Title: 5 Stars Hotels in Southern Indiana, United States of America from CA $180 - Find Cheap Southern Indiana Hotels With 5 Stars | Expedia.ca

[Southern Indiana Travel Guide](https://expedia.ca/Southern-Indiana.dx6059635)[Hotels in Southern Indiana](https://expedia.ca/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[Vacation Rentals in Southern Indiana](https://expedia.ca/Southern-Indiana-Vacation-Rentals.d6059635.Travel-Guide-VacationRentals)[Flights to Southern Indiana](https://expedia.ca/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[Southern Indiana Car Rentals](https://expedia.ca/Car-Rentals-In-Southern-Indiana.d6059635.Car-Rental-Guide)[Southern Indiana Vacation Packages](https://expedia.ca/Southern-Indiana.d6059635.Destination-Travel-Guides)

![Belle of Louisville which includes a bay or harbour and a ferry as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# 5 Stars Hotels in Southern Indiana, United States of America from CA $180

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Check availability on Southern Indiana 5 Star Hotels

Tonight

[Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6059635&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Southern-Indiana-Hotels.s50-0-d6059635.Travel-Guide-Filter-Hotels)[

Sign up, it's free

](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Southern-Indiana-Hotels.s50-0-d6059635.Travel-Guide-Filter-Hotels)

## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Southern Indiana.

![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Galt House Hotel Trademark Collection by Wyndham

140 North Fourth Street Louisville KY

CA $184

CA $216 total

Dec 20 - Dec 21

includes taxes & fees

8.8/10 Excellent! (3,837 reviews)

[](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information)

![Omni Louisville Hotel](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Omni Louisville Hotel

400 S. 2nd Street Louisville KY

CA $230

CA $271 total

Jan 2 - Jan 3, 2026

includes taxes & fees

9.2/10 Wonderful! (1,711 reviews)

[](https://expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information)

![Embassy Suites Louisville Downtown](https://images.trvl-media.com/lodging/10000000/9030000/9027600/9027531/e02820b0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Embassy Suites Louisville Downtown

501 South Fourth Street Louisville KY

CA $153

CA $180 total

Dec 28 - Dec 29

includes taxes & fees

8.8/10 Excellent! (1,097 reviews)

[](https://expedia.ca/Louisville-Hotels-Embassy-Suites-Louisville-Downtown.h9027531.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Southern Indiana.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=6059635&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Southern Indiana

Live music, casinos, and sights from Patoka Lake Swimming Beach to Patoka Lake—discover it all in Southern Indiana.

[See all hotels in Southern Indiana](https://www.expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27&adults=2&regionId=6059635)

![Belle of Louisville which includes a bay or harbour and a ferry as well as a small group of people](https://images.trvl-media.com/place/6062661/de2e6e20-7fec-4f19-8f1c-b6f175615380.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Southern Indiana Hotel Reviews

## Find out more about Southern Indiana

Luxury is the name of the game at the best 5 Stars hotels in Southern Indiana. If you want to vacation like a true VIP, these are the places to go; from spacious resorts to boutique-inspired hot spots, the top Southern Indiana 5 Stars hotels are dedicated to immersing you in the ultimate experience. Want to relax with a serene treatment at a designer spa? These properties offer them.

Interested in tasting delicious dishes from top chefs? The gourmet restaurants at the 5 Stars Southern Indiana hotels have you covered. You’ll even find first-class hotels near the city’s must-see attractions and most upscale entertainment districts. Plus, when you book your trip with Expedia.ca, you’ll get access to fantastic rates and seasonal discounts, so you can take advantage of a cheap deal on 5 Stars hotels Southern Indiana without giving up even an inch of quality. Everything your heart desires (and a few perks designed to make it skip a beat): That’s what’s on offer when you plan a trip to the hotels with 5 Stars in Southern Indiana.

## Frequently asked questions

### How much does it cost to stay in a 5-star hotel in Southern Indiana?

> - Search for the lowest price per night from CA $180

### What makes a hotel 5 stars in Southern Indiana?

### Are there any 5-star all-inclusive resorts in Southern Indiana?

## Explore a world of travel with Expedia

- Lodging
- Flights
- Packages
- Cars
- More ways to book

- [Hotels near Cumberland River ](https://www.expedia.ca/Cumberland-River-Hotels.0-l681609143447191552-0.Travel-Guide-Filter-Hotels)
- [Hotels near Kentucky Lake ](https://www.expedia.ca/Kentucky-Lake-Hotels.0-l6059618-0.Travel-Guide-Filter-Hotels)
- [Hotels near Lake Barkley ](https://www.expedia.ca/Lake-Barkley-Hotels.0-l553248635976193790-0.Travel-Guide-Filter-Hotels)
- [Hotels near Ohio River ](https://www.expedia.ca/Ohio-River-Hotels.0-l681940626945888256-0.Travel-Guide-Filter-Hotels)
- [Aparthotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Apart-Hotels.d6233674-aaApartHotels.Travel-Guide-Accommodation)
- [B&B in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Bed-And-Breakfast.d6233674-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Cabin Rentals in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Cabins.d6233674-aaCabins.Travel-Guide-Accommodation)
- [Chalets in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Chalets.d6233674-aaChalets.Travel-Guide-Accommodation)
- [Condo Rentals in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Condos.d6233674-aaCondos.Travel-Guide-Accommodation)
- [Adults Only Resorts & in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Adults-Only-Resorts.0-0-d6233674-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels)
- [Beach Hotel Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Beach-Hotel.0-0-d6233674-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Best Western Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Best-Western.0-0-d6233674--bBestWestern.Travel-Guide-Filter-Hotels)
- [Boutique Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Boutique-Hotel.0-0-d6233674-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Cheap-Hotels.0-0-d6233674-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Golf Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Golf-Hotel.0-0-d6233674-tGolfHotel.Travel-Guide-Filter-Hotels)
- [Historic Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Historic-Hotel.0-0-d6233674-tHistoricHotel.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotel-With-Pool.0-0-d6233674-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels with Balconies in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotels-With-Balconies.0-0-d6233674-tHotelswithBalconies.Travel-Guide-Filter-Hotels)
- [Hotels with Waterslides in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Hotels-With-Waterslides.0-0-d6233674-tHotelswithWaterslides.Travel-Guide-Filter-Hotels)
- [Lake Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Lake-Hotels.0-0-d6233674-tLakeHotels.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Luxury-Hotel.0-0-d6233674-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Marriott Hotels & Resorts in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Marriott-Hotels-Resorts.0-0-d6233674--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels)
- [Motel 6 Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Motel-6.0-0-d6233674--bMotel6.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Pet-Friendly-Hotel.0-0-d6233674-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Romantic Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Romantic-Hotel.0-0-d6233674-tRomanticHotel.Travel-Guide-Filter-Hotels)
- [Spa Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Spa-Hotel.0-0-d6233674-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Hotels-Waterpark-Hotels.0-0-d6233674-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Ohio River Valley Hotels ](https://www.expedia.ca/Ohio-River-Valley-Hotels.d6233674.Travel-Guide-Hotels)
- [Treehouses in Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley-Treehouses.d6233674-aaTreehouses.Travel-Guide-Accommodation)
- [Boutique Hotels in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Boutique-Hotel.0-0-d6233889-tBoutiqueHotel.Travel-Guide-Filter-Hotels)
- [Casino Hotels in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Casino-Hotel.0-0-d6233889-tCasinoHotel.Travel-Guide-Filter-Hotels)
- [Hotels & Resorts for Couples in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Couples-Resorts-Hotels.0-0-d6233889-tCouplesResortsHotels.Travel-Guide-Filter-Hotels)
- [Hotels with smoking rooms in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Hotels-With-Smoking-Rooms.0-0-d6233889-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
- [Red Roof Inn Hotels in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Red-Roof-Inn.0-0-d6233889--bRedRoofInn.Travel-Guide-Filter-Hotels)
- [Waterpark Hotels in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Hotels-Waterpark-Hotels.0-0-d6233889-tWaterparkHotels.Travel-Guide-Filter-Hotels)
- [Southeastern Indiana Hotels ](https://www.expedia.ca/Southeastern-Indiana-Hotels.d6233889.Travel-Guide-Hotels)
- [Motels in Southeastern Indiana ](https://www.expedia.ca/Southeastern-Indiana-Motels.d6233889-aaMotels.Travel-Guide-Accommodation)
- [Cheap Hotels in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Hotels-Cheap-Hotels.0-0-d6233876-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Historic Hotels in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Hotels-Historic-Hotel.0-0-d6233876-tHistoricHotel.Travel-Guide-Filter-Hotels)
- [Hotels with Hot Tubs in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Hotels-Hotels-With-Hot-Tubs.0-0-d6233876-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Hotels-Pet-Friendly-Hotel.0-0-d6233876-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Red Roof Inn Hotels in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Hotels-Red-Roof-Inn.0-0-d6233876--bRedRoofInn.Travel-Guide-Filter-Hotels)
- [Southwestern Indiana Hotels ](https://www.expedia.ca/Southwestern-Indiana-Hotels.d6233876.Travel-Guide-Hotels)
- [Resorts in Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana-Resort-Hotels.d6233876-aaResortHotels.Travel-Guide-Accommodation)

- [Flights to Ohio River Valley ](https://www.expedia.ca/Cheap-Flights-To-Ohio-River-Valley.d6233674.Travel-Guide-Flights)
- [Flights to Southwestern Indiana ](https://www.expedia.ca/Cheap-Flights-To-Southwestern-Indiana.d6233876.Travel-Guide-Flights)
- [Flights from Calgary to Ohio River Valley ](https://www.expedia.ca/lp/flights/178245/6233674/calgary-to-ohio-river-valley)
- [Flights from Dallas to Ohio River Valley ](https://www.expedia.ca/lp/flights/178253/6233674/dallas-to-ohio-river-valley)
- [Flights from Miami to Ohio River Valley ](https://www.expedia.ca/lp/flights/178286/6233674/miami-to-ohio-river-valley)
- [Flights from Minneapolis - St. Paul to Ohio River Valley ](https://www.expedia.ca/lp/flights/178287/6233674/minneapolis-st-paul-to-ohio-river-valley)
- [Flights from Orlando to Ohio River Valley ](https://www.expedia.ca/lp/flights/178294/6233674/orlando-to-ohio-river-valley)
- [Flights from Toronto to Ohio River Valley ](https://www.expedia.ca/lp/flights/178314/6233674/toronto-to-ohio-river-valley)
- [Flights from Vancouver to Ohio River Valley ](https://www.expedia.ca/lp/flights/178315/6233674/vancouver-to-ohio-river-valley)
- [Flights from Edmonton to Ohio River Valley ](https://www.expedia.ca/lp/flights/180002/6233674/edmonton-to-ohio-river-valley)
- [Flights from Québec City to Ohio River Valley ](https://www.expedia.ca/lp/flights/180017/6233674/quebec-city-to-ohio-river-valley)
- [Flights from Fort Lauderdale to Ohio River Valley ](https://www.expedia.ca/lp/flights/601750/6233674/fort-lauderdale-to-ohio-river-valley)
- [Flights from Newark to Ohio River Valley ](https://www.expedia.ca/lp/flights/601760/6233674/newark-to-ohio-river-valley)
- [Flights from Buffalo to Ohio River Valley ](https://www.expedia.ca/lp/flights/602674/6233674/buffalo-to-ohio-river-valley)
- [Flights from Birmingham to Ohio River Valley ](https://www.expedia.ca/lp/flights/602981/6233674/birmingham-to-ohio-river-valley)
- [Flights from Ohio River Valley ](https://www.expedia.ca/lp/flights/6233674/flights-from-ohio-river-valley)

- [Kentucky Lake ](https://www.expedia.ca/Kentucky-Lake-United-States-of-America.d6059618.Vacation-Attraction)
- [Visit Ohio River Valley ](https://www.expedia.ca/Ohio-River-Valley.dx6233674)
- [Visit Southwestern Indiana ](https://www.expedia.ca/Southwestern-Indiana.dx6233876)

- [Advantage Rent-A-Car Rental Cars in Ohio River Valley ](https://www.expedia.ca/Advantage-Rent-A-Car-Car-Rentals-In-Ohio-River-Valley.d6233674-c3.Car-Rental-Guide-Suppliers)
- [Pickup Car Rentals in Ohio River Valley ](https://www.expedia.ca/Pickup-Car-Rentals-In-Ohio-River-Valley.d6233674-tPickup.Car-Rental-Guide-Class)
- [Thrifty Car Rental Rental Cars in Ohio River Valley ](https://www.expedia.ca/Thrifty-Car-Rental-Car-Rentals-In-Ohio-River-Valley.d6233674-c45.Car-Rental-Guide-Suppliers)

- [Book 5 Star Hotels in Southern Indiana on Expedia.com ](https://www.expedia.com/5Star-Southern-Indiana-Hotels.s50-0-d6059635.Travel-Guide-Filter-Hotels)