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Sep 23 - Sep 24
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Sep 24 - Sep 25
This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

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Our top choices for Cairo hotels

A bedroom with a bed, a leather chair, a nightstand, and a wall-mounted TV.
A room with two leather chairs, a small table with a lamp, a patterned rug, a stone wall, and a painting of a mountainous landscape.
A breakfast bar with a green wall, a flat-screen TV, and various breakfast items.
A modern bathroom with a large bathtub, a flat-screen TV, and a built-in microwave.

1. Super 8 by Wyndham Moberly MO

Super 8 by Wyndham Moberly MO
Moberly
United States
Anthony
CA $113
CA $127 total
includes taxes & fees
Oct 4 - Oct 5
Super 8 by Wyndham Moberly MO
A hotel room with a large bed, a separate sitting area, a bathtub, and a view of the outdoors.
A hotel lobby with a grey sofa, red cushions, a clock, and a dining area with red chairs and tables.
A hotel lobby with a vending machine stocked with snacks and beverages, a refrigerator with drinks, and a seating area with a sofa and chairs.

2. Comfort Inn & Suites Moberly

Comfort Inn & Suites Moberly
Moberly
United States
Stephanie
CA $184
CA $207 total
includes taxes & fees
Oct 18 - Oct 19
Comfort Inn & Suites Moberly
A compact kitchen with wooden cabinets, a coffee machine, and a dining area with metal chairs.
A neatly made bed with a brown quilted bedspread, a decorative pillow with a heart-shaped towel, and a bedside table with a lamp.
A living room with a black leather sofa, two black chairs, a potted plant, and a small table.
A compact kitchenette with a microwave, a small refrigerator, a coffee maker, and a telephone on a wooden dresser.

3. Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr
Macon
United States
Lisa
CA $96
CA $102 total
includes taxes & fees
Oct 2 - Oct 3
Americas Best Value Inn & Suites Macon at Sunset Dr
A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.
A motel with a sign advertising free continental breakfast and internet service.
A kitchen counter with fruits, a blender, and a refrigerator with a game display.
A reception area with a counter, a trash bin, and a seating area with chairs.

4. Travelier Motel

Travelier Motel
Macon
United States
Jessica
CA $98
CA $117 total
includes taxes & fees
Oct 2 - Oct 3
Travelier Motel
A neatly made bed with a white quilt, a dark wooden headboard, a bedside lamp, a red chair, and a wall decoration.
A room with a large window, a red chair, and a wall-mounted air conditioner.
A long, narrow hallway with carpeted floors, doors on both sides, and a red chair in the distance.
A building with a brick facade, a wooden door, and a neon 'OPEN' sign.

5. Prairie View Inn

Prairie View Inn
Shelbina
United States
Randy
CA $128
CA $140 total
includes taxes & fees
Sep 30 - Oct 1
Prairie View Inn
A covered porch with two rocking chairs and a view of a forest.
A kitchen with wooden cabinets, a white refrigerator, and a tiled floor.
A traditional living room with a sofa, armchairs, a coffee table, a dining table with chairs, a piano, and a chandelier.
A dining room with a wooden table, chairs, a chandelier, and a painting on the wall.

6. Charming Paris Home w/ Porch: Hunt + Unwind!

Charming Paris Home w/ Porch: Hunt + Unwind!
Paris
CA $229
CA $433 total
includes taxes & fees
Sep 27 - Sep 28
Charming Paris Home w/ Porch: Hunt + Unwind!
A hotel room with a bed, a sofa, a desk, a chair, and a small table.
A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with curtains.
A Super 8 hotel with a covered entrance and multiple windows.
A kitchenette with a coffee maker, toaster, microwave, and various kitchen utensils.

7. Super 8 by Wyndham Macon

Super 8 by Wyndham Macon
Macon
United States
Austin
CA $124
CA $135 total
includes taxes & fees
Sep 27 - Sep 28
Super 8 by Wyndham Macon
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Top Cairo Hotel Reviews

tiny cabin located I mile from Long Branch State park Marina, Beach & Boat ramp

tiny cabin located I mile from Long Branch State park Marina, Beach & Boat ramp

10/10 Excellent
"What a gem of a stay! We wanted to find a place to stay near Kirksville. This was about a 40 minutes drive but it gave us the ability to have our own dwelling to cook our own food knowing we travel with a dog! Thank you Julie, we hope to return in the spring!"
Kimberly 2-night trip
Posted 2 days ago
tiny cabin located I mile from Long Branch State park Marina, Beach & Boat ramp
Prairie View Inn

Prairie View Inn

8/10 Good
"A really nice man, I believe the owner, checked me in. I didn’t see any staff after that. It was quiet and convenient for my stay on my Friends and Family Tour ‘26. I wasn’t expecting the Taj Mahal but I was pleasantly surprised at the comfortable bed and the clean room. A bonus, there’s a great coffee shop called Mia’s in Shelbina. It’s in the grocery store with a drive up."
Dianna 2-night trip
Posted 2 weeks ago
Prairie View Inn
Historic Clark Cabin w/ Deck & Fishing Pond Access

Historic Clark Cabin w/ Deck & Fishing Pond Access

10/10 Excellent
"I loved the stay all together. The cabin was amazing . The view was very relaxing. The open space on the property second to none. The host was very nice and patient . I can’t wait to visit again in coming back to this very cabin again. Looking forward to it. Incredible stay. Thanks"
Johnny P. 2-night trip
Posted 2 weeks ago
Historic Clark Cabin w/ Deck & Fishing Pond Access
Charming Paris Home w/ Porch: Hunt + Unwind!

Charming Paris Home w/ Porch: Hunt + Unwind!

8/10 Good
"The house and property was absolutely beautiful. Definitely a piece of history there. The one side of the house kind of reminded you of a museum. They have everything there that you could think of that you would need for cooking or just sitting out back and relaxing on the deck they've got you covered. The only complaint that I have is the air freshener that they use pumping through the vents. Very very strong. Takes a little bit to get used to but once you do you don't notice it But all in all I would give this place a 9 out of a 10. Very quiet beautiful area even got to see your mama and baby deer in the backyard so that was pretty nice."
Kathi L. 3-night trip
Posted 2 weeks ago
Charming Paris Home w/ Porch: Hunt + Unwind!
Spacious 5-bedroom log cabin home with 2 ponds and 50 acres just outside Moberly

Spacious 5-bedroom log cabin home with 2 ponds and 50 acres just outside Moberly

10/10 Excellent
"This place was perfect for our families guys weekend. They enjoyed playing bags, shooting pool, fishing, grilling, and sitting on the porch hanging out. They had plenty of room to spread out in this spacious property. The property was well stocked and clean. The yard around the lakes was well maintained allowing easy access for fishing which was extra appreciated! The host was super responsive to questions in advance. We will definitely be back again and appreciate having such an amazing place to stay when we’re in the area."
Lindsay B. 2-night trip
Posted 3 weeks ago
Spacious 5-bedroom log cabin home with 2 ponds and 50 acres just outside Moberly
Teal Nest - at The Lodges of Long Branch

Teal Nest - at The Lodges of Long Branch

10/10 Excellent
"We had a wonderful stay at this cabin! Everything was absolutely lovely, and there were so many thoughtful personal touches that made us feel comfortable and right at home. The cabin was welcoming, cozy, and had everything we needed for a relaxing weekend getaway. We truly enjoyed our stay and would definitely recommend it to others!The only small issue we noticed was that the bed was very, very squeaky whenever we moved, which made it a little difficult to be completely quiet at night. Other than that, everything was wonderful, and we would happily stay here again!"
Angela C. 2-night trip
Posted 3 weeks ago
Teal Nest - at The Lodges of Long Branch
Comfort Inn & Suites Moberly

Comfort Inn & Suites Moberly

10/10 Excellent
"This was my second time visiting the hotel and was only 2 miles from my daughter college. Everything was good. The breakfast was even good"
Stephanie 2-night trip
Posted 1 month ago
Comfort Inn & Suites Moberly
Convenience Haven/Modern 3BR 2BA Home in Macon, MO, Briggs Convenience Haven

Convenience Haven/Modern 3BR 2BA Home in Macon, MO, Briggs Convenience Haven

10/10 Excellent
"Very clean and perfect for what we needed. I’m town for a family funeral and the space was perfect. We planned for 6 but ended up with only 4 of us but would have been fine for up to 7. Checkin was easy. Host was accessible. Will definitely be using this property on future visits!"
Michelle F. 4-night trip
Posted 1 month ago
Convenience Haven/Modern 3BR 2BA Home in Macon, MO, Briggs Convenience Haven
Unwind on Vine

Unwind on Vine

10/10 Excellent
"Nice home, easy check in-would stay there again."
Glenda B. 3-night trip
Posted 2 months ago
Unwind on Vine

More cheap stays in Cairo

Americas Best Value Inn & Suites Macon at Sunset Dr

Americas Best Value Inn & Suites Macon at Sunset Dr

28933 Sunset Drive Macon MO
CA $96
CA $102 total
Oct 2 - Oct 3
includes taxes & fees
6.8/10 (380 reviews)
Americas Best Value Inn & Suites Macon at Sunset Dr
Travelier Motel

Travelier Motel

201 E Briggs Dr Macon MO
CA $98
CA $117 total
Oct 2 - Oct 3
includes taxes & fees
Travelier Motel
Super 8 by Wyndham Moberly MO

Super 8 by Wyndham Moberly MO

300 E Highway 24 Moberly MO
CA $113
CA $127 total
Oct 4 - Oct 5
includes taxes & fees
Super 8 by Wyndham Moberly MO
Super 8 by Wyndham Macon

Super 8 by Wyndham Macon

203 E Briggs Dr Macon MO
CA $124
CA $135 total
Sep 27 - Sep 28
includes taxes & fees
Super 8 by Wyndham Macon
Prairie View Inn

Prairie View Inn

711 North Highway 15 Shelbina MO
CA $128
CA $140 total
Sep 30 - Oct 1
includes taxes & fees
8.2/10 Very good! (165 reviews)
Prairie View Inn
Comfort Inn & Suites Moberly

Comfort Inn & Suites Moberly

1801 W Outer Rd Moberly MO
CA $184
CA $207 total
Oct 18 - Oct 19
includes taxes & fees
8.4/10 Very good! (461 reviews)
Comfort Inn & Suites Moberly

Hotels in Cairo with star rating

Frequently asked questions

What is the best area to stay in Cairo?
The best area to stay in Cairo, Missouri, is near the intersection of US-24 and US-63, as this provides the most convenient access to local amenities and onward travel.This area, though not a distinct neighbourhood, is the commercial heart of Cairo. You'll find the town's main gas station, a few local eateries, and the primary access points to the surrounding highways. It's a practical base for exploring the region.For travellers passing through, perhaps on a road trip, staying close to this intersection offers unparalleled convenience. You can easily refuel, grab a bite, and quickly get back on the road without navigating through residential areas.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Cairo.
How much is the nightly rate at a Cairo hotel?
Prices for hotels in Cairo often vary, but you can find a great deal from CA $102 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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