Title: 4 Stars Hotels in Mesopotamia, Argentina from CA $75 - Find Cheap Mesopotamia Hotels With 4 Stars | Expedia.ca

  

[Mesopotamia Travel Guide](https://expedia.ca/Mesopotamia.dx6208836)[Hotels in Mesopotamia](https://expedia.ca/Mesopotamia-Hotels.d6208836.Travel-Guide-Hotels)[Vacation Rentals in Mesopotamia](https://expedia.ca/Mesopotamia-Vacation-Rentals.d6208836.Travel-Guide-VacationRentals)[Flights to Mesopotamia](https://expedia.ca/Cheap-Flights-To-Mesopotamia.d6208836.Travel-Guide-Flights)[Mesopotamia Car Rentals](https://expedia.ca/Car-Rentals-In-Mesopotamia.d6208836.Car-Rental-Guide)[Mesopotamia Vacation Packages](https://expedia.ca/Mesopotamia.d6208836.Destination-Travel-Guides)

![Mesopotamia showing a river or creek and forests](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/196000/196544-Mesopotamia.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# 4 Stars Hotels in Mesopotamia, Argentina from CA $75

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)

### 

Change your mind

Book hotels with free cancellation

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)

### 

Treat yourself

Sign in to save 10% or more on thousands of hotels

[Sign in](https://www.expedia.ca/login)

![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)

### 

Be picky

Search almost a million properties worldwide

## Check availability on Mesopotamia 4 Star Hotels

Tonight

[Oct 30 - Oct 31](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-30&endDate=2025-10-31&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Oct 31 - Nov 1](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-31&endDate=2025-11-01&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6208836&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Mesopotamia 4 Star Hotels

![Dining](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/cfb1c595.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/c7dff903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/000bdc72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Esplendor by Wyndham Savoy Rosario

Rosario Centro

8.6/10

Excellent

(441)

"Excellent hotel Everything very comfortable, and convenient"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cecilia Marina

CA $109

CA $109 total

Nov 2 - Nov 3

[](https://www.expedia.ca/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/13fc6ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/f21bc2e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/09bc75f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/10000000/9850000/9845300/9845278/903afdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterTower Hotel

Santa Fe

8.8/10

Excellent

(206)

"Excelent place to stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angel

CA $123

CA $123 total

Nov 9 - Nov 10

[](https://www.expedia.ca/Santa-Fe-Hotels-InterTower-Hotel.h9845278.Hotel-Information)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/65a9aa22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/ba8eff35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/ed3d5f57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/788d16ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dazzler by Wyndham Rosario

Rosario

8.8/10

Excellent

(185)

"Convenient if you like shopping and the hotel very good amenities "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Daniela

CA $106

CA $106 total

Nov 2 - Nov 3

[](https://www.expedia.ca/Rosario-Hotels-Dazzler-By-Wyndham-Rosario.h20265319.Hotel-Information)

![Casino](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/a75881f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/da57c485.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception hall](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/028ca893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/2000000/1200000/1197100/1197026/d7ac2335.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Amérian Hotel Casino Gala

Resistencia

9.0/10

Wonderful

(164)

"Great service and attention!. I highly recommend this hotel . "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stella

[](https://www.expedia.ca/Resistencia-Hotels-Amerian-Hotel-Casino-Gala.h1197026.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/45830686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/386d872f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/2caaf7cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/118000000/117160000/117154200/117154160/f67a3e06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Marriott Corrientes Hotel

Corrientes

CA $187

CA $187 total

Nov 7 - Nov 8

[](https://www.expedia.ca/Corrientes-Hotels-Marriott-Corrientes-Hotel.h117154160.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/e7b50f9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool, open 9:00 AM to 9:00 PM, sun loungers](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/3f7af7b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/64dd1add.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite (Parana)](https://images.trvl-media.com/lodging/11000000/10640000/10633700/10633627/8470c987.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Puerto Norte Design Hotel

Rosario

9.2/10

Wonderful

(142)

"Super comfortable and luxurious with amazing view of the river. The staff was courteous enough and parking was easy and right in front of the hotel. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katie

[](https://www.expedia.ca/Rosario-Hotels-Puerto-Norte-Design-Hotel.h10633627.Hotel-Information)

![Rooftop terrace](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/c5d48d1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food court](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/1ce8f635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/1dcc67c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/50000000/49090000/49086600/49086569/962c6c78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Los Silos Hotel

Santa Fe

9.2/10

Wonderful

(27)

"Unique, interesting, and very nice. Staff was outstanding. We will be back soon"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Russell

CA $154

CA $154 total

Nov 30 - Dec 1

[](https://www.expedia.ca/Santa-Fe-Parana-Hotels-Los-Silos-Hotel.h49086569.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1740000/1733400/1733362/ba76bcfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/2000000/1740000/1733400/1733362/df109415.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1740000/1733400/1733362/5dea5a07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1740000/1733400/1733362/e02bcc0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ros Tower Hotel

Rosario Centro

8.6/10

Excellent

(311)

"The breakfast was excellent, the hotel a bit outdated but still great for Rosario."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lisa

[](https://www.expedia.ca/Rosario-Hotels-Ros-Tower-Hotel.h1733362.Hotel-Information)

![Aerial view](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/3b6899cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/4349e1ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/6fa88a7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/4000000/3030000/3023900/3023891/14f061b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pullman Rosario City Center Hotel

Rosario

8.6/10

Excellent

(272)

"Nice"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

juan

[](https://www.expedia.ca/Rosario-Hotels-Pullman-Rosario-City-Center-Hotel.h3023891.Hotel-Information)

![41-inch TV with satellite channels](https://images.trvl-media.com/lodging/1000000/90000/82800/82767/05ab0316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![41-inch TV with satellite channels](https://images.trvl-media.com/lodging/1000000/90000/82800/82767/24338ad5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/90000/82800/82767/54b4cb2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Room, 1 Queen Bed](https://images.trvl-media.com/lodging/1000000/90000/82800/82767/45dd36ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Solans Presidente

Rosario Centro

8.6/10

Excellent

(145)

"Excelente "

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Marcelo

[](https://www.expedia.ca/Rosario-Hotels-Hotel-Solans-Presidente.h82767.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/c114ee3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/c058d200.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/c58abaf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/3000000/2810000/2803600/2803582/3140cd55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Alondra Casa De Huéspedes

Corrientes

9.2/10

Wonderful

(65)

"Estive no La Alondra em 2018 e achei fantatisco. agora deixou muito a desejar. atendimento nada simpatico. banheiro com problemas, cafe da manha super demorado."

![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg)

arnaldo

[](https://www.expedia.ca/Corrientes-Hotels-La-Alondra-Casa-De-Huespedes.h2803582.Hotel-Information)

![2 bedrooms, premium bedding, pillowtop beds, individually decorated](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/9cad496d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/5f45ac2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment | Private kitchen](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/3ee5dbf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Duplex | Living area](https://images.trvl-media.com/lodging/100000000/99270000/99269400/99269311/1eee7dc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Agustín 1 Apart

Parana

9.0/10

Wonderful

(4)

"Meu problema foi só a garagem, o apartamento é ótimo, limpeza estava impecável."

![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg)

Jose rodrigo kallas

CA $75

CA $75 total

Nov 2 - Nov 3

[](https://www.expedia.ca/Parana-Hotels-Agustin-1-Apart.h99269311.Hotel-Information)

![Standard Room](https://images.trvl-media.com/lodging/107000000/106450000/106442400/106442332/21c041c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, soundproofing, free WiFi](https://images.trvl-media.com/lodging/107000000/106450000/106442400/106442332/8de1ebf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Room | Private kitchen](https://images.trvl-media.com/lodging/107000000/106450000/106442400/106442332/d7971d61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room | Private kitchen](https://images.trvl-media.com/lodging/107000000/106450000/106442400/106442332/54539f26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apart Hotel Ribera del Baradero

Baradero

CA $148

CA $148 total

Nov 12 - Nov 13

[](https://www.expedia.ca/Baradero-Hotels-Apart-Hotel-Ribera-Del-Baradero.h106442332.Hotel-Information)

![City view](https://images.trvl-media.com/lodging/111000000/110110000/110102000/110101965/cb7e701b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite, Kitchen, City View](https://images.trvl-media.com/lodging/111000000/110110000/110102000/110101965/9c6e52c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Suite, Kitchen, City View](https://images.trvl-media.com/lodging/111000000/110110000/110102000/110101965/dded7234.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Luxury Duplex](https://images.trvl-media.com/lodging/111000000/110110000/110102000/110101965/e99fcc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ámbar Suites

Rosario Centro

[](https://www.expedia.ca/Rosario-Hotels-Ambar-Suites.h110101965.Hotel-Information)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/97000000/96510000/96506400/96506339/ab4ac05a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/97000000/96510000/96506400/96506339/5ed2f5c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room](https://images.trvl-media.com/lodging/97000000/96510000/96506400/96506339/eb0983a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room](https://images.trvl-media.com/lodging/97000000/96510000/96506400/96506339/4d75b5c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### HOTEL TERMAS VICTORIA Wellness Spa

Victoria

9.0/10

Wonderful

(2)

"El hotel está ubicado en un lugar muy bueno, muy tranquilo, buenas instalaciones y buena disposición de las mismas, la vista es increíble "

![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg)

Mirna

[](https://www.expedia.ca/HOTEL-TERMAS-VICTORIA-Spa-Reuniones.h96506339.Hotel-Information)

![Poolside bar](https://images.trvl-media.com/lodging/5000000/4920000/4916900/4916858/b42faffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/5000000/4920000/4916900/4916858/d91442d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4920000/4916900/4916858/4c19ce64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/5000000/4920000/4916900/4916858/0aa543c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Pedro Palace Hotel

San Pedro

8.8/10

Excellent

(6)

"EL HOTEL ES MUY LINDO, ACONDICVIONADO PERO CON UN DEJO DE EPOCA QUE TE HACE SENTIR MUY BIEN. LOS EMPLEADOS MUY ATENTOS A TODAS LAS NECESIDADES. LO PASAMOS MUY PERO MUY BIEN"

![Argentina](https://a.travel-assets.com/egds/marks/flags/ar.svg)

ENRIQUE CARLOS

[](https://www.expedia.ca/San-Pedro-Hotels-San-Pedro-Palace-Hotel.h4916858.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38240000/38239800/38239705/7f9bf546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Villa, 4 Bedrooms, Private Pool](https://images.trvl-media.com/lodging/39000000/38240000/38239800/38239705/825dc588.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Villa, 4 Bedrooms, Private Pool | Living room](https://images.trvl-media.com/lodging/39000000/38240000/38239800/38239705/1b476d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/39000000/38240000/38239800/38239705/701cff77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Lua

Gualeguaychú

[](https://www.expedia.ca/Gualeguaychu-Hotels-Villa-Lua.h38239705.Hotel-Information)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Mesopotamia-Hotels.s40-0-d6208836.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Mesopotamia-Hotels.s40-0-d6208836.Travel-Guide-Filter-Hotels)

## Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Mesopotamia.

![Bagú Urbano](https://images.trvl-media.com/lodging/5000000/4390000/4388000/4387932/5e4f0852_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Bagú Urbano

Bolivar 2176, Posadas, Misiones

[Get rates](https://expedia.ca/Hotel-Search?startDate=13%2F11%2F2025&endDate=14%2F11%2F2025&selected=4387932&PinnedHotelID=4387932&HadPinnedHotel=true&regionId=6208836)

8.4/10 Very Good! (343 reviews)

[](https://expedia.ca/Posadas-Hotels-Hotel-Urbano-Posadas.h4387932.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Mesopotamia.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40)

You can also use these popular filters to refine your search.

[Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40&star=40&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40&star=40&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40&star=40&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40&star=40&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=31%2F10%2F2025&endDate=01%2F11%2F2025&regionId=6208836&star=40&star=40&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Mesopotamia

The awe-inspiring Iguazú Falls is the centerpiece attraction of this northeastern Argentine region, which also hosts the country’s biggest carnival celebration.

[See all hotels in Mesopotamia](https://www.expedia.ca/Hotel-Search?startDate=2025-11-13&endDate=2025-11-14&adults=2&regionId=6208836)

![Mesopotamia showing a river or creek and forests](https://images.trvl-media.com/place/6208836/ca0c6990-9932-4f38-bee6-e89ce7080803.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high)

## Top Mesopotamia Hotel Reviews

![Dazzler by Wyndham Rosario](//images.trvl-media.com/lodging/21000000/20270000/20265400/20265319/65a9aa22_y.jpg)

### Dazzler by Wyndham Rosario

10/10 Excellent

"Convenient if you like shopping and the hotel very good amenities "

[](https://expedia.ca/Rosario-Hotels-Dazzler-By-Wyndham-Rosario.h20265319.Hotel-Information)

![Esplendor by Wyndham Savoy Rosario](//images.trvl-media.com/lodging/3000000/2810000/2803500/2803473/36b8ac51_y.jpg)

### Esplendor by Wyndham Savoy Rosario

10/10 Excellent

"Excellent hotel Everything very comfortable, and convenient"

[](https://expedia.ca/Rosario-Hotels-Esplendor-By-Wyndham-Savoy-Rosario.h2803473.Hotel-Information)

## Find out more about Mesopotamia

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Mesopotamia are calling your name. Known for providing first-rate service in amazing locations, each of the Mesopotamia 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Mesopotamia. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Mesopotamia, Argentina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Mesopotamia hotels with 4 Stars provide everything you need to unwind in style.

## Explore a world of travel with Expedia

-   More ways to book

-   [Book 4 Star Hotels in Mesopotamia on Expedia.com.ar](https://www.expedia.com.ar/4Estrella-Mesopotamia-Hoteles.s40-0-d6208836.Guia-filtrada-de-Hoteles)