A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Vacation Rentals

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Our top choices for Mytilene vacation rentals

Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very good, (86 reviews)
"Lovely mansion house and a great breakfast."
United States
Malcolm
The price is CA $189
CA $223 total
includes taxes & fees
Jul 14 - Jul 15
Loriet Hotel

Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (6 reviews)
"A HIDDEN GEM near the airport! This brand new 16 room hotel just opened two months ago. Exceptionally quiet! the breakfast buffet was outstanding, and the staff were the friendliest people we've ever encountered. Their warm hospitality made our stay truly special. HIGHLY RECOMMENDED !"
United States
Nikolaos
The price is CA $134
CA $150 total
includes taxes & fees
Jun 30 - Jul 1
Akti Vigla Premium

Villa SYKAMIA

Villa SYKAMIA
ΜΥΤΙΛΗΝΗ
Villa SYKAMIA

Villa PETRA

Villa PETRA
ΜΥΤΙΛΗΝΗ
The price is CA $388
CA $441 total
includes taxes & fees
Jul 1 - Jul 2
Villa PETRA

Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (34 reviews)
"Beautiful quiet nice little place.Very cosy !!"
Australia
Anonymous traveller
The price is CA $283
CA $314 total
includes taxes & fees
Jul 1 - Jul 2
Elies Residences

Experience Comfort in our Newly Remodeled 5A

Experience Comfort in our Newly Remodeled 5A
Mitilini
2.0 out of 10, (1 review)
The price is CA $64
CA $127 total
includes taxes & fees
Jul 14 - Jul 15
Experience Comfort in our Newly Remodeled 5A

Gianni's House

Gianni's House
Polichnitos
10.0 out of 10, Exceptional, (1 review)
"A nice, quiet, comfy and simple place. I felt welcomed. The village is the same. I really enjoyed it."
Canada
Jean-Philippe
The price is CA $97
CA $143 total
includes taxes & fees
Jun 30 - Jul 1
Gianni's House

Casa Di Nonno-jacuzzi Mountain View Stay in Lesvos

Casa Di Nonno-jacuzzi Mountain View Stay in Lesvos
Lesvos
The price is CA $196
CA $278 total
includes taxes & fees
Jul 2 - Jul 3
Casa Di Nonno-jacuzzi Mountain View Stay in Lesvos

Ouzo Stone House 1, with private pool

Ouzo Stone House 1, with private pool
Lesvos
The price is CA $553
CA $630 total
includes taxes & fees
Jun 30 - Jul 1
Ouzo Stone House 1, with private pool

The house of ilias , next to the beach

The house of ilias , next to the beach
Ευρειακη
8.0 out of 10, Very good, (1 review)
"Haus war für sechs Personen sehr gut und hatte sehr viel Platz. Gastgeber war immer nett und hat bei Fragen schnell geantwortet. Die Restaurant im Ort direkt kann ich nur empfehlen. Nur ein Fernsehen hat im Haus gefällt. "
Germany
Georgios R.
The price is CA $242
CA $275 total
includes taxes & fees
Jul 5 - Jul 6
The house of ilias , next to the beach

Ouzo Stone House 2, with private pool

Ouzo Stone House 2, with private pool
Lesvos
10.0 out of 10, Exceptional, (1 review)
The price is CA $690
CA $780 total
includes taxes & fees
Jul 19 - Jul 20
Ouzo Stone House 2, with private pool
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mytilene Hotel Reviews

Find out more about Mytilene

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Mytilene. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Frequently asked questions

Are there vacation rentals in Mytilene?

Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.

What's the top vacation rental that Mytilene has to offer?

Villa Lauriet Kratigos - Private Escape With Views: This highly rated vacation home rental in Mytilene is located on the beach and has a garden, a barbecue grill, and free WiFi to put you at ease in your new surroundings. This vacation rental also comes with free parking to give you added peace of mind. Some other homes for rent in Mytilene include Spacious , modern beachfront maisonette in a verdant suburb near the city centre and V House Cozy & Quiet Escape.

How many vacation rentals will I find in Mytilene?

Choose from 16 Expedia vacation rentals in Mytilene for a memorable vacation.

What’s there to see and do in Mytilene?

Enjoy the outdoors at Thermi Beach and Thermes Gera Hot Springs, or simply take in cultural attractions like Olive-press Museum of Archipelagos Society and Theophilos Museum. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.

What’s a vacation rental in Mytilene like?

A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.