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A coastal resort with beachfront villas and a clear blue sky.

Search Lodges in Panacea from CA $155

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    Recommended hotels in Panacea

    1. The Panacea Motel

    A pink door with a window, set in a corrugated metal exterior with wooden trim.

    2. Cozy Panacea Retreat #3 (King)

    A tree silhouetted against a sunset sky, a body of water, and a snowy landscape.

    3. romantic get away for 2 right on the Ochlockonee river

    A cozy living room with a brown leather sofa, a dining table set with plates, and a view of the sea through large windows.

    4. Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat

    A modern kitchen with a wooden countertop, a built-in sink, and a dining area with a table and chairs.

    5. Tiny Tides Waterfront Cottage

    A covered outdoor area with a wooden deck, white furniture, and a view of the water.

    6. Private beach winter escape on the bay with fishing and kayaks

    A dock extending into a body of water with a covered structure at the end.

    7. Point & Paddle Waterfront Retreat @Alligator Point

    A porch with wicker chairs and a small table, overlooking a lake and trees.

    8. Queen Kitchenette by the Bay #16

    A wooden bench in a natural setting with a lake and trees in the background.

    9. 09) Queen Kitchenette by the Bay

    A wooden bench in a natural setting with a lake and trees in the background.

    10. Queen Kitchenette by the Bay #13

    A wooden bench in a natural setting with a lake and trees in the background.

    11. Cozy Panacea Retreat #3 (King)

    A wooden bench in a natural setting with a lake and trees in the background.

    12. Queen Kitchenette by the Bay #10

    A wooden bench in a natural setting with a lake and trees in the background.

    13. Perfect Panacea 1 Bedroom Apt, #2

    A wooden bench in a natural setting with a lake and trees in the background.

    14. Queen Kitchenette by the Bay #15

    A wooden bench in a natural setting with a lake and trees in the background.

    15. Queen Kitchenette by the Bay #11

    A wooden bench in a natural setting with a lake and trees in the background.

    16. Queen Kitchenette by the Bay #14

    A wooden bench in a natural setting with a lake and trees in the background.

    17. Cozy Panacea Retreat #7 (King)

    A wooden bench in a natural setting with a lake and trees in the background.

    18. The Best Beach-Front House “Get-A-Way” in Florida

    A wooden deck with wicker chairs and a long table, overlooking a beach and ocean.

    19. Breezy Home w/ Grills, Pool & Beach Access!

    A wooden boardwalk surrounded by lush green vegetation and tall trees.

    20. Queen Kitchenette by the Bay #8

    A wooden bench in a natural setting with a lake and trees in the background.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Learn more about Panacea

    Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

    See all hotels in Panacea

    A coastal resort with beachfront villas and a clear blue sky.

    Top reviews in Panacea

    Best Western Wakulla Inn & Suites

    A fountain with a dolphin statue in a courtyard, surrounded by buildings with arched windows and a pool with blue mosaic tiles.

    Wildwood Inn

    A spacious indoor area with tiled flooring, multiple tables and chairs, a stone fireplace, and a glass door entrance.

    St James Bay Golf & Pickleball Resort

    A bar area with a long counter, stools, and a variety of bottles and glasses.

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