Title: Pet-friendly Vacations in Southeast Missouri 2025/2026 | Expedia.ca ![](https://images.trvl-media.com/place/553248635976196024/558eb86b-b1ac-4ef2-8a0c-6bebbb1e2aae.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Pet-friendly Vacations ## Book a Hotel + Flight or Car together to unlock savings Stay added Flight added Car - Economy - Premium economy - Business class - First class Leaving from Going to Dates Travellers ## Room 1 Adults ChildrenAges 2 to 17 InfantsYounger than 2 I only need accommodation for part of my trip - ## Plan, book, travel with confidence ### Better together Save up to CA $1,096 when you book a flight and hotel together\* ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package ### Rest easy Plan, book, and manage your trip all in one place ## Pet-friendly Hotels in Southeast Missouri ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive, Cape Girardeau, MO - 5 hours drive from Mark Twain National Forest Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ... 9.4/10 Exceptional! (1,019 reviews) "Everything was great especially the staff" Reviewed on Oct 16, 2025 [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru By Hilton Cape Girardeau 2520 Veterans Memorial Dr, Cape Girardeau, MO - 5 hours drive from Mark Twain National Forest Stay at this hotel in Cape Girardeau. Enjoy free breakfast, free parking, and a fitness center. Popular attractions Cape Girardeau Conservation Nature Center ... 9.4/10 Exceptional! (78 reviews) "Nice staff at the front desk, large comfortable room, very nice hotel!" Reviewed on Oct 16, 2025 [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy, Cape Girardeau, MO - 5 hours drive from Mark Twain National Forest Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ... 9/10 Wonderful! (1,008 reviews) "The hotel was nice, clean, and had a comfortable mattress." Reviewed on Oct 11, 2025 [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) [See all 595 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## More Vacations Ideas [Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Southeast Missouri Hotels](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Southeast Missouri Vacation Rentals](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacations](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)