Title: Cheap Vacations in Southeast Missouri 2026 | Expedia.ca ![](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Cheap Vacations ## Book a Hotel + Flight or Car together to unlock savings Photo by JG Morris - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Cheap Hotels in Southeast Missouri ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO - 3 hours drive from Mark Twain National Forest Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ... 8/10 Very Good! (1,002 reviews) Clean room, nice folks. Free WiFi. No bells here, bring your own shampoo and conditioner and if you’re over 5 feet, maybe your own bath towel :) Reviewed on Mar 16, 2026 [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO - 4 hours drive from Mark Twain National Forest Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ... 8.4/10 Very Good! (752 reviews) Convenient stop on our longer trip Reviewed on Mar 16, 2026 [](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO - 5 hours drive from Mark Twain National Forest Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ... 9/10 Wonderful! (1,003 reviews) Clean room, great breakfast. The lady that worked breakfast was very nice and worked hard. I gave her a tip. You dont see that much at hotels Reviewed on Mar 15, 2026 [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) [See all 620 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ## More Vacations Ideas [Flights to Southeast Missouri ](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[ Southeast Missouri Hotels ](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[ Southeast Missouri Vacation Rentals ](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[ Southeast Missouri Car Rentals ](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[ Southeast Missouri Vacations ](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)[ Things to do in Southeast Missouri ](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app