### Three Cultures Square 4.4/5 (206 reviews) Enjoy an outing to Three Cultures Square during your stay in Piedras Negras. While in this relaxing area, find time to visit its casinos. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6276688) ## Frequently asked questions ### What's the area like around Sanctuary of Guadalupe? ### What's the best place to stay close to Sanctuary of Guadalupe? ### How many hotels can I expect to find near Sanctuary of Guadalupe? ### If I need to cancel the hotel reservation for my stay near Sanctuary of Guadalupe, will I receive a refund? ### What can I see and do near Sanctuary of Guadalupe?