Name: Hotel Anastassiou
Price range: CA $69

Your Mesopotamia Vacation

Our vacation packages to Mesopotamia let you create your own adventure. Tailor your getaway to your style and interests and make the most of your time in this wonderful city. Fill your schedule with tours of Kastoria Lake, Kastoria Aquarium and Holy Prophet Elias Church, some of the top attractions you really should see during a trip to Mesopotamia. Your ideal Mesopotamia vacation is a few clicks away. Search airfares, hotels and more on Expedia for an adventure that's tailored to suit your style.

Top Mesopotamia Vacation Deals

Price found within the past 48 hours. Click for updated prices.

Davitel Tobacco Hotel

CA $1,230

per person

Sep 12 - Sep 14

found 17 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Thessaloniki (SKG)

8/10 Very good! (397 reviews)

Room was simple but clean, staff was courteous and helpful.

Reviewed on Jan 6, 2026

Sani Beach

CA $2,633

per person

Sep 16 - Sep 22

found 1 day ago

Roundtrip non-stop flight included

Toronto (YTO) to Thessaloniki (SKG)

9.8/10 Exceptional! (94 reviews)

Beautiful resort, with amazing facilities and friendly and helpful staff. Chris at Bousoulas beach was a stand out staff memeber. Excellent service and took care of our every needs. Christina, the front office manager went above and beyond to make sure our second visit was perfect. We will be returning next year indefinitely.

Reviewed on Jun 9, 2026

ON Residence

Thessaloniki City Centre

CA $1,320

per person

Sep 12 - Sep 14

found 17 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Thessaloniki (SKG)

9.8/10 Exceptional! (196 reviews)

Amazing boutique hotel experience. Would recommend 100% and would definitely stay again. It was clean, cute, amazing views of the water, excellent breakfast, friendly and knowledgeable staff. A 10/10

Reviewed on May 27, 2026

Capsis Bristol Boutique Hotel

Thessaloniki City Centre

CA $1,231

per person

Sep 12 - Sep 14

found 17 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Thessaloniki (SKG)

9/10 Wonderful! (140 reviews)

Very nice room. Very freindly and helpful staff. Excellent breakfast and evening meal menu.

Reviewed on Jun 19, 2026

The Excelsior Small Luxury Hotels of the World

Thessaloniki City Centre

CA $1,292

per person

Sep 12 - Sep 14

found 17 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Thessaloniki (SKG)

9.6/10 Exceptional! (429 reviews)

L’accueil attentif du personnel et la qualité de l’établissement quant au confort et aux petits-déjeuners rendent le séjour très agréable.

Reviewed on Jun 14, 2026

Ready to book your vacation to Mesopotamia?

Choose your dates

Mesopotamia Hotel Deals

To Spiti tis Sofias

Mesopotamia Kastoria Western Macedonia

Fully refundableReserve now, pay when you stay

CA $92

CA $108 total

Jul 15 - Jul 16

includes taxes & fees

10/10 Exceptional! (1 review)

Le meilleur de notre séjour

"Tout simplement le meilleur de notre voyage en Grèce. Simple mais tellement mieux qu'ailleurs. Accueil parfait, chambre confortable et petit déjeuner de roi. Je reviendrais à 100% si je passe dans le coin."

Reviewed on Aug 18, 2025

Limneon Resort & Spa

4th km National Road Kastoria Athens Kastoria

Fully refundableReserve now, pay when you stay

CA $136

CA $179 total

Jul 20 - Jul 21

includes taxes & fees

9.2/10 Wonderful! (204 reviews)

"We had only a one night stay but it was lovely. Outdoor pool and breakfast were nice, bed is comfortable. The indoor pool and sauna area really need updating. But they are usable."

Reviewed on Jun 21, 2026

Hotel Anastassiou

1st km Highway Kastoria-Athens Kastoria Western Macedonia

Fully refundableReserve now, pay when you stay

CA $69

CA $81 total

Jul 3 - Jul 4

includes taxes & fees

See all 49 properties in Mesopotamia

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.