Title: Hotels by Best Western in St. Charles from CA $148 | Expedia.ca

[St. Charles Travel Guide](https://expedia.ca/St-Charles.dx183431)[Hotels in St. Charles](https://expedia.ca/St-Charles-Hotels.d183431.Travel-Guide-Hotels)[Vacation Rentals in St. Charles](https://expedia.ca/St-Charles-Vacation-Rentals.d183431.Travel-Guide-VacationRentals)[Flights to St. Charles](https://expedia.ca/Cheap-Flights-To-St-Charles.d183431.Travel-Guide-Flights)[St. Charles Car Rentals](https://expedia.ca/Car-Rentals-In-St-Charles.d183431.Car-Rental-Guide)[St. Charles Vacation Packages](https://expedia.ca/St-Charles.d183431.Destination-Travel-Guides)

![St. Charles is a rural Community in South East Minnesota](https://images.trvl-media.com/place/183431/30533b3b-ce9f-42e7-b976-83514176ce7e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/183431/30533b3b-ce9f-42e7-b976-83514176ce7e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

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[Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

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In two weeks

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for St. Charles Best Western

![Indoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3837h2560x3y0-1092e125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2560x4y0-89209858.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Accessible, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2557x4y0-117f61d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave (Living Room)](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/ec5f8616.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

[](https://www.expedia.ca/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information)

Rochester

8.4/10

Very good

(809 reviews)

"Check in staff was great! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paulette

CA $129

CA $148 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top St. Charles Hotel Reviews

![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg)

### Kahler Grand Hotel

10/10 Excellent

"Clean room "

[](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information)

![Holiday Inn Express Rochester South - Mayo Area by IHG](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/62a372dd_y.jpg)

### Holiday Inn Express Rochester South - Mayo Area by IHG

10/10 Excellent

"."

[](https://expedia.ca/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information)

![SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys](https://images.trvl-media.com/lodging/1000000/110000/102000/101902/39da8a7c_y.jpg)

### SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent

"When I told my husband where we were staying he was not pleased at all. He wanted something closer to the hospital.When we got there he went and checked us in and check out the room he was very pleased. There was hot drinks always ready. The room was very clean and comfortable. The staff was extremely accommodating.We will stay there again. We left to go back home and stayed in another hotel and the second we walked in the room we both said this is not the SpringHill Suites. SpringHill Suites thank you for a memorable experience."

[](https://expedia.ca/Rochester-Hotels-SpringHill-Suites-By-Marriott-Rochester-Mayo-ClinicSt-Marys.h101902.Hotel-Information)

![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg)

### Hampton Inn Rochester-South

10/10 Excellent

"The staff were very caring, they texted us during our stay to make sure we were doing good or if we needed anything. Room was clean very efficient, breakfast was great many options, as well as the parking no problems. Will definitely come back. Oh and great location, not to far from Mayo Clinic and everything you need is close."

[](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information)

![Home2 Suites by Hilton Rochester Mayo Clinic Area](https://images.trvl-media.com/lodging/24000000/23520000/23512700/23512633/444e106b_y.jpg)

### Home2 Suites by Hilton Rochester Mayo Clinic Area

10/10 Excellent

"It has been a Great stay & very clean & quiet! Staff has been great also. "

[](https://expedia.ca/Rochester-Hotels-Home2-Suites-By-Hilton-Rochester-Mayo-Clinic-Area.h23512633.Hotel-Information)

![Aspen Suites](https://images.trvl-media.com/lodging/1000000/910000/904700/904615/6c7e0658_y.jpg)

### Aspen Suites

10/10 Excellent

"Very clean and nice staff"

[](https://expedia.ca/Rochester-Hotels-Aspen-Suites.h904615.Hotel-Information)

![Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys](https://images.trvl-media.com/lodging/11000000/10950000/10947300/10947270/9bad372e_y.jpg)

### Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

10/10 Excellent

"Great execution of all facets of a good hotel."

[](https://expedia.ca/Rochester-Hotels-Fairfield-Inn-Suites-Rochester-Mayo-Clinic-AreaSt-Marys.h10947270.Hotel-Information)

![Spark by Hilton Rochester South](https://images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg)

### Spark by Hilton Rochester South

10/10 Excellent

"Amazing all around! "

[](https://expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information)

![The Berkman](https://images.trvl-media.com/lodging/47000000/46300000/46291500/46291477/50c22b07_y.jpg)

### The Berkman

10/10 Excellent

"Amazing"

[](https://expedia.ca/Rochester-Hotels-Berkman-Hotel.h46291477.Hotel-Information)

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