Title: Book the Best Seneca FAMILY FRIENDLY Hotels from CA $72 - Kid-Friendly Hotels in Seneca, SC | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Family Hotels Tonight [Feb 4 - Feb 5](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-02-04&endDate=2026-02-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Tomorrow [Feb 5 - Feb 6](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-02-05&endDate=2026-02-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=family_friendly) ## Our top choices for Seneca family-friendly hotels ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/e45ab30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/2c84c92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area [](https://www.expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) Seneca 9.4/10 Exceptional (206 reviews) "Spotless, friendly staff, great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cari CA $171 CA $188 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/51000000/50270000/50261400/50261396/fc19a084.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/51000000/50270000/50261400/50261396/84e2f8d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/51000000/50270000/50261400/50261396/6f1e18f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/51000000/50270000/50261400/50261396/52fb0c78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tucker Farm Cottage on Century Farm [](https://www.expedia.ca/Seneca-Hotels-Tucker-Farm-Cottage-On-Century-Farm.h50261396.Hotel-Information) Seneca 10/10 Exceptional (33 reviews) "Excellent stay, beautiful area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Barbara W. CA $218 CA $527 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Seneca-Hotels-Tucker-Farm-Cottage-On-Century-Farm.h50261396.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/1ece8b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/5ddade10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Big Golf House- 10 miles to Clemson [](https://www.expedia.ca/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information) Seneca 10/10 Exceptional (2 reviews) "Absolutely! Perfect space for our needs, so for accommodating for our family & pet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gennifer Q. CA $322 CA $735 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/7bfcd263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/bf812e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/1692b12e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/fa054611.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) Seneca 10/10 Exceptional (5 reviews) "Great place with a lot close by" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aldor D. CA $290 CA $431 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/299db208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/98c8974f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d37b415d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/fc891652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) Seneca 9.6/10 Exceptional (8 reviews) "Owner was on point with contact prior to arrival and during stay. Check in was super easy and property was clean and decorated nicely. Everything that we needed was already at the house. There is a marina close by with restaurant also." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benjamin J. CA $445 CA $948 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/735219a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/91ac5b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) Serenity Bay 9.8/10 Exceptional (130 reviews) "A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) stacy s. CA $512 CA $977 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/9bab6d34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/3f88a754.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/227b33b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/850000/848800/848780/0160650e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) Anderson 9.0/10 Wonderful (592 reviews) "Clean, quiet, comfortable stay- staff is always friendly and helpful!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori CA $151 CA $168 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/Anderson-Hotels-Holiday-Inn-Express-Hotel-Suites-Anderson-I-85.h848780.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/5000000/4590000/4584800/4584724/ebee5c42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/5000000/4590000/4584800/4584724/c95bdf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4590000/4584800/4584724/aacced25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4590000/4584800/4584724/d2634e11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rodeway Inn Anderson North - Clemson [](https://www.expedia.ca/Anderson-Hotels-Rodeway-Inn.h4584724.Hotel-Information) Anderson 7.8/10 Good (322 reviews) "Room was spotless an the stay was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benito CA $83 CA $92 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/Anderson-Hotels-Rodeway-Inn.h4584724.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/269fcec4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/5926289d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/c069e415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/10000/2600/2544/743fe535.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Clemson near University [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) Anderson 7.0/10 Good (895 reviews) "Bueno was " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Alejandro CA $65 CA $72 total includes taxes & fees Feb 19 - Feb 20 [](https://www.expedia.ca/Anderson-Hotels-Quality-Inn-Clemson-Near-University.h2544.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency)](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/60d71ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/4f8e319f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/26b1d839.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19100/19019/3e3a13ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Clemson - University Area [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Clemson 8.2/10 Very good (1,001 reviews) "Room was extremely clean, continental breakfast was amazing with many options, and staff were very friendly. Great hotel! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Delaney CA $138 CA $153 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/Anderson-Hotels-Comfort-Inn-Suites-Clemson-University-Area.h19019.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20®ionId=6548&adults=2&travelerType=family_friendly&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at family-friendly hotels in Seneca Breakfast included Pool All-inclusive 4 stars 5 stars ## Top Seneca Hotel Reviews ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "Our room was very clean and the staff were very nice and courteous!" [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Woman at the front desk " [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Our stay was very nice. Clean room. The outside was clean. " [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Days Inn by Wyndham Seneca / Clemson Area](https://images.trvl-media.com/lodging/1000000/20000/14900/14854/9f69229a_y.jpg) ### Days Inn by Wyndham Seneca / Clemson Area 10/10 Excellent "Very nice and helpful at the fronte desk. Nice room and very comfortable bed" [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) ![Fall fun at the cabin! Convenient to Lake Keowee and Clemson](https://images.trvl-media.com/lodging/19000000/18970000/18968900/18968828/9c91f86d_y.jpg) ### Fall fun at the cabin! Convenient to Lake Keowee and Clemson 10/10 Excellent "It was a lovely place to stay!" [](https://expedia.ca/Anderson-Hotels-Fall-Fun-At-The-Cabin-Convenient-To-Lake-Keowee-And-Clemson.h18968828.Hotel-Information) ## Frequently asked questions ### What's Seneca like for family-friendly vacations? ### What's the best accommodation for families in Seneca? ### When's the best time to book a family-friendly vacation in Seneca? ### What's there to see and do with your family in Seneca? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central ](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central ](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Starwood Capital Hotels in Central ](https://www.expedia.ca/Central-Hotels-Starwood-Capital.0-0-d10503--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Central Hotels ](https://www.expedia.ca/Central-Hotels.d10503.Travel-Guide-Hotels) - 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