Santo Spirito
Florence
Visit Santo Spirito
Popular places to visit
Piazza Santo Spirito
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and stunning cathedral in this vibrant area.
Porta Romana
Porta Romana is just one of the places to see in Arcetri, so why not enjoy the other things to explore during your travels? Discover the acclaimed art scene and churches in this vibrant area.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Santo Spirito Basilica
Learn about the local history of Florence when you spend time at Santo Spirito Basilica. Stroll along the riverfront or visit the churches in this vibrant area.
Torrigiani Garden
Explore the great outdoors at Torrigiani Garden, a lovely green space in Florence. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.
Santa Maria della Carmine
You can learn about the history of Florence with a visit to Santa Maria della Carmine. Visit the stunning cathedral and notable monuments in this vibrant area.
Things to do
City Sightseeing Florence Hop-on Hop-off Bus Tour
CA $47
per adult
76% of travellers recommend
Small-Group Wine Tasting Experience in the Tuscan Countryside
CA $143
per adult
98% of travellers recommend
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
CA $56
per adult
88% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
CA $32
per adult
82% of travellers recommend
Florence Accademia Gallery Tour with Entrance Ticket Included
CA $77
per adult
92% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
CA $209
per adult
100% of travellers recommend
Santo Spirito Hotel Deals
Hotel Horto Convento
Viale Ariosto, 13 Florence FI
The price is CA $234 per night from Jul 20 to Jul 21
CA $234
CA $280 total
Jul 20 - Jul 21
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (675 reviews)
"Staff was amazing.The bartender dam was fantastic.We had a fantastic time.Great location, easy to walk to everything.. Breakfast was amazing as well"
Reviewed on Jun 19, 2026
La Torre Del Cestello
Via Borgo San Frediano, 8 Florence FI
The price is CA $189 per night from Jul 9 to Jul 10
CA $189
CA $230 total
Jul 9 - Jul 10
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (264 reviews)
"Great location in Oltrarno; clean, comfortable and well-appointed room; helpful and responsive staff. Ask for restaurant recommendations, they won’t disappoint."
Reviewed on Jun 14, 2026
Palazzo Mannaioni Suites
Via Maffia 9 - 17r Florence FI
The price is CA $331 per night from Jun 30 to Jul 1
CA $331
CA $387 total
Jun 30 - Jul 1
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (1,128 reviews)
"WIFI coverage in the room was poor, and the reception staff did not accept the fact. The room was too small that you eventually cannot take a good shower. Not really worth it."
Reviewed on Jun 14, 2026
UNA Hotels Vittoria Firenze
Via Pisana 59 Florence FI
The price is CA $137 per night from Jul 5 to Jul 6
CA $137
CA $173 total
Jul 5 - Jul 6
includes taxes & fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
Reviewed on May 12, 2026
Foresteria Valdese di Firenze - Casa per Ferie
Via dei Serragli 49 Florence FI
The price is CA $135 per night from Jul 14 to Jul 15
CA $135
CA $168 total
Jul 14 - Jul 15
includes taxes & fees
Stay at this guesthouse in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (226 reviews)
"Excellent experience. The staff was very helpful and nice all throughout."
Reviewed on Jun 19, 2026
Torre di Bellosguardo
Via Roti Michelozzi 2 Florence FI
The price is CA $791 per night from Jun 22 to Jun 23
CA $791
CA $892 total
Jun 22 - Jun 23
includes taxes & fees
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Ponte Vecchio and Uffizi Gallery ...
9/10 Wonderful! (103 reviews)
"This was by far the best hotel I have ever stayed at, as someone who travels solo often sometimes you are just looking for some peace and not having to do everything on your own. I am in awe of the property. If you are looking for privacy, story book views, and gardens this is the place to be. The ..."
Reviewed on Oct 29, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Santo Spirito
Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
Historic Centre of Florence
Cathedral of Santa Maria del Fiore and Piazza della Signoria are a few top attractions in Historic Centre of Florence. Hop around the city on the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop and check out the area's fascinating museums, stunning cathedral, and stunning river views.
Duomo
Cathedral of Santa Maria del Fiore and Uffizi Gallery are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Signoria and Uffizi Gallery are top sights worth seeing.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
Santa Croce
Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.
Santo Spirito
Explore a world of travel with Expedia
- 4 Star Hotels in Florence
- Hotels near Boboli Gardens
- Winery Hotels in Province of Florence
- Province of Florence Hotels
- All Inclusive Resorts and in Tuscany
- Beach Hotel Hotels in Tuscany
- Family Hotels in Tuscany
- Honeymoon Resorts and in Tuscany
- Hotels with a Pool in Tuscany
- Luxury Hotels in Tuscany
- Spa Hotels in Tuscany
- Winery Hotels in Tuscany
- Tuscany Hotels
- Duomo Hotels
- Apartments in Florence
- B&B in Florence
- All Inclusive Resorts and in Florence
- Cheap Hotels in Florence
- Hotels with Free Airport Shuttle in Florence
- Hotels with Free Breakfast in Florence
- Florence Hotels
- Hotels near Florence
- Apartments in Florence Santa Maria Novella Station
- Hotels near Florence Santa Maria Novella Station
- Cheap Hotels in Oltrarno
- Family Hotels in Oltrarno
- Luxury Hotels in Oltrarno
- Spa Hotels in Oltrarno
- Oltrarno Hotels
- Hotels near Palazzo Antinori
- Hotels near Piazza del Carmine
- Hotels near Piazza della Repubblica
- Hotels near Piazza della Signoria
- Hotels near Piazza di Santa Maria Novella
- Hotels near Piazza Santo Spirito
- Hotels near Pitti Palace
- Hotels near Ponte Vecchio
- B&B in Province of Florence
- Castles in Province of Florence
- San Giovanni Hotels
- Cheap Hotels in Santa Maria Novella
- Santa Maria Novella Hotels
- Hotels near Santa Trinita Church
- Farmstay in Tuscany
- Apartments in Tuscany
- B&B in Tuscany
- Castles in Tuscany
- Villas in Tuscany
- Hotels near Uffizi Gallery
- Visit Arcetri
- Boboli Gardens
- Visit Calenzano
- Visit Callai
- Visit Campi Bisenzio
- Visit Candeli
- Visit Chiocchio
- Visit Compiobbi
- Visit Campo di Marte
- Visit Careggi Rifredi
- Visit Coverciano
- Visit Isolotto
- Visit Oltrarno
- Visit San Lorenzo
- Visit Santa Croce
- Visit Santa Maria Novella
- Florence Vacations
- Visit Florence
- Galileo Museum - Institute and Museum of the History of Science
- Visit Galluzzo
- Visit L'ugolino
- Visit Lungarno del Tempio
- Visit Poggio alla Malva
- Visit Pontassieve
- Visit Ponte a Ema
- Province of Florence Vacations
- Visit Province of Florence
- Visit San Jacopo Al Girone
- Visit Sant'Andrea in Percussina
- Visit Sesto Fiorentino
- Visit Signa
- Visit Tavarnuzze
- Tuscany Vacations
- Visit Tuscany
- Uffizi Gallery
- Visit Vallina
- All inclusive Vacation Packages Tuscany
