Title: Hotels by La Quinta Inn & Suites in Matlacha from CA $105 | Expedia.ca [Matlacha Travel Guide](https://expedia.ca/Matlacha.dx601098)[Hotels in Matlacha](https://expedia.ca/Matlacha-Hotels.d601098.Travel-Guide-Hotels)[Vacation Rentals in Matlacha](https://expedia.ca/Matlacha-Vacation-Rentals.d601098.Travel-Guide-VacationRentals)[Flights to Matlacha](https://expedia.ca/Cheap-Flights-To-Matlacha.d601098.Travel-Guide-Flights)[Things to do in Matlacha](https://expedia.ca/Things-To-Do-In-Matlacha.d601098.Travel-Guide-Activities)[Matlacha Car Rentals](https://expedia.ca/Car-Rentals-In-Matlacha.d601098.Car-Rental-Guide)[Matlacha Vacation Packages](https://expedia.ca/Matlacha.d601098.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/495000/495852-matlacha.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by La Quinta Inn & Suites in Matlacha from CA $105 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=601098&startDate=2025-11-04&endDate=2025-11-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=601098&startDate=2025-11-05&endDate=2025-11-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=601098&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=601098&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Matlacha La Quinta Inn & Suites Hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/4ec8c9b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/8f32b7a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11200/11134/w3000h1997x0y3-c76bf6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway Fort Myers 8.0/10 Very good (1003) "Clean and comfortable room, friendly staff!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $133 CA $149 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/9b4d626a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/1f7729f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/24b97ddc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1560000/1551400/1551348/2a531aa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn and Suites Fort Myers I-75 Daniels Corridor 6.6/10 (1006) "Pleasant and helpful staff, quiet hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nadine CA $95 CA $105 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Fort-Myers-Airport.h1551348.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-18&endDate=2025-11-19®ionId=601098&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Hotels-La-Quinta-Inn-Suites.0-0-d601098--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FMatlacha-Hotels-La-Quinta-Inn-Suites.0-0-d601098--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) ## Top Matlacha Hotel Reviews ![Margaritaville Beach Resort Fort Myers ](//images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg) ### Margaritaville Beach Resort Fort Myers 10/10 Excellent "Balcony nice and resort great. Pool and beach" [](https://expedia.ca/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](//images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "Room was amazing. Cool, clean, and cozy. Molly was great during check-in. Definitely going back. " [](https://expedia.ca/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway](//images.trvl-media.com/lodging/1000000/20000/11200/11134/b06bf9be_y.jpg) ### La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway 10/10 Excellent "Excellent" [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Ft-Myers-Sanibel-Gateway.h11134.Hotel-Information) ![Sanibel Island Beach Resort](//images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "👌" [](https://expedia.ca/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Hilton Garden Inn Ft Myers](//images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Great staff and clean room " [](https://expedia.ca/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Doubletree by Hilton Fort Myers at Bell Tower Shops](//images.trvl-media.com/lodging/1000000/20000/12400/12375/704cf90c_y.jpg) ### Doubletree by Hilton Fort Myers at Bell Tower Shops 10/10 Excellent "My room was very clean and the staff was extremely helpful and friendly. " [](https://expedia.ca/Fort-Myers-Hotels-Doubletree-By-Hilton-Fort-Myers-At-Bell-Tower-Shops.h12375.Hotel-Information) ![Edison Beach House](//images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/fb0b7d7c_y.jpg) ### Edison Beach House 10/10 Excellent "Check-in and check-out was seamless, all of the staff were happy to be of assistance, rooms were clean, right on the beach. Walking distance to a handful of bars and restaurants. When we return to Fort Meyers Beach we will definitely stay at the Edison House again." [](https://expedia.ca/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) ![Baymont by Wyndham Fort Myers Central](//images.trvl-media.com/lodging/1000000/30000/23400/23367/7ff8face_y.jpg) ### Baymont by Wyndham Fort Myers Central 10/10 Excellent "Room was good, staff was great, good area" [](https://expedia.ca/Fort-Myers-Hotels-La-Quinta-Inn-By-Wyndham-Fort-Myers-Central.h23367.Hotel-Information) ![Marriott Sanibel Harbour Resort & Spa](//images.trvl-media.com/lodging/1000000/10000/3100/3079/ac9a3a07_y.jpg) ### Marriott Sanibel Harbour Resort & Spa 10/10 Excellent "The staff was so welcoming and kind. Upon arrival, Frank welcomed me warmly, and upon departure, Nelson was equally kind. The front desk staff and restaurant personnel were wonderful as was the food I enjoyed there. It was a relaxing week at the hotel and its beautiful setting on Sanibel." 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[Coral Oaks Golf Course](https://www.expedia.ca/Coral-Oaks-Golf-Course-Burnt-Store.d6295914.Vacation-Attraction) - [Visit Matlacha Isles-Matlacha Shores](https://www.expedia.ca/Matlacha-Isles-Matlacha-Shores.dx553248635975849540) - [Pine Island Vacations](https://www.expedia.ca/Pine-Island.d553248635083900600.Destination-Travel-Guides) - [Visit Pine Island](https://www.expedia.ca/Pine-Island.dx553248635083900600) - [Sun Splash Water Park](https://www.expedia.ca/Sun-Splash-Water-Park-Hancock.d6127772.Vacation-Attraction) - [Car rentals near Pine Island](https://www.expedia.ca/Car-Rentals-In-Pine-Island.d553248635083900600.Car-Rental-Guide) - [Zezgo Rental Cars in Pine Island](https://www.expedia.ca/ZezGo-Car-Rentals-In-Pine-Island.d553248635083900600-c1122.Car-Rental-Guide-Suppliers) - [Things to do in Pine Island](https://www.expedia.ca/Things-To-Do-In-Pine-Island.d553248635083900600.Travel-Guide-Activities) - [Things to do in Pineland](https://www.expedia.ca/Things-To-Do-In-Pineland.d553248635975849749.Travel-Guide-Activities) - [Book La Quinta Inn & Suites in Matlacha on Expedia.com](https://www.expedia.com/Matlacha-Hotels-La-Quinta-Inn-Suites.0-0-d601098--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels)