A pier extending into calm waters with a small boat docked at the end.

Panacea Vacation Rentals

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Our top choices for Panacea vacation rentals

1. Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience

Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience
Panacea
10.0 out of 10, Exceptional, (25 reviews)
"Great place to stay while fishing"
United States
Benjamin S.
The price is CA $190
CA $444 total
includes taxes & fees
Aug 31 - Sep 1
Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience

2. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
9.0 out of 10, Wonderful, (2 reviews)
"Great communication. Comfortable"
United States
Faith V.
The price is CA $196
CA $246 total
includes taxes & fees
Sep 2 - Sep 3
Cozy Panacea Retreat #3 (King)

3. Tiny Tides Waterfront Cottage

Tiny Tides Waterfront Cottage
Panacea
10.0 out of 10, Exceptional, (11 reviews)
"What a perfect escape! We thoroughly enjoyed our stay at Tiny Tides. The cozy, comfortable vibe, the peaceful location, and the easy access to everything made our trip truly special. We had a fantastic time and will definitely be back soon!"
United States
Jason W.
The price is CA $222
CA $538 total
includes taxes & fees
Aug 29 - Aug 30
Tiny Tides Waterfront Cottage

4. romantic get away for 2 right on the Ochlockonee river

romantic get away for 2 right on the Ochlockonee river
Panacea
6.0 out of 10, (2 reviews)
"Wonderful accommodations-clean and comfortable. "
United States
Laurie K.
The price is CA $181
CA $433 total
includes taxes & fees
Sep 3 - Sep 4
romantic get away for 2 right on the Ochlockonee river

5. Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks

Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks
Panacea
10.0 out of 10, Exceptional, (4 reviews)
"Had a great stay! We would book here again."
United States
Ashley D.
The price is CA $265
CA $651 total
includes taxes & fees
Sep 8 - Sep 9
Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks

6. Point & Paddle Waterfront Retreat @Alligator Point

Point & Paddle Waterfront Retreat @Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"We really enjoyed the place. It was quiet, cozy, and perfect for a quick getaway with our family. I would highly recommend others checking this place out and tho we don’t visit the area much we would love staying here again!"
United States
Scott A.
The price is CA $263
CA $672 total
includes taxes & fees
Aug 30 - Aug 31
Point & Paddle Waterfront Retreat @Alligator Point

7. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
The price is CA $196
CA $246 total
includes taxes & fees
Sep 2 - Sep 3
Cozy Panacea Retreat #3 (King)

8. Queen Kitchenette by the Bay #13

Queen Kitchenette by the Bay #13
Panacea
The price is CA $196
CA $246 total
includes taxes & fees
Sep 6 - Sep 7
Queen Kitchenette by the Bay #13

9. Cozy Panacea Retreat #7 (King)

Cozy Panacea Retreat #7 (King)
Panacea
The price is CA $196
CA $246 total
includes taxes & fees
Sep 20 - Sep 21
Cozy Panacea Retreat #7 (King)

10. Perfect Panacea 1 Bedroom Apt, #2

Perfect Panacea 1 Bedroom Apt, #2
Panacea
The price is CA $196
CA $246 total
includes taxes & fees
Sep 13 - Sep 14
Perfect Panacea 1 Bedroom Apt, #2

11. The Best Beach-Front House “Get-A-Way” in Florida

The Best Beach-Front House “Get-A-Way” in Florida
Panacea
10.0 out of 10, Exceptional, (99 reviews)
"Excellent beach front location, wonderful amenities like beach chairs, umbrellas, toys and towels made the stay easy and stress free! "
United States
Juliet H.
The price is CA $373
CA $899 total
includes taxes & fees
Aug 31 - Sep 1
The Best Beach-Front House “Get-A-Way” in Florida

12. Queen Kitchenette by the Bay #8

Queen Kitchenette by the Bay #8
Panacea
The price is CA $244
CA $302 total
includes taxes & fees
Aug 30 - Aug 31
Queen Kitchenette by the Bay #8

13. Panacea Cozy Retreat #6 (DQ)

Panacea Cozy Retreat #6 (DQ)
Panacea
The price is CA $245
CA $304 total
includes taxes & fees
Sep 1 - Sep 2
Panacea Cozy Retreat #6 (DQ)

14. Panacea Cozy Retreat #4 (DQ)

Panacea Cozy Retreat #4 (DQ)
Panacea
The price is CA $245
CA $307 total
includes taxes & fees
Aug 31 - Sep 1
Panacea Cozy Retreat #4 (DQ)

15. NEW - St. Teresa Beach Escape w/ Private Beach Acc

NEW - St. Teresa Beach Escape w/ Private Beach Acc
Lanark Village
10.0 out of 10, Exceptional, (2 reviews)
"This house was very comfortable, beds, pillows, towels, sofa, etc. Quiet, peaceful, serene setting. Close proximity to beach and the pool was an added bonus!Thank you for a very enjoyable stay!"
United States
Debra M.
The price is CA $435
CA $1,104 total
includes taxes & fees
Aug 31 - Sep 1
NEW - St. Teresa Beach Escape w/ Private Beach Acc

16. 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Alligator Point
10.0 out of 10, Exceptional, (131 reviews)
"Beautiful house with awesome views of the gulf and the bay from all rooms. Fenced in yard was perfect for our dog. Location is very relaxing. I can't wait to go back."
United States
V G.
The price is CA $1,247
CA $3,105 total
includes taxes & fees
Aug 30 - Aug 31
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

17. Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf

Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf
Crawfordville
10.0 out of 10, Exceptional, (81 reviews)
"What a great property! The house is fully equipped for your stay and the sunrises are breathtaking!"
United States
Donna M.
The price is CA $168
CA $426 total
includes taxes & fees
Aug 31 - Sep 1
Reel Pelican Paradise located in Paradise village, Shellpoint Beach on the Gulf

18. Enjoy Crawfordville at the Courtyard’s Pelican Cottage.

Enjoy Crawfordville at the Courtyard’s Pelican Cottage.
Crawfordville
10.0 out of 10, Exceptional, (138 reviews)
"Super cute cottage, roomy and equipped with everything you would need for your stay. I enjoyed a cup of hot tea on the front porch on the day it rained. Lots of great restaurants nearby. Owner was very helpful and answered our questions right away. Hope to come back soon!"
United States
Jennifer W.
The price is CA $132
CA $301 total
includes taxes & fees
Aug 31 - Sep 1
Enjoy Crawfordville at the Courtyard’s Pelican Cottage.

19. Enjoy Crawfordville at the Courtyard’s Oyster Cottage

Enjoy Crawfordville at the Courtyard’s Oyster Cottage
Crawfordville
10.0 out of 10, Exceptional, (70 reviews)
"Wonderful stay, everything clean and comfortable."
United States
Robert G.
The price is CA $138
CA $310 total
includes taxes & fees
Sep 8 - Sep 9
Enjoy Crawfordville at the Courtyard’s Oyster Cottage

20. Dragonfly on the Canal Golf cart included!

Dragonfly on the Canal Golf cart included!
Crawfordville
10.0 out of 10, Exceptional, (56 reviews)
"Was a great spacious place. We stayed for graduation weekend and could not have been happier. The porch is amazing!"
United States
Kristy B.
The price is CA $193
CA $460 total
includes taxes & fees
Aug 29 - Aug 30
Dragonfly on the Canal Golf cart included!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panacea Hotel Reviews

Find out more about Panacea

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Panacea. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in Panacea?

Yes, there are vacation rentals in Panacea close to Gulf Specimen Public Aquarum, or you can go with a secluded option if you'd like a relaxing place to stay. Visitors to Panacea speak positively about the beaches and seafood restaurants in this destination.

What are some of the best vacation rentals in Panacea?

Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has a patio, a barbecue grill, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Another good choice for your trip to Panacea is Best deal at Alligator Point.

How many vacation rentals are there in Panacea?

Choose from 179 Expedia vacation rentals in Panacea for a memorable vacation.

What’s there to see and do in Panacea?

Mashes Sand Beach and Alligator Point Beach are a couple of lovely local spots to enjoy the outdoors, whereas family-friendly attractions include Gulf Specimen Public Aquarum. While here, Bald Point State Park and Wilson Beach are other places worth a visit.

What’s a vacation rental in Panacea like?

Vacation rentals are privately owned properties where you can stay for a few weeks or just a few days in Panacea. Vacation rentals offer amenities like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a popular choice for family trips or small group gatherings.