Title: Hotels by Best Western in Dona Ana from CA $125 | Expedia.ca [Dona Ana Travel Guide](https://expedia.ca/Dona-Ana.dx3000350236)[Hotels in Dona Ana](https://expedia.ca/Dona-Ana-Hotels.d3000350236.Travel-Guide-Hotels)[Vacation Rentals in Dona Ana](https://expedia.ca/Dona-Ana-Vacation-Rentals.d3000350236.Travel-Guide-VacationRentals)[Flights to Dona Ana](https://expedia.ca/Cheap-Flights-To-Dona-Ana.d3000350236.Travel-Guide-Flights)[Dona Ana Car Rentals](https://expedia.ca/Car-Rentals-In-Dona-Ana.d3000350236.Car-Rental-Guide)[Dona Ana Vacation Packages](https://expedia.ca/Dona-Ana.d3000350236.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Dona Ana from CA $125 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 22 - Oct 23](https://www.expedia.ca/Hotel-Search?regionId=3000350236&startDate=2025-10-22&endDate=2025-10-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=3000350236&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=3000350236&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=3000350236&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Dona Ana Best Western Hotels ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/269dd61d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/c6ba58b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20506/89e377bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Mission Inn Las Cruces 8.8/10 Excellent (1212) "I've stayed in this location before and enjoyed the quiet environment" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jill CA $107 CA $125 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=3000350236&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDona-Ana-Hotels-Best-Western.0-0-d3000350236--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDona-Ana-Hotels-Best-Western.0-0-d3000350236--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Dona Ana Hotel Reviews ![Comfort Suites Las Cruces I-25 North](//images.trvl-media.com/lodging/11000000/10330000/10320300/10320201/c5bb6ea5_y.jpg) ### Comfort Suites Las Cruces I-25 North 10/10 Excellent "Thumbs up" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Suites-Las-Cruces-I-25-North.h10320201.Hotel-Information) ![Springhill Suites By Marriott Las Cruces](//images.trvl-media.com/lodging/1000000/210000/203700/203622/ee15ba4f_y.jpg) ### Springhill Suites By Marriott Las Cruces 10/10 Excellent "Love the setup of the room. The bathroom was very spacious, cleaned, and comfortable. " [](https://expedia.ca/Las-Cruces-Hotels-Springhill-Suites-By-Marriott-Las-Cruces.h203622.Hotel-Information) ![Best Western Mission Inn](//images.trvl-media.com/lodging/1000000/30000/20600/20506/90d9a325_y.jpg) ### Best Western Mission Inn 10/10 Excellent "I've stayed in this location before and enjoyed the quiet environment" [](https://expedia.ca/Las-Cruces-Hotels-Best-Western-Mission-Inn.h20506.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain](//images.trvl-media.com/lodging/1000000/80000/75400/75365/62ae9c45_y.jpg) ### La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain 10/10 Excellent "Family and I only stopped to get some sleep. Hotel was very clean and quiet, just what we needed. " [](https://expedia.ca/Las-Cruces-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Las-Cruces-Organ-Mountain.h75365.Hotel-Information) ![Drury Inn & Suites Las Cruces](//images.trvl-media.com/lodging/2000000/1730000/1723300/1723204/0bffe062_y.jpg) ### Drury Inn & Suites Las Cruces 10/10 Excellent "Everything exceeded expectations. 50/50 chance, we were on the freeway side which was noticeable." [](https://expedia.ca/Las-Cruces-Hotels-Drury-Inn-Suites-Las-Cruces.h1723204.Hotel-Information) ![Comfort Inn & Suites Las Cruces Mesilla](//images.trvl-media.com/lodging/2000000/1360000/1353900/1353805/518ac77c_y.jpg) ### Comfort Inn & Suites Las Cruces Mesilla 10/10 Excellent "The hotel in general seemed well run, and there was an attitude of excellence demonstrated by the staff in the attention given to cleanliness, detail, and friendliness. They must like their work!" [](https://expedia.ca/Las-Cruces-Hotels-Comfort-Inn-Suites-Las-Cruces-Mesilla.h1353805.Hotel-Information) ![Hampton Inn & Suites Las Cruces I-10](//images.trvl-media.com/lodging/13000000/12820000/12817800/12817768/a6b6426a_y.jpg) ### Hampton Inn & Suites Las Cruces I-10 10/10 Excellent "excellent hotel" [](https://expedia.ca/Las-Cruces-Hotels-Hampton-Inn-Suites-Las-Cruces-I-10.h12817768.Hotel-Information) ![Days Inn by Wyndham Las Cruces](//images.trvl-media.com/lodging/1000000/20000/15100/15035/4e26c2df_y.jpg) ### Days Inn by Wyndham Las Cruces 10/10 Excellent ". " [](https://expedia.ca/Las-Cruces-Hotels-Days-Inn-By-Wyndham-Las-Cruces.h15035.Hotel-Information) ![Hotel Encanto de Las Cruces](//images.trvl-media.com/lodging/1000000/30000/21300/21267/5b5c1a96_y.jpg) ### Hotel Encanto de Las Cruces 10/10 Excellent " A fantastic hotel! We were just traveling through and stayed one night. Everything about this hotel was wonderful. 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