Photo by Southernmost Illinois Tourism Bureau
Find Hotels by Independent in Southern Illinois
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check prices for these dates
Top Southern Illinois Hotel Reviews
Drury Plaza Hotel Mt. Vernon
10/10 Excellent
Explore a world of travel with Expedia
- Hunter's Retreat
- Keyesport Hotels
- Mount Erie Hotels
- Washington County Hotels
- Mount Vernon Hotels
- Benton Hotels
- Adults Only Resorts & in Southern Illinois
- Mcleansboro Hotels
- Holiday Inn Express & Suites Salem by IHG
- 3 Star Hotels in Royalton
- Eldorado Hotels
- Cabin Rentals in Carlyle
- Drury Inn & Suites Hotels in Fayetteville
- Farmstay in Dowell
- Treehouse w/ Hot Tub near Shawnee National Forest
- Modern Pond
- Farmstay in Sunfield
- Villas in Benton
- Cozy Lake of Egypt Cabin & Pond
- Carmi Hotels
- Cabin Rentals in Salem
- Hotels near Franklin County Fairgrounds
- Villas in Buckner
- Cabin Rentals in Waltonville
- Best Western Plus Centralia Hotel & Suites
- Apartments in Cisne
- Super 8 by Wyndham Du Quoin
- Quality Inn & Suites Marion
- Pet-Friendly Hotels in Mount Vernon
- Rv Parks in Cutler
- Guest Houses in Dowell
- Drury Inn & Suites Marion
- B&B in Du Quoin
- Motels in Carlyle
- Tamaroa Hotels
- Keenes Hotels
- Vacation Homes in Corinth
- Condo Rentals in Carterville
- Harrisburg Hotels
- America's Best Inns Hotels in Waltonville
- Hotel Wedding Venues Hotels in Southern Illinois
- Best location on Lake of Egypt by land and by water!
- Holiday Inn Express & Suites Mount Vernon by IHG
- Hotels with Hot Tubs in Carlyle
- Villas in Galatia
- B&B in Centralia
- Cottages in Zeigler
- Lgbt Friendly Hotels in Mount Vernon
- 3 Star Hotels in Keenes
- Hotels with an Indoor Pool in Harrisburg
- Resorts in Harrisburg
- Hotels with Balconies in Marion
- Super 8 by Wyndham Salem
- Thompsonville Hotels
- University Inn of Carbondale by Hotel O
- Johnston City Hotels
- Hotels with smoking rooms in Marion
- Carbondale Hotels
- Marion Hotels
- Cabin Rentals in Omaha
- B&B in Patoka
- Du Quoin Hotels
- Hotels with a Pool in Southern Illinois
- Apartments in Fairfield
- Galatia Hotels
- Belle Prairie City Hotels
- Flights from Cutler
- Flights to Benton
- Flights from Benton
- Flights to Southern Illinois
- Flights from Carterville
- Flights from Ewing
- Flights to Mount Vernon
- Flights from Macedonia
- Flights to Ina
- Flights from Columbus (CMH) to Carbondale (MDH)
- Flights to Patoka
- Flights to Fairfield
- Flights to Centralia
- Flights from Cisne
- Flights from Elkville
- Flights to Marion
- Flights from Christopher
- Flights from Mount Vernon
- Flights from Vancouver (YVR) to Mount Vernon (MVN)
- Flights from Belle Rive
- Flights from Toronto (YYZ) to Carbondale (MDH)
- Flights to Carbondale
- Flights to Du Quoin
- Flights from Waltonville
- Flights from Cleveland (CLE) to Carbondale (MDH)
- Flights from Phoenix (PHX) to Carbondale (MDH)
- Flights to Flora