Cheap Vacations in Southeast Missouri 2026

Photo by JG Morris

Plan, book, travel with confidence
Better together
Save up to CA $4,200 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

4 Night Cheap holidays in Southeast Missouri

Price found within the past 48 hours. Click for updated prices.

Comfort Inn Festus - St Louis South

CA $1,045

per person

Oct 7 - Oct 11

found 9 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

7.8/10 Good! (978 reviews)

Clean room and relaxing 1-night stay

Reviewed on Aug 18, 2026

Don't see what you're looking for?

See all available trips from Columbus to Southeast Missouri

View all trips

Cheap Hotels in Southeast Missouri

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

4 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

8.4/10 Very good! (815 reviews)

"Close to I55 reasonable rate. (Good) What i didn't care for was the cleaning solution that was used was to strong! Had to get air freshener for room to block the cleaner."

Reviewed on Aug 17, 2026

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

5 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

8/10 Very good! (1,005 reviews)

"Clean and nice."

Reviewed on Aug 17, 2026

See all 673 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.