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Check prices for these dates, December 13–14, 2026
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.
Located 9.9 mi (15.9 km) from O Brien, Cozy hotel suite in peaceful Mayo with AC, WiFi, fitness room is a favorite aparthotel to consider.
On Expedia, you'll find 9 hotels and other lodging options in O Brien. Though you won't find many aparthotels, we can suggest places to stay that are similar such as a condo or apartment.
Suwannee River and Ichetucknee River are a couple of lovely local spots to get outside and enjoy nature. In the larger area, you’ll find Ichetucknee Springs State Park and Lafayette Blue Springs State Park.
An aparthotel is a hybrid hotel and apartment, with the amenities of a traditional hotel, and more space and privacy found in an apartment. By booking an aparthotel, you can book a longer stay and absorb more of the local color in O Brien. Enjoy home cooking in the private kitchen and having extra space to spread out while you're in town.