Photo by Nico Barner

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Pet-friendly Hotels in Eastern Panama

HOTEL ISLA GRANDE

Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province

2 hours drive from Cayos Holandeses

Book a stay at this beach hotel in Isla Grande. Enjoy free breakfast, a beach locale, and onsite spa services. Popular attractions Isla Mamey and Portobelo National ...

Ciel y Miel

Caillle Principale Cacique Provincia de Colón

2 hours drive from Cayos Holandeses

Book a stay at this beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...

10/10 Exceptional! (10 reviews)

"The views from this mountain-top boutique hotel are extraordinary."

Reviewed on Feb 1, 2026

Hotel Cocotal

La Guaira Isla Grande Provincia de Colón

2 hours drive from Cayos Holandeses

Stay at this hotel in Isla Grande. Enjoy free breakfast, free WiFi, and 20 restaurants. Popular attractions Isla Mamey and Portobelo National Park are located ...

See all 187 properties in Eastern Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.