Title: Book the Best Picayune SPA Resorts from CA $129 - Spa Hotels in Picayune, MS | Expedia.ca [Hotels in Picayune](https://expedia.ca/Picayune-Hotels.d9372.Travel-Guide-Hotels)[Vacation Rentals in Picayune](https://expedia.ca/Picayune-Vacation-Rentals.d9372.Travel-Guide-VacationRentals)[Flights to Picayune](https://expedia.ca/Cheap-Flights-To-Picayune.d9372.Travel-Guide-Flights)[Picayune Car Rentals](https://expedia.ca/Car-Rentals-In-Picayune.d9372.Car-Rental-Guide)[Picayune Vacation Packages](https://expedia.ca/Picayune.d9372.Destination-Travel-Guides) ![A great blue heron in a swamp](https://images.trvl-media.com/place/9372/7fddd38d-614f-4323-956a-7714ea7f8ebb.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Picayune, MS from CA $129 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Picayune Spa Hotels Tonight [Nov 18 - Nov 19](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-11-18&endDate=2025-11-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 19 - Nov 20](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-11-19&endDate=2025-11-20&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-11-21&endDate=2025-11-23&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 28 - Nov 30](https://www.expedia.ca/Hotel-Search?regionId=9372&startDate=2025-11-28&endDate=2025-11-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Picayune Spa Hotels ![Couples treatment rooms, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/530000/526700/526688/bbb4c10e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 8:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/530000/526700/526688/d677d4b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Buffet](https://images.trvl-media.com/lodging/1000000/530000/526700/526688/e8266f44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/530000/526700/526688/173421d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hollywood Casino Gulf Coast Bay St Louis 8.0/10 Very good (1003) "Checkin was easy and staff were friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeff CA $102 CA $129 total includes taxes & fees Nov 20 - Nov 21 [](https://www.expedia.ca/Biloxi-Hotels-Hollywood-Casino-Gulf-Coast.h526688.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-03&endDate=2025-12-04®ionId=9372&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Top Picayune Hotel Reviews ### Country Inn & Suites by Radisson, Covington, LA 10/10 Excellent "All of the above" [](https://expedia.ca/Hammond-Hotels-Country-Inn-Suites-By-Radisson.h2804087.Hotel-Information) ### Homewood Suites Slidell 10/10 Excellent "Yes" [](https://expedia.ca/New-Orleans-Hotels-Homewood-Suites-Slidell.h3618226.Hotel-Information) ### Hollywood Casino Gulf Coast 10/10 Excellent "The room was spotless. The staff was courteous. The only problem that we had was with the TV and I told One we will watch it. It was going in and out. It happened during the day to as well." [](https://expedia.ca/Biloxi-Hotels-Hollywood-Casino-Gulf-Coast.h526688.Hotel-Information) ### Ramada by Wyndham Diamondhead I-10/Gulfport 10/10 Excellent "It was spot on !" [](https://expedia.ca/Biloxi-Hotels-Ramada-By-Wyndham-Diamondhead-I-10Gulfport.h49812.Hotel-Information) ### Courtyard by Marriott New Orleans Covington/Mandeville 10/10 Excellent "Room was amazing hot tub and pool were perfect staff was very friendly and helpful we will definitely be coming back. The wife and i really enjoyed our little get away cant wait to book our next visit " [](https://expedia.ca/Hammond-Hotels-Courtyard-By-Marriott-New-Orleans-CovingtonMandeville.h64156.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Picayune? > Book one of our wonderful spa hotels and treat yourself from the moment you arrive. Take part in recreational activities such as golfing during your vacation. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your holiday. ### What's there to see and do in Picayune? > When you're in Picayune, enjoy exploring the sights and attractions here including Crosby Arboretum, Picayune City Hall, and Millbrook Country Club. If you have extra time while you're in the area, you might want to see M. M. Roberts Stadium and Crosby Memorial Library. ### What is a Picayune spa hotel? > Spa hotels in Picayune provide lodging and have a full on-site spa which offers services like facials as well as beauty treatments. Some also offer in-room treatments. 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