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Mecenate Palace

Mecenate Palace

Via Carlo Alberto 3, Rome 00185

4.0 out of 5.0
4.3 out of 5 (2,789 reviews)

This 2-building Rome hotel lies steps from Piazza Santa Maria Maggiore, 500 meters south of the Termini rail station, and nea …

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Hotel Portamaggiore

Hotel Portamaggiore

Piazza di Porta Maggiore 25, Rome 00185

3.0 out of 5.0
3.4 out of 5 (967 reviews)

Located in Esquilino, this hotel is within 1 mi (2 km) of Porta Maggiore, Basilica di Santa Maria Maggiore, and Teatro …

C$76
Napoleon Hotel

Napoleon Hotel

Piazza Vittorio Emanuele II 105, Rome 00185

4.0 out of 5.0
4.3 out of 5 (1,968 reviews)

Set in a quiet 19th-century building, this family-run hotel is 500 meters from Rome's St Maria Maggiore cathedral, 1 kilomete …

C$259
Best Western Hotel President

Best Western Hotel President

Via Emanuele Filiberto 173, Rome 00185

4.0 out of 5.0
4.1 out of 5 (349 reviews)

Located in Esquilino, this hotel is within 1 mi (2 km) of Porta Maggiore, Basilica di Santa Maria Maggiore, and Colosseum. …

C$144
Ariston

Ariston

Via Turati Filippo 16, Rome 00185

4.0 out of 5.0
4 out of 5 (374 reviews)

Centrally located in Rome, this hotel is near Santa Prassede, Basilica di Santa Maria Maggiore, and Teatro dell'Opera di Roma …

C$161
B&B In the Center You Too

B&B In the Center You Too

Via Emanuele Filiberto 50, Rome 00185

4 out of 5 (141 reviews)

Located in Esquilino, this bed & breakfast is within a 15-minute walk of Basilica di San Giovanni in Laterano and Basilica di …

C$73
Champagne Palace Hotel

Champagne Palace Hotel

Via Principe Amedeo 82, Rome 00185

4.0 out of 5.0
3.2 out of 5 (974 reviews)

Located in Esquilino, this hotel is within a 10-minute walk of Basilica di Santa Maria Maggiore and Teatro dell'Opera di Roma …

C$100
Radisson Blu es. Hotel, Roma

Radisson Blu es. Hotel, Roma

Via Filippo Turati 171, Rome 00185

5.0 out of 5.0
3.6 out of 5 (668 reviews)

Located in the heart of Rome near the Termini railway Station, this hotel is 30 minutes by express train to Fiumicino Airport …

C$181
NH Collection Roma Palazzo Cinquecento

NH Collection Roma Palazzo Cinquecento

Piazza Dei Cinquecento, 90, Rome 00185

5.0 out of 5.0
4.6 out of 5 (193 reviews)

Located in Esquilino, this luxury hotel is within 1 mi (2 km) of Trevi Fountain and Colosseum. Circus Maximus is 1.9 mi (3. …

C$344
Hotel Romantica

Hotel Romantica

Via Principe Amedeo 77/c, Rome 00185

2.0 out of 5.0
3.8 out of 5 (110 reviews)

Located in Esquilino, this hotel is within a 10-minute walk of Basilica di Santa Maria Maggiore and Teatro dell'Opera di Roma …

C$59

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Esquilino Hotel Guide

If you’re searching for the perfect little spot to base your next Roman holiday, take a look at the hotels in Esquilino, Rome. Perched on a hillside on the edge of San Giovanni, this unassuming neighborhood is home to sights, sounds and local treasures galore. Explore the Piazza Vittorio. Try some regional specialties at the markets. Discover the city’s multicultural vibe. When you stay at an Esquilino hotel, Rome becomes your personal playground.

Esquilino hotels are also among the best spots to experience an alternative view of Roman life: a contemporary personality that extends well beyond the most heavily traveled tourist attractions. A large portion of the action happens near the Via Cavour and Termini rail station, but venture beyond these bustling central spaces for a peek at the everyday atmosphere. African eateries dot the landscape just north of Termini, and the Via Merulana is a great place for an evening stroll. For the most unforgettable experience, however, search for Esquilino hotel deals near the Piazza Vittorio. This charming space is anchored by the locally loved Mercato Esquilino, and this sprawling market is among the most amazing places in the city to shop for Middle Eastern, Asian and traditionally Italian treats.

Of course, the culinary treasures don’t stop there. The best Esquilino hotels are situated in the middle of a foodie paradise, and you could easily spend an entire week sampling specialties at the bakeries, cafes, and tucked-away eateries. Stop for an espresso on a relaxed patio, and settle in for a people-watching session. It’s a fantastic way to pass the time in true Roman style.

Can’t wait to book your Esquilino vacations? Browse the trip-planning tools at Expedia to find airfare and hotel deals, compare prices, and make your reservation. When you travel with us, Rome is in the palm of your hands.