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Search Guest Houses in Oxford from CA $106

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    Check prices for these dates, December 14–15, 2026

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    Our top choices for Oxford guest houses

    1. Dog Friendly New Tiny Home Near Duke

    A modern building with a wooden deck and a metal fence.

    2. Tiny Home in the Bull City-Walk to Duke Hospital

    A modern entrance with a double door, a bench, and a welcome mat.

    3. Downtown Centric, Tucked Away, Fenced, PetsOK

    A two-story house with a balcony, a fenced deck, and a small garden area.

    4. Stylish and Modern Guesthouse in Downtown Durham

    A compact kitchen with a microwave, stove, and sink, a small trash bin, and a staircase leading to an upper level.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Learn more about Oxford

    Stroll past historic tobacco warehouses and elegant Victorian homes in this charming small town with a vibrant Main Street. Visit during the annual Hot Sauce Contest or explore Granville County Museum to discover the region's rich agricultural heritage.

    See all hotels in Oxford

    A red brick building with a white dome and a flagpole with flags.

    Top reviews in Oxford

    Charles Bass House Bed & Breakfast

    A hot tub with wooden steps and a bench, surrounded by windows and plants.

    Hampton Inn & Suites Durham University Medical Center

    A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

    JB Duke Hotel

    An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

    The Berry Hill Resort & Conference Center

    An indoor swimming pool with a high ceiling and wooden beams, surrounded by lounge chairs and potted plants.

    Hampton Inn Henderson

    A reception area with a reception desk, seating area with sofas and chairs, a wall-mounted clock, and a large window with a view.

    Hilton Garden Inn Durham/University Medical Center

    A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

    Hampton Inn & Suites Durham/North I-85

    A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

    Comfort Inn & Suites Oxford South

    A hotel room with two beds, a desk, a television, and a window with curtains.

    University Inn Durham next to Duke University Medical Center

    A long, narrow hallway with dark walls and wooden flooring.

    The Durham Hotel

    An outdoor cafe with tables and chairs, umbrellas, and a bicycle parked nearby.

    AC Hotel Durham

    A modern living room with a sectional sofa, a bar area, and a dining space.

    Residence Inn Durham McPherson/Duke University Medical Cntr

    An outdoor patio with wicker furniture, a stone fire pit, and a brick building in the background.

    Hampton Inn Raleigh / Town Of Wake Forest

    A hotel lobby with a fireplace, seating area, bar, and a television.

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