
Hannibal Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Hannibal Vacation
Excellent adventures await when you lock in a vacation package to Hannibal. Whether you're a history buff, foodie or just a traveler who loves to experience new places, there's something for everyone in this exciting city. Fill your spare time with tours of Mark Twain Boyhood Home and Museum, Mark Twain Cave and Cameron Cave and Mark Twain Cave, some of the attractions you shouldn't miss during your trip to Hannibal. Stop daydreaming and start traveling. Explore the broad range of options on Expedia today and put your Hannibal vacation plans into gear!
Top Hannibal Vacation Deals


Moonrise Hotel
Reviewed on Jun 5, 2026

Alhonna Resort LLC
Reviewed on May 31, 2026


The Royal Sonesta Chase Park Plaza St. Louis
Reviewed on Jun 5, 2026
Hannibal Hotel Deals

Quality Inn & Suites Hannibal West
"Generally clean great breakfast only one roll Of toilet paper and no tissues"
Reviewed on Jun 6, 2026

Best Western On The River
"Nice enough place and super close to the Mark Twain sights. I think gold with kids would appreciate the indoor pool in the ‘courtyard’. No car chargers available which is disappointing in this day and age."
Reviewed on Jun 6, 2026

Comfort Inn & Suites - Hannibal
"Overall, our two-night stay was just about what we expected from a hotel of this nature. The staff was friendly and helpful, the pool was open and average. Most areas of the hotel were relatively well-maintained and clean. The elevator door motor seemed to struggle with every opening and closing, ..."
Reviewed on Jun 6, 2026
Discover the most popular places to visit in Hannibal
Mark Twain Boyhood Home and Museum
Find out about the history of Hannibal when you take a trip to Mark Twain Boyhood Home and Museum. While in this walkable area, you can savor the top-notch restaurants.







