Title: Seneca Vacation Home Rentals from CA $418: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # Seneca Vacation Rentals ### Change your mind Book hotels with free cancellation ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-17&endDate=2025-10-19&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-26&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-07&endDate=2025-11-09&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-05&endDate=2025-12-07&adults=2&lodging=VACATION_HOME&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Browse Select Seneca Vacation Homes ![Property grounds](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/e0c6bce4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/d703ded8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/7a250fe8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/119000000/118120000/118111500/118111429/094cb5d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 1-bedroom farmhouse in marvelous Seneca with WiFi, AC Seneca 10/10 Exceptional (6) CA $160 CA $287 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Seneca-Hotels-Charming-1-Bedroom-Farmhouse-In-Marvelous-Seneca-With-WiFi.h118111429.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/56040807.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/a5c191d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/57b2b9a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/ab8a784d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson Seneca 10/10 Exceptional (2) "Great place with a lot close by" CA $249 CA $415 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/a25c3100.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/651434b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/9e2b77c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, travel crib, free WiFi, bed sheets](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/bd51a502.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Downtown 10/10 Exceptional (15) "Wonderful hosts and a great home. Very close to downtown Seneca and Clemson. Clean house with a great layout. Highly recommend!" CA $221 CA $473 total includes taxes & fees Oct 9 - Oct 10 [](https://www.expedia.ca/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/c008b5ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/bca2b689.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/1da4db10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/45872750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Clemson Cottage - 3.6 mi. to Memorial Stadium Seneca 10/10 Exceptional (12) "Adorable and clean home convenient to Clemson’s campus. We enjoyed our stay and Tyler was an exceptional host! " CA $279 CA $577 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/1ece8b8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/9e13146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Big Golf House- 10 miles to Clemson Seneca CA $356 CA $788 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information) ![TV, stereo](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/061a9e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/5b49cdd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/dbdc80ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/4b055900.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Timber Trail Estate: Stunning Views + Waterfront Seneca 6.4/10 (5) "Main floor was clean but basement and loft, cleaners missed a lot. It was very dusty with lots of cobwebs. Cleaners have missed a lot of places over and over again. The downstairs deck was full of pollen and so dirty we couldn’t sit out there. Wish there was an umbrella on top deck- no shade or cover when rains. Wish there was somewhere to put suitcases but w no closet space and no dresser tops, suitcases were all over floors. Was just hoping for a cleaner space for what we paid. Overall it was... CA $242 CA $733 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Seneca-Hotels-Lake-Keowee-Retreat-4BR-With-Hot-Tub-Dock.h106116530.Hotel-Information) ![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/ac405b8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/9b76782a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/3a34d432.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/dea343e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium Seneca 9.4/10 Exceptional (6) "Perfect for visiting Clemson student. Great location, clean, and well stocked. Owners were very responsive. Would definitely stay here again!" CA $526 CA $1,057 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/a1808626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/644a4539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger Serenity Bay 9.8/10 Exceptional (126) "A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!" CA $488 CA $948 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/121000000/120250000/120246100/120246086/bb9aa52a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/121000000/120250000/120246100/120246086/d58b5067.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120250000/120246100/120246086/3bd9ce2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120250000/120246100/120246086/9be3cc78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Southern Oaks Lavonia CA $139 CA $235 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Lavonia-Hotels-The-Inn-At-Southern-Oaks-Located-In-Historic-Lavonia.h120246086.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/121000000/120280000/120274500/120274493/87b0cd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120274500/120274493/fb84399d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120280000/120274500/120274493/b1333c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120274500/120274493/01e4cc27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Southern Oaks located in Historic Lavonia, GA, close to Lake Hartwell Lavonia CA $139 CA $235 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Lavonia-Hotels-The-Inn-At-Southern-Oaks-Located-In-Historic-Lavonia.h120274493.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/121000000/120280000/120276700/120276638/31446e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/121000000/120280000/120276700/120276638/bbd80dff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120276700/120276638/79bd7618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120280000/120276700/120276638/17bc1e00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at Southern Oaks located in Historic Lavonia, GA, close to Lake Hartwell Lavonia CA $139 CA $235 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Lavonia-Hotels-The-Inn-At-Southern-Oaks-Located-In-Historic-Lavonia.h120276638.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/134a8147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/596dbd79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/0e18a612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/b6f2f270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Black Bear Hideaway Pickens CA $112 CA $313 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Pickens-Hotels-Black-Bear-Hideaway.h120648317.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/b7a1f289.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/de9f5026.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, foosball, books](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/d57b249b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/6ec12c0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Welcome To Downtown Pickens close to Clemson and Lake Keowee Pickens 10/10 Exceptional (28) "This house is fantastic. It is in a great location, whether you're staying local, driving into Easley and Greenville, or taking the scenic roads toward the mountains. This was our third stay at this property, and we really love this place. Perhaps the most cherished memory from this most recent stay is showing my daughter fireflies in the evening." CA $151 CA $364 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Pickens-Hotels-Welcome-To-Downtown-Pickens-Close-To-Clemson-And-Lake-Keowee.h89406578.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100340000/100330600/100330565/b137370a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/101000000/100340000/100330600/100330565/7d94b763.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/101000000/100340000/100330600/100330565/c495bdd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100340000/100330600/100330565/d532f56d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sunny Side Cottage: Cozy Stay by Anderson U! Anderson 9.8/10 Exceptional (18) "This home is older and as with all older homes that aren’t remodeled, it has an unusual layout. It’s in a cute neighborhood and was located close to our destination. Iwas clean and decorated nicely and the beds were comfortable. We would stay there again. " CA $136 CA $502 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Anderson-Hotels-Charming-Bungalow-One-Block-To-Anderson-University.h100330565.Hotel-Information) ![Signature House, 4 Bedrooms, Patio | Living room](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/877220d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | In-room dining](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/84421426.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/63caaad7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | Private kitchen](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/f8ba8fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Hartwell Frank Howard Home Clemson Anderson CA $167 CA $418 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Anderson-Hotels-Lake-Hartwell-Frank-Howard-Home-Clemson.h89473761.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/107000000/106680000/106674000/106673955/aaad0f75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/107000000/106680000/106674000/106673955/92637102.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/107000000/106680000/106674000/106673955/2871771b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/107000000/106680000/106674000/106673955/0c40c2ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside & the Livin’s Easy! Fam Fun on the lake! Hartwell 10/10 Exceptional (2) "The house was very nice to stay with great deck. The amenities were not provided, not extra towels, kitchen supplies were missing like dishwashing liquid, paper towels, etc. It was a beautiful location so we enjoyed. The property manager to take care of the supplies and cleanliness of the carpets. Overall nice place would recommend to other friends with a request to for the updates for a 5 star rating." CA $156 CA $576 total includes taxes & fees Oct 8 - Oct 9 [](https://www.expedia.ca/Hartwell-Hotels-Lakeside-The-Livins-Easy-Fam-Fun-On-The-Lake.h106673955.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/90000000/89510000/89505000/89504913/0672d79e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89510000/89505000/89504913/39145565.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89510000/89505000/89504913/693c950f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/90000000/89510000/89505000/89504913/4d8dd5ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson Memorabilia House Frank Howard III’s Home Clemson 8.6/10 Excellent (16) "Great location!" CA $110 CA $356 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Clemson-Hotels-Clemson-Memorabilia-House-Frank-Howard-IIIs-Home.h89504913.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/148da8bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/1d01e9bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/bf825374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/6516543e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Apple Cottage Pickens 9.8/10 Exceptional (24) "The cottage was so cozy. So cute and well stocked with all we needed. Loved our stay. " CA $112 CA $232 total includes taxes & fees Oct 15 - Oct 16 [](https://www.expedia.ca/Pickens-Hotels-Country-Apple-Cottage.h103157886.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/115000000/114250000/114246100/114246098/a86b4cfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/115000000/114250000/114246100/114246098/359c01d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/115000000/114250000/114246100/114246098/203cf46d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/115000000/114250000/114246100/114246098/8c65cea6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 2-bedroom cottage in downtown Anderson SC. Anderson 10/10 Exceptional (7) "Very nicely kept property. Wonderful place to stay." CA $167 CA $378 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Anderson-Hotels-Charming-2-Bedroom-Cottage-In-Downtown-Anderson-SC.h114246098.Hotel-Information) ![Private kitchen](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/27d2c52a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/53a9cfc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/455a379a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/c3e07b7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Downtown Easley Home Easley 8.6/10 Excellent (4) "The house was great for our one night stay. The house was clean and stocked. We had to leave early and didn't spend the entire night. But the host was gracious and easy to communicate with. Would recommend!" CA $124 CA $325 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Easley-Hotels-Downtown-Easley-Home.h102137027.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-21&endDate=2025-10-22®ionId=6548&adults=2&lodging=VACATION_HOME&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. ](//images.trvl-media.com/lodging/34000000/33730000/33728200/33728167/be98782f_y.jpg) ### 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. 10/10 Excellent "Plenty of space for whole family ( all seniors). Beautiful view. Everything you need for your stay. Jim and Gail made check in a breeze. Rent yourself a boat and explore the lake! Or just relax on the deck. Took a trip to the lost sea in Tennessee. Perfect lake house!" [](https://expedia.ca/Anderson-Hotels-Beautiful-43.h33728167.Hotel-Information) ![Lakeside Lodge Clemson](//images.trvl-media.com/lodging/41000000/40220000/40217400/40217319/9732d3ff_y.jpg) ### Lakeside Lodge Clemson 10/10 Excellent "Perfect for what I needed!" [](https://expedia.ca/Anderson-Hotels-Lakeside-Lodge-Clemson.h40217319.Hotel-Information) ![Best Western Seneca-Clemson](//images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0_y.jpg) ### Best Western Seneca-Clemson 10/10 Excellent "We had a nice stay. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Postcard Cabins Lake Hartwell](//images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/296ab501_y.jpg) ### Postcard Cabins Lake Hartwell 10/10 Excellent "Clean. Peaceful. " [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](//images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Best way to save hundreds of dollars when Clemson Football is playing during your stay." [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Large family home with dock on Lake Keowee! ](//images.trvl-media.com/lodging/34000000/33750000/33743600/33743502/816aa8b2_y.jpg) ### Large family home with dock on Lake Keowee! 10/10 Excellent "Very good experience. Very nice property. Owner very responsive. " [](https://expedia.ca/Seneca-Hotels-Large-Family-Home-With-Dock-On-Lake-Keowee.h33743502.Hotel-Information) ![Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub](//images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/6343a107_y.jpg) ### Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub 10/10 Excellent "Beautiful home with beautiful view of the lake." [](https://expedia.ca/Seneca-Hotels-Beautiful-Waterfront-Home-On-A-Private-Cove-In-Lake-Keowee-W-Hot-Tub.h61640625.Hotel-Information) ![Tru by Hilton Seneca Clemson](//images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Very friendly and clean " [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Excellent staff, clean property and room and close to amenities." [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ## Find out more about Seneca ## Seneca Vacation Homes information | Number of reviews | | | --- | --- | | Accommodation | 563 Vacation Homes | | Lowest Price | CA $418 | | Highest Price | CA $1,023 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Central](https://www.expedia.ca/Central-Hotels-Boutique-Hotel.0-0-d10503-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Central](https://www.expedia.ca/Central-Hotels-Business-Hotel.0-0-d10503-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central](https://www.expedia.ca/Central-Hotels-Golf-Hotel.0-0-d10503-tGolfHotel.Travel-Guide-Filter-Hotels) - 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