Title: Book the Best Los Osos SPA Resorts from CA $223 - Spa Hotels in Los Osos, CA | Expedia.ca [Los Osos Travel Guide](https://expedia.ca/Los-Osos.dx9873)[Hotels in Los Osos](https://expedia.ca/Los-Osos-Hotels.d9873.Travel-Guide-Hotels)[Vacation Rentals in Los Osos](https://expedia.ca/Los-Osos-Vacation-Rentals.d9873.Travel-Guide-VacationRentals)[Flights to Los Osos](https://expedia.ca/Cheap-Flights-To-Los-Osos.d9873.Travel-Guide-Flights)[Los Osos Car Rentals](https://expedia.ca/Car-Rentals-In-Los-Osos.d9873.Car-Rental-Guide)[Los Osos Vacation Packages](https://expedia.ca/Los-Osos.d9873.Destination-Travel-Guides) ![Such a nice place!](https://images.trvl-media.com/place/553248621532639980/2c5ca4d7-c91a-4938-ad4a-7fa3b4914016.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Lisa Travelfeet # Find Spa Hotels in Los Osos, CA from CA $223 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Los Osos Spa Hotels Tonight [Nov 8 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-11-08&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 9 - Nov 10](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-11-09&endDate=2025-11-10&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=9873&startDate=2025-11-21&endDate=2025-11-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Los Osos Spa Hotels ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/09f8fafa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/4adefcff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room, 2 Queen Beds | Exterior](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/6a62dfc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/2000000/1840000/1839900/1839838/af3dfd64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sea Pines Resort Los Osos 8.2/10 Very good (406) "wonderful peaceful getaway in beautiful Los Osos, CA" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia CA $223 CA $283 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Sea-Pines-Resort.h1839838.Hotel-Information) ![Caveman | Bathroom](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/29ce234c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Highway Suite](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/59b09fa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/5a091377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | Terrace/patio](https://images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/01a54722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Madonna Inn San Luis Obispo 9.2/10 Wonderful (1289) "Absolutely amazing stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zachary A CA $181 CA $254 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/9e66f2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/3e5ffcce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/1d10b621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/37000000/36120000/36117600/36117545/323aabf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Agrarian Hotel, BW Signature Collection Arroyo Grande 9.6/10 Exceptional (1001) "Great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy CA $196 CA $223 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-The-Agrarian-Hotel.h36117545.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/46c8343c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/10b1b07e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/d2bd3038.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Honeymoon Suite, 1 King Bed, Non Smoking, Ocean View](https://images.trvl-media.com/lodging/36000000/35830000/35826200/35826166/8e1a2a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cayucos Sunset Inn B&B Cayucos 9.8/10 Exceptional (192) "Fantastic location, beautiful rooms, absolutely incredible breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dianne CA $245 CA $276 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Cayucos-Sunset-Inn-Bed-And-Breakfast.h35826166.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/42ac20df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/786b3840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/dd32277b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Sundeck](https://images.trvl-media.com/lodging/49000000/48260000/48257700/48257614/18ffa136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### HOTEL CERRO, Autograph Collection Downtown San Luis Obispo 9.2/10 Wonderful (462) "Best hotel in SLO. Great location to walk to anywhere downtown. Beautiful rooms. Bathroom could have used a second sink, but overall top notch. Loved the rooftop pool with bar. Very friendly staff. Will be back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Helmut CA $284 CA $370 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-Cerro.h48257614.Hotel-Information) ![Morro Suite | Living area](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/96137871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Tolosa Terrace King](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/cdd4facb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Paseo King Room](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/0c2ec67b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/38000000/37240000/37233000/37232966/b4e2ccc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel San Luis Obispo Downtown San Luis Obispo 9.4/10 Exceptional (539) "Beautiful design, so lovely. Ended up staying on property. Great staff:)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kelly CA $416 CA $472 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Hotel-San-Luis-Obispo.h37232966.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/c2c4905d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gift shop](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/5276bae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Double Room (Great Room) | Room amenity](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/5728603e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature Room, 1 King Bed (Spa Room) | Library](https://images.trvl-media.com/lodging/2000000/1510000/1507200/1507108/2d3891c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Avila La Fonda Hotel Avila Beach 9.6/10 Exceptional (1002) "Staff was fantastic and the rooms large and clean. Delicious croissant for breakfast and hosted wine and charcuterie in the evening. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Keith CA $247 CA $278 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Avila-Beach-Hotels-Avila-La-Fonda-Hotel.h1507108.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-22&endDate=2025-11-23®ionId=9873&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Los Osos Hotel Reviews ![Madonna Inn](//images.trvl-media.com/lodging/2000000/1200000/1191000/1190976/1ea42b7b_y.jpg) ### Madonna Inn 10/10 Excellent "Great room - Merry. 20 foot ceiling with pink glittery wall paper and a large gold and crystal light fixtures and giant chandelier. Quirky hotel (as expected) but well maintained. Nice pool area. Signature pink cloud cocktail was very . . . pink (and tasted fine)! Wonderful meal at the steak house. Pink champagne cake was pretty amazing and lived up to the hype. Waterfall urinal in men's room near the restaurant was over the top! Would stay here again. Should have broken up the long drive from LA to the Bay Area with a stay here long ago. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Madonna-Inn.h1190976.Hotel-Information) ![Oxford Suites Pismo Beach](//images.trvl-media.com/lodging/1000000/10000/3100/3089/b427747a_y.jpg) ### Oxford Suites Pismo Beach 10/10 Excellent "Great breakfast!" [](https://expedia.ca/San-Luis-Obispo-Hotels-Oxford-Suites-Pismo-Beach.h3089.Hotel-Information) ![Lamplighter Inn & Suites](//images.trvl-media.com/lodging/1000000/190000/181200/181126/92ba94b3_y.jpg) ### Lamplighter Inn & Suites 10/10 Excellent "This is my 2nd stay and I liked it a lot. The 24 hour office is a plus. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Lamplighter-Inn-Suites.h181126.Hotel-Information) ![Embassy Suites by Hilton San Luis Obispo](//images.trvl-media.com/lodging/1000000/20000/15500/15406/48c2929b_y.jpg) ### Embassy Suites by Hilton San Luis Obispo 10/10 Excellent "Nice breakfast clean room very helpful staff" [](https://expedia.ca/San-Luis-Obispo-Hotels-Embassy-Suites-By-Hilton-San-Luis-Obispo.h15406.Hotel-Information) ![Shore Cliff Hotel](//images.trvl-media.com/lodging/1000000/10000/9800/9742/ff9d613b_y.jpg) ### Shore Cliff Hotel 10/10 Excellent "Staff, view, amenities." [](https://expedia.ca/San-Luis-Obispo-Hotels-Shore-Cliff-Hotel.h9742.Hotel-Information) ![Apple Farm](//images.trvl-media.com/lodging/1000000/40000/39500/39435/f5438f41_y.jpg) ### Apple Farm 10/10 Excellent "I did not try the pool or hot tub" [](https://expedia.ca/San-Luis-Obispo-Hotels-Apple-Farm.h39435.Hotel-Information) ![Edgewater Inn And Suites](//images.trvl-media.com/lodging/1000000/900000/894000/893902/3d1c5694_y.jpg) ### Edgewater Inn And Suites 10/10 Excellent "Room was very clean, staff friendly, extras like snacks and grab and go breakfast. Will stay here again." [](https://expedia.ca/San-Luis-Obispo-Hotels-Edgewater-Inn-And-Suites.h893902.Hotel-Information) ![Cottage Inn By The Sea](//images.trvl-media.com/lodging/1000000/160000/151000/150921/c54d7346_y.jpg) ### Cottage Inn By The Sea 10/10 Excellent "Beautiful views and it is a very clean hotel" [](https://expedia.ca/San-Luis-Obispo-Hotels-Cottage-Inn-By-The-Sea.h150921.Hotel-Information) ![Sandcastle Hotel on the Beach](//images.trvl-media.com/lodging/1000000/50000/41000/40915/89d1e3f1_y.jpg) ### Sandcastle Hotel on the Beach 10/10 Excellent "We had a fantastic stay! Lovely views, room and staff. Bed is so comfortable. We will definitely be back! " [](https://expedia.ca/San-Luis-Obispo-Hotels-Sandcastle-Hotel-On-The-Beach.h40915.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Los Osos? > Forget the stress of everyday life and book yourself a hotel with a spa. Check out the beaches in Los Osos - worth a picture or two! Take part in recreational activities such as golfing during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation. ### What is the best spa hotel in Los Osos? > [Sea Pines Resort](https://www.expedia.ca/San-Luis-Obispo-Hotels-Sea-Pines-Resort.h1839838.Hotel-Information) is a top spa hotel featuring a golf course, a bar, and a restaurant. Spend an afternoon at the spa where you'll find deep-tissue massages, hot stone massages, and couples treatments. ### How many spa hotels will I find in Los Osos? > Among Expedia's 43 accommodation options in Los Osos, there is 1 spa hotel. ### What's there to see and do in Los Osos? > Experience Los Osos with a stop at Elfin Forest Preserve, Montaña de Oro State Park, and Morro Bay State Park. If you have a bit of extra time while you're in the area, you might want to check out Los Osos Oaks State Reserve and Morro Coast Audubon Society Sweet Springs Nature Preserve. ### What is a Los Osos spa hotel? > Spa hotels in Los Osos provide lodging and have an on-site spa which offers services such as facials as well as body treatments. Some also offer in-room treatments. 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