Title: Book the Best Los Osos SPA Resorts from CA $196 - Spa Hotels in Los Osos, CA | Expedia.ca [Los Osos Travel Guide](https://expedia.ca/Los-Osos.dx9873)[Hotels in Los Osos](https://expedia.ca/Los-Osos-Hotels.d9873.Travel-Guide-Hotels)[Vacation Rentals in Los Osos](https://expedia.ca/Los-Osos-Vacation-Rentals.d9873.Travel-Guide-VacationRentals)[Flights to Los Osos](https://expedia.ca/Cheap-Flights-To-Los-Osos.d9873.Travel-Guide-Flights)[Los Osos Car Rentals](https://expedia.ca/Car-Rentals-In-Los-Osos.d9873.Car-Rental-Guide)[Los Osos Vacation Packages](https://expedia.ca/Los-Osos.d9873.Destination-Travel-Guides) ![Such a nice place!](https://images.trvl-media.com/place/553248621532639980/2c5ca4d7-c91a-4938-ad4a-7fa3b4914016.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lisa Travelfeet ![](https://images.trvl-media.com/place/553248621532639980/2c5ca4d7-c91a-4938-ad4a-7fa3b4914016.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Los Osos Spa Hotels Tonight [Mar 10 - Mar 11](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2026-03-10&endDate=2026-03-11&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 11 - Mar 12](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2026-03-11&endDate=2026-03-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2026-03-13&endDate=2026-03-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2026-03-20&endDate=2026-03-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Los Osos hotels with a spa ![Caveman | Bathroom](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/29ce234c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/1ea42b7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Madonna Suite | Bathroom](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/a4e68773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, in-room safe, individually decorated](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/63206dec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Madonna Inn [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) San Luis Obispo 9.2/10 Wonderful (1,394 reviews) "Nice room, clean, friendly staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Roxana CA $202 CA $276 total includes taxes & fees Mar 16 - Mar 17 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Exclusive Suite, Private Bathroom (PREMIER CALIFORNIA KING - Bay View)](https://images.trvl-media.com/lodging/117000000/116800000/116793800/116793728/e10d36bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Individually decorated, individually furnished, soundproofing, free WiFi](https://images.trvl-media.com/lodging/117000000/116800000/116793800/116793728/70d6de9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/117000000/116800000/116793800/116793728/1b0d9ce0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sauna](https://images.trvl-media.com/lodging/117000000/116800000/116793800/116793728/f92f0d18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Inn at Rose's Landing [](https://www.expedia.ca/Morro-Bay-Hotels-Inn-At-Roses-Landing.h116793728.Hotel-Information) Downtown Morro Bay 9.8/10 Exceptional (8 reviews) "Central location Easy parking Clean, newly remodeled room with extensive range of amenities available Staff was extremely friendly and helpful " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Emily CA $255 CA $293 total includes taxes & fees Mar 11 - Mar 12 [](https://www.expedia.ca/Morro-Bay-Hotels-Inn-At-Roses-Landing.h116793728.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/d2bd3038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 1 King Bed, Jetted Tub, Ocean View | Balcony](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/2d60e382.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/10b1b07e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Honeymoon Suite, 1 King Bed, Non Smoking, Ocean View](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/8e1a2a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cayucos Sunset Inn B&B [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Cayucos-Sunset-Inn-Bed-And-Breakfast.h35826166.Hotel-Information) Cayucos 9.8/10 Exceptional (208 reviews) "Very nice accommodations, staff extremely friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacqueline CA $209 CA $235 total includes taxes & fees Mar 12 - Mar 13 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Cayucos-Sunset-Inn-Bed-And-Breakfast.h35826166.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/dea8ddbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Spa](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/9fba6166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/f7fb843a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/bd2697e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Agrarian Hotel, BW Signature Collection [](https://www.expedia.ca/San-Luis-Obispo-Hotels-The-Agrarian-Hotel.h36117545.Hotel-Information) Arroyo Grande 9.6/10 Exceptional (1,003 reviews) "Very nice place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chritine CA $173 CA $196 total includes taxes & fees Mar 12 - Mar 13 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-The-Agrarian-Hotel.h36117545.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/c2c4905d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/74e3dfcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/fa3c39d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, pillowtop beds](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/1386e090.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Avila La Fonda Hotel [](https://www.expedia.ca/Avila-Beach-Hotels-Avila-La-Fonda-Hotel.h1507108.Hotel-Information) Avila Beach 9.6/10 Exceptional (1,003 reviews) "The room was spotless and lovely. The staff were very helpful and kind. The amenities were fabulous and the location was perfect!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lillie CA $264 CA $297 total includes taxes & fees Mar 12 - Mar 13 [](https://www.expedia.ca/Avila-Beach-Hotels-Avila-La-Fonda-Hotel.h1507108.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/088fc1a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/bda10fa4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Morro Suite | Living area](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/96137871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/3f29ecb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel San Luis Obispo [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-San-Luis-Obispo.h37232966.Hotel-Information) Downtown San Luis Obispo 9.6/10 Exceptional (586 reviews) "Great space, friendly staff and good restaurants - we thoroughly enjoyed ourselves. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) michelle CA $518 CA $588 total includes taxes & fees Mar 16 - Mar 17 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-San-Luis-Obispo.h37232966.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/42ac20df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/94f85976.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/8a3ff3f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/22fcbd4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOTEL CERRO, Autograph Collection [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-Cerro.h48257614.Hotel-Information) Downtown San Luis Obispo 9.2/10 Wonderful (477 reviews) "Beautiful property. Great location. Very clean and modern. My only complaint is the price for valet a night ($45) and the incidental cost a night ($125), seems a bit steep for a hotel in SLO. Nonetheless, there is a public parking building kitty corner from the property for $16 a night. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy CA $405 CA $507 total includes taxes & fees Mar 15 - Mar 16 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-Cerro.h48257614.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-24&endDate=2026-03-25®ionId=9873&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Los Osos Pool Breakfast included Hot tub 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_9873) ## Top Los Osos Hotel Reviews ![Madonna Inn](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/63206dec_y.jpg) ### Madonna Inn 8/10 Good "We had a great time at the Madonna Inn, the only drawback was that we only stayed one night, we should have stayed longer to enjoy all that it has to offer. Next time we will definitely stay longer. It was great fun choosing our room, and am already looking forward to staying there again." [](https://expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Embassy Suites by Hilton San Luis Obispo](https://images.trvl-media.com/lodging/1000000/20000/15500/15406/be1d8b89_y.jpg) ### Embassy Suites by Hilton San Luis Obispo 10/10 Excellent "Even if we were given a room on the 1st floor, it was surprisingly quiet. Amenities are topnotch, clean room, q " [](https://expedia.ca/San-Luis-Obispo-Hotels-Embassy-Suites-By-Hilton-San-Luis-Obispo.h15406.Hotel-Information) ![Best Western Casa Grande Inn](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/4cda8af4_y.jpg) ### Best Western Casa Grande Inn 2/10 Terrible "The room was not clean when I got in. Clearly the glitter on the side table overlooked by staff. I was exhausted from driving so I just laid down and woke up because the thermostat was malfunctioning and I couldn’t get it to work so at 76 degrees I was roasting. Called the front desk at 1:00 in the morning and Adam couldn’t fix it either and started to scold me about not calling right away and why didn’t I open the window? I was exhausted and fell asleep that’s why, and I didn’t open the window because I needed quiet and I was in a room next to the elevator and people talking. He offered me another room at 1:30 in the morning and I declined because my stuff was out and that would have meant gathering everything, totally waking up and not getting proper sleep for all I had to do in the morning. How is it that a 20 year old staff gets to scold a guest about how they should behave? I called the front desk in the morning and she was equally as rude, telling me I “refused” to move IN THE MIDDLE OF THE NIGHT— Let me make this clear. I did not REFUSE. I hoped I could get through the night— What I want to know is when did Best Western make it a policy to be rude to guests and make it the guest’s fault for not being up to par. After the morning call I tried to sleep until check out, put the privacy tag on my door and just as I fell to sleep, maintenance completely ignoring my DO NOT DISTURB sign. I mean, what is this? I have to pay for rudeness and disrespect? " [](https://expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![Spyglass Inn](https://images.trvl-media.com/lodging/1000000/50000/41300/41235/9593cdf6_y.jpg) ### Spyglass Inn 10/10 Excellent "The Spyglass Inn was a perfect location for my wife and I. The room with an ocean view balcony was great. Nice walkway to the adjoining hotels. Will definitely stay here again. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Spyglass-Inn.h41235.Hotel-Information) ![Edgewater Inn And Suites](https://images.trvl-media.com/lodging/1000000/900000/894000/893902/3beb869e_y.jpg) ### Edgewater Inn And Suites 2/10 Terrible "Friendly staff. Clean room. Nice ocean view" [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ![Apple Farm](https://images.trvl-media.com/lodging/1000000/40000/39500/39435/880cde75_y.jpg) ### Apple Farm 8/10 Good "Nice property , decent rooms , we stayed on the side with no elevator which could be a problem for many. can be noisy when people walking outside etc... overall was nice , just don't like when Hotels charge parking extra to park yourself just to use the Lot. Should be included unless they have a valet and park for you. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![Cottage Inn By The Sea](https://images.trvl-media.com/lodging/1000000/160000/151000/150921/a9c907e0_y.jpg) ### Cottage Inn By The Sea 10/10 Excellent "Love the access to the beach, fireplaces , and the pool. It’s close to the pier and downtown " [](https://expedia.ca/San-Luis-Obispo-Hotels-Cottage-Inn-By-The-Sea.h150921.Hotel-Information) ![Oxford Suites Pismo Beach](https://images.trvl-media.com/lodging/1000000/10000/3100/3089/010bbafb_y.jpg) ### Oxford Suites Pismo Beach 10/10 Excellent "Better Beautiful Place to stay " [](https://expedia.ca/San-Luis-Obispo-Hotels-Oxford-Suites-Pismo-Beach.h3089.Hotel-Information) ![SeaCrest OceanFront Hotel](https://images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/b40c24d9_y.jpg) ### SeaCrest OceanFront Hotel 8/10 Good "Nice ocean view clean room nice and accommodating staff " [](https://expedia.ca/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ## Frequently asked questions ### Which hotels in Los Osos offer the best spa experiences? > The 3-star Sea Pines Resort, with an 8.2 rating, offers a full-service spa with an extensive treatment menu that includes deep tissue and hot stone massages. The spa features dedicated couples' treatment rooms, providing a serene environment for shared relaxation. ### How much does a spa hotel in Los Osos cost? ### Is it cheaper to book a spa hotel in Los Osos with flights as part of a package deal? ### Are there hotels in Los Osos that offer couples' spa treatments? > This 3-star hotel, with an 8.2 rating, offers couples' treatment rooms, allowing for a shared and intimate spa experience. The full-service spa provides a variety of treatments, including hot stone and deep tissue massages, for which advance notice is recommended. ### Are there any unique spa experiences available in Los Osos? > Sycamore Mineral Springs Resort & Spa, located approximately 10.8 miles from Los Osos, offers a distinctive experience with hot tubs filled with natural mineral spring water, located on a scenic hillside under oak trees. Guests can enjoy soaking in these mineral waters, often accompanied by local wine. > > > AcuGlo Acupuncture in Los Osos provides a unique blend of ancient Chinese healing and modern beauty techniques, including facial acupuncture, gua sha, facial reflexology, and herbal remedies, offering a wellness experience beyond traditional spa services. > > > Nearby resorts such as The Cliffs Hotel and Spa and Avila Lighthouse Suites also offer spa packages with massages, facials, and relaxing amenities, providing more conventional spa experiences. ### How can I save on a spa hotel in Los Osos with Expedia? ### Can I cancel my spa hotel reservation on Expedia? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [3 Star Hotels in Morro Bay ](https://www.expedia.ca/3Star-Morro-Bay-Hotels.s30-0-d8976.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Morro Bay ](https://www.expedia.ca/5Star-Morro-Bay-Hotels.s50-0-d8976.Travel-Guide-Filter-Hotels) - 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