Title: 10 Best Hotels in Otay Mesa, San Diego for 2025 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Hotels in Otay Mesa, San Diego ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Otay Mesa Resort [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&lodging=HOTEL_RESORT) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&lodging=APART_HOTEL) Spa [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=SPA_ON_SITE) Pool [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=POOL) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=OCEAN_VIEW) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&lodging=APARTMENT) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&travelerType=family_friendly) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=HOT_TUB) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&lodging=COTTAGE) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=WATER_PARK) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&amenities=PETS) Condo [](https://www.expedia.ca/Hotel-Search?destination=Otay+Mesa%2C+San+Diego%2C+California%2C+United+States+of+America®ionId=6263723&latLong=32.559475%2C-116.973465&adults=2&startDate=2025-10-18&d1=2025-10-18&endDate=2025-10-20&d2=2025-10-20&lodging=CONDO) ## Check prices for these dates Tonight [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-04&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 5 - Oct 6](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-05&endDate=2025-10-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Otay Mesa hotels and places to stay ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/c6a042c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1001) "Clean, friendly staff and yummy breakfast :)" CA $138 CA $157 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Non Smoking (Mobility, Transfer Shower)](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1d234b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG Otay Mesa 8.0/10 Very good (1467) "Very good to stayed " CA $165 CA $187 total includes taxes & fees Oct 10 - Oct 11 [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/4480f6ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/a314a493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/dd3cca67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/89000000/88400000/88398500/88398416/63587042.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Palihotel San Diego Gaslamp Quarter Gaslamp Quarter, 24.5 km from Otay Mesa 8.8/10 Excellent (1873) "would definitely stay again!" CA $157 CA $182 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Palihotel-San-Diego.h88398416.Hotel-Information) ![Serves dinner and happy hour](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/ce3fee83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/93444558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/e3d5bf14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/11100/11026/d9883b91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Horton Grand, Downtown/Gaslamp Quarter 24.3 km from Otay Mesa 9.0/10 Wonderful (2584) "Great location and lovely staff. " CA $186 CA $253 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/San-Diego-Hotels-The-Horton-Grand.h11026.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a0a6825c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/49bcb235.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/a9bcd444.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2920000/2918200/2918129/e3befa7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter Gaslamp Quarter, 24.1 km from Otay Mesa 9.0/10 Wonderful (1144) "Great stay! " CA $236 CA $274 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-Residence-Inn-By-Marriott-San-Diego-DowntownGaslamp-Quarter.h2918129.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/d5ea2f3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![City view](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/88f9cd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside 25.7 km from Otay Mesa 8.4/10 Very good (5959) "Great stay near the airport." CA $212 CA $287 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/54935ba5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/ddc5f050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/4d9ff339.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom, City View (1 Queen and 1 Sofabed) | Living area](https://images.trvl-media.com/lodging/1000000/20000/16300/16266/3de76bc8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Gaslamp Plaza Suites Gaslamp Quarter, 24.6 km from Otay Mesa 8.8/10 Excellent (1007) "Had a great stay " CA $151 CA $171 total includes taxes & fees Oct 6 - Oct 7 [](https://www.expedia.ca/San-Diego-Hotels-Gaslamp-Plaza-Suites.h16266.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/d85ecd0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/60472bda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/23e38216.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hard Rock Hotel San Diego Gaslamp Quarter, 24 km from Otay Mesa 9.0/10 Wonderful (2974) "Loved staying here. Will definitely stay again " CA $250 CA $354 total includes taxes & fees Oct 31 - Nov 1 [](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/43298e98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/038c4b57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/289d71c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/11600/11553/f7c3fa7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada Suites by Wyndham San Diego/Hotel Circle Area 28.5 km from Otay Mesa 6.2/10 (1011) "comfortable, easy access, friendly staff" CA $106 CA $121 total includes taxes & fees Oct 7 - Oct 8 [](https://www.expedia.ca/San-Diego-Hotels-Ramada-Suites-By-Wyndham-San-Diego.h11553.Hotel-Information) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/91baa1e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily cooked-to-order breakfast for a fee](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/8bb8fc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/a5cb77af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Marina Gateway Hotel 16.9 km from Otay Mesa 9.2/10 Wonderful (3299) "Great hotel" CA $180 CA $198 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/4877ef6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/7bb755a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/1194fa32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/1000000/20000/11400/11395/c517acec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Cordova Hotel on Coronado Island 23.5 km from Otay Mesa 8.8/10 Excellent (1003) "We love this hotel. It gives a feel of having your own apartment on the island. The rooms is are clean and comfortable. The staff is welcoming and accommodating. The location is perfect. Close walking distance to the beach, dining, shopping, as well as the famous Del across the street. " CA $250 CA $317 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Coronado-Hotels-El-Cordova-Hotel-On-Coronado-Island.h11395.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Suite, 2 Double Beds, Roll-in Shower, City View](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/c0dfd2f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/589f8e80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/75ec9582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Sofia Hotel 24.9 km from Otay Mesa 8.4/10 Very good (1591) "Close to a lot of areas, would stay here again." CA $139 CA $195 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Premium bedding, pillowtop beds, desk, blackout drapes](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/c31e05e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/53d75480.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/ec632047.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11490000/11486100/11486063/1fbe17de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Staypineapple, Hotel Z, Gaslamp San Diego Gaslamp Quarter, 24.2 km from Otay Mesa 9.4/10 Exceptional (1001) "Great staff and clean rooms" CA $208 CA $281 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/San-Diego-Hotels-Staypineapple.h11486063.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/5feb0059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/aeb717a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/30e922d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing Impaired) | Bathroom](https://images.trvl-media.com/lodging/1000000/10000/5000/4926/a4925138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham El Cajon/San Diego 26.8 km from Otay Mesa 7.8/10 Good (1001) "Great place " CA $97 CA $107 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/El-Cajon-Hotels-Super-8-By-Wyndham-El-Cajon-CA.h4926.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2d82864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/423e7241.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/a3c5905c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/25900/25840/c2540b7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loews Coronado Bay Resort 17.2 km from Otay Mesa 8.8/10 Excellent (1037) "Beautiful quiet hotel." CA $278 CA $372 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Coronado-Hotels-Loews-Coronado-Bay-Resort.h25840.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/3b915004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking (Balcony)](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/139a6c49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/w4000h2664x0y0-982a04e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87140000/87138000/87137975/76ddbc07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott San Diego Downtown Gaslamp Quarter Gaslamp Quarter, 24.4 km from Otay Mesa 8.8/10 Excellent (932) "Would definitely stay again!" CA $225 CA $260 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/San-Diego-Hotels-AC-Hotel-By-Marriott-San-Diego-Downtown-Gaslamp-Quarter.h87137975.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/243b93bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/8f3ed06e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/d154e491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/23900/23816/7f37543f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Bristol Hotel San Diego 24.9 km from Otay Mesa 8.4/10 Very good (1385) "Very nice staff from check in, clean rooms, quiet and comfortable. " CA $186 CA $216 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Diego-Hotels-The-Bristol-Hotel-San-Diego.h23816.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/fe340c37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/bd7d0518.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Suite, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/165a3a80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2220000/2217800/2217787/0c67e9c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Chula Vista/San Diego 13.8 km from Otay Mesa 6.2/10 (1004) "The staff was incredibly helpful" CA $100 CA $110 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Chula-Vista-Hotels-Red-Roof-Inn-PLUS-Chula-Vista.h2217787.Hotel-Information) ![Standard Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/2b01136a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/81f394e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/325ce31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Smoking](https://images.trvl-media.com/lodging/2000000/1180000/1176000/1175963/1e9b6911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham San Diego-East/El Cajon 27.3 km from Otay Mesa 7.6/10 Good (1004) "Place was nice and comfy. Decent stay at a very genuine price. " CA $110 CA $121 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/El-Cajon-Hotels-Days-Inn-By-Wyndham-San-Diego-EastEl-Cajon.h1175963.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/aa7dcb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/a7e21110.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/bb4bfc7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20500/20454/965cd455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus La Mesa San Diego 24.5 km from Otay Mesa 8.2/10 Very good (1004) "Excelent place to stay." CA $138 CA $152 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/La-Mesa-Hotels-Best-Western-Plus-La-Mesa-San-Diego.h20454.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-18&endDate=2025-10-19®ionId=6263723&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FOtay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels) ## Where to stay in Otay Mesa Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. - Downtown San Diego - Gaslamp Quarter - Pacific Beach - Mission Beach - Ocean Beach ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481093-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480742-Maritime-Museum-Of-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476416-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480743-Maritime-Museum-Of-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/476000/476415-Downtown-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=800123) ![Downtown San Diego map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:yfwfEzeejUaMaj%40fa%40k%5CbLaPx%40qOkGcWu%40i%5B%60DgKrIcFdRgF%7CrAsAHjJvK%60IqKjOFzR%7EP%7CI%7BH%7CO%7CIfNma%40hn%40%7B%40fIe%5ChZma%40t%40o%40kSei%40E_FfEiEnLwEd%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Cs9sAV_TcaQK48f0iT1-t86hPRE=) ### Downtown San Diego Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options. [See properties](https://www.expedia.ca/Hotel-Search?regionId=800123) ![Gaslamp Quarter showing street scenes, night scenes and a city](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22037-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/475000/475881-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480435-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480422-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480432-San-Diego-Gaslamp-Quarter.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6130021) ![Gaslamp Quarter map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mmtfEh%7CbjUAwJqIDCm%5B%60x%40OmEpJ%7DPD%40zAiE%40A_B%7BEBFj%5B_HH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=68cMX7ldk9-J6tcepLMBQKKwvpY=) ### Gaslamp Quarter Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6130021) ![Pacific Beach Park showing a sandy beach](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152283-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park which includes rugged coastline, a coastal town and surfing](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152049-San-Diego.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a sandy beach and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152293-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park featuring a beach](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152300-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Pacific Beach Park which includes a beach bar and drinks or beverages](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/152000/152301-Pacific-Beach.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=6185751) ![Pacific Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:agfgEvyujUgHcNcG%60IiBwN%7BKtBkf%40inCoKyIyEoFcHy%40aKoT%60mBq_B%7Cl%40aZb%40xB%7DAlAuMdQsExHkAvMbB%7CVpV_F%7CGrk%40tPgDhDlTbMbDlZu%40%60V%7EDxQfMtAlJg%40xH_GxEkRnGkUrA%7DP%60IiFbTv%40lR%60J%7CNcKjBzCfUec%40%60L%7BUxIkP%60IuM%7CH&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=5FbBeekgWkepp0jnCE7WEy_Qh88=) ### Pacific Beach Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway. [See properties](https://www.expedia.ca/Hotel-Search?regionId=6185751) ![Belmont Park which includes a garden and rides](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22160-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Belmont Park featuring street scenes and rides as well as a large group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22159-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Belmont Park which includes a city, rides and street scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/22000/22161-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187064-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Belmont Park ![Belmont Park](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187072-Belmont-Park.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Belmont Park [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=553248635998112279) ![Mission Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ec%7DfE%7CgujU_Die%40%7BAYqk%40sBclAvBeNh%40wNtAcg%40%60H_DqUxGwAlD%7EF%60Dm%40v%40%40Bb%40tDIhRqFnGs%40nEBzOdBzF%40xI%7DAvNwH%60BMfBZt%40m%40EhIzJy%40hNJI%7DIrBvAjErA%7EJb%40%7CMcEjJsFzArBfF%7EcA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=hFrZWtAC8u-2IGYk_Bcs7ztzP5Q=) ### Mission Beach Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park. [See properties](https://www.expedia.ca/Hotel-Search?regionId=553248635998112279) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481019-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/480000/480252-San-Diego-City.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481012-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481011-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/481000/481016-Ocean-Beach-Nei.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=177689) ![Ocean Beach map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:eq%7CfEneujUqO%7ByCl%5CdMdL%7B%40pnB%60%60BoUlb%40crB%60I&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=lCc_uj9JIfh1kP738Xl1bJJqo_A=) ### Ocean Beach Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego. [See properties](https://www.expedia.ca/Hotel-Search?regionId=177689) ## Top Otay Mesa Hotel Reviews ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Stay was excellent room always cleaned and beds made promptly. Room was very spacious and view of the bay with balcony amazing. Location is excellent." [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Pendry San Diego](//images.trvl-media.com/lodging/17000000/16300000/16299000/16298963/05d0e601_y.jpg) ### Pendry San Diego 10/10 Excellent "Hotel is pretty and is in a great location to be able to walk to shops, restaurants and bars " [](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "It was centrally located,. I had private car and they had parking in. It was perfect for me, the rooms were comfortable and clean. Pretty view." [](https://expedia.ca/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Hard Rock Hotel San Diego](//images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean room" [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Thanks " [](https://expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![The Sofia Hotel](//images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Clean room, friendly staff " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Had a comfortable stay" [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "We stayed for 9 nights and had an awesome time! Staff was friendly and accommodating. " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Great ocean view located right on wide beach. Hotel is awesome." [](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ## Find out more about Otay Mesa ### Top reasons to visit Otay Mesa - **Family-Friendly Activities:** Otay Mesa offers various entertainment options suitable for families, including local theatres and shopping centres. - **Scenic Outdoor Spots:** Enjoy the beauty of Otay Lake and urban parks for outdoor adventures and relaxation. - **Convenient Location:** Easily access downtown San Diego for a mix of culture, entertainment, and stunning city views. - **Diverse Accommodations:** Explore a range of lodging options, from pet-friendly hotels to family-oriented guesthouses. - **Vibrant Community:** Experience the welcoming atmosphere and friendly locals that define the charm of Otay Mesa. ### Find great hotels near Otay Mesa Otay Mesa, San Diego, offers a variety of accommodation options to cater to every traveller's needs, from hotels to guesthouses. Whether you're seeking a pet-friendly retreat, a family-friendly environment, or a business-oriented stay, you'll discover a range of choices that promise comfort and convenience. Explore popular motels and the best hotels in the area, ensuring a memorable visit to this vibrant border community. - **[Best Western Plus Marina Gateway Hotel:](https://www.expedia.ca/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information)** Nestled 17.7km from Otay Mesa, the Best Western Plus Marina Gateway Hotel offers a delightful family and eco-friendly experience. Perfect for those who enjoy a golf-themed vacation, this property boasts an eco-certification, showcasing its commitment to sustainability. Guests can take advantage of amenities such as a children's pool, mini-golf, and essential safety features for kids, making it an ideal choice for families. With its focus on green practices and recreational activities, this hotel ensures a memorable stay for eco-conscious travellers. - **[Ramada by Wyndham San Diego National City:](https://www.expedia.ca/National-City-Hotels-Ramada-By-Wyndham-San-Diego-National-City.h19676.Hotel-Information)** Located 17.7km from Otay Mesa, the Ramada by Wyndham San Diego National City is a 3-star hotel that caters to families, adventure seekers, and business travellers alike. This property is well-equipped with a business centre, conference space, and meeting rooms open 24 hours for those on a work trip. Meanwhile, adventure enthusiasts can explore nearby mountain biking, parasailing, and snorkeling opportunities. Families will appreciate the complimentary cribs for younger guests, ensuring comfort and convenience for all visitors. - **[Hard Rock Hotel San Diego:](https://www.expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information)** Situated 24.1km from Otay Mesa, the Hard Rock Hotel San Diego is a vibrant destination for adventure lovers and the LGBTQIA community. This 4-star hotel provides a unique atmosphere filled with music and energy. Guests can indulge in various adventure sports, including kayaking and skydiving, all located nearby. With its welcoming vibe and commitment to inclusivity, the Hard Rock Hotel promises an unforgettable experience for those seeking excitement and a lively social scene. ### Where to stay near Otay Mesa Discover the vibrant charm of Otay Mesa, a family-friendly neighbourhood in San Diego. With its convenient location, you can easily explore downtown San Diego, where you’ll find a blend of culture, entertainment, and stunning city views. Enjoy the welcoming atmosphere and friendly locals, perfect for a romantic getaway or a budget-friendly adventure. Don't miss the opportunity to experience the unique vibes that make this region an excellent choice for your vacation. - **[San Diego:](https://www.expedia.ca/San-Diego-Hotels.d3073.Travel-Guide-Hotels)** As a vibrant coastal city, San Diego is the heart of the region, encompassing Otay Mesa. This city boasts a diverse array of attractions, perfect for families seeking outdoor adventures and beach experiences. With a yearly influx of visitors peaking in March to April and July, you can enjoy beautiful weather while exploring theme parks, stunning beaches, and a lively shopping scene. Don't miss out on iconic landmarks like Balboa Park or the historic Gaslamp Quarter, where you can indulge in local cuisine and culture. - **[Ocean View Hills:](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels.0-n553248635976008220-0.Travel-Guide-Filter-Hotels)** Located just 4.8km from Otay Mesa, Ocean View Hills is a charming neighbourhood that offers a mix of family-friendly activities and entertainment. The area sees a surge of visitors from April through August, making it a lively spot for those looking for a romantic outing or a fun family day. Enjoy a visit to local theatres or explore nearby shopping centres and malls. The proximity to beautiful beaches and theme parks makes it an ideal destination for a relaxing day out. - **[San Ysidro:](https://www.expedia.ca/San-Ysidro-Hotels.d8380.Travel-Guide-Hotels)** Situated 6.4km from Otay Mesa, San Ysidro is a bustling city known for its vibrant shopping scene and cultural experiences. With visitor numbers peaking in June and July, it’s a fantastic spot for families and business travellers alike. Explore the large shopping centres and theatres, or take a stroll to nearby landmarks and beaches. Whether you're looking for a laid-back day or a bustling shopping spree, San Ysidro is sure to provide a memorable experience. ### Things to do near Otay Mesa Otay Mesa is an ideal destination for families seeking entertainment and city-themed adventures. Visitors can explore shopping centres and malls, along with local theatres for a fun night out. For a memorable stay, look for nearby resorts and discover the best attractions in the area, making your vacation a delightful experience. **Shopping** Experience shopping in Otay Mesa at [Las Americas Premium Outlets](https://www.expedia.ca/Las-Americas-Premium-Outlets-Hotels.0-l6150696-0.Travel-Guide-Filter-Hotels), only 6.4km away, offering a vibrant mix of entertainment and family-friendly options. Alternatively, visit [Otay Ranch Town Center](https://www.expedia.ca/Otay-Ranch-Town-Center-Hotels.0-l939107945015521280-0.Travel-Guide-Filter-Hotels), also 6.4km away, for a great selection of shops in a bustling atmosphere. **Recreation** The [Chula Vista Elite Athlete Training Center](https://www.expedia.ca/Chula-Vista-Elite-Athlete-Training-Center-Hotels.0-l6127999-0.Travel-Guide-Filter-Hotels) offers an energizing atmosphere for sports enthusiasts, while [Eastlake Country Club](https://www.expedia.ca/Eastlake-Country-Club-Hotels.0-l553248621532638607-0.Travel-Guide-Filter-Hotels) provides a scenic golfing experience amidst nature. For tranquility, visit [Mount Helix Park](https://www.expedia.ca/Mount-Helix-Park-Hotels.0-l553248621532638445-0.Travel-Guide-Filter-Hotels), where you can unwind and rejuvenate in a peaceful outdoor setting. **Adventure** [Sesame Place San Diego](https://www.expedia.ca/Sesame-Place-San-Diego-Hotels.0-l6266353-0.Travel-Guide-Filter-Hotels), located 4.8km from Otay Mesa, offers a thrilling waterpark experience with exciting slides and family-friendly attractions. For more adventure, visit [Sky Zone San Diego Indoor Trampoline Park](https://www.expedia.ca/Sky-Zone-San-Diego-Indoor-Trampoline-Park-Hotels.0-l553248621532638609-0.Travel-Guide-Filter-Hotels), 11.3km away, where you can bounce and flip in a fun-filled atmosphere. [White Water Canyon](https://www.expedia.ca/White-Water-Canyon-Hotels.0-l553248621532638602-0.Travel-Guide-Filter-Hotels), also 4.8km from Otay Mesa, boasts exhilarating water rides and an entertaining ambiance for all ages. **Nightlife** Enjoy an unforgettable evening at the [North Island Credit Union Amphitheatre](https://www.expedia.ca/North-Island-Credit-Union-Amphitheatre-Hotels.0-l6128061-0.Travel-Guide-Filter-Hotels), offering a vibrant atmosphere with live performances. For some excitement, visit [Len Moore Skate Park](https://www.expedia.ca/Len-Moore-Skate-Park-Hotels.0-l6266345-0.Travel-Guide-Filter-Hotels) or [Atlantis Laser Tag](https://www.expedia.ca/Atlantis-Laser-Tag-Hotels.0-l553248621532638600-0.Travel-Guide-Filter-Hotels), both providing thrilling arcade adventures just a short drive away from Otay Mesa. *\*Distances are measured in a straight line; actual driving distances may vary depending on the route.* ### Booking tips and Expedia advantages for Otay Mesa To save money during your visit to Otay Mesa, plan your trip between November and January, when accommodation prices are lower. Aim to book your stay on a Tuesday for the best rates, avoiding the pricier Saturdays. Use Expedia to find great hotel deals by filtering options based on your budget and combining reservations for flights and activities. Additionally, explore free local attractions and consider using public transport to minimize costs while enjoying the area. - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay around Otay Mesa are November to January, where the prices are slightly lower. This is in comparison to June to August, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay around Otay Mesa is Tuesday. The most expensive day to stay around Otay Mesa is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to refine your preferences, such as your budget, preferred location, and desired hotel type. To find the best prices and deals, simply sort the price filter from lowest to highest. - **Consider bundling your trip:** You can potentially save some money by combining your Otay Mesa hotel reservation with your flights and activities through an Expedia package. ### Find the best attractions near Otay Mesa Otay Mesa offers a delightful blend of family-friendly activities and urban attractions, making it perfect for a city-themed vacation. Visitors can enjoy the scenic Otay Lake and urban parks, along with various event venues that host exciting conferences and gatherings. Whether you're seeking outdoor adventures or cultural experiences, Otay Mesa caters to all. Explore the local beaches for relaxation and fun, ensuring a memorable trip for everyone in the family. - **[San Ysidro Border Crossing:](https://www.expedia.ca/San-Ysidro-Border-Crossing-Hotels.0-l553248621551385128-0.Travel-Guide-Filter-Hotels)** Experience the bustling atmosphere at one of the busiest land border crossings in the world. Located only 4.8km from Otay Mesa, you'll find friendly people and vibrant local culture, making it a unique gateway between Canada and Mexico. - **[San Diego Convention Center:](https://www.expedia.ca/San-Diego-Convention-Center-Hotels.0-l6125294-0.Travel-Guide-Filter-Hotels)** Situated 24.1km away, this impressive venue hosts various conferences and events. With its modern architecture and business-centric vibe, it’s an excellent spot for networking and enjoying the hustle of San Diego’s professional scene. - **[Coronado Beach:](https://www.expedia.ca/Coronado-Beach-Hotels.0-l6068513-0.Travel-Guide-Filter-Hotels)** Also located 24.1km from Otay Mesa, this stunning beach offers picturesque views and a relaxing atmosphere. With soft sands and gentle waves, it's perfect for sunbathing, swimming, or leisurely strolls along the shoreline. ### Best time to go to Otay Mesa The best time to visit Otay Mesa can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Otay Mesa falls in August, when visitor numbers are average and weather is sunny with no rain. The coolest average temperature around Otay Mesa falls in February, visitor numbers are average and weather is sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | --- | --- | --- | --- | --- | --- | | January | 57.4°F (14.1°C) | Light Rain | Sunny | Slightly Low | Slightly Low | | February | 56.8°F (13.8°C) | Light Rain | Sunny | Average | Average | | March | 58.1°F (14.5°C) | No Rain | Mostly Sunny | Average | Average | | April | 60.6°F (15.9°C) | No Rain | Sunny | Average | Average | | May | 62.6°F (17.0°C) | No Rain | Sunny | Average | Average | | June | 66.4°F (19.1°C) | No Rain | Sunny | Slightly High | Slightly High | | July | 70.5°F (21.4°C) | No Rain | Sunny | Slightly High | Slightly High | | August | 72.3°F (22.4°C) | No Rain | Sunny | Average | Slightly High | | September | 72.0°F (22.2°C) | No Rain | Sunny | Slightly High | Average | | October | 68.2°F (20.1°C) | No Rain | Sunny | Slightly Low | Average | | November | 62.6°F (17.0°C) | No Rain | Sunny | Average | Slightly Low | | December | 57.4°F (14.1°C) | Light Rain | Mostly Sunny | Slightly Low | Slightly Low | ### The nearest major airports for your trip to Otay Mesa When visiting Otay Mesa, you have several airport options. San Diego International Airport ([SAN](https://www.expedia.ca/San-Diego-Intl-Airport-Hotels.0-aSAN-0.Travel-Guide-Filter-Hotels)) is located 29.0km away, with nearby luxury hotels such as the 5-star [Pendry San Diego](https://www.expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) and [The US Grant](https://www.expedia.ca/San-Diego-Hotels-THE-US-GRANT.h10802.Hotel-Information), both within 4.8km. Tijuana Airport ([TIJ](https://www.expedia.ca/General-Abelardo-L-Rodriguez-Intl-Airport-Hotels.0-aTIJ-0.Travel-Guide-Filter-Hotels)) is only 1.4km from Otay Mesa, offering convenient access to hotels like the 4.5-star [Quartz Hotel & SPA](https://www.expedia.ca/Tijuana-Hotels-Quartz-Hotel-SPA.h36996325.Hotel-Information) and Real Inn Tijuana, both 4.8km away. For those considering Carlsbad Airport ([CLD](https://www.expedia.ca/McClellan-Palomar-Airport-Hotels.0-aCLD-0.Travel-Guide-Filter-Hotels)), it's 44.8km distant, with excellent accommodations such as the 5-star [Park Hyatt Aviara Resort](https://www.expedia.ca/Carlsbad-Hotels-Park-Hyatt-Aviara-Resort.h60576.Hotel-Information), just 3.2km from the airport. Each airport provides various transportation services to their respective hotels. ## Frequently asked questions ### What are the best family hotels in Otay Mesa? > [Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) is an excellent choice for families seeking comfort and convenience during their stay. This hotel offers thoughtfully designed rooms with connecting options, ensuring that families can stay close together. With amenities like free cribs and sofa beds, you can rest easy knowing that your little ones will have a cozy place to sleep at night. Guests appreciate the daily housekeeping, which provides a straightforward experience, and the complimentary buffet breakfast, superb for fueling up before a day of adventure. > > > > Another family-friendly option in Otay Mesa is [Quality Suites San Diego Otay Mesa](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information). Rated 7.2 by travellers, this hotel features a refreshing pool where kids can splash and play, making it a great place to unwind after a busy day. The hotel's connecting rooms and child-friendly window designs prioritize safety and comfort, ensuring that both parents and children feel at home. Additionally, the provision of free amenities for children adds extra value, making it easier for families to enjoy their stay without worrying about additional costs. ### What are the best spa hotels in Otay Mesa? > For a comfortable stay in Otay Mesa, the [Quality Suites San Diego Otay Mesa](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) is a solid choice, holding a review score of 7.2. This hotel provides accessible spa amenities, allowing guests to unwind and rejuvenate during their visit. ### What hotels in Otay Mesa offer free breakfast? > The [Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) is a great choice for travellers seeking convenience and comfort. This family-friendly hotel not only offers free breakfast, including a delicious buffet, but also features spacious suites equipped with a sofa bed, making it easy to accommodate families of all sizes. Guests appreciate the outdoor pool, great for unwinding after a day of exploring, along with complimentary amenities such as toiletries, WiFi, and self-parking. With a customer review rating of 7.8, it's clear that families find value in the quality service and facilities provided. > > > > Another option in Otay Mesa is the [Quality Suites San Diego Otay Mesa](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information), which also offers a complimentary breakfast to start your day right. This hotel features an outdoor pool and hot tub, ideal for relaxation and family fun. The Quality Suites is particularly appealing for those requiring accessible parking and facilities, and with a review score of 7.2, it provides a comfortable experience for guests looking for extra conveniences. ### What are the best budget hotels in Otay Mesa? > The Holiday Inn Express Hotel & Suites San Diego Otay Mesa is an excellent budget-friendly option, boasting a review score of 7.8. Families will appreciate the complimentary buffet breakfast, which makes mornings easy, and the outdoor pool is superb for a refreshing dip after a day of adventures. With free Wi-Fi and spacious suites featuring sofa beds, this hotel ensures everyone has enough room to relax. Plus, the availability of cribs and rollaway beds at no extra charge makes it convenient for families traveling with little ones. > > > > Another great choice for budget-conscious travellers is the [Quality Suites San Diego Otay Mesa](https://www.expedia.ca/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information), which has a review score of 7.2. This hotel offers a range of amenities geared towards families, including a free breakfast and outdoor pool, which is sure to keep kids entertained. The rooms are designed with child-friendly window features, providing peace of mind for parents. Self-parking is complimentary as well, making it easy for families to explore the local area without worrying about extra fees. ### Can I cancel my hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Otay Mesa hotel for you. ### How can I save on a Otay Mesa hotel booking with Expedia? > Before booking your Otay Mesa hotel, remember to join Expedia's free travel rewards program. Just sign up and sign in to access our lowest Member Prices as well as members-only perks. You could also enjoy savings by bundling together your hotel and flights on Expedia. ### How much is the nightly rate at a Otay Mesa hotel? > Hotel prices in Otay Mesa often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates. ## Explore a world of travel with Expedia - Lodging - Flights - Cars - More ways to book - [Hotels near Beyer Blvd Trolley Station](https://www.expedia.ca/Beyer-Blvd-Trolley-Station-Hotels.d6186828.Travel-Guide-Hotels) - [Bonita Hotels](https://www.expedia.ca/Bonita-Hotels.d177687.Travel-Guide-Hotels) - [Hotels near Brown Field Municipal](https://www.expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Hotels near Chula Vista Center](https://www.expedia.ca/Chula-Vista-Center-Hotels.0-l553248621560505608-0.Travel-Guide-Filter-Hotels) - [Hotels near Chula Vista Elite Athlete Training Center](https://www.expedia.ca/Chula-Vista-Elite-Athlete-Training-Center-Hotels.0-l6127999-0.Travel-Guide-Filter-Hotels) - [Hotels near Chula Vista Municipal Golf Course - Mountain](https://www.expedia.ca/Chula-Vista-Municipal-Golf-Course-Mountain-Hotels.0-l553248621532638603-0.Travel-Guide-Filter-Hotels) - [Eastlake Hotels](https://www.expedia.ca/Eastlake-Chula-Vista-Hotels.0-n553248635976008506-0.Travel-Guide-Filter-Hotels) - [Hotels near Eastlake Country Club](https://www.expedia.ca/Eastlake-Country-Club-Hotels.0-l553248621532638607-0.Travel-Guide-Filter-Hotels) - [Hotels near Iris Avenue Trolley Station](https://www.expedia.ca/Iris-Avenue-Trolley-Station-Hotels.d6186826.Travel-Guide-Hotels) - [Hotels near Kaiser Permanente Otay Mesa Medical Offices](https://www.expedia.ca/Kaiser-Permanente-Otay-Mesa-Medical-Offices-Hotels.0-l553248634333595416-0.Travel-Guide-Filter-Hotels) - [Hotels near Las Americas Premium Outlets](https://www.expedia.ca/Las-Americas-Premium-Outlets-Hotels.0-l6150696-0.Travel-Guide-Filter-Hotels) - [Nestor Hotels](https://www.expedia.ca/Nestor-San-Diego-Hotels.0-n553248635976476281-0.Travel-Guide-Filter-Hotels) - [Hotels near North Island Credit Union Amphitheatre](https://www.expedia.ca/North-Island-Credit-Union-Amphitheatre-Hotels.0-l6128061-0.Travel-Guide-Filter-Hotels) - [Ocean View Hills Hotels](https://www.expedia.ca/Ocean-View-Hills-San-Diego-Hotels.0-n553248635976008220-0.Travel-Guide-Filter-Hotels) - [Otay Hotels](https://www.expedia.ca/Otay-Chula-Vista-Hotels.0-n177685-0.Travel-Guide-Filter-Hotels) - [Otay Mesa West Hotels](https://www.expedia.ca/Otay-Mesa-West-San-Diego-Hotels.0-n553248625809641010-0.Travel-Guide-Filter-Hotels) - [Otay Ranch Village 1 Hotels](https://www.expedia.ca/Otay-Ranch-Village-1-Chula-Vista-Hotels.0-n553248635976473906-0.Travel-Guide-Filter-Hotels) - [Otay Ranch Village West Hotels](https://www.expedia.ca/Otay-Ranch-Village-West-Chula-Vista-Hotels.0-n553248635976473051-0.Travel-Guide-Filter-Hotels) - [Rancho del Rey Hotels](https://www.expedia.ca/Rancho-Del-Rey-Chula-Vista-Hotels.0-n553248635976480627-0.Travel-Guide-Filter-Hotels) - [Rancho - Del Rey II Hotels](https://www.expedia.ca/Rancho-Del-Rey-II-Chula-Vista-Hotels.0-n553248635976470133-0.Travel-Guide-Filter-Hotels) - [San Diego Hotels](https://www.expedia.ca/San-Diego-Hotels.d3073.Travel-Guide-Hotels) - [San Miguel Ranch Hotels](https://www.expedia.ca/San-Miguel-Ranch-Chula-Vista-Hotels.0-n553248635976480437-0.Travel-Guide-Filter-Hotels) - [Hotels near San Ysidro Border Crossing](https://www.expedia.ca/San-Ysidro-Border-Crossing-Hotels.0-l553248621551385128-0.Travel-Guide-Filter-Hotels) - [San Ysidro Hotels](https://www.expedia.ca/San-Ysidro-Hotels.d8380.Travel-Guide-Hotels) - [Hotels near San Ysidro Transit Center Station](https://www.expedia.ca/San-Ysidro-Transit-Center-Station-Hotels.d6186831.Travel-Guide-Hotels) - [Hotels near Sesame Place San Diego](https://www.expedia.ca/Sesame-Place-San-Diego-Hotels.0-l6266353-0.Travel-Guide-Filter-Hotels) - [Hotels near Sharp Chula Vista Medical Center](https://www.expedia.ca/Sharp-Chula-Vista-Medical-Center-Hotels.0-l553248621560505607-0.Travel-Guide-Filter-Hotels) - [Hotels near Sky Zone San Diego Indoor Trampoline Park](https://www.expedia.ca/Sky-Zone-San-Diego-Indoor-Trampoline-Park-Hotels.0-l553248621532638609-0.Travel-Guide-Filter-Hotels) - [South Bay Hotels](https://www.expedia.ca/South-Bay-Hotels.d6056572.Travel-Guide-Hotels) - [South San Diego Hotels](https://www.expedia.ca/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels) - [Flights from Brown Field Municipal](https://www.expedia.ca/lp/airports/sdm/flights-from-brown-field-municipal-airport) - [Flights from Aspen (ASE) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ase/sdm/aspen-to-san-diego) - [Flights from Barcelona (BCN) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bcn/sdm/barcelona-to-san-diego) - [Flights from Bakersfield (BFL) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bfl/sdm/bakersfield-to-san-diego) - [Flights from León (BJX) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bjx/sdm/leon-to-san-diego) - [Flights from Bangkok (BKK) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bkk/sdm/bangkok-to-san-diego) - [Flights from Bellingham (BLI) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bli/sdm/bellingham-to-san-diego) - [Flights from Nashville (BNA) to San Diego (SDM)](https://www.expedia.ca/lp/flights/bna/sdm/nashville-to-san-diego) - [Flights from Burlington (BTV) to San Diego (SDM)](https://www.expedia.ca/lp/flights/btv/sdm/burlington-to-san-diego) - [Flights from Paris (CDG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/cdg/sdm/paris-to-san-diego) - [Flights from Calipatria (CLR) to San Diego (SDM)](https://www.expedia.ca/lp/flights/clr/sdm/calipatria-to-san-diego) - [Flights from Charlotte (CLT) to San Diego (SDM)](https://www.expedia.ca/lp/flights/clt/sdm/charlotte-to-san-diego) - [Flights from Compton (CPM) to San Diego (SDM)](https://www.expedia.ca/lp/flights/cpm/sdm/compton-to-san-diego) - [Flights from Cancun (CUN) to San Diego (SDM)](https://www.expedia.ca/lp/flights/cun/sdm/cancun-to-san-diego) - [Flights from Cincinnati (CVG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/cvg/sdm/cincinnati-to-san-diego) - [Flights from Barstow (DAG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/dag/sdm/barstow-to-san-diego) - [Flights from Denver (DEN) to San Diego (SDM)](https://www.expedia.ca/lp/flights/den/sdm/denver-to-san-diego) - [Flights from Dallas (DFW) to San Diego (SDM)](https://www.expedia.ca/lp/flights/dfw/sdm/dallas-to-san-diego) - [Flights from Detroit (DTW) to San Diego (SDM)](https://www.expedia.ca/lp/flights/dtw/sdm/detroit-to-san-diego) - [Flights from Ensenada (ESE) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ese/sdm/ensenada-to-san-diego) - [Flights from Newark Liberty Intl. Airport (EWR) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ewr/sdm/newark-liberty-intl-airport-to-san-diego) - [Flights from Fresno (FAT) to San Diego (SDM)](https://www.expedia.ca/lp/flights/fat/sdm/fresno-to-san-diego) - [Flights from Sierra Vista (FHU) to San Diego (SDM)](https://www.expedia.ca/lp/flights/fhu/sdm/sierra-vista-to-san-diego) - [Flights from Fort Lauderdale (FLL) to San Diego (SDM)](https://www.expedia.ca/lp/flights/fll/sdm/fort-lauderdale-to-san-diego) - [Flights from Hong Kong (HKG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/hkg/sdm/hong-kong-to-san-diego) - [Flights from Hayward (HWD) to San Diego (SDM)](https://www.expedia.ca/lp/flights/hwd/sdm/hayward-to-san-diego) - [Flights from Houston (IAH) to San Diego (SDM)](https://www.expedia.ca/lp/flights/iah/sdm/houston-to-san-diego) - [Flights from Jacksonville (JAX) to San Diego (SDM)](https://www.expedia.ca/lp/flights/jax/sdm/jacksonville-to-san-diego) - [Flights from Las Vegas (LAS) to San Diego (SDM)](https://www.expedia.ca/lp/flights/las/sdm/las-vegas-to-san-diego) - [Flights from Long Beach (LGB) to San Diego (SDM)](https://www.expedia.ca/lp/flights/lgb/sdm/long-beach-to-san-diego) - [Flights from London (LHR) to San Diego (SDM)](https://www.expedia.ca/lp/flights/lhr/sdm/london-to-san-diego) - [Flights from Manchester (MAN) to San Diego (SDM)](https://www.expedia.ca/lp/flights/man/sdm/manchester-to-san-diego) - [Flights from Miami (MIA) to San Diego (SDM)](https://www.expedia.ca/lp/flights/mia/sdm/miami-to-san-diego) - [Flights from Minneapolis (MSP) to San Diego (SDM)](https://www.expedia.ca/lp/flights/msp/sdm/minneapolis-to-san-diego) - [Flights from New Orleans (MSY) to San Diego (SDM)](https://www.expedia.ca/lp/flights/msy/sdm/new-orleans-to-san-diego) - [Flights from Marysville (MYV) to San Diego (SDM)](https://www.expedia.ca/lp/flights/myv/sdm/marysville-to-san-diego) - [Flights from New York (NYC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/nyc/sdm/new-york-to-san-diego) - [Flights from Ogden (OGD) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ogd/sdm/ogden-to-san-diego) - [Flights from Oklahoma City (OKC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/okc/sdm/oklahoma-city-to-san-diego) - [Flights from Oslo (OSL) to San Diego (SDM)](https://www.expedia.ca/lp/flights/osl/sdm/oslo-to-san-diego) - [Flights from Portland (PDX) to San Diego (SDM)](https://www.expedia.ca/lp/flights/pdx/sdm/portland-to-san-diego) - [Flights from Perth (PER) to San Diego (SDM)](https://www.expedia.ca/lp/flights/per/sdm/perth-to-san-diego) - [Flights from Phoenix (PHX) to San Diego (SDM)](https://www.expedia.ca/lp/flights/phx/sdm/phoenix-to-san-diego) - [Flights from Pasco (PSC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/psc/sdm/pasco-to-san-diego) - [Flights from Richmond (RIC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ric/sdm/richmond-to-san-diego) - [Flights from Rochester (ROC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/roc/sdm/rochester-to-san-diego) - [Flights from San Antonio (SAT) to San Diego (SDM)](https://www.expedia.ca/lp/flights/sat/sdm/san-antonio-to-san-diego) - [Flights from Seattle (SEA) to San Diego (SDM)](https://www.expedia.ca/lp/flights/sea/sdm/seattle-to-san-diego) - [Flights from San Francisco (SFO) to San Diego (SDM)](https://www.expedia.ca/lp/flights/sfo/sdm/san-francisco-to-san-diego) - [Flights from Shreveport (SHV) to San Diego (SDM)](https://www.expedia.ca/lp/flights/shv/sdm/shreveport-to-san-diego) - [Flights from San José del Cabo (SJD) to San Diego (SDM)](https://www.expedia.ca/lp/flights/sjd/sdm/san-jose-del-cabo-to-san-diego) - [Flights from Sacramento (SMF) to San Diego (SDM)](https://www.expedia.ca/lp/flights/smf/sdm/sacramento-to-san-diego) - [Flights from Orange County (SNA) to San Diego (SDM)](https://www.expedia.ca/lp/flights/sna/sdm/orange-county-to-san-diego) - [Flights from Sydney (SYD) to San Diego (SDM)](https://www.expedia.ca/lp/flights/syd/sdm/sydney-to-san-diego) - [Flights from Syracuse (SYR) to San Diego (SDM)](https://www.expedia.ca/lp/flights/syr/sdm/syracuse-to-san-diego) - [Flights from Tijuana (TIJ) to San Diego (SDM)](https://www.expedia.ca/lp/flights/tij/sdm/tijuana-to-san-diego) - [Flights from Tucson (TUS) to San Diego (SDM)](https://www.expedia.ca/lp/flights/tus/sdm/tucson-to-san-diego) - [Flights from Lake Tahoe (TVL) to San Diego (SDM)](https://www.expedia.ca/lp/flights/tvl/sdm/lake-tahoe-to-san-diego) - [Flights from Edmonton (YEG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yeg/sdm/edmonton-to-san-diego) - [Flights from Halifax (YHZ) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yhz/sdm/halifax-to-san-diego) - [Flights from Sudbury (YSB) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ysb/sdm/sudbury-to-san-diego) - [Flights from Toronto (YTO) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yto/sdm/toronto-to-san-diego) - [Flights from Montreal (YUL) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yul/sdm/montreal-to-san-diego) - [Flights from Vancouver (YVR) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yvr/sdm/vancouver-to-san-diego) - [Flights from Winnipeg (YWG) to San Diego (SDM)](https://www.expedia.ca/lp/flights/ywg/sdm/winnipeg-to-san-diego) - [Flights from Saskatoon (YXE) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yxe/sdm/saskatoon-to-san-diego) - [Flights from Calgary (YYC) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yyc/sdm/calgary-to-san-diego) - [Flights from Toronto (YYZ) to San Diego (SDM)](https://www.expedia.ca/lp/flights/yyz/sdm/toronto-to-san-diego) - [Flights from Zürich (ZRH) to San Diego (SDM)](https://www.expedia.ca/lp/flights/zrh/sdm/zurich-to-san-diego) - [Rental cars Brown Field Municipal airport](https://www.expedia.ca/Car-Rentals-In-Brown-Field-Municipal.d6031787.Car-Rental-Guide) - [Book Hotels in Otay Mesa on Expedia.com](https://www.expedia.com/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels) - Explore a world of travel with Expedia ### Hotels in top San Diego neighborhoods - [Hotels in Downtown San Diego](https://expedia.ca/Downtown-San-Diego-San-Diego-Hotels.0-n800123-0.Travel-Guide-Filter-Hotels) - [Hotels in Gaslamp Quarter](https://expedia.ca/Gaslamp-Quarter-San-Diego-Hotels.0-n6130021-0.Travel-Guide-Filter-Hotels) - [Hotels in Pacific Beach](https://expedia.ca/Pacific-Beach-San-Diego-Hotels.0-n6185751-0.Travel-Guide-Filter-Hotels) - [Hotels in Mission Beach](https://expedia.ca/Mission-Beach-San-Diego-Hotels.0-n553248635998112279-0.Travel-Guide-Filter-Hotels) - [Hotels in Ocean Beach](https://expedia.ca/Ocean-Beach-San-Diego-Hotels.0-n177689-0.Travel-Guide-Filter-Hotels) - [Hotels in Point Loma](https://expedia.ca/Point-Loma-San-Diego-Hotels.0-n6171538-0.Travel-Guide-Filter-Hotels) - [Hotels in Mission Valley](https://expedia.ca/Mission-Valley-San-Diego-Hotels.0-n800124-0.Travel-Guide-Filter-Hotels) - [Hotels in Central Mission Beach](https://expedia.ca/Central-Mission-Beach-San-Diego-Hotels.0-n553248635975748394-0.Travel-Guide-Filter-Hotels) - [Hotels in Old Town San Diego](https://expedia.ca/Old-Town-San-Diego-San-Diego-Hotels.0-n6347116-0.Travel-Guide-Filter-Hotels) - [Hotels in Little Italy](https://expedia.ca/Little-Italy-San-Diego-Hotels.0-n6161280-0.Travel-Guide-Filter-Hotels) - [Hotels in North Pacific Beach](https://expedia.ca/North-Pacific-Beach-San-Diego-Hotels.0-n553248635976383450-0.Travel-Guide-Filter-Hotels) - [Hotels in Crown Point](https://expedia.ca/Crown-Point-San-Diego-Hotels.0-n553248635976468673-0.Travel-Guide-Filter-Hotels) - [Hotels in South Mission Beach](https://expedia.ca/South-Mission-Beach-San-Diego-Hotels.0-n553248635975748186-0.Travel-Guide-Filter-Hotels) - [Hotels in North Park](https://expedia.ca/North-Park-San-Diego-Hotels.0-n6346499-0.Travel-Guide-Filter-Hotels) - [Hotels in Carmel Valley](https://expedia.ca/Carmel-Valley-San-Diego-Hotels.0-n553248633938969513-0.Travel-Guide-Filter-Hotels) - [Hotels in East Village](https://expedia.ca/East-Village-San-Diego-Hotels.0-n553248633849130034-0.Travel-Guide-Filter-Hotels) - [Hotels in Hillcrest](https://expedia.ca/Hillcrest-San-Diego-Hotels.0-n6191797-0.Travel-Guide-Filter-Hotels) - [Hotels in University City](https://expedia.ca/University-City-San-Diego-Hotels.0-n553248635976008131-0.Travel-Guide-Filter-Hotels) - [Hotels in Point Loma Heights](https://expedia.ca/Point-Loma-Heights-San-Diego-Hotels.0-n553248632557191746-0.Travel-Guide-Filter-Hotels) - [Hotels in Del Cerro](https://expedia.ca/Del-Cerro-San-Diego-Hotels.0-n553248635976469597-0.Travel-Guide-Filter-Hotels) ### Hotels near popular San Diego Attractions - [Hotels near Cross Border Xpress](https://expedia.ca/Cross-Border-Xpress-Hotels.0-l938550730988875776-0.Travel-Guide-Filter-Hotels) - [Hotels near San Diego Zoo](https://expedia.ca/San-Diego-Zoo-Hotels.0-l502547-0.Travel-Guide-Filter-Hotels) - [Hotels near San Diego Convention Center](https://expedia.ca/San-Diego-Convention-Center-Hotels.0-l6125294-0.Travel-Guide-Filter-Hotels) - [Hotels near Mission Bay](https://expedia.ca/Mission-Bay-Hotels.0-l6185904-0.Travel-Guide-Filter-Hotels) - [Hotels near San Ysidro Border Crossing](https://expedia.ca/San-Ysidro-Border-Crossing-Hotels.0-l553248621551385128-0.Travel-Guide-Filter-Hotels) - [Hotels near Petco Park](https://expedia.ca/Petco-Park-Hotels.0-l6034816-0.Travel-Guide-Filter-Hotels) - [Hotels near Mission Beach](https://expedia.ca/Mission-Beach-Hotels.0-l506109-0.Travel-Guide-Filter-Hotels) - [Hotels near Balboa Park](https://expedia.ca/Balboa-Park-Hotels.0-l507458-0.Travel-Guide-Filter-Hotels) - [Hotels near San Diego State University](https://expedia.ca/San-Diego-State-University-Hotels.0-l502542-0.Travel-Guide-Filter-Hotels) - [Hotels near Hotel Circle](https://expedia.ca/Hotel-Circle-Hotels.0-l6270979-0.Travel-Guide-Filter-Hotels) ### More Hotel Options in Otay Mesa - [Beach Hotel in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Beach-Hotel.0-n6263723-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Business-Hotel.0-n6263723-0-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Casino Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Casino-Hotel.0-n6263723-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Cheap-Hotels.0-n6263723-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Family-Hotel.0-n6263723-0-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Golf-Hotel.0-n6263723-0-tGolfHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Historic-Hotel.0-n6263723-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotels-With-Free-Breakfast.0-n6263723-0-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotels-With-Free-Parking.0-n6263723-0-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotels-With-Hot-Tubs.0-n6263723-0-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Hotels with Wifi in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotel-With-Wifi.0-n6263723-0-tHotelwithwifi.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotel-With-Pool.0-n6263723-0-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with smoking rooms in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hotels-With-Smoking-Rooms.0-n6263723-0-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Luxury-Hotel.0-n6263723-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Shopping Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Shopping-Hotel.0-n6263723-0-tShoppingHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Spa-Hotel.0-n6263723-0-tSpaHotel.Travel-Guide-Filter-Hotels) - [Winery Hotels in Otay Mesa](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Winery-Hotel.0-n6263723-0-tWineryHotel.Travel-Guide-Filter-Hotels) ### More Accommodation Types in Otay Mesa - [Vacation Homes in San Diego](https://expedia.ca/San-Diego-Private-Vacation-Homes.d3073-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Apartments in San Diego](https://expedia.ca/San-Diego-Apartments.d3073-aaApartments.Travel-Guide-Accommodation) - [Condo Rentals in San Diego](https://expedia.ca/San-Diego-Condos.d3073-aaCondos.Travel-Guide-Accommodation) - [Cottages in San Diego](https://expedia.ca/San-Diego-Cottages.d3073-aaCottages.Travel-Guide-Accommodation) - [Villas in San Diego](https://expedia.ca/San-Diego-Villas.d3073-aaVillas.Travel-Guide-Accommodation) - [Guest Houses in San Diego](https://expedia.ca/San-Diego-Guest-Houses.d3073-aaGuestHouses.Travel-Guide-Accommodation) - [Aparthotels in San Diego](https://expedia.ca/San-Diego-Apart-Hotels.d3073-aaApartHotels.Travel-Guide-Accommodation) - [Resorts in San Diego](https://expedia.ca/San-Diego-Resort-Hotels.d3073-aaResortHotels.Travel-Guide-Accommodation) - [Motels in San Diego](https://expedia.ca/San-Diego-Motels.d3073-aaMotels.Travel-Guide-Accommodation) - [Hostels in San Diego](https://expedia.ca/San-Diego-Hostels.d3073-aaHostels.Travel-Guide-Accommodation) - [B&B in San Diego](https://expedia.ca/San-Diego-Bed-And-Breakfast.d3073-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Houseboats in San Diego](https://expedia.ca/San-Diego-Houseboats.d3073-aaHouseboats.Travel-Guide-Accommodation) - [Inns in San Diego](https://expedia.ca/San-Diego-Inns.d3073-aaInns.Travel-Guide-Accommodation) - [Farmstay in San Diego](https://expedia.ca/San-Diego-Agritourism.d3073-aaAgritourism.Travel-Guide-Accommodation) - [Cabin Rentals in San Diego](https://expedia.ca/San-Diego-Cabins.d3073-aaCabins.Travel-Guide-Accommodation) - [RV Parks in San Diego](https://expedia.ca/San-Diego-RV-Parks.d3073-aaRVParks.Travel-Guide-Accommodation) - [Condo Resorts in San Diego](https://expedia.ca/San-Diego-Condominium-Resort.d3073-aaCondominiumResort.Travel-Guide-Accommodation) - [Residences in San Diego](https://expedia.ca/San-Diego-Residences.d3073-aaResidences.Travel-Guide-Accommodation) ### Hotels Close to Nearby Airports - [Hotels near San Diego Intl. Airport](https://expedia.ca/San-Diego-Intl-Airport-Hotels.0-aSAN-0.Travel-Guide-Filter-Hotels) - [Hotels near Brown Field Municipal Airport](https://expedia.ca/Brown-Field-Municipal-Airport-Hotels.0-aSDM-0.Travel-Guide-Filter-Hotels) - [Hotels near Gillespie Field Airport](https://expedia.ca/Gillespie-Field-Airport-Hotels.0-aSEE-0.Travel-Guide-Filter-Hotels) - [Hotels near Montgomery Field Airport](https://expedia.ca/Montgomery-Field-Airport-Hotels.0-aMYF-0.Travel-Guide-Filter-Hotels) - [Hotels near McClellan-Palomar Airport](https://expedia.ca/McClellan-Palomar-Airport-Hotels.0-aCLD-0.Travel-Guide-Filter-Hotels) ### Otay Mesa Hotels by Star Rating - [2 Star Hotels in Otay Mesa](https://expedia.ca/2Star-Otay-Mesa-San-Diego-Hotels.s20-n6263723-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Otay Mesa](https://expedia.ca/3Star-Otay-Mesa-San-Diego-Hotels.s30-n6263723-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Otay Mesa](https://expedia.ca/4Star-Otay-Mesa-San-Diego-Hotels.s40-n6263723-0.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Otay Mesa](https://expedia.ca/5Star-Otay-Mesa-San-Diego-Hotels.s50-n6263723-0.Travel-Guide-Filter-Hotels) ### Otay Mesa Hotels by Brand - [Best Western Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Best-Western.0-n6263723-0--bBestWestern.Travel-Guide-Filter-Hotels) - [Hilton Hotels Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Hilton-Hotels.0-n6263723-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Independent Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Independent.0-n6263723-0--bIndependent.Travel-Guide-Filter-Hotels) - [Marriott Hotels & Resorts Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Marriott-Hotels-Resorts.0-n6263723-0--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Motel-6.0-n6263723-0--bMotel6.Travel-Guide-Filter-Hotels) - [Noble House Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Noble-House.0-n6263723-0--bNobleHouse.Travel-Guide-Filter-Hotels) - [Wyndham Extra Holidays Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Wyndham-Extra-Holidays.0-n6263723-0--bWyndhamExtraHolidays.Travel-Guide-Filter-Hotels) - [Wyndham Hotels Hotels](https://expedia.ca/Otay-Mesa-San-Diego-Hotels-Wyndham-Hotels.0-n6263723-0--bWyndhamHotels.Travel-Guide-Filter-Hotels) ### Explore more hotels - [Kings Inn San Diego](https://expedia.ca/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) - [The Little Italy Hotel Downtown San Diego](https://expedia.ca/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) - [Hilton San Diego Mission Valley](https://expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) - [Hotel del Coronado, Curio Collection by Hilton](https://expedia.ca/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) - [Pendry San Diego](https://expedia.ca/San-Diego-Hotels-Pendry-San-Diego.h16298963.Hotel-Information) - [Bay Club Hotel & Marina](https://expedia.ca/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) - [Legacy Resort Hotel & Spa](https://expedia.ca/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) - [The Sofia Hotel](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) - [Sheraton San Diego Resort](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) - [Marriott Marquis San Diego Marina](https://expedia.ca/San-Diego-Hotels-Marriott-Marquis-San-Diego-Marina.h24394.Hotel-Information) - [Hyatt Regency Mission Bay Spa and Marina](https://expedia.ca/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) - [DoubleTree by Hilton Hotel San Diego - Mission Valley](https://expedia.ca/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) [See a list of all hotels in San Diego](https://expedia.ca/All-San-Diego-Hotels.d3073.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Otay Mesa on Expedia.com](https://www.expedia.com/Otay-Mesa-San-Diego-Hotels.0-n6263723-0.Travel-Guide-Filter-Hotels) ### Expedia's Latest Trends Hotels - [Ocean Beach hotels](https://expedia.ca/Ocean-Beach-San-Diego-Hotels.0-n177689-0.Travel-Guide-Filter-Hotels) - [Koreatown hotels](https://expedia.ca/Koreatown-Los-Angeles-Hotels.0-n6156068-0.Travel-Guide-Filter-Hotels) - [Union Square hotels](https://expedia.ca/Union-Square-San-Francisco-Hotels.0-n800129-0.Travel-Guide-Filter-Hotels) - [Downtown San Diego hotels](https://expedia.ca/Downtown-San-Diego-San-Diego-Hotels.0-n800123-0.Travel-Guide-Filter-Hotels) - [Downtown San Francisco hotels](https://expedia.ca/Downtown-San-Francisco-San-Francisco-Hotels.0-n6151902-0.Travel-Guide-Filter-Hotels) - [Pacific Beach hotels](https://expedia.ca/Pacific-Beach-San-Diego-Hotels.0-n6185751-0.Travel-Guide-Filter-Hotels) - [Mission Valley hotels](https://expedia.ca/Mission-Valley-San-Diego-Hotels.0-n800124-0.Travel-Guide-Filter-Hotels) - [Downtown Palm Springs hotels](https://expedia.ca/Downtown-Palm-Springs-Palm-Springs-Hotels.0-n6289495-0.Travel-Guide-Filter-Hotels) - [Downtown Los Angeles hotels](https://expedia.ca/Downtown-Los-Angeles-Los-Angeles-Hotels.0-n800058-0.Travel-Guide-Filter-Hotels) - [Little Italy hotels](https://expedia.ca/Little-Italy-San-Diego-Hotels.0-n6161280-0.Travel-Guide-Filter-Hotels) - [Gaslamp Quarter hotels](https://expedia.ca/Gaslamp-Quarter-San-Diego-Hotels.0-n6130021-0.Travel-Guide-Filter-Hotels) - [Fisherman's Wharf hotels](https://expedia.ca/Fishermans-Wharf-San-Francisco-Hotels.0-n800128-0.Travel-Guide-Filter-Hotels) - [Old Town San Diego hotels](https://expedia.ca/Old-Town-San-Diego-San-Diego-Hotels.0-n6347116-0.Travel-Guide-Filter-Hotels) - [Hollywood hotels](https://expedia.ca/Hollywood-Los-Angeles-Hotels.0-n8365-0.Travel-Guide-Filter-Hotels) Packages - [Hollywood Vacations](https://expedia.ca/Hollywood.d8365.Destination-Travel-Guides) General - [Visit Hollywood Hills](https://expedia.ca/Los-Angeles-Hollywood-Hills.dx553248635074843803) - [Visit Fisherman's Wharf](https://expedia.ca/San-Francisco-Fishermans-Wharf.dx800128) - [Visit Downtown San Francisco](https://expedia.ca/San-Francisco-Downtown-San-Francisco.dx6151902) - [Visit Bel Air](https://expedia.ca/Los-Angeles-Bel-Air.dx78229) - [Visit Union Square](https://expedia.ca/San-Francisco-Union-Square.dx800129) - [Visit Ocean Beach](https://expedia.ca/San-Diego-Ocean-Beach.dx177689) - [Visit Crenshaw](https://expedia.ca/Los-Angeles-Crenshaw.dx553248635976008502) - [Visit Little Italy](https://expedia.ca/San-Diego-Little-Italy.dx6161280) - [Visit Pacific Beach](https://expedia.ca/San-Diego-Pacific-Beach.dx6185751) - [Visit Old Town San Diego](https://expedia.ca/San-Diego-Old-Town-San-Diego.dx6347116) - [Visit Laurel Canyon](https://expedia.ca/Los-Angeles-Laurel-Canyon.dx553248635976475747) - [Visit Hollywood](https://expedia.ca/Los-Angeles-Hollywood.dx8365) - [Visit Downtown San Diego](https://expedia.ca/San-Diego-Downtown-San-Diego.dx800123) - [Visit Gaslamp Quarter](https://expedia.ca/San-Diego-Gaslamp-Quarter.dx6130021) - [Visit Downtown Los Angeles](https://expedia.ca/Los-Angeles-Downtown-Los-Angeles.dx800058)