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A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Vacation Rentals

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    • Check prices for these dates

    Check prices for these dates, December 15–16, 2026

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    Our top choices for Mytilene vacation rentals

    1. Loriet Hotel

    A large stone building with a central entrance, flanked by palm trees and a stone pathway leading to the entrance.

    2. Akti Vigla Premium

    A balcony with a view of the ocean, featuring a sofa, a table, and a railing.

    3. Elies Residences

    Two wicker chairs by a pool with a clear reflection, surrounded by trees.

    4. Your refuge overlooking port

    A hotel room with a bed, a nightstand with a lamp, a view of the city through the window, and a painting on the wall.

    5. Comfort guaranteed in our recently renovated 5A

    A kitchen with a dining area, granite countertops, and a view through the glass door.

    6. Villa ERESOS

    Two wicker chairs by a pool with a clear reflection, surrounded by trees.

    7. Villa PETRA

    An aerial view of a rectangular swimming pool surrounded by wooden deck areas with lounge chairs and umbrellas.

    8. Villa SIGRI

    An aerial view of a rectangular swimming pool surrounded by wooden deck areas with lounge chairs and umbrellas.

    9. The Heart of Mytilene

    A patio area with a glass door leading to an interior space, white outdoor furniture, and a potted tree.

    10. Villa SYKAMIA

    Two wicker chairs by a pool with a clear reflection, surrounded by trees.

    11. Casa Di Nonno-Jacuzzi Mountain View Stay in Lesvos

    A coastal area with a beach, boats, and buildings.

    12. Gianni's House

    An outdoor patio with a table and chairs, a potted plant, and a stone wall.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Aparthotels

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    Top Mytilene Hotel Reviews

    Galazio Asteri I

    A pool area with lounge chairs and umbrellas, surrounded by greenery and a clear sky.

    Olive Green Studios and Apartments

    A modern outdoor seating area with a view of the sea, featuring a sofa, a wooden table, and a potted plant.

    Theofilos Paradise Boutique Hotel

    A buffet with various food items including fruits, vegetables, and desserts.

    Hotel Lesvion

    Reception

    Mythical Coast Wellness Retreat

    A resort with a pool, outdoor seating, and a view of the sea at dusk.

    Heliotrope Hotels

    A hotel with a swimming pool, outdoor seating, and a view of the sea.

    Loriet Hotel

    A large stone building with a central entrance, flanked by palm trees and a stone pathway leading to the entrance.

    Find out more about Mytilene

    Everything you need to know about Mytilene vacation rentals

    Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mytilene vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

    There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mytilene vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

    Mytilene vacation rentals: An excellent choice for every season

    Whenever you want to travel, a warm welcome awaits you in Mytilene. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

    Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Mytilene vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. The selection of Mytilene vacation rentals we have selected for you start as low as CA $72 per night. Entering your travel dates in the search wizard you might find even better deals!

    How to find incredible deals on Mytilene rentals

    At Expedia, we put the best Mytilene vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

    To find some top Mytilene rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mytilene vacation.

    If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mytilene. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

    Frequently Asked Questions

    Are there vacation rentals in Mytilene?

    Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.

    What's the top vacation rental that Mytilene has to offer?

    Spacious , modern beachfront maisonette in a verdant suburb near the city centre: This Mytilene vacation home rental is on the beach and equipped with air-conditioning and laundry facilities to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Some other homes for rent in Mytilene include V House Cozy & Quiet Escape and Villa Laurette Kratigos, Private Escape with Views.

    How many vacation rentals will I find in Mytilene?

    Choose from 15 Expedia vacation rentals in Mytilene for a memorable vacation.

    What’s there to see and do in Mytilene?

    Enjoy the outdoors at Thermes Gera Hot Springs and Thermi Beach, or simply take in cultural attractions like Ecclesiastical Byzantine Museum and Theriade Library and Museum of Modern Art. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.

    What’s a vacation rental in Mytilene like?

    A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.