Title: Book the Best Los Osos SPA Resorts from CA $222 - Spa Hotels in Los Osos, CA | Expedia.ca [Los Osos Travel Guide](https://expedia.ca/Los-Osos.dx9873)[Hotels in Los Osos](https://expedia.ca/Los-Osos-Hotels.d9873.Travel-Guide-Hotels)[Vacation Rentals in Los Osos](https://expedia.ca/Los-Osos-Vacation-Rentals.d9873.Travel-Guide-VacationRentals)[Flights to Los Osos](https://expedia.ca/Cheap-Flights-To-Los-Osos.d9873.Travel-Guide-Flights)[Los Osos Car Rentals](https://expedia.ca/Car-Rentals-In-Los-Osos.d9873.Car-Rental-Guide)[Los Osos Vacation Packages](https://expedia.ca/Los-Osos.d9873.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/82ae60cf1761badedca5aae03e4e0866.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Los Osos, CA from CA $222 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Los Osos Spa Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-18&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-19&endDate=2025-10-20&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Los Osos Spa Hotels ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/09f8fafa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/af3dfd64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room, 2 Queen Beds | Exterior](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/6a62dfc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/4adefcff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sea Pines Resort Los Osos 8.2/10 Very good (405) "All around an amazing place to stay." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Gabriel CA $189 CA $245 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Sea-Pines-Resort.h1839838.Hotel-Information) ![Caveman | Bathroom](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/29ce234c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/d6246a9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Terrace/patio](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/01a54722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/5a091377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Madonna Inn San Luis Obispo 9.2/10 Wonderful (1281) "Absolutely amazing stay" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Zachary A CA $192 CA $266 total includes taxes & fees Nov 18 - Nov 19 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/9e66f2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/323aabf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/3e5ffcce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/4e72b30d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Agrarian Hotel, BW Signature Collection Arroyo Grande 9.6/10 Exceptional (1008) "Great location" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy CA $195 CA $222 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-The-Agrarian-Hotel.h36117545.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/46c8343c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/d2bd3038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/57423573.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Honeymoon Suite, 1 King Bed, Non Smoking, Ocean View](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/8e1a2a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cayucos Sunset Inn B&B Cayucos 9.8/10 Exceptional (192) "Great place to stay" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Jason CA $245 CA $275 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Cayucos-Sunset-Inn-Bed-And-Breakfast.h35826166.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/42ac20df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/786b3840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/18ffa136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/41f2d375.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOTEL CERRO, Autograph Collection Downtown San Luis Obispo 9.2/10 Wonderful (460) "We had a great stay" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) ADALBERT CA $283 CA $370 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-Cerro.h48257614.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/c2c4905d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/cd3bd54d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Room, 1 King Bed (Spa Room) | Library](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/2d3891c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Double Room (Great Room) | Room amenity](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/5728603e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Avila La Fonda Hotel Avila Beach 9.6/10 Exceptional (1004) "Very nice hotel. Great for and rest and relaxation kind of vacation" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Princess CA $254 CA $286 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Avila-Beach-Hotels-Avila-La-Fonda-Hotel.h1507108.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/f3abfe0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/88590a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Paseo King Room](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/0c2ec67b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/088fc1a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel San Luis Obispo Downtown San Luis Obispo 9.6/10 Exceptional (531) "Beautiful design, so lovely. Ended up staying on property. Great staff:)" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) kelly CA $459 CA $521 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-San-Luis-Obispo.h37232966.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=9873&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Los Osos Hotel Reviews ![Cottage Inn By The Sea](//images.trvl-media.com/lodging/1000000/160000/151000/150921/76ac3c06_y.jpg) ### Cottage Inn By The Sea 10/10 Excellent "Friendly staff comfortable property great views" [](https://expedia.ca/San-Luis-Obispo-Hotels-Cottage-Inn-By-The-Sea.h150921.Hotel-Information) ![Hilton Garden Inn San Luis Obispo/Pismo Beach](//images.trvl-media.com/lodging/2000000/1620000/1619200/1619196/2231ae59_y.jpg) ### Hilton Garden Inn San Luis Obispo/Pismo Beach 10/10 Excellent "Staff is good and very quiet place " [](https://expedia.ca/San-Luis-Obispo-Hotels-Hilton-Garden-Inn-San-Luis-Obispo-Pismo-Beach.h1619196.Hotel-Information) ![Inn at the Pier Pismo Beach, Curio Collection by Hilton](//images.trvl-media.com/lodging/19000000/18680000/18676000/18675941/93bfb2d1_y.jpg) ### Inn at the Pier Pismo Beach, Curio Collection by Hilton 10/10 Excellent "Great staff and everything is very close " [](https://expedia.ca/San-Luis-Obispo-Hotels-Inn-At-The-Pier.h18675941.Hotel-Information) ![Pismo Lighthouse Suites](//images.trvl-media.com/lodging/1000000/20000/11000/10966/791e4270_y.jpg) ### Pismo Lighthouse Suites 10/10 Excellent "Loved it will be there again soon " [](https://expedia.ca/San-Luis-Obispo-Hotels-Pismo-Lighthouse-Suites.h10966.Hotel-Information) ![Apple Farm](//images.trvl-media.com/lodging/1000000/40000/39500/39435/f5438f41_y.jpg) ### Apple Farm 10/10 Excellent "Love it here!!" [](https://expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![SeaCrest OceanFront Hotel](//images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/w3000h1999x0y0-15b2e131_y.jpg) ### SeaCrest OceanFront Hotel 10/10 Excellent "The beach view was beautiful and breathtaking. If you're looking for peace and serenity ✨️ 😌 this is it. The parking lot had construction on the pavement because it was blocked off with a black tarp so we couldn't park next to our room so that was the downside. I think the continental breakfast is made just for kids only not for adults. Not a hearty breakfast just enough to get by." [](https://expedia.ca/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ![Madonna Inn](//images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/1ea42b7b_y.jpg) ### Madonna Inn 10/10 Excellent "Absolutely amazing stay" [](https://expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Sandcastle Hotel on the Beach](//images.trvl-media.com/lodging/1000000/50000/41000/40915/89d1e3f1_y.jpg) ### Sandcastle Hotel on the Beach 10/10 Excellent "Nice beach view by fireplace " [](https://expedia.ca/San-Luis-Obispo-Hotels-Sandcastle-Hotel-On-The-Beach.h40915.Hotel-Information) ![Edgewater Inn And Suites](//images.trvl-media.com/lodging/1000000/900000/894000/893902/3d1c5694_y.jpg) ### Edgewater Inn And Suites 10/10 Excellent "Clean rooms across from pool & jacuzzi " [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Los Osos? > Forget the stress of everyday life and book yourself a hotel with a spa. Check out the beaches in Los Osos - worth a picture or two! Take part in recreational activities such as golfing during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation. ### What is the best spa hotel in Los Osos? > [Sea Pines Resort](https://www.expedia.ca/San-Luis-Obispo-Hotels-Sea-Pines-Resort.h1839838.Hotel-Information) is a top spa hotel featuring a golf course, a bar, and a restaurant. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages, and couples treatments. ### How many spa hotels will I find in Los Osos? > Among Expedia's 43 accommodation options in Los Osos, there is 1 spa hotel. ### What's there to see and do in Los Osos? > Experience Los Osos with a stop at Elfin Forest Preserve, Montaña de Oro State Park, and Morro Bay State Park. If you have a bit of extra time while you're in the area, you might want to check out Los Osos Oaks State Reserve and Morro Coast Audubon Society Sweet Springs Nature Preserve. ### What is a Los Osos spa hotel? > Spa hotels in Los Osos provide lodging and have an on-site spa which offers services such as facials as well as body treatments. Some also offer in-room treatments. 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