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Santo Domingo Vacation Rentals

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Check prices for these dates, December 14–15, 2026

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Our top choices for Santo Domingo vacation rentals

1. La Placita - Apartamentos

A living room with two dark blue sofas, a wooden coffee table, and a ceiling fan.

Location: Las Tablas
Guest rating: 8.4/10 (Very good, 5 reviews)
Price: CA $140, CA $154 total, includes taxes & fees, Nov 17 - Nov 18, for Our top choices for Santo Domingo vacation rentals
Review: Great location since it is near the main park, restaurants. My only feedback is about communication since the phone number provided was routing my calls directly to voicemail but overall great place for small families, by Jorge

2. Chitre Villa by Otium

A swimming pool with a red and blue hammock, a stone wall, and a modern building with large windows.

Location: Monagrillo
Price: CA $188, CA $207 total, includes taxes & fees, Nov 25 - Nov 26, for Our top choices for Santo Domingo vacation rentals

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Santo Domingo Hotel Reviews

Hotel Presidente

A swimming pool with a tiled roof structure adjacent to it.

Location: Las Tablas
Review: Balcony was not worththe request. Nice horel overall good bbq pit 1/2 block away., by Gerald, March 3, 2026, rated 10/10 Excellent

Casa Magna Panama

Location: Las Tablas
Review: Very clean and welcoming, by Patricia, April 10, 2026, rated 10/10 Excellent

Alaya Panama – Private Retreat & Wellness Resort

A dome-shaped accommodation with a private hot tub and a wooden deck.

Location: Canas
Review: Our stay in Alaya was the perfect getaway from our good Canadian winters. The dome was a beautiful experience and made for a very romantic stay when relaxing under the stars on the suspended net before jumping in our private hot tub. The space was incredibly clean and the staff was always ready to help. The restaurant had a farm to table concept (they have their own permaculture farm on the land) and was beyond our expectations, not to mention the breathtaking view of the valleys and the ocean..., by Didier, March 4, 2024, rated 10/10 Excellent

Casa Lajagua

A circular pool surrounded by lounge chairs and palm trees, with a building in the background.

Location: Pedasí
Review: Casa Lajagua B&B will always be one of our most favourite and cherished accommodation destinations. I can't say enough good things about April and Craig the owners and hosts who became friends. The breakfasts were gourmet meals. April is closely involved with the community and regularly made dinner reservations for us. We would gladly recommend all the restaurants we tried. We stayed for 6 nights and were sad we had to leave. The pool and landscaped grounds gave us the impression that we..., by Jacqui_and_D, March 14, 2018, rated 10/10 Excellent

Hotel Faranda Guayacanes, a member of Radisson Individuals

A swimming pool with lounge chairs and umbrellas, a covered seating area, and a stone wall.

Location: Chitre
Review: Beautiful hotel ! Front desk staff were excellent and so friendly. They are a great representation for the hotel. We dealt with both the young guy and girl Sorry I didn't get there names. We had stayed on our way south of Panama a few days before and actually changed our plans so we could stay another night upon our return., by Ron, February 2, 2026, rated 10/10 Excellent

Pedasi Sport Club

A covered pool area with a wooden pergola, a pool, and a view of a building in the background.

Location: Pedasí
Review: Pool was clean and nice temperature. There were 2 barking dogs on the property- looked like strays. A bit annoying but the room and grounds were nice., by daniel, January 22, 2026, rated 10/10 Excellent

Casa Loma

A covered corridor with tiled flooring, wooden chairs, and a table with a newspaper.

Location: Pedasí
Review: My travels to Casa Loma was amazing. I had to travel to Pedasi due to my dog Sam a beautiful Chocolate Labrador. I had to board him when I had to fly back to the USA. He was to old to fly anymore and his health had gotten bad and the vet needed to put him down. So Sam I were able to spend a few days together at Casa Loma before the vet euthanized him. I am so grateful for my stay. The property was beautiful, clean and comfortable. The breakfast was wonderful as well as the lady that..., by Janice, June 4, 2022, rated 10/10 Excellent

Baruch Tropical Ranch

A hotel room with two beds, a desk, a chair, a TV, and a sliding glass door leading to an outdoor area.

Location: Pocrí
Review: What a wonderful hidden gem. A beautiful place with birds singing, friendly dogs and cats. The place is clean and comfortable and bonus breakfast with hot coffee delivered to your door. This truly is a gem. Totally recommend a stay here., by Brenda, July 1, 2026, rated 10/10 Excellent

Find out more about Santo Domingo

Everything you need to know about Santo Domingo vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santo Domingo vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santo Domingo vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santo Domingo vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santo Domingo. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santo Domingo vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. The selection of Santo Domingo vacation rentals we have selected for you start as low as CA $57 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Santo Domingo rentals

At Expedia, we put the best Santo Domingo vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santo Domingo rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santo Domingo vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santo Domingo. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Are there vacation rentals in Santo Domingo?

Yes, you can find vacation rentals close to top points of interest in Santo Domingo, or you can go with a more remote option if you're looking for a relaxing stay.

What's the top vacation rental that Santo Domingo has to offer?

Minimalist House In Chitre: This vacation home rental outside of Santo Domingo has air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include an oven, a microwave, and a coffee maker.

What can I see and do in Santo Domingo?

El Uverito Beach and Cerro La Teta are a couple of lovely local spots to get outside and enjoy nature. Playa Las Comadres and Iguana Island National Park are a couple of places you'll find in the larger area.

What are vacation rentals like in Santo Domingo?

Vacation rentals are privately owned accommodations you can book for a couple days or more in Santo Domingo. Vacation rentals offer extras such as laundry facilities and kitchens so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can provide a sense of security away from public hotel elevators and busy concierge desks while still allowing you the enjoyment of travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for family trips or small group gatherings.