Cheap Hotels in Southeast Missouri

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

5 hours drive from Mark Twain National Forest

Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...

8.8/10 Excellent! (1,000 reviews)

Great Hotel for the Price

"My family was driving back from vacation and needed a last minute place to rest for the night. It was overall a great stay for the price. They had a portable crib for my toddler along with popcorn in the lobby. The staff were friendly and accommodating. Lots of choices for nearby restaurants."

Reviewed on Aug. 3, 2025

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO

5 hours drive from Mark Twain National Forest

Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...

9/10 Wonderful! (1,000 reviews)

Good stay

"Good location, right off the interstate and close to stores and food. They are in the process of remodeling so hard to determine how nice it will be upon completion. Room was clean. Would stay here again."

Reviewed on Aug. 2, 2025

Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

3 hours drive from Mark Twain National Forest

Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

7.8/10 Good! (1,000 reviews)

"Love that pets can stay free."

Reviewed on Aug. 3, 2025

See all 589 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.