Medical Center Area Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
  • Breakfast meal
    Jul 31 - Aug 3

    By the Sea Guests Bed & Breakfast & Suites + Flight

    Dennis Port
    3 nights
    3.5 star property
    9.2/10 - Wonderful (185 reviews)
    "."
    Reviewed October 16, 2025
    Roundtrip • Toronto (YTZ) - Boston (BOS)
    YTZ - BOS • Nonstop BOS - YYZ • Nonstop
    CA $1,461
    CA $970
    per traveller
    found 6 hours ago
    By the Sea Guests Bed & Breakfast & Suites
  • Suite, Multiple Beds (John Adams Presidential Suite)
    Aug 18 - Aug 23

    Boston Harbor Hotel + Flight

    North End
    5 nights
    5.0 star property
    9.8/10 - Exceptional (1,004 reviews)
    "Wonderful classic harbor front hotel. Very nice front desk. Would stay again"
    Reviewed May 25, 2026
    Roundtrip • Edmonton (YEG) - Boston (BOS)
    YEG - BOS • 1 stop BOS - YEG • 1 stop
    CA $4,426
    CA $2,301
    per traveller
    found 6 hours ago
    Boston Harbor Hotel
  • Reception
    Aug 1 - Aug 8

    The Inn at Hastings Park, Relais & Chateaux - Boston + Flight

    Lexington
    7 nights
    4.0 star property
    9.6/10 - Exceptional (256 reviews)
    "Splendid bed and breakfast"
    Reviewed April 29, 2026
    Roundtrip • Toronto (YTZ) - Boston (BOS)
    YTZ - BOS • Nonstop BOS - YTZ • Nonstop
    CA $3,275
    CA $2,014
    per traveller
    found 1 day ago
    The Inn at Hastings Park, Relais & Chateaux - Boston
  • Lobby
    Aug 18 - Aug 23

    Fairmont Copley Plaza, Boston + Flight

    Back Bay
    5 nights
    4.5 star property
    9.0/10 - Wonderful (1,243 reviews)
    "The property was very tired and not worth the price."
    Reviewed May 23, 2026
    Roundtrip • Edmonton (YEG) - Boston (BOS)
    YEG - BOS • 1 stop BOS - YEG • 1 stop
    CA $2,600
    CA $1,693
    per traveller
    found 6 hours ago
    Fairmont Copley Plaza, Boston
  • Breakfast, lunch and brunch served
    Jun 30 - Jul 3

    The Langham, Boston + Flight

    Downtown Boston
    3 nights
    5.0 star property
    9.8/10 - Exceptional (1,003 reviews)
    "Wonderful club level"
    Reviewed May 24, 2026
    Roundtrip • Edmonton (YEG) - Boston (BOS)
    YEG - BOS • 1 stop BOS - YEG • 1 stop
    CA $2,498
    CA $1,664
    per traveller
    found 1 day ago
    The Langham, Boston

Where to stay in Medical Center Area

Find the best Medical Center Area areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center Area
Downtown Boston

Downtown Boston

4.5/5(197 area reviews)

Densely packed with highrise buildings, this area boasts landmarks like Custom House Tower and is close to Quincy Market, Faneuil Hall, and the Old State House. Find headquarters of major banks, hotels, and investment firms here.

Find hotels in Downtown Boston

Medical Center Area Hotel Deals

Seaport Hotel Boston

Seaport Hotel Boston

4 out of 5
1 Seaport Lane Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $285 per night from May 29 to May 30
CA $285
CA $379 total
May 29 - May 30
includes taxes & fees
9.6/10 Exceptional! (4,369 reviews)
"Brianna at the front desk was excellent. Customer service is her middle name! GT"

Reviewed on May 25, 2026

Seaport Hotel Boston
The Revolution Hotel

The Revolution Hotel

3.5 out of 5
40 Berkeley Street Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $227 per night from Jun 7 to Jun 8
CA $227
CA $264 total
Jun 7 - Jun 8
includes taxes & fees
9/10 Wonderful! (2,632 reviews)
"Staff are friendly . Perfect hotel perfect distance from places I wanted to visit !"

Reviewed on May 24, 2026

The Revolution Hotel
Omni Boston Hotel at the Seaport

Omni Boston Hotel at the Seaport

5 out of 5
450 Summer Street Boston MA
Fully refundableReserve now, pay when you stay
The price is CA $248 per night from May 29 to May 30
CA $248
CA $345 total
May 29 - May 30
includes taxes & fees
9.2/10 Wonderful! (4,657 reviews)
"This hotel and the staff were impeccable!"

Reviewed on May 25, 2026

Omni Boston Hotel at the Seaport
See all 4,176 properties in Medical Center Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Medical Center Area vacation package cost?
From as little as , you can create your own Medical Center Area package the way you want. Simply bundle hotels, flights and car rentals and we'll reward you with discounts.
How do I get a cheap travel package to Medical Center Area?
Bundling your flight and hotel with Expedia won't just save precious time — it'll save you a nice amount too. A Medical Center Area vacation package makes it simple to arrange your ideal trip. With more than 550 airlines across the world to pick from, finding flights that fit your busy schedule will be no sweat. In addition to that, we have over 1,000,000 hotels globally to choose from. Now that's what you call choice. No matter who you are, Expedia puts the world within your reach.
Where should I stay in Medical Center Area?
Visitors come from all over the world to experience Fenway Park and TD Garden in Medical Center Area. Stay within walking distance of these top attractions to make sightseeing easy.
What are the top hotels in Medical Center Area?
If it's comfort and convenience you want, you can't beat The Inn at Longwood Medical. Spend your evenings relaxing here and your days roaming around Medical Center Area's finest sights.
How far in advance should I book my Medical Center Area vacation?
While prices change from time to time, we generally suggest booking your vacation as early as possible. Most international airfares can be compared on Expedia up to 12 months in advance. If you're booking last minute, you might still be in luck. Cheap journeys to Medical Center Area sometimes emerge only weeks before departure.
What does an Expedia Medical Center Area travel package include?
Packages include flights, rental cars and hotels, but you can combine any of them to create your dream Medical Center Area escape. You can also add on fun things like activities and experiences once you've made your booking. You're in control! When you bundle your bookings with Expedia, you'll get access to discounts you won't find elsewhere.
What should I know before booking a Medical Center Area travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've created your package, you can add on sightseeing tours or experiences. Your next awesome vacation is only a few clicks away.
Can I choose my airline with a Medical Center Area Expedia vacation package?
You certainly can. We offer more than 550 airline partners across the globe, so fly with the carrier that's a good fit for your needs.
If I'm not able to travel, can I cancel my Medical Center Area vacation package?
If your travel plans in Medical Center Area have changed, it's good to know that you can amend or cancel your booking. If you made your booking within the last 24 hours, you may be eligible to receive a refund. If your booking was made more than 24 hours ago, your airline, hotel or car rental company may charge a cancellation fee. For more information, visit our Customer Service Portal.

Discover the most popular places to visit in Medical Center Area

Isabella Stewart Gardner Museum

Isabella Stewart Gardner Museum

A world-renowned private collection of art and cultural treasures awaits at this small yet lavish museum.

Isabella Stewart Gardner Museum

Dana-Farber Cancer Institute

Though Dana-Farber Cancer Institute might be what brings you to town, perhaps you'll have a chance to explore more of Boston while you are here.

Dana-Farber Cancer Institute

Things to do

Boston Hop-On Hop-Off Trolley Tour

Boston Old Town Trolley Hop-on Hop-Off City Tour

CA $79
per adult
90% of travellers recommend
Boston Old Town Trolley Hop-on Hop-Off City Tour
View Boston Observation Deck Admission Tickets

View Boston Observation Deck Admission Tickets

CA $47
per adult
88% of travellers recommend
View Boston Observation Deck Admission Tickets
Boston CityPASS: Admission to Top 4 Boston Attractions

Boston CityPASS®: Admission to Top 4 Attractions

CA $115
per adult
92% of travellers recommend
Boston CityPASS®: Admission to Top 4 Attractions
See all activities in Boston
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.