Use Expedia to help you arrange a flight to Tupelo, MS (TUP-Tupelo Regional) airport, and then choose from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you want to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Tupelo has to offer. During your visit, you might want to enjoy the shopping which Tupelo is known for.