Title: Book The Best Hotels in Greencastle, MO for 2026 from CA $82 - Fully Refundable Options - Expedia.ca

[Hotels in Greencastle](https://expedia.ca/Greencastle-Hotels.d553248634983462000.Travel-Guide-Hotels)[Vacation Rentals in Greencastle](https://expedia.ca/Greencastle-Vacation-Rentals.d553248634983462000.Travel-Guide-VacationRentals)[Greencastle Car Rentals](https://expedia.ca/Car-Rentals-In-Greencastle.d553248634983462000.Car-Rental-Guide)

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- ##  
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## Go beyond your typical stay in Greencastle

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Greencastle%2C+Missouri%2C+United+States+of+America&regionId=553248634983462000&latLong=40.262523%2C-92.877981&adults=2&startDate=2026-03-03&d1=2026-03-03&endDate=2026-03-05&d2=2026-03-05&amenities=PETS)

## Check prices for these dates

Tonight

[Feb 17 - Feb 18](https://www.expedia.ca/Hotel-Search?regionId=553248634983462000&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel)

Tomorrow

[Feb 18 - Feb 19](https://www.expedia.ca/Hotel-Search?regionId=553248634983462000&startDate=2026-02-18&endDate=2026-02-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel)

This weekend

[Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248634983462000&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel)

Next weekend

[Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248634983462000&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel)

## Our top choices for Greencastle hotels

![Dining](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/8a5baebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/1e205061.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/b08ddc86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/w1021h682x0y0-c9b85e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Kirksville

[](https://www.expedia.ca/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information)

Kirksville

7.6/10

Good

(396 reviews)

"The staff was friendly and provided excellent service!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Don

CA $89

CA $110 total

includes taxes & fees

Feb 24 - Feb 25

[](https://www.expedia.ca/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/fa987a1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free cribs/infant beds, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/a7e2219f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, towels](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/7f07ee5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/9afc2091.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Knights Inn Kirksville

[](https://www.expedia.ca/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information)

Kirksville

7.2/10

Good

(251 reviews)

"Room was clean… quiet… "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

CA $87

CA $98 total

includes taxes & fees

Mar 18 - Mar 19

[](https://www.expedia.ca/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/fd2e50c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/9c660a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/08bb1016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/d203c711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Kirksville-University Area

[](https://www.expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

Kirksville

9.2/10

Wonderful

(168 reviews)

"Great breakfast let me check in early was very nice "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jamie

CA $86

CA $97 total

includes taxes & fees

Feb 23 - Feb 24

[](https://www.expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/f4cdd5fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/f3c5f510.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/80d5a891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn by Wyndham Kirksville

[](https://www.expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)

Kirksville

6.6/10

(1,000 reviews)

"Room was clean, organized. Staff was welcoming "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Vaishali

CA $73

CA $82 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/f363e21b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/a8acc085.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/ee47dad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Kirksville - University Area by IHG

[](https://www.expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

Kirksville

9.2/10

Wonderful

(519 reviews)

"Excellent service and stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Taylor

CA $162

CA $184 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/c19d4fbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Refrigerator & Microwave](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/de278a36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/68baa0ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Kirksville

[](https://www.expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)

Kirksville

9.2/10

Wonderful

(592 reviews)

"Better than a typical hotel, premium bedding, great lobby space for families to gather."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lynn

CA $167

CA $189 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)

![Superior Studio Suite, 1 King Bed, Non Smoking | Jetted tub](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/b428c708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/33e2a913.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/fe067a47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/a2f46102.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont by Wyndham Kirksville University Area

[](https://www.expedia.ca/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information)

Kirksville

7.6/10

Good

(901 reviews)

"Friendly staff, clean rooms"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dorothy

CA $82

CA $92 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-03&endDate=2026-03-04&regionId=553248634983462000&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Top Greencastle Hotel Reviews

## Recent Reviews in Greencastle

![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg)

### Holiday Inn Express & Suites Kirksville - University Area by IHG

10/10 Excellent

"Good breakfast. Clean rooms. "

[](https://expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

![Country Cabin In The Woods](https://images.trvl-media.com/lodging/105000000/104310000/104308300/104308277/529c3996_y.jpg)

### Country Cabin In The Woods

10/10 Excellent

"The cabin never disappoints. Highly recommend. Hope to stay there again soon."

[](https://expedia.ca/Kirksville-Hotels-Located-10-Minutes-From-Thousand-Hills-And-15-Minutes-From-Kirksville.h104308277.Hotel-Information)

![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg)

### Days Inn by Wyndham Kirksville

10/10 Excellent

"Room was clean and a great price."

[](https://expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)

![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302_y.jpg)

### Hampton Inn Kirksville

10/10 Excellent

"Clean and welcoming hotel and room. Very helpful staff. Excellent stay."

[](https://expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)

![Country's Edge Retreat](https://images.trvl-media.com/lodging/121000000/120070000/120065000/120064921/58c67ab5_y.jpg)

### Country's Edge Retreat

10/10 Excellent

"Clean, neat and peaceful location. Wonderfully quiet location, ten minute drive from food shopping and activities. Worth the stay."

[](https://expedia.ca/Greentop-Hotels-Countrys-Edge-Retreat.h120064921.Hotel-Information)

![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4_y.jpg)

### Super 8 by Wyndham Kirksville-University Area

10/10 Excellent

"We were only there 8 hours. Had a great night sleep. Clean and check in was easy and quick. Would stay again!!"

[](https://expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

![Little Blue Cottage - Charming 1-bedroom cottage in Kirksville](https://images.trvl-media.com/lodging/109000000/108400000/108390200/108390143/acd401ea_y.jpg)

### Little Blue Cottage - Charming 1-bedroom cottage in Kirksville

10/10 Excellent

"Everything was excellent!"

[](https://expedia.ca/Kirksville-Hotels-Little-Blue-Cottage-Charming-1-Bedroom-Cottage-In-Kirksville.h108390143.Hotel-Information)

![Waterfront Lake Cabin](https://images.trvl-media.com/lodging/64000000/63090000/63085100/63085080/71a15897_y.jpg)

### Waterfront Lake Cabin

10/10 Excellent

"Beautiful lake front property, the host and the home were amazing! Enjoyed the stay very much! "

[](https://expedia.ca/Unionville-Hotels-Waterfront-Lake-Cabin.h63085080.Hotel-Information)

![Knights Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/fa987a1d_y.jpg)

### Knights Inn Kirksville

10/10 Excellent

"Room was clean… quiet… "

[](https://expedia.ca/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information)

## More cheap stays in Greencastle

![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn by Wyndham Kirksville

3805 S Baltimore St Kirksville MO

CA $73

CA $82 total

Mar 1 - Mar 2

includes taxes & fees

6.6/10 (1,000 reviews)

[](https://expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)

![Baymont by Wyndham Kirksville University Area](https://images.trvl-media.com/lodging/1000000/130000/125500/125458/0cfe6b5f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont by Wyndham Kirksville University Area

2702 South Franklin Kirksville MO

CA $82

CA $92 total

Feb 22 - Feb 23

includes taxes & fees

7.6/10 Good! (901 reviews)

[](https://expedia.ca/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information)

![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Super 8 by Wyndham Kirksville-University Area

1101 Country Club Dr Kirksville MO

CA $86

CA $97 total

Feb 23 - Feb 24

includes taxes & fees

9.2/10 Wonderful! (168 reviews)

[](https://expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

![Quality Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/20500/20482/2dd82658_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Quality Inn Kirksville

2209 N Baltimore St Kirksville MO

CA $89

CA $110 total

Feb 24 - Feb 25

includes taxes & fees

7.6/10 Good! (396 reviews)

[](https://expedia.ca/Macon-Hotels-Quality-Inn-Kirksville.h20482.Hotel-Information)

![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express & Suites Kirksville - University Area by IHG

2523 South Franklin St. Kirksville MO

CA $162

CA $184 total

Feb 22 - Feb 23

includes taxes & fees

9.2/10 Wonderful! (519 reviews)

[](https://expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Kirksville

2604 N. Baltimore Street Kirksville MO

CA $167

CA $189 total

Mar 1 - Mar 2

includes taxes & fees

9.2/10 Wonderful! (592 reviews)

[](https://expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)

## Hotels in Greencastle with star rating

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

12 properties

[](https://expedia.ca/2Star-Greencastle-Hotels.s20-0-d553248634983462000.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in Greencastle?

> This area offers the most convenience, as it's where you'll find the limited number of local amenities. While Greencastle is a small community, staying near the main highway ensures you're close to any available local businesses. It's a relaxed setting, typical of rural Missouri.
> 
>   
> For visitors seeking a quiet escape or a base for exploring the surrounding countryside, this central area is ideal. It provides easy access to the main routes for day trips to nearby conservation areas or larger towns. Couples looking for a peaceful retreat will appreciate the unhurried pace.
> 
>   
> Families might find the practicality of staying central beneficial, as it simplifies access to any local eateries or shops.

### When is the best time to go to Greencastle?

> For those who enjoy pleasant weather for outdoor activities, late spring, particularly May and early June, offers mild temperatures and blooming flora, making it ideal for exploring the local countryside and enjoying the natural surroundings. It's a great time for gentle walks and appreciating the peaceful rural setting.
> 
>   
> Similarly, early autumn, from September to mid-October, provides comfortable temperatures and the beautiful visual spectacle of changing leaves. This period is superb for scenic drives and experiencing the area's natural beauty without the summer heat or winter chill.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Greencastle hotel booking with Expedia?

### How much is the nightly rate at a Greencastle hotel?

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