Title: The 10 Best Hotels Near Looe Key National Marine Sanctuary, from CA $195 | Expedia.ca [United States of America Travel Guide](https://expedia.ca/United-States-Of-America.dx201)[Vacation Rentals in United States of America](https://expedia.ca/Destinations-In-United-States-Of-America.d201.Vacation-Rental-Destinations)[Flights to United States of America](https://expedia.ca/Destinations-In-United-States-Of-America.d201.Flight-Destinations)[Looe Key National Marine Sanctuary Car Rentals](https://expedia.ca/Car-Rentals-In-Looe-Key-National-Marine-Sanctuary.d553248621533115813.Car-Rental-Guide)[Looe Key National Marine Sanctuary Vacations](https://expedia.ca/Looe-Key-National-Marine-Sanctuary-United-States-Of-America.d553248621533115813.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Looe Key National Marine Sanctuary, from CA $195 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=553248621533115813&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=553248621533115813&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=553248621533115813&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248621533115813&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Looe Key National Marine Sanctuary hotels ![Exterior](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/63d12f01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Double Room, 2 Queen Beds | Terrace/patio](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/13570c88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/2a9d6b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/9eff678c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Looe Key Reef Resort [](https://www.expedia.ca/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) 12.6 km from Looe Key National Marine Sanctuary 7.4/10 Good (1001) "Was nice roo.s and close to my charter boat captain " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicholas CA $174 CA $195 total includes taxes & fees Jan 5 - Jan 6, 2026 [](https://www.expedia.ca/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) ![House](https://images.trvl-media.com/lodging/112000000/111880000/111873000/111872953/93e2a835.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/112000000/111880000/111873000/111872953/ea10b4e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/112000000/111880000/111873000/111872953/dbc7418b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House](https://images.trvl-media.com/lodging/112000000/111880000/111873000/111872953/ab69be49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Starlight Serenity - Hideaway w Stunning Views [](https://www.expedia.ca/Summerland-Key-Hotels-Starlight-Serenity-Hideaway-W-Stunning-Views.h111872953.Hotel-Information) 18.5 km from Looe Key National Marine Sanctuary CA $382 CA $890 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Summerland-Key-Hotels-Starlight-Serenity-Hideaway-W-Stunning-Views.h111872953.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28®ionId=553248621533115813&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Looe Key National Marine Sanctuary Hotel Reviews ![Parmer's Resort](https://images.trvl-media.com/lodging/6000000/5570000/5561500/5561465/6492712a_y.jpg) ### Parmer's Resort 10/10 Excellent "Room was clean and comfortable." [](https://expedia.ca/Little-Torch-Key-Hotels-Parmers-Resort.h5561465.Hotel-Information) ![Looe Key Reef Resort](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/63d12f01_y.jpg) ### Looe Key Reef Resort 10/10 Excellent "Was nice roo.s and close to my charter boat captain " [](https://expedia.ca/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) ![Ocean Depth Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152453/4bef164b_y.jpg) ### Ocean Depth Room Barnacle Resort 10/10 Excellent "Enjoyed our short stay in the Ocean Depth Room. Utilized the shared kitchen to cook breakfast and eat on the beach each morning. Would def stay there again." [](https://expedia.ca/Big-Pine-Key-Hotels-Ocean-Depth-Room-Barnacle-Bed-And-Breakfast.h111152453.Hotel-Information) ![One of the very few beach houses with a daily, rental license in the Keys.](https://images.trvl-media.com/lodging/39000000/38420000/38413600/38413504/ccc6991c_y.jpg) ### One of the very few beach houses with a daily, rental license in the Keys. 10/10 Excellent "If you are looking to see spectacular sunrises in the Keys, this location is great. Kitchen is well stocked with everything you need. " [](https://expedia.ca/Summerland-Key-Hotels-Acreage-Beach-House-W-Pool-Billiards.h38413504.Hotel-Information) ![Star Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152457/9bf80e17_y.jpg) ### Star Room Barnacle Resort 10/10 Excellent "We loved the location - quiet and secluded - away from everything but not so far away that you felt isolated. All very clean and amenities were as described." [](https://expedia.ca/Big-Pine-Key-Hotels-Star-Room-Barnacle-Bnb.h111152457.Hotel-Information) ![Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise](https://images.trvl-media.com/lodging/30000000/29940000/29935200/29935101/f156629a_y.jpg) ### Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise 10/10 Excellent "Nice hm really appreciated the ramp instead of stairs. Could use some nonstick pans to cook in. " [](https://expedia.ca/Summerland-Key-Hotels-DeepWideFlow-Though-Canal.h29935101.Hotel-Information) ![Treehouse Private Village Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152459/d1e84791_y.jpg) ### Treehouse Private Village Barnacle Resort 8/10 Good "Great location, quiet with great views!" [](https://expedia.ca/Big-Pine-Key-Hotels-Treehouse-Private-Village.h111152459.Hotel-Information) ![Gorgeous Beachfront Home with a pool. Water views from every direction.](https://images.trvl-media.com/lodging/37000000/36320000/36314300/36314286/d96b30e5_y.jpg) ### Gorgeous Beachfront Home with a pool. Water views from every direction. 10/10 Excellent "We have been coming to the keys for years, this has to be top 3 places to stay. Absolutely beautiful. Plenty of room. Deer come up every day. Definitely will stay here again! " [](https://expedia.ca/Big-Pine-Key-Hotels-As-Seen-On-BEACH-HUNTERS-Sn7-Ep5-Feel-Like-You-Are-On-Your-Own-Private-Island.h36314286.Hotel-Information) ![Barnacle Resort](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/048a25f3_y.jpg) ### Barnacle Resort 10/10 Excellent "No communication when I couldn’t get into my room. Horrible situation. DO NOT STAY AT THIS PROPERTY!! Total scam. " [](https://expedia.ca/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) ## Hotels near other Looe Key National Marine Sanctuary attractions ### Munson Island Commune with nature and explore the great outdoors at Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874556621345521664) ### Big Munson Island Commune with nature and explore the great outdoors at Big Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555262665744384) ### Newfound Harbor Keys Commune with nature and explore the great outdoors at Newfound Harbor Keys during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874556615670603776) ### Hopkins Island Commune with nature and explore the great outdoors at Hopkins Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555017892454400) ### Cook Island Commune with nature and explore the great outdoors at Cook Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635976197877) ### Pye Key Commune with nature and explore the great outdoors at Pye Key during your travels in Summerland Key. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555935142699008) ### Coupon Bight Aquatic Preserve Commune with nature and explore the great outdoors at Coupon Bight Aquatic Preserve during your travels in Big Pine Key. While in this relaxing area, you can enjoy the restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6177699) ## Frequently asked questions ### What's the area like around Looe Key National Marine Sanctuary? ### What's the best place to stay close to Looe Key National Marine Sanctuary? ### If I need to cancel the hotel reservation for my stay near Looe Key National Marine Sanctuary, will I receive a refund? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - [Bahia Honda Key Hotels ](https://www.expedia.ca/Bahia-Honda-Key-Hotels.d553248635083902001.Travel-Guide-Hotels) - [Bay Point Hotels ](https://www.expedia.ca/Bay-Point-Hotels.d553248635976383913.Travel-Guide-Hotels) - [Big Coppitt Key Hotels ](https://www.expedia.ca/Big-Coppitt-Key-Hotels.d553248635975850102.Travel-Guide-Hotels) - [Big Pine Key Hotels ](https://www.expedia.ca/Big-Pine-Key-Hotels.d7195.Travel-Guide-Hotels) - [Big Torch Key Hotels ](https://www.expedia.ca/Big-Torch-Key-Hotels.d553248635974614531.Travel-Guide-Hotels) - 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