Santo Domingo Vacation Packages

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Your Santo Domingo Vacation

Memorable adventures await when you book a Santo Domingo vacation package. Whether you're a foodie, history enthusiast or just a traveler who loves discovering new places, there's something for everyone in this interesting city. If your trip to Santo Domingo includes some sightseeing, don't miss well-known attractions like El Uverito Beach, Belisario Porras Park and Playa Las Comadres. That dream Santo Domingo vacation is just clicks away. Browse flights, hotels and more on Expedia for a getaway that's tailored to suit your travel style.

Top Santo Domingo Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B
Central Hotel Bocas del Toro
Megapolis Hotel Panamá
Central Hotel Panama Casco Viejo
Playa Caracol Residences Vacation Rental

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Santo Domingo Hotel Deals

Hotel Faranda Guayacanes, a member of Radisson Individuals

Hotel Faranda Guayacanes, a member of Radisson Individuals

3 out of 5
Via Circunvalacion S/n Chitre Herrera
Fully refundableReserve now, pay when you stay
The price is CA $100 per night from Feb 22 to Feb 23
CA $100
CA $110 total
Feb 22 - Feb 23
includes taxes & fees
7.8/10 Good! (304 reviews)
Room was spotless. It was very small but ok for an over night stay. Dinner in the restaurant was excellent. Seafood casserole was too top notch. Breakfast was good too.

Reviewed on Feb 6, 2026

Hotel Faranda Guayacanes, a member of Radisson Individuals
Casa Lajagua

Casa Lajagua

3 out of 5
Calle principal de Pedasi Pedasí Panama
The price is CA $115 per night from Feb 24 to Feb 25
CA $115
CA $127 total
Feb 24 - Feb 25
includes taxes & fees
9/10 Wonderful! (86 reviews)
April and staff have built up a wonderful rustic location with a lovely and peaceful atmosphere but close enough to town by foot. The Al Fresco breakfast was lovely especially the homemade chocolate cake! April was very attentive as i was a bit under the weather but she helped me out.

Reviewed on Jan 2, 2026

Casa Lajagua
Hotel Presidente

Hotel Presidente

3.5 out of 5
Calle Moises Espino Las Tablas
The price is CA $108 per night from Feb 20 to Feb 21
CA $108
CA $119 total
Feb 20 - Feb 21
includes taxes & fees
9/10 Wonderful! (117 reviews)
We return year after year

Reviewed on Feb 2, 2026

Hotel Presidente
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.