Title: O Brien Vacation Packages & Trips 2026 from CA $875 | Expedia.ca [Hotels in O Brien](https://expedia.ca/O-Brien-Hotels.d3000431472.Travel-Guide-Hotels)[Vacation Rentals in O Brien](https://expedia.ca/O-Brien-Vacation-Rentals.d3000431472.Travel-Guide-VacationRentals)[O Brien Car Rentals](https://expedia.ca/Car-Rentals-In-O-Brien.d3000431472.Car-Rental-Guide) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # O Brien Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Top O Brien Vacation Deals Price found within the past 48 hours. Click for updated prices. ![Nature Coast Inn and Cottages](https://images.trvl-media.com/lodging/90000000/89340000/89338300/89338219/fba14b3d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Nature Coast Inn and Cottages CA $875 per person Mar 11 - Mar 18 found 1 day ago Roundtrip non-stop flight included Québec (YQB) to Gainesville (GNV) 9.2/10 Wonderful! (94 reviews) The room was very clean. The grounds had a nice set of adult swings, we sat out each night. And the beds were great Reviewed on Jan 25, 2026 ![Quality Inn near Manatee Springs State Park](https://images.trvl-media.com/lodging/1000000/10000/3800/3774/4b965efb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Quality Inn near Manatee Springs State Park CA $962 per person Mar 11 - Mar 18 found 1 day ago Roundtrip non-stop flight included Québec (YQB) to Gainesville (GNV) 7.6/10 Good! (858 reviews) The room were clean the staff were friendly overall it was a great Thanksgiving weekend Reviewed on Jan 29, 2026 ![Days Inn by Wyndham Chiefland](https://images.trvl-media.com/lodging/1000000/60000/52900/52826/c5ad8776_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Days Inn by Wyndham Chiefland CA $921 per person Mar 11 - Mar 18 found 1 day ago Roundtrip non-stop flight included Québec (YQB) to Gainesville (GNV) 6/10 (1,000 reviews) Room not well maintained but the hotel was in a safe area and everything worked Reviewed on Jan 27, 2026 ## Ready to book your vacation to O Brien? Choose your dates ## O Brien Hotel Deals ![Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!](https://images.trvl-media.com/lodging/92000000/91440000/91435900/91435872/c7d330d9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! obrien FL 9.8/10 Exceptional! (33 reviews) Very welcoming and personable hosts. They came over to relatives house and had dinner with us. Very relaxed environment with family and friends. Reviewed on Jan 11, 2026 [Get rates](https://expedia.ca/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=91435872&PinnedHotelID=91435872&HadPinnedHotel=true®ionId=3000431472) [](https://expedia.ca/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=91435872&PinnedHotelID=91435872&HadPinnedHotel=true®ionId=3000431472) ![Holiday Inn Express & Suites Alachua - Gainesville Area by IHG](https://images.trvl-media.com/lodging/23000000/22860000/22858300/22858269/e851cfaf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Holiday Inn Express & Suites Alachua - Gainesville Area by IHG 16367 NW 167TH BLVD Alachua FL Fully refundable CA $148 CA $166 total Feb 22 - Feb 23 includes taxes & fees 9.4/10 Exceptional! (1,000 reviews) Room was spotless and staff was great. Reviewed on Feb 2, 2026 [](https://expedia.ca/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=22858269&PinnedHotelID=22858269&HadPinnedHotel=true®ionId=3000431472) ![La Quinta Inn & Suite by Wyndham Lake City](https://images.trvl-media.com/lodging/49000000/48290000/48281500/48281488/2886b571_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Quinta Inn & Suite by Wyndham Lake City 165NW CALI DRIVE Lake City FL Fully refundableReserve now, pay when you stay CA $143 CA $161 total Feb 11 - Feb 12 includes taxes & fees 8.6/10 Excellent! (1,065 reviews) Very clean, and felt safe. Close to restaurants and quiet. Very nice hotel. Reviewed on Feb 1, 2026 [](https://expedia.ca/Hotel-Search?startDate=11%2F02%2F2026&endDate=12%2F02%2F2026&selected=48281488&PinnedHotelID=48281488&HadPinnedHotel=true®ionId=3000431472) [See all 355 properties in O Brien](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=09%2F02%2F2026&endDate=10%2F02%2F2026®ionId=3000431472) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## Explore a world of travel with Expedia \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app