Mytilene Vacation Packages

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    Save up to CA $1,096 when you book a flight and hotel together*
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Your Mytilene Vacation

Unforgettable adventures await when you lock in a Mytilene vacation package. Whether you're a history buff, foodie or just a traveler who loves to see new places, there's something for everyone in this exciting city. A trip to Mytilene is an excellent opportunity to do some sightseeing. Be sure to visit popular attractions like Mytilini Castle, University of the Aegean and Museum of the Memorial of the Refugees of 1922. Your Mytilene vacation is just clicks away. Explore hotels, airfares and more on Expedia for a trip that's tailored to suit your travel style.

Mytilene Beach Vacation

Get set to live out those beachy daydreams on your upcoming Mytilene vacation. Set off on a lovely stroll, take in the sweeping ocean views and collect unique seashells during your trip to Mytilene. Located just 10 kilometres from the city center, Thermi Beach is the place to be for many travelers. Look through our Mytilene packages and watch your travel budget stretch further!

Things You Should Know About Mytilene

  • If you want that beachside lifestyle, have a look at our Mytilene beach hotels. Beautiful water views and refreshing sea air — what more could anyone want?
  • Take a look at Sunrise Resort Hotel and Elysion Hotel. These hotels might just be perfect for your vacation in Mytilene.
  • There are plenty of activities that keep the 28,300 or so residents of Mytilene busy. A quick look at our Mytilene things to do page will let you in on everything this place has to offer.
  • If you're searching for things to do while you're in town, add University of the Aegean, Thermi Beach and Port of Mytilene to your travel schedule. Also, take a look at our Mytilene vacation deals to save money on your experiences, hotels and more.

Ready to book your vacation to Mytilene?

 

Choose your dates

Mytilene Hotel Deals

Mythical Coast Wellness Retreat

Mythical Coast Wellness Retreat

5 out of 5
Agrilia, Lesvos
The price is CA $178 per night from Sep 8 to Sep 9
CA $178
CA $219 total
Sep 8 - Sep 9
includes taxes & fees
8.6/10 Excellent! (39 reviews)
"Very average but nice and quiet. Would rate it a 3 star hotel. Service very bland. No smiles. Dinner overpriced, took a very long time and was underwhelming. We were put at a table in the lobby because the restaurant was closed for an event. Room was clean. But very cheap low grade 1 star hotel amenities ..."

Reviewed on Nov. 2, 2024

Mythical Coast Wellness Retreat
Heliotrope Hotels

Heliotrope Hotels

4 out of 5
Varia, Mytilene, Lesvos, Lesvos Island
Fully refundableReserve now, pay when you stay
The price is CA $226 per night from Aug 24 to Aug 25
CA $226
CA $264 total
Aug 24 - Aug 25
includes taxes & fees
8.4/10 Very Good! (185 reviews)
"Great people. Beautiful island"

Reviewed on Jul. 21, 2025

Heliotrope Hotels
Theofilos Paradise Boutique Hotel

Theofilos Paradise Boutique Hotel

4 out of 5
7, Skra str, Hatzidimitriou Park, Mytilene, Lesvos
The price is CA $216 per night from Sep 9 to Sep 10
CA $216
CA $258 total
Sep 9 - Sep 10
includes taxes & fees
9.6/10 Exceptional! (152 reviews)
"For a small island seperated from the mainland, this hotel exceeded my expectations. Clean, spacious rooms and the new, modern building made the difference. No mold or moldy smell in the rooms. Central AC cooled the rooms very quickly when needed. The bed was really comfortable. The hotel is situated ..."

Reviewed on Aug. 13, 2025

Theofilos Paradise Boutique Hotel
See all 164 properties in Mytilene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Mytilene vacation package cost?
You'll find cheap prices on Expedia for your Mytilene getaway. However, a range of factors like the length of stay, hotel choice and season will determine how much your vacation to Mytilene costs.
What are the cheapest months to go to Mytilene?
If you're looking to snag a cheap Mytilene vacation package, consider travelling in February, March and December. You're likely to find better rates on hotels and flights during these months — perfect for a budget-friendly getaway.
How many days is enough for Mytilene?
Allow around 3 days for your Mytilene vacation in order to enjoy everything that makes this place special. Wander around popular areas, including Pirgi and Loutra. Then tick off top sights such as Olive-press Museum of Archipelagos Society and Temple of Messon. With a good itinerary, you'll be kept busy with room for some downtime too. Want to venture beyond Mytilene? Consider fitting in an excursion or two.
Is it worth booking a vacation package to Mytilene?
Popular for its history, festivals and family-friendly attractions, a Mytilene vacation is a hit with all kinds of visitors. Be sure to check out leading sights like Olive-press Museum of Archipelagos Society and Temple of Messon, and consider renting some wheels for day trips to experience even more.
How to find the best Mytilene package deals?
Finding a cheap Mytilene package deal is a cinch with Expedia. After you've entered your destination and trip dates under our "Packages" tab, set your maximum budget, apply a couple of filters and browse what's available. You can customize your search by "Amenities," "Property type," "Traveller experience" and more. Order the results by "Price: low to high" to discover the most economical Mytilene package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider travelling on a weekday, when prices are usually lower.
Is it cheaper to book a Mytilene vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically snag a better deal than booking each component separately. And you'll still enjoy the freedom to create a personalized Mytilene vacation by choosing your favourite accommodation type, airline and car class.
When to book a vacation package to Mytilene?
If you're planning a spontaneous Mytilene adventure, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can land amazing deals on your hotels and flights by booking ahead.
How to plan a trip to Mytilene?

  1. Choose when to go: Check your schedule and get packing. Your preferred season and the type of activities available will also help you decide when to vacation in Mytilene.
  2. Figure out your budget: Make sure you have enough money to pay for everything from transportation and meals to flights and experiences. Your hotel will probably be the largest expense during your trip to Mytilene.
  3. Decide how long to go away for: Now that you're up to speed on Mytilene, you can work out the right length of your break. Create a draft itinerary and allocate enough time for all the things you want to do.
  4. Combine your hotel and flights: Epic destination, check. Length of stay, check. All that's left is to find a Mytilene vacation package that brings all your bookings together.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.