Title: Seneca Vacation Home Rentals from CA $231: Search Top Private Vacation Homes for Rent | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates In two weeks [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-01-30&endDate=2026-02-01&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-03-13&endDate=2026-03-15&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In three months [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-04-10&endDate=2026-04-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In four months [May 8 - May 10](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2026-05-08&endDate=2026-05-10&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca vacation homes ![Private kitchen](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/40d3b059.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/45872750.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/ec808a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/97000000/96160000/96153700/96153668/89ea8ad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information) 10/10 Exceptional (12 reviews) "Adorable and clean home convenient to Clemson’s campus. We enjoyed our stay and Tyler was an exceptional host! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mandy H. CA $250 CA $550 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Seneca-Hotels-The-Clemson-Cottage-36-Mi-To-Memorial-Stadium.h96153668.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/0834ba3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/e2e2f98a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/c941d493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/121000000/120090000/120082600/120082534/ab96edf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information) 8.0/10 Very good (3 reviews) "Everything was in great condition! Items provided were good quality. You can tell a lot of time and thought has been put into this property. We would love to stay again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alisa W. CA $228 CA $403 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Seneca-Hotels-Lakefront-Tiny-Home-Retreat-On-Hartwell-Near-CU.h120082534.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/7bfcd263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/bf812e86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/1692b12e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/fa054611.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) 10/10 Exceptional (5 reviews) "Great place with a lot close by" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aldor D. CA $347 CA $507 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/c027128d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/5ddade10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/9e13146e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/120000000/119750000/119746400/119746321/84d2a4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information) 10/10 Exceptional (2 reviews) "Absolutely! Perfect space for our needs, so for accommodating for our family & pet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gennifer Q. CA $328 CA $751 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Seneca-Hotels-The-Big-Seneca-Golf-House-7-Miles-To-Death-Valley.h119746321.Hotel-Information) ![4 bedrooms, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/41018e46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/aad65738.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/50a9d9d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, printers](https://images.trvl-media.com/lodging/115000000/114850000/114843800/114843702/d0ce4a3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information) 10/10 Exceptional (1 review) "We truly enjoyed our stay at Johnson’s Cove. The property was super clean. The kitchen was one of the best stocked rentals I have stayed in. The mattress we slept on was better than our mattress at home. The communication with the owner was fast and she was quick to respond. We rented a pontoon for the day and the dock was easy to use for loading and unloading/restroom. We will surely rent there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca G. CA $458 CA $1,103 total includes taxes & fees Feb 11 - Feb 12 [](https://www.expedia.ca/Seneca-Hotels-Johnsons-Cove-Lakefront-Retreat-With-EV-Charger-Family-And-Pet-Friendly.h114843702.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/fc891652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/f0fe695d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/98c8974f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/d37b415d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) 9.6/10 Exceptional (8 reviews) "Owner was on point with contact prior to arrival and during stay. Check in was super easy and property was clean and decorated nicely. Everything that we needed was already at the house. There is a marina close by with restaurant also." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benjamin J. CA $453 CA $965 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/8cc7e5ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, stereo](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/061a9e84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, iron/ironing board, internet, bed sheets](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/9b67ec16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, stereo](https://images.trvl-media.com/lodging/107000000/106120000/106116600/106116530/c36ae870.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Seneca [](https://www.expedia.ca/Seneca-Hotels-Lake-Keowee-Retreat-4BR-With-Hot-Tub-Dock.h106116530.Hotel-Information) 6.4/10 (5 reviews) "Main floor was clean but basement and loft, cleaners missed a lot. It was very dusty with lots of cobwebs. Cleaners have missed a lot of places over and over again. The downstairs deck was full of pollen and so dirty we couldn’t sit out there. Wish there was an umbrella on top deck- no shade or cover when rains. Wish there was somewhere to put suitcases but w no closet space and no dresser tops, suitcases were all over floors. Was just hoping for a cleaner space for what we paid. Overall it was... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristen F. CA $245 CA $738 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Seneca-Hotels-Lake-Keowee-Retreat-4BR-With-Hot-Tub-Dock.h106116530.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games, stereo](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/735219a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/91ac5b27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Serenity Bay [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) 9.8/10 Exceptional (130 reviews) "A wonderful stay! The house offered many different spaces and the lake access/dock was perfect!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) stacy s. CA $416 CA $864 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/b7a1f289.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/7411cba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/830174bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/90000000/89410000/89406600/89406578/df53fc33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Pickens [](https://www.expedia.ca/Pickens-Hotels-Welcome-To-Downtown-Pickens-Close-To-Clemson-And-Lake-Keowee.h89406578.Hotel-Information) 9.8/10 Exceptional (30 reviews) "Great location, close to great restaurants and downtown. Beautiful area!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tom B. CA $150 CA $356 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Pickens-Hotels-Welcome-To-Downtown-Pickens-Close-To-Clemson-And-Lake-Keowee.h89406578.Hotel-Information) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/8dd3309b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/56576d34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/3600e2eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103160000/103157900/103157886/bf825374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Pickens [](https://www.expedia.ca/Pickens-Hotels-Country-Apple-Cottage.h103157886.Hotel-Information) 10/10 Exceptional (31 reviews) "The cottage was so cozy. So cute and well stocked with all we needed. Loved our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kat C. CA $111 CA $231 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Pickens-Hotels-Country-Apple-Cottage.h103157886.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/c3e07b7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/37659ef0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/77ff9e22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/103000000/102140000/102137100/102137027/e74d1995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Easley [](https://www.expedia.ca/Easley-Hotels-Downtown-Easley-Home.h102137027.Hotel-Information) 8.0/10 Very good (7 reviews) "The house was great for our one night stay. The house was clean and stocked. We had to leave early and didn't spend the entire night. But the host was gracious and easy to communicate with. Would recommend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) CANDY B. CA $165 CA $381 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Easley-Hotels-Downtown-Easley-Home.h102137027.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/116000000/115980000/115971000/115970996/55091aba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/116000000/115980000/115971000/115970996/362874ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/116000000/115980000/115971000/115970996/0184ebde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/116000000/115980000/115971000/115970996/948683e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Easley [](https://www.expedia.ca/Easley-Hotels-Magical-Plant-Based-Loft-Downtown-Easley-Near-Silos-And-Doodle-Trail.h115970996.Hotel-Information) 10/10 Exceptional (1 review) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) tracy CA $205 CA $434 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/Easley-Hotels-Magical-Plant-Based-Loft-Downtown-Easley-Near-Silos-And-Doodle-Trail.h115970996.Hotel-Information) ![Marina](https://images.trvl-media.com/lodging/110000000/109020000/109017200/109017166/b3b4e7a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/110000000/109020000/109017200/109017166/2f6af40b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/110000000/109020000/109017200/109017166/d9700a40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/110000000/109020000/109017200/109017166/7f158818.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Anderson [](https://www.expedia.ca/Anderson-Hotels-ClemsonMarinaParkPassPizzaOvenKayaksFirePit.h109017166.Hotel-Information) 10/10 Exceptional (8 reviews) "Nice property , very well maintained. Host was super-responsive." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Slava M. CA $192 CA $645 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Anderson-Hotels-ClemsonMarinaParkPassPizzaOvenKayaksFirePit.h109017166.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/120000000/119510000/119508600/119508523/39d00a08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/120000000/119510000/119508600/119508523/6b0c75e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/120000000/119510000/119508600/119508523/7a42280d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/120000000/119510000/119508600/119508523/2bd04317.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Easley [](https://www.expedia.ca/Easley-Hotels-2-Bed-Pink-Paradise-Near-Easley-SC-Silos.h119508523.Hotel-Information) 10/10 Exceptional (1 review) "This is a beautiful place to stay in, large rooms loved the open kitchen adjoining the living area. Me and my husband and my daughter and son in law stayed here for a weekend. We were in town for my granddaughters Volleyball games, and we were an easy 7 min drive from the event venue. We had lunch across the street from the townhouse at the Silos and later that evening went back for live music. We would stary again and Dane was a great host! Only word of advice is if you cannot do stairs this is... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda W. CA $192 CA $415 total includes taxes & fees Jan 20 - Jan 21 [](https://www.expedia.ca/Easley-Hotels-2-Bed-Pink-Paradise-Near-Easley-SC-Silos.h119508523.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113520000/113518400/113518324/611292d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/114000000/113520000/113518400/113518324/a1094559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/114000000/113520000/113518400/113518324/dfa77891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113520000/113518400/113518324/f3b8854d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Pendleton [](https://www.expedia.ca/Pendleton-Hotels-Charming-3-Bedroom-House-In-Pendleton-With-AC.h113518324.Hotel-Information) 10/10 Exceptional (4 reviews) " Property was as listed and in good condition and very convenient to Clemson. Owner very responsive and great place to rent." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $160 CA $543 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Pendleton-Hotels-Charming-3-Bedroom-House-In-Pendleton-With-AC.h113518324.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/0e18a612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/87fa1a3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/7923d847.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/121000000/120650000/120648400/120648317/b3a97246.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Pickens [](https://www.expedia.ca/Pickens-Hotels-Black-Bear-Hideaway.h120648317.Hotel-Information) 9.4/10 Exceptional (3 reviews) "Great location to hiking trails." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeromy S. CA $125 CA $330 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Pickens-Hotels-Black-Bear-Hideaway.h120648317.Hotel-Information) ![Smart TV, fireplace, books, printers](https://images.trvl-media.com/lodging/94000000/93160000/93152800/93152735/81095175.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/94000000/93160000/93152800/93152735/fc8eb4fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93160000/93152800/93152735/50362d59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/94000000/93160000/93152800/93152735/22d8032f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Toccoa [](https://www.expedia.ca/Toccoa-Hotels-The-Brick-House-At-Currahee.h93152735.Hotel-Information) 9.8/10 Exceptional (85 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim S. CA $150 CA $316 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Toccoa-Hotels-The-Brick-House-At-Currahee.h93152735.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/64000000/63370000/63362400/63362340/90e5f707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/64000000/63370000/63362400/63362340/w526h683x258y0-c92d694d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach](https://images.trvl-media.com/lodging/64000000/63370000/63362400/63362340/a391c7d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/64000000/63370000/63362400/63362340/w526h683x258y0-9354d088.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Pendleton [](https://www.expedia.ca/Pendleton-Hotels-The-Rustic-Rectangle.h63362340.Hotel-Information) 10/10 Exceptional (10 reviews) "Cozy, clean and quiet! Loved that we could have our dogs stay with us! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer T. CA $185 CA $396 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Pendleton-Hotels-The-Rustic-Rectangle.h63362340.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/114000000/113930000/113928500/113928424/a31ec2c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/114000000/113930000/113928500/113928424/3dceaffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/114000000/113930000/113928500/113928424/64f187a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113930000/113928500/113928424/8905f49d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Westminster [](https://www.expedia.ca/Westminster-Hotels-Lake-Front-With-Dock-Covered-Slip-On-Lake-Hartwell-The-Reese-Retreat.h113928424.Hotel-Information) 8.6/10 Excellent (8 reviews) "Awesome lake house. Hope to stay again in the future at some point!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) steven r. CA $175 CA $479 total includes taxes & fees Jan 15 - Jan 16 [](https://www.expedia.ca/Westminster-Hotels-Lake-Front-With-Dock-Covered-Slip-On-Lake-Hartwell-The-Reese-Retreat.h113928424.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115870000/115867600/115867530/b4ac5a43.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/116000000/115870000/115867600/115867530/e3de46f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/116000000/115870000/115867600/115867530/a291d4e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/116000000/115870000/115867600/115867530/b793e985.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Vacation Home in Easley [](https://www.expedia.ca/Easley-Hotels-Urban-Stay-W-Cozy-And-Relaxing-Spaces-2-Bed-25-Bath-Near-Downtown-Easley.h115867530.Hotel-Information) 10/10 Exceptional (1 review) "The Bonnie was very comfortable, new, very clean, modern, and we enjoyed our stay very much! Great communication with the owners, very close and convenient to shops, restaurants and entertainment in Easley . Easy driving distance to Greenville and Clemson. We will happily choose to stay here again! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy M. CA $192 CA $415 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Easley-Hotels-Urban-Stay-W-Cozy-And-Relaxing-Spaces-2-Bed-25-Bath-Near-Downtown-Easley.h115867530.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-28&endDate=2026-01-29®ionId=6548&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true) ## Find vacation rentals that suit your style Cabins [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=CABIN) Private vacation homes [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=VACATION_HOME) Cottages [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=COTTAGE) Apartments [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=APARTMENT) Condos [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=CONDO) Aparthotels [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=APART_HOTEL) Villas [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=VILLA) Chalets [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=CHALET) Houseboats [](https://www.expedia.ca/Hotel-Search?destination=Seneca%2C+South+Carolina%2C+United+States+of+America®ionId=6548&latLong=34.685654%2C-82.953201&adults=2&startDate=2026-04-14&d1=2026-04-14&endDate=2026-04-17&d2=2026-04-17&lodging=HOUSE_BOAT) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSeneca-Private-Vacation-Homes.d6548-aaPrivateVacationHomes.Travel-Guide-Accommodation) ## Top Seneca Hotel Reviews ![Days Inn by Wyndham Anderson](https://images.trvl-media.com/lodging/1000000/10000/6400/6344/ce467f24_y.jpg) ### Days Inn by Wyndham Anderson 10/10 Excellent "We stayed at this hotel over the weekend to celebrate our anniversary, and it turned into one of the best hotel experiences we’ve ever had. My fiancée and I were looking for something special, and Jennifer suggested their decorated room for occasions like this. I trusted her recommendation, and I’m so glad I did. The moment we walked into the room, we were honestly amazed. It was beautifully decorated from top to bottom. The bed setup was perfect, the details were thoughtful, and the atmosphere felt romantic and relaxing. The jacuzzi tub inside the bedroom was the highlight. It made the whole experience feel extra special. We truly enjoyed every moment of our stay and created memories we’ll always remember. I would highly recommend this hotel to anyone celebrating a special occasion." [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Anderson.h6344.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](https://images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "The staff especially stood out. The online check in and the front desk was an absolute breeze! I am pleased as all heck. The room was clean and is well laid out for me to work. I greatly appreciate it." [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Tru by Hilton Seneca Clemson](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323330/10f1fcf8_y.jpg) ### Tru by Hilton Seneca Clemson 10/10 Excellent "Perfect stay for a weekend. Lots of shopping and restaurants nearby. Clean safe area annd the staff was wonderful!" [](https://expedia.ca/Anderson-Hotels-Tru-By-Hilton-Seneca-Clemson.h34323330.Hotel-Information) ![6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.](https://images.trvl-media.com/lodging/58000000/57860000/57854500/57854431/90607bc4_y.jpg) ### 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water. 10/10 Excellent "We had an amazing weekend! The house was comfortable and relaxing. The check-in and check-out process were very easy. " [](https://expedia.ca/Anderson-Hotels-Newly-Furnished-And-Renovated-Lake-House-Directly-On-Hartwell.h57854431.Hotel-Information) ![Quality Inn Seneca Clemson Area US-123](https://images.trvl-media.com/lodging/1000000/80000/76800/76800/375f69b2_y.jpg) ### Quality Inn Seneca Clemson Area US-123 10/10 Excellent "Hotel was clean, inside and out. Front desk staff was very kind and helpful. " [](https://expedia.ca/Anderson-Hotels-Quality-Inn-Seneca-US-123.h76800.Hotel-Information) ![Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub](https://images.trvl-media.com/lodging/62000000/61650000/61640700/61640625/6343a107_y.jpg) ### Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub 10/10 Excellent "Great well stocked house, comfortable beds, had everything we needed and more." [](https://expedia.ca/Seneca-Hotels-Beautiful-Waterfront-Home-On-A-Private-Cove-In-Lake-Keowee-W-Hot-Tub.h61640625.Hotel-Information) ![Hampton Inn & Suites Seneca-Clemson Area](https://images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Check-in was fast and efficient. Our room was clean and spacious. Temperature control was great. Beds were comfy. The breakfast each morning was great, providing sources of protein and fruits as well as the typical continental selections, but they actually had a vat of grits that were just about the right thickness and consistency - just what a Southern boy needs!" [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy](https://images.trvl-media.com/lodging/111000000/110490000/110487400/110487306/8c11b789_y.jpg) ### Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy 10/10 Excellent "Excellent stay." [](https://expedia.ca/Seneca-Hotels-Postcard-Cabins-Lake-Hartwell.h110487306.Hotel-Information) ![ Enjoy one of our RV units son less of a headache for you this vacation!](https://images.trvl-media.com/lodging/118000000/117650000/117644500/117644416/c0b82041_y.jpg) ### Enjoy one of our RV units son less of a headache for you this vacation! 10/10 Excellent "My partner and I stayed 5 nights and we enjoyed it so much. It's such a convenient place to reside for a get away. If you're looking for that "outback" feeling but want to be cozy; look no further. Communication was always qick with responses and was more than willing to help with anything we needed! We would definitely stay again." [](https://expedia.ca/Seneca-Hotels-Cozy-Campground-In-Enchanting-Seneca-With-AC.h117644416.Hotel-Information) ## Find out more about Seneca ## Seneca Vacation Homes information | Number of reviews | 347 | | ----------------- | ------------------ | | Accommodation | 659 Vacation Homes | | Lowest Price | CA $231 | | Highest Price | CA $1,103 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Aparthotels in Central ](https://www.expedia.ca/Central-Apart-Hotels.d10503-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Central ](https://www.expedia.ca/Central-Bed-And-Breakfast.d10503-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Boutique Hotels in Central ](https://www.expedia.ca/Central-Hotels-Boutique-Hotel.0-0-d10503-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Central ](https://www.expedia.ca/Central-Hotels-Business-Hotel.0-0-d10503-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Golf Hotels in Central ](https://www.expedia.ca/Central-Hotels-Golf-Hotel.0-0-d10503-tGolfHotel.Travel-Guide-Filter-Hotels) - 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