Cayos Zapatilla Adventure Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Flight and Adventure hotel deals in Cayos Zapatilla

Price found within the past 48 hours. Click for updated prices.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
CA $1,399
per person
Oct 18 - Oct 24
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at breakfast, may disturb your sleep.

Reviewed on Aug 10, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
CA $1,430
per person
Oct 18 - Oct 24
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,628 reviews)
Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
CA $1,544
per person
Oct 4 - Oct 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.6/10 Exceptional! (398 reviews)
Todo fue excelente!

Reviewed on Aug 13, 2026

Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

Casco Viejo
CA $1,644
per person
Oct 6 - Oct 11
found 4 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9.8/10 Exceptional! (28 reviews)
Well appointed, friendly staff on site and excellent location. Noise from the outside does get in but it didnt bother us too much. Would definitely stay again!

Reviewed on Jul 28, 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

San Francisco
CA $1,446
per person
Oct 4 - Oct 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9/10 Wonderful! (1,058 reviews)
Everything was amazing! Great area. Amazing staff. Christin was phenomenal!!!

Reviewed on Aug 11, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips

5* Adventure holidays in Cayos Zapatilla

Price found within the past 48 hours. Click for updated prices.
Renaissance Panama City Hotel

Renaissance Panama City Hotel

Bella Vista
CA $1,320
per person
Oct 4 - Oct 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.8/10 Excellent! (269 reviews)
Great experience

Reviewed on Aug 11, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
CA $1,544
per person
Oct 4 - Oct 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.6/10 Exceptional! (398 reviews)
Todo fue excelente!

Reviewed on Aug 13, 2026

The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

CA $1,616
per person
Oct 4 - Oct 9
found 1 day ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8/10 Very good! (1,003 reviews)
The hotel was awesome. Smells really good once u enter the lobby. It was very clean. The staff were really friendly, accommodating and nice. Shout out to Brayan and Edilsa from the reception area on accommodating my requests. Overall, wonderful experience.

Reviewed on Aug 12, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips

3 Night Adventure holidays in Cayos Zapatilla

Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
CA $1,115
per person
Oct 10 - Oct 12
found 1 day ago
Roundtrip non-stop flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,628 reviews)
Casa Mallet by Wynwood House

Casa Mallet by Wynwood House

Casco Viejo
CA $1,479
per person
Oct 9 - Oct 12
found 22 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (28 reviews)
Well appointed, friendly staff on site and excellent location. Noise from the outside does get in but it didnt bother us too much. Would definitely stay again!

Reviewed on Jul 28, 2026

Hotel San Felipe

Hotel San Felipe

Casco Viejo
CA $1,286
per person
Oct 9 - Oct 12
found 22 hours ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.4/10 Exceptional! (430 reviews)
Staff very pleasant

Reviewed on Aug 13, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips

4 Night Adventure holidays in Cayos Zapatilla

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
CA $1,064
per person
Oct 8 - Oct 12
found 16 hours ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.6/10 Excellent! (1,718 reviews)
The place was very clean every day someone came and clean our room. Enjoyed the breakfast. Very easy to travel around, you just had to walk out of the hotel and taxis were there to take you where ever you needed to go

Reviewed on Aug 12, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
CA $1,134
per person
Oct 8 - Oct 12
found 16 hours ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
8.4/10 Very good! (1,628 reviews)
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
CA $1,132
per person
Oct 8 - Oct 12
found 16 hours ago
Roundtrip flight included
Montreal (YMQ) to Panama City (PTY)
9.2/10 Wonderful! (1,010 reviews)
Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at breakfast, may disturb your sleep.

Reviewed on Aug 10, 2026

Don't see what you're looking for?
See all available trips from Columbus to Cayos Zapatilla
View all trips

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.