Title: Defiance Vacation Home Rentals from CA $197: Search Top Private Vacation Homes for Rent | Expedia.ca

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![Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6160337/5138d652-49fb-41de-8fd4-a7bb27471f3e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2026-02-13&endDate=2026-02-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2026-03-27&endDate=2026-03-29&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2026-04-24&endDate=2026-04-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[May 22 - May 24](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2026-05-22&endDate=2026-05-24&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Defiance vacation homes

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100820000/100819700/100819682/f0fef17d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/101000000/100820000/100819700/100819682/74105de3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/101000000/100820000/100819700/100819682/3158546a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100820000/100819700/100819682/a03d491d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Saint Charles

[](https://www.expedia.ca/St-Louis-Hotels-The-Below-Deck-Suite.h100819682.Hotel-Information)

9.0/10

Wonderful

(2 reviews)

"Overall good place for a family. The neighborhood is quiet and there is a good amount of space. Easy to find and to get places. You will hear the people upstairs and one bed was very squeaky. It was very clean and the couches are very comfy. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy B.

CA $140

CA $329 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-The-Below-Deck-Suite.h100819682.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71510000/71507600/71507563/w905h683x60y0-7da69c98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/72000000/71510000/71507600/71507563/w507h683x260y0-03493f60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/72000000/71510000/71507600/71507563/ca1dea43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/72000000/71510000/71507600/71507563/c41d38d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Union

[](https://www.expedia.ca/Union-Hotels-TJs-Country-Getaway.h71507563.Hotel-Information)

10/10

Exceptional

(45 reviews)

"It had everything you need for a relaxing stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Judith

CA $101

CA $197 total

includes taxes & fees

Feb 7 - Feb 8

[](https://www.expedia.ca/Union-Hotels-TJs-Country-Getaway.h71507563.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335731/8dcec7f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335731/413f9d12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335731/c8cfaaff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, individually decorated, individually furnished, free WiFi](https://images.trvl-media.com/lodging/100000000/99340000/99335800/99335731/a8766db2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Washington

[](https://www.expedia.ca/Washington-Hotels-Stylish-Home-Near-Wine-Country-JZ-Vacation-Rentals.h99335731.Hotel-Information)

8.0/10

Very good

(1 review)

"Great communication, had a couple of leaks and shower flooded but the maintenance came right away to fix it. Overall clean, AC/Heat unit in each room, big kitchen, wonderful sitting area and decor."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stacy

CA $217

CA $555 total

includes taxes & fees

Feb 1 - Feb 2

[](https://www.expedia.ca/Washington-Hotels-Stylish-Home-Near-Wine-Country-JZ-Vacation-Rentals.h99335731.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/76000000/75200000/75190800/75190737/049741ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75200000/75190800/75190737/a52c3cbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/76000000/75200000/75190800/75190737/8112c5ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75200000/75190800/75190737/27db235b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Washington

[](https://www.expedia.ca/Washington-Hotels-Cozy-Little-House-Blocks-From-The-Park-Fair-Grounds.h75190737.Hotel-Information)

10/10

Exceptional

(60 reviews)

"Amazing host, clean easy access. Will stay here again if available"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeanie S.

CA $166

CA $346 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Washington-Hotels-Cozy-Little-House-Blocks-From-The-Park-Fair-Grounds.h75190737.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/115000000/114140000/114138900/114138882/a5f9eb31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Paper towels](https://images.trvl-media.com/lodging/115000000/114140000/114138900/114138882/0fa9edc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![5 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/115000000/114140000/114138900/114138882/a8dd4cd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/115000000/114140000/114138900/114138882/fa6cdd37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Saint Charles

[](https://www.expedia.ca/St-Louis-Hotels-Saint-Charles-White-House.h114138882.Hotel-Information)

8.6/10

Excellent

(4 reviews)

"It was great Needed towels but otherwise great"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer R.

CA $175

CA $436 total

includes taxes & fees

Jan 28 - Jan 29

[](https://www.expedia.ca/St-Louis-Hotels-Saint-Charles-White-House.h114138882.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/89000000/88660000/88660000/88659965/68999da7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88660000/88660000/88659965/c286090f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88660000/88660000/88659965/w3900h2591x0y4-c1cce84b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/89000000/88660000/88660000/88659965/893add03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Saint Charles

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-2-Bed-Townhome-By-StayLage.h88659965.Hotel-Information)

9.0/10

Wonderful

(9 reviews)

"Great location, clean, and management was informative and reacted to any needs quickly. Would recommend to anyone."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nathan D.

CA $121

CA $379 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-2-Bed-Townhome-By-StayLage.h88659965.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102260000/102252500/102252443/eaf810ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/103000000/102260000/102252500/102252443/d4e26647.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/103000000/102260000/102252500/102252443/4d333dda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/103000000/102260000/102252500/102252443/aa8990d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Wentzville

[](https://www.expedia.ca/St-Louis-Hotels-4-Bedroom-Wentzville-Home-By-StayLage.h102252443.Hotel-Information)

9.8/10

Exceptional

(6 reviews)

"Amazing for attending the fireworks festivals nearby. Great shops walking distance for coffee and food"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tom K.

CA $222

CA $674 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-4-Bedroom-Wentzville-Home-By-StayLage.h102252443.Hotel-Information)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93610000/93608300/93608223/f64528bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93610000/93608300/93608223/d2c2d0b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/94000000/93610000/93608300/93608223/599af13c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/94000000/93610000/93608300/93608223/27a515ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Washington

[](https://www.expedia.ca/Washington-Hotels-Cozy-Historic-WashMo-Home.h93608223.Hotel-Information)

9.2/10

Wonderful

(27 reviews)

"Lovely stay, well done on the updates of the house. Upstairs is a little cold, but otherwise it was a great weekend rental. Close to the river, so easy walking "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Valerie R.

CA $141

CA $329 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/Washington-Hotels-Cozy-Historic-WashMo-Home.h93608223.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/112000000/111720000/111715700/111715679/1cb8c44d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/112000000/111720000/111715700/111715679/442037dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/112000000/111720000/111715700/111715679/60088b65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/112000000/111720000/111715700/111715679/8380970f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in O'Fallon

[](https://www.expedia.ca/St-Louis-Hotels-Quaint-And-Cozy-Hamlet.h111715679.Hotel-Information)

9.6/10

Exceptional

(14 reviews)

"Wonderful for families! Host had many little welcoming extras."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephanie W.

CA $162

CA $510 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-Quaint-And-Cozy-Hamlet.h111715679.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/92000000/92000000/91995900/91995861/d6731308.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/92000000/92000000/91995900/91995861/b94a9333.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/92000000/91995900/91995861/1e5c9718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Beach](https://images.trvl-media.com/lodging/92000000/92000000/91995900/91995861/f5ad840b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Fenton

[](https://www.expedia.ca/St-Louis-Hotels-Nice-Home-Safe-Quiet-4-BR-25-B-6-Queen-Beds.h91995861.Hotel-Information)

9.4/10

Exceptional

(28 reviews)

"It was a great stay and perfect for our mix of people. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paula N.

CA $241

CA $509 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-Nice-Home-Safe-Quiet-4-BR-25-B-6-Queen-Beds.h91995861.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/45000000/44130000/44124700/44124669/d4de2daa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/45000000/44130000/44124700/44124669/a3e58321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/45000000/44130000/44124700/44124669/216e0674.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/45000000/44130000/44124700/44124669/0aa09261.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Pacific

[](https://www.expedia.ca/Pacific-Hotels-Pet-And-Kid-Friendly-Duplex-With-2-Bedrooms.h44124669.Hotel-Information)

9.6/10

Exceptional

(47 reviews)

"The property was clean, spacious, and accommodating for our dogs. The area was quiet with plenty of places to walk our dogs and relax. Highly recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Penny R.

CA $184

CA $238 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Pacific-Hotels-Pet-And-Kid-Friendly-Duplex-With-2-Bedrooms.h44124669.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/84000000/83430000/83427300/83427286/c944cb8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83430000/83427300/83427286/6086e9e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83430000/83427300/83427286/43b62f3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/84000000/83430000/83427300/83427286/fa572f5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Washington

[](https://www.expedia.ca/Washington-Hotels-Fully-Remodeled-1880-Downtown-Brick-House.h83427286.Hotel-Information)

10/10

Exceptional

(44 reviews)

"Perfect house for a weekend in Washington. Location close to town with several coffee shops , restaurants, bars. Night time was noisy outside on the Main Street at stop sign I. Front of house loud screeching tires late at night but other then that great spot! Accommodations outstanding and hosts were fantastic from start to finish! Would definitely recommend this to everyone!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Patti S.

CA $252

CA $496 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Washington-Hotels-Fully-Remodeled-1880-Downtown-Brick-House.h83427286.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393465/a8ea8aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393465/e82c5584.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393465/3bc19e44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83400000/83393500/83393465/fbe5fbf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in St. Charles Historic District

[](https://www.expedia.ca/St-Louis-Hotels-The-Original-Custom-House.h83393465.Hotel-Information)

9.8/10

Exceptional

(35 reviews)

"The location is excellent. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

McRay H.

CA $166

CA $470 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-The-Original-Custom-House.h83393465.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/93000000/92210000/92203300/92203228/dc1bb429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/93000000/92210000/92203300/92203228/48d1cc06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, WiFi](https://images.trvl-media.com/lodging/93000000/92210000/92203300/92203228/33267681.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/93000000/92210000/92203300/92203228/0f42d269.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in St. Charles Historic District

[](https://www.expedia.ca/St-Louis-Hotels-5th-Street-1-Historic-5th-Street-House-Fully-Rehabbed-1.h92203228.Hotel-Information)

9.2/10

Wonderful

(12 reviews)

"House was beautiful. Very nice quiet stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amy S.

CA $116

CA $323 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/St-Louis-Hotels-5th-Street-1-Historic-5th-Street-House-Fully-Rehabbed-1.h92203228.Hotel-Information)

![2 bedrooms, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109520000/109512000/109511946/189d7825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109520000/109512000/109511946/796200a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/110000000/109520000/109512000/109511946/b9af5850.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/110000000/109520000/109512000/109511946/cb34dd92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in O Fallon

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-Townhome-Retreat-By-StayLage.h109511946.Hotel-Information)

9.8/10

Exceptional

(10 reviews)

"Great quiet neighborhood close to everything!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jen D.

CA $183

CA $535 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-Townhome-Retreat-By-StayLage.h109511946.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987663/32ed27b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987663/c57248a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987663/d4da784c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987663/a2f82899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in St. Charles Historic District

[](https://www.expedia.ca/St-Louis-Hotels-Hilltop-Haven-Chic-4BR-Home-In-St-Charles.h103987663.Hotel-Information)

9.8/10

Exceptional

(22 reviews)

"A beautiful place with Victorian charm and modern amenities! This was the perfect place for our family."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathleen D.

CA $188

CA $845 total

includes taxes & fees

Feb 18 - Feb 19

[](https://www.expedia.ca/St-Louis-Hotels-Hilltop-Haven-Chic-4BR-Home-In-St-Charles.h103987663.Hotel-Information)

![Smart TV, books](https://images.trvl-media.com/lodging/83000000/82760000/82756500/82756479/016cf9b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/83000000/82760000/82756500/82756479/5742a366.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/83000000/82760000/82756500/82756479/f2f70f1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/83000000/82760000/82756500/82756479/45965e2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Saint Charles

[](https://www.expedia.ca/St-Louis-Hotels-Casa-De-Saint-Charles.h82756479.Hotel-Information)

9.2/10

Wonderful

(17 reviews)

"We group of senior ladies thoroughly enjoyed our weekend at Casa de Saint Charles. The accommodations were perfect, inside and out. Our hosts were very accessible and made sure all our wants and needs were taken care of. What a wonderful home! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosalind W.

CA $175

CA $427 total

includes taxes & fees

Jan 28 - Jan 29

[](https://www.expedia.ca/St-Louis-Hotels-Casa-De-Saint-Charles.h82756479.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/91000000/90020000/90014900/90014834/cea3d97c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, desk, WiFi, bed sheets](https://images.trvl-media.com/lodging/91000000/90020000/90014900/90014834/57959b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, oven, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/91000000/90020000/90014900/90014834/ef940c9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/91000000/90020000/90014900/90014834/d084e094.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Saint Charles

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-2-Bedroom-Townhome-By-StayLage.h90014834.Hotel-Information)

7.8/10

Good

(12 reviews)

"Perfect size"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Barbie D.

CA $121

CA $379 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/St-Louis-Hotels-Spacious-2-Bedroom-Townhome-By-StayLage.h90014834.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987661/297b8e79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987661/99325b43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, offices](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987661/d1c26363.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/104000000/103990000/103987700/103987661/29d9fd63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in St. Charles Historic District

[](https://www.expedia.ca/St-Louis-Hotels-Chic-Farmhouse-At-Historic-Frenchtown-4BR-House.h103987661.Hotel-Information)

10/10

Exceptional

(22 reviews)

"The house was perfect for our stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Susan F.

CA $101

CA $737 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/St-Louis-Hotels-Chic-Farmhouse-At-Historic-Frenchtown-4BR-House.h103987661.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/45000000/44130000/44125200/44125181/dbee5634.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/45000000/44130000/44125200/44125181/e4bc8707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/45000000/44130000/44125200/44125181/18a39163.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/45000000/44130000/44125200/44125181/7336166d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Pacific

[](https://www.expedia.ca/Pacific-Hotels-Kid-And-Pet-Friendly-2-Nd-Floor-Duplex.h44125181.Hotel-Information)

9.0/10

Wonderful

(28 reviews)

"We had a great time. We will definately be back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shayla Y.

CA $199

CA $263 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Pacific-Hotels-Kid-And-Pet-Friendly-2-Nd-Floor-Duplex.h44125181.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-09&endDate=2026-02-10&regionId=6353634&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=CABIN)

Aparthotels

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=APART_HOTEL)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=VACATION_HOME)

Condos

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=CONDO)

Villas

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=VILLA)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=COTTAGE)

Chalets

[](https://www.expedia.ca/Hotel-Search?destination=Defiance%2C+Missouri%2C+United+States+of+America&regionId=6353634&latLong=38.632504%2C-90.778183&adults=2&startDate=2026-04-26&d1=2026-04-26&endDate=2026-04-29&d2=2026-04-29&lodging=CHALET)

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## Top Defiance Hotel Reviews

![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg)

### Ameristar Casino Resort and Spa

10/10 Excellent

"Spotless room"

[](https://expedia.ca/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information)

![Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West](https://images.trvl-media.com/lodging/2000000/1660000/1659000/1658956/ad47a940_y.jpg)

### Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent

"No complaints "

[](https://expedia.ca/St-Louis-Hotels-Larkspur-Landing-Extended-Stay-Suites-St-Louis-Riverport-Airport-West.h1658956.Hotel-Information)

![Sleep Inn & Suites O'Fallon MO - Technology Drive](https://images.trvl-media.com/lodging/16000000/15590000/15583900/15583887/133d5cf7_y.jpg)

### Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent

"A very nice one night stay on our roadtrip! The staff are very friendly and available, the place was clean, quiet and safe and the breakfast was fresh and hot. Would definitely stay here again. "

[](https://expedia.ca/St-Louis-Hotels-Sleep-Inn-Suites-OFallon-MO-Technology-Drive.h15583887.Hotel-Information)

![Hampton Inn St. Charles St. Peters](https://images.trvl-media.com/lodging/1000000/30000/20200/20181/8c366380_y.jpg)

### Hampton Inn St. Charles St. Peters

10/10 Excellent

"Quick checkin - clean room"

[](https://expedia.ca/St-Louis-Hotels-Hampton-Inn-St-LouisSt-Charles.h20181.Hotel-Information)

![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg)

### The Wildwood Hotel

10/10 Excellent

"Yes, the breakfast menu was very nice"

[](https://expedia.ca/St-Louis-Hotels-The-Wildwood-Hotel.h1768149.Hotel-Information)

![Comfort Suites St Charles - St Louis](https://images.trvl-media.com/lodging/1000000/670000/664500/664414/55d0714b_y.jpg)

### Comfort Suites St Charles - St Louis

10/10 Excellent

"Room was very nice and super close to I-70\. Every interaction with a staff member was fantastic. I appreciate friendly people who care about the guests. Definitely will stay there again. "

[](https://expedia.ca/St-Louis-Hotels-Comfort-Suites-St-Charles-St-Louis.h664414.Hotel-Information)

![Country Inn & Suites by Radisson, St. Charles Historic District](https://images.trvl-media.com/lodging/2000000/1340000/1330400/1330309/529fe0ff_y.jpg)

### Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Yes"

[](https://expedia.ca/St-Louis-Hotels-Country-Inn-Suites-By-Radisson.h1330309.Hotel-Information)

![Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham](https://images.trvl-media.com/lodging/1000000/50000/42200/42122/bfca870c_y.jpg)

### Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"Friendly staff. Good hot breakfast options. Clean room"

[](https://expedia.ca/St-Louis-Hotels-Drury-Inn-Suites-St-Louis-Fenton.h42122.Hotel-Information)

![Relax Inn Saint Charles ](https://images.trvl-media.com/lodging/2000000/1010000/1000800/1000712/3d3bc786_y.jpg)

### Relax Inn Saint Charles 

10/10 Excellent

"Calidad 100% buenos precios"

[](https://expedia.ca/St-Louis-Hotels-Relax-Inn-Saint-Charles.h1000712.Hotel-Information)

## Find out more about Defiance

## Defiance Vacation Homes information

| Number of reviews | 422                |
| ----------------- | ------------------ |
| Accommodation     | 269 Vacation Homes |
| Lowest Price      | CA $197            |
| Highest Price     | CA $845            |

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