Title: Top Hotels in Santo Tomé Department | Expedia.ca [Vacation Rentals in Santo Tomé Department](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Vacation-Rental-Destinations)[Santo Tomé Department Car Rentals](https://expedia.ca/Destinations-In-Santo-Tome-Department.d553248635975751431.Car-Rental-Destinations)[Santo Tomé Department Vacations](https://expedia.ca/Santo-Tome-Department.d553248635975751431.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Santo Tomé Department Hotels ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 6 - Oct 7](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-06&endDate=2025-10-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 7 - Oct 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-07&endDate=2025-10-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=553248635975751431&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Hotels in Santo Tomé Department ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santo-Tome-Department.d553248635975751431.Hotel-Destinations) ## Top Santo Tomé Department Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Santo Tomé Department - [Gobernador Virasoro Hotels](https://expedia.ca/Gobernador-Virasoro-Hotels.d3000428985.Travel-Guide-Hotels) ### Explore more hotels - [Wild Wetlands Lodge](https://expedia.ca/Ituzaingo-Hotels-Wild-Wetlands-Lodge.h103441567.Hotel-Information) - [Puerto Valle Hotel de Esteros](https://expedia.ca/Ituzaingo-Hotels-Puerto-Valle-Hotel-De-Esteros.h2346397.Hotel-Information) [See a list of all hotels in Santo Tomé Department](https://expedia.ca/All-Santo-Tome-Department-Hotels.d553248635975751431.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Santo Tomé Department on Expedia.com.ar](https://www.expedia.com.ar/Destinos-En-Departamento-Santo-Tome.d553248635975751431.Destinos-con-Hoteles) ### Expedia's Latest Trends Hotels - [Tokyu Stay Shibuya](https://expedia.ca/Tokyo-Hotels-Tokyu-Stay-Shibuya.h2692097.Hotel-Information) - [Bahia Principe Grand Samana - Adults Only](https://expedia.ca/Samana-Hotels-Bahia-Principe-Luxury-Samana-Adults-Only.h11843755.Hotel-Information) - 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAyAAAAMgAQAAAADzCzvFAAAFWUlEQVR4Xu3bQXIbOQyFYbq88DJH0FF4NPJoOoqOkKUWLnMEECTRdNsZ1FSmKsr/NmKjQXy9o1qJU/sfkvbC7whIKCChgIQCEgpIKCChgIQCEgpIKCChgIQCEgpIKCChgIQCEgpIKCChgIQCEgpIKCChgIQCEgpIKCChgIQCEopD3tOWyyi9tHZNb4/mR0nzU6q53dNj+03WpZd8ypoMkkD2NpCesiaDJJC9DaSnrMnPipR1pROXm3vx1rd7xDb+lEeZOc4CAQEBkYBoQDQgM9areZtI6TevUrXGmuzY19JNPgzR0nGjBAQERD5AQBIIiOV7RGPb32aXJculrUFAEgiIBSSBgKT/jNRe0PfpmR9zk1y9ygLkItXaCyC9aS1BQECu/TYISG9ay+MNRd7dYHNPHsVKL24zCEgDAdlvgPSAgLQdOcZvv36euJe2lDUZ5KS0pazJICelLWVNBjkpbSlrMshJaUtZk0FOSlvKmgxyUtpS1mSHnES3t/Yhr9hNJtp2RZq8dbuurwMCchKQLSAgJwHZ8ryIHdXr9PY/Z7d2k5+za7L/36VdPll6bF3WLhAQDUhPlh5bl7ULBEQD0pOlx9Zl7XpWpD4mjgNdJmoMucuBrog9Su4l26ju7AIBaSAgGhCQBvI9oge6xc74Nl0rJUFq78mHjevprMsFJIH0vRoQubQuF5AE0vdqQOTSulyeF/l0oAsyYq6c8S/yip3cGb82glhAQEBAJCAgv0TK2P7WJ3pXo65ED/T1KBbdeCxJQEBAQEBAQHwcovG/XWtvTfrb9b79Q/p8yTa2+XSlN2plLTUgICAgIBYQkHdp0wNdJ1rvPOPvsk5j4nClS6Ml7XKPYgEBAem3QUBAGojmiJTRu0qWLJc2sSY99s21R7FvAhaQBgICAgJyKFmyXILsiL08r0x3TdwfxbLeuveAgICMgIBsAQF5n4OzTLRqPbxiT2R13WS9u/bAFhAQEBCQGRCQtiO+V/auN+WrXMpELWmXlSzq6hl/3CgBAQHpAQEBAelxiGW8YtulnfE6MaVLL9pE7br1he/SFBvQQEBmQFyXptiABgIyA+K6NMUGtOdFZOKHvDzLncdEPfbV1ZJNtJIe6BbbqJnFGRCQBtJAQEBAVlzp00SLHuj+R28pjRfxL0o2ywICAnJWAgFpICB2w3rvMvgySprHgS4fX/3CvZ5uds2AgICMgICAgGhlLRdylYmWmuxPmXzUzeNRLIr4p5sBAQEZRZAGAuIDYoj1yp3em9xv1xbpavIoGutaae0mH9alo9YSBETvgIAchoBoQP5S5CR++1t3LeNRrKv01fxysEoSEJCTgICASEBA/ETNRarVFaxLXsSTIdJlJX03t3z3C/cxF6lWV7AuEAkISM9FqtUVrAtEAgLSc5FqdQXr+hOQsq50e5tI3kovs+8mt0tfX81wJQkICIibeDXAlSQgICBu4tUAV5I8L6Kn93yffu9XOvHez/gmiP4lsZZc19h4dCUgGhCQERAQ624gIF8j+g/MWZvTfHn+sKEy8XW6147YrBkQEBAQEBCQIKLJ2vwoabQrt3u/p4h9E/BdMyBaAgFJICAgIFZZS0VWrFe2+4kr2TXXUdIu3egCoqWVOkogfrtPds11lED8dp/smusogfjtPtk111EC8dt9smuuowTit/tk11xH6V8gx1ykKi/P6xV7ltp8n75Jq3w5GGe8lF7nWgLSQDYDBATEAtL+euT3BSQUkFBAQgEJBSQUkFBAQgEJBSQUkFBAQgEJBSQUkFBAQgEJBSQUkFBAQgEJBSQUkFBAQgEJBSQUkFBAQgEJ5XmQfwDBVemZr/PWSQAAAABJRU5ErkJggg==)