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Pet-friendly Hotels in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

4 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.6/10 Exceptional! (1,017 reviews)

"Great location excellent staff very clean room, great breakfast from 7–10 am, 5:30-7 Happy Hr w/ snack food.."

Reviewed on Jul 12, 2026

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

1001 Veterans Blvd Festus MO

2 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

7.8/10 Good! (1,009 reviews)

"The room had mold in the air conditioner and the refund wasn’t processed like it was supposed to be."

Reviewed on Jul 12, 2026

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

4 hours drive from Johnson's Shut-ins State Park

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...

8/10 Very good! (976 reviews)

"Nice indoor pool. And nice king bed suite with full size fridge stove top for cooking and a dishwasher. Nice for long stayrs"

Reviewed on Jul 12, 2026

See all 662 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.