A large waterfall cascading down a cliff, surrounded by dense forest and rocky terrain.

CA $224 Cheap Flights from Des Moines (DSM) to Buffalo (BUF)

View CA $224 flight on Mon, Oct 5, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap flights from Des Moines (DSM) to Buffalo (BUF)

Prices were available within the past 7 days and start at CA $224 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) cost?
You can find cheap one-way flights from CA $224 and cheap return flights DSM to BUF with Expedia. One-way flights typically cost between CA$245 and CA$954, and return flights often range between CA$666 and CA$1238. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when DSM to BUF ticket fares go up or down.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
January is typically the cheapest month to fly from Des Moines International Airport (DSM) to Buffalo Niagara International Airport (BUF), with average return fares around CA$299. January sees lower prices because it falls after the holiday travel rush, when demand drops and airlines compete for bookings. Other cheap months to fly from Des Moines International Airport (DSM) to Buffalo Niagara International Airport (BUF) include August and September.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Enter DSM to BUF and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
American Airlines is one of the cheapest airlines offering connecting return flights from Des Moines Intl. (DSM) to Buffalo Niagara Intl. (BUF), with tickets starting from around CA$665 for flights that can be booked for departure within the next year. These prices are per adult, for economy/coach class. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The cheapest months to fly from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) are typically January and September, with average return flights around CA$299. The most popular months for this route are May and November, meaning you'll find plenty of flight options during these times. While there isn't a single month that is both the cheapest and most popular, if you're looking for the best value, January or September are your best bets for lower fares.
How many flights per day from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
There are approximately 32 connecting flights per day from Des Moines International (DSM) to Buffalo Niagara International (BUF). Some common connection points include O'Hare International (ORD), Denver International (DEN), and Midway International (MDW).
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The earliest flight from Des Moines Intl. (DSM) to Buffalo Niagara Intl. (BUF) typically departs around 5:00 AM local time. This flight is operated by American Airlines and is a seasonal service, active only in March. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
You'll find the most flights from Des Moines International Airport (DSM) to Buffalo Niagara International Airport (BUF) on a Saturday, with around 22 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include American Airlines, United, and Delta. Flight schedules are quite consistent throughout the week, with Saturday offering only slightly more flights than other days.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
The most popular departure times for flights from Des Moines Intl. (DSM) to Buffalo Niagara Intl. (BUF) are in the early morning, from 6am to 9am. Many major carriers, including American Airlines, Delta and United, offer flights during this window. Many travellers prefer this time as it allows for an early start to their journey, often arriving at their destination with plenty of time left in the day.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
There are no nonstop flights from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.). The shortest flights typically involve one stop, taking around 4 hours 18 minutes. Flights with two or more stops usually take longer, averaging about 10 hours. The distance between these two airports is approximately 1,236 kilometres. Keep in mind that actual travel times can vary based on layover duration, routing, and weather conditions.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
Select the "Business class" and "First class" filters when looking for DSM to BUF flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Buffalo, NY (BUF) from Des Moines, IA (DSM)?
If you're planning to travel to Buffalo from Des Moines Intl. (DSM), you can fly directly into Buffalo Niagara Intl. (BUF) which offers domestic flights and connections. Some flights may connect through major hubs like Lambert-St. Louis Intl. (STL), Denver Intl. (DEN), or O'Hare Intl. (ORD) before reaching Buffalo. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Buffalo, NY (BUF-Buffalo Niagara Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Buffalo Niagara Intl.
Distance
1228 km

Book with confidence

Des Moines to Buffalo Flights

The easy way to book your flights from Des Moines to Buffalo 

With Expedia, it’s simple to find and book flights to Buffalo from Des Moines whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Buffalo Niagara Intl., too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Des Moines to Buffalo today, tomorrow, or this week.  

 

Save dollars with cheap flights from Des Moines Intl., DSM to Buffalo Niagara Intl., BUF 

Sort your search results by price to find great deals on your flight from Des Moines to Buffalo—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Buffalo from Des Moines currently is just rising to .  

Here are more money-saving tips: 

  • Fly in when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Buffalo  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Buffalo from Des Moines 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Buffalo with Expedia today.

Des Moines to Buffalo Flights

Explore a world of travel with Expedia

*Available to Expedia members.