Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
per person
Sep 23 - Sep 27
found 4 hours ago
Roundtrip flight included
Montreal (YUL) to St. Louis (STL)
8.2/10 Very Good! (756 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul. 26, 2025

Isle of Capri Casino Hotel Boonville

Isle of Capri Casino Hotel Boonville

3 out of 5
per person
Sep 8 - Sep 15
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
8.2/10 Very Good! (814 reviews)
Nice place, huge room

Reviewed on Jul. 29, 2025

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
per person
Oct 17 - Oct 19
found 4 hours ago
Roundtrip non-stop flight included
Montreal (YUL) to St. Louis (STL)
9/10 Wonderful! (1,549 reviews)
For the price, this hotel was great. A cheap clean stopover in St. Louis. We were very happy to have cafes and restaurants within walking distance too! And parking was free.

Reviewed on Jul. 30, 2025

Capitol Plaza Hotel Jefferson City

Capitol Plaza Hotel Jefferson City

3.5 out of 5
per person
Sep 8 - Sep 15
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to St. Louis (STL)
6.8/10 (1,005 reviews)
Like always a great stay and easy parking and in and out

Reviewed on Jul. 27, 2025

The Principal Hotel

The Principal Hotel

3.5 out of 5
per person
Sep 23 - Sep 27
found 4 hours ago
Roundtrip flight included
Montreal (YUL) to St. Louis (STL)
9.8/10 Exceptional! (88 reviews)
Very clean quiet , room excellent ,mattress very comfortable, extra towels Overall experience awesome.

Reviewed on Jul. 26, 2025

Ready to book your vacation to Southeast Missouri?

 

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Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is CA $77 per night from Aug 13 to Aug 14
CA $77
CA $88 total
Aug 13 - Aug 14
includes taxes & fees
8/10 Very Good! (1,000 reviews)
"I was very impressed with this motel. Very clean and the staff was very friendly and helpful. The breakfast was delicious!!!"

Reviewed on Jul. 28, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is CA $145 per night from Aug 3 to Aug 4
CA $145
CA $164 total
Aug 3 - Aug 4
includes taxes & fees
9.2/10 Wonderful! (365 reviews)
Great Economical Place to Stay
"It was a great place to stay. Even though a casino is attached to the hotel, it seemed like we were in a nice secluded area of Cape Girardeau. Everything was like new and very nice. Even had a Starbucks so we were able to get a refreshment before we got back on the road. The only down side was that ..."

Reviewed on Jul. 29, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is CA $124 per night from Aug 4 to Aug 5
CA $124
CA $140 total
Aug 4 - Aug 5
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
5 stars
"Hotel was extremely nice and comfortable. Unfortunately my family was unable to take advantage of the drinks and snacks in the lobby due to several youth volleyball teams also staying at the hotel. They took over the lobby and pool area and were so loud we couldn’t hear the hotel staff checking us ..."

Reviewed on Jul. 24, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
See all 588 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Southeast Missouri

Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Century Casino Caruthersville

What to do in Southeast Missouri

Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

CA $141
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just CA $979. Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.