Distrito Santa Isabel Vacation Rentals from CA $114: Short-Term Rentals for 2026

Our top choices for Distrito Santa Isabel vacation rentals

1. san blas luxury tour

Nusatupo

CA $211 total

includes taxes & fees

Aug 14 - Aug 15

Basic Cabin, Multiple Beds, Balcony, Sea View | Beach/ocean view

2. San Blas Tour Aridub

Narganá

CA $201 total

includes taxes & fees

Aug 14 - Aug 15

On the beach, sun loungers, beach towels

3. BEAUTIFUL APARTMENT IN FRONT OF THE SEA

Portobelo

Rosa M.

CA $247 total

includes taxes & fees

Aug 15 - Aug 16

4. San Blas Private Oceanfront Cabin

Narganá

CA $536 total

includes taxes & fees

Aug 15 - Aug 16

5. Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

Panamá

CA $195 total

includes taxes & fees

Aug 16 - Aug 17

6. Private Over-Water Cabins on San Blas Island

Narganá

CA $459 total

includes taxes & fees

Aug 15 - Aug 16

7. Cozy and Safe Environment Close to the Airport.

Panamá

CA $114 total

includes taxes & fees

Sep 1 - Sep 2

8. La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

Panamá

CA $397 total

includes taxes & fees

Aug 16 - Aug 17

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Top Distrito Santa Isabel Hotel Reviews

Casa Congo - Rayo Verde - Restaurante

10/10 Excellent

"Beautiful views, amazing food at the restaurant, loved the art and vibes. Very authentic Carribean experience."

Ciel y Miel

10/10 Excellent

"Ciel y Miel is a beautiful boutique eco-lodge, but it’s important to know what to expect. It’s located inside a national park, so the final road is dirt and very remote. You park at the lower entrance and the staff drives you to the rooms. Our first night was an adjustment after a long drive. The property was very quiet (we visited during the low season), and the jungle sounds took some getting used to. By morning, we realized how peaceful and beautiful it really was. The rooms are spacious and clean with incredible views. The furniture is a little dated, and the room had a musty smell at first, which is common in the humid climate when A/C isn’t running. The infinity pool, beach club, and beach are stunning. The staff will drive you to the beach anytime, and they can arrange a boat trip to an even more secluded beach. I didn’t see 4 pools like advertised but it could be a seasonal thing. The highlight was the staff, especially José Enrique, who went above and beyond to make our stay special. The chef was outstanding—every meal was delicious and worth the price which was a bit high. (Skip the Aperol Spritz.) One suggestion: the listing advertises 4 pools, 3 restaurants, and a spa, but during our stay only 2 pools and 1 restaurant were available. It would be helpful if seasonal amenities were noted. My advice: arrive before sunset, stay at least 2 nights, and embrace the quiet. We left with wonderful memories and would happily return."

Ranchos de Chalia

10/10 Excellent

"Here's a natural, conversational review in English: We had a wonderful stay here. The hotel is beautiful, with an amazing pool overlooking both the ocean and the rainforest. Everything was very clean, and the beds were extremely comfortable. The staff were incredibly friendly and welcoming. The owner even helped arrange transportation for us to a nearby island beach, which we really appreciated. The water was crystal clear and perfect for swimming. The food was also excellent. We have some dietary restrictions, but there were still plenty of delicious options for us. The fried fish was outstanding, the chicken was delicious, and the breakfast was one of the highlights of our stay. We stayed in a smaller room, but it was very comfortable. There was a king-size bed for us, and our adult children each had their own separate bed. I highly recommend this place. Honestly, it’s the kind of destination where you can completely relax and never feel the need to leave the property. It was a true 100% vacation experience."

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

10/10 Excellent

"This was an incredible stay with so many lovely preparation of meals from Lucy and Jose. They were helpful and so thoughtful. We rested, relaxed, and spent leisurely days being together as a family. If only this happened more often! What a great trip. I am sad it ended so soon. Thank you to a wonderful host, Leticia, who went above and beyond helpful. "

Find out more about Distrito Santa Isabel

Everything you need to know about Distrito Santa Isabel vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Distrito Santa Isabel vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Distrito Santa Isabel vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Distrito Santa Isabel vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Distrito Santa Isabel. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Distrito Santa Isabel vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Distrito Santa Isabel vacation rentals we have selected for you start as low as CA $114 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Distrito Santa Isabel rentals

At Expedia, we put the best Distrito Santa Isabel vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Distrito Santa Isabel rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Distrito Santa Isabel vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Distrito Santa Isabel. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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Our top choices for Distrito Santa Isabel vacation rentals

1. san blas luxury tour

2. San Blas Tour Aridub

3. BEAUTIFUL APARTMENT IN FRONT OF THE SEA

4. San Blas Private Oceanfront Cabin

5. Beautiful 2-bedroom apartment in Cerro Azul for your jungle getaway

6. Private Over-Water Cabins on San Blas Island

7. Cozy and Safe Environment Close to the Airport.

8. La Husseyenda. Private Birdwatching Retreat in Cerro Azul’s Mountains in Panama

9. Your Menus de la Montaña country house awaits you

10. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

11. Hummingbird House/Casa de Colibri

12. Deluxe Beachfront 4-bedroom house in Colón Province

13. Hacienda La Perezosa in Cerro Azul

14. Tiny Cabin

Find vacation rentals that suit your style

Top Distrito Santa Isabel Hotel Reviews

Casa Congo - Rayo Verde - Restaurante

Ordovician Beach Resort

Ciel y Miel

Ranchos de Chalia

Private Ocean-Front Cabin with private bathroom on San Blas Island

Konsenda San Blas

BEACH FRONT HOUSE SURROUNDeD BY 2 PRIVATE BEACHES

Find out more about Distrito Santa Isabel