Title: 4 Stars Hotels in Seneca, South Carolina from CA $215 - Find Cheap Seneca Hotels With 4 Stars | Expedia.ca [Seneca Travel Guide](https://expedia.ca/Seneca.dx6548)[Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Cindy Keese # 4 Stars Hotels in Seneca, South Carolina from CA $215 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca 4 Star Hotels Tonight [Oct 16 - Oct 17](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-16&endDate=2025-10-17&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-17&endDate=2025-10-18&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca 4 Star Hotels ![Superior Room, 2 Queen Beds](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0de8634b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/db1c155b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0a5500d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Shepherd Hotel Downtown Clemson Clemson 9.8/10 Exceptional (704) "Very nice hotel, great staff" CA $265 CA $295 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/56d69457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/cbe6a617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson Clemson 9.6/10 Exceptional (547) "Great place for visiting the university " CA $193 CA $215 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/286fc023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7b9d65c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Single Room](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/8c83b96e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/a42189bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Liberty Hall Bed and Breakfast Pendleton 10/10 Exceptional (74) "Beautiful home, very clean, easy self check in. I unfortunately was not able to join breakfast during my stay, but the host gave me a goodie bag to go, which was much appreciated! " CA $163 CA $252 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) ![42-inch flat-screen TV with digital channels](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/482c64a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat) | Private kitchen](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/b137546b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat) | Dining](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/d130503a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat)](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/9b0f1ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Southern Sunshine Retreat Easley [](https://www.expedia.ca/Easley-Hotels-Southern-Sunshine-Retreat.h111648957.Hotel-Information) ![Signature House, 4 Bedrooms, Patio | Living room](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/877220d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | Private kitchen](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/f8ba8fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/63caaad7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | In-room dining](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/84421426.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Hartwell Frank Howard Home Clemson Anderson [](https://www.expedia.ca/Anderson-Hotels-Lake-Hartwell-Frank-Howard-Home-Clemson.h89473761.Hotel-Information) ![Family House, 4 Bedrooms, Patio, Courtyard View | Terrace/patio](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/d35914d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Patio, Courtyard View | Private kitchen](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/f91516fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Patio, Courtyard View](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/1bcec3cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Patio, Courtyard View | Living room](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/3a71303d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Belvedere Anderson 8.0/10 Very good (1) "Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? " [](https://www.expedia.ca/Anderson-Hotels-Belvedere.h105550047.Hotel-Information) ![Dock](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/ed9aaf39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 3 Bedrooms, Kitchen, Lake View | Living room](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/9fa04f2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 3 Bedrooms, Kitchen, Lake View | Private kitchen](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/1d672e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/5d51f2ba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 228 Lakeland Anderson [](https://www.expedia.ca/Anderson-Hotels-228-Lakeland.h111438806.Hotel-Information) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Living room](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/16c3a46b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Living room](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/6fe9e4ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Private kitchen](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/e2eac5f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/13d7b1e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendleton Pendleton [](https://www.expedia.ca/Pendleton-Hotels-Pendleton.h105574095.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Seneca-Hotels.s40-0-d6548.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Seneca-Hotels.s40-0-d6548.Travel-Guide-Filter-Hotels) ## Learn more about Seneca Escape to Seneca! Enjoy its sports, lake views, and coffee. [See all hotels in Seneca](https://www.expedia.ca/Hotel-Search?startDate=2025-10-30&endDate=2025-10-31&adults=2®ionId=6548) ![](https://mediaim.expedia.com/destination/2/29e46f4f8050a1df2512f3a6a1598c99.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high) Photo by Cindy Keese ## Top Seneca Hotel Reviews ## Find out more about Seneca If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Seneca are calling your name. Known for providing first-rate service in amazing locations, each of the Seneca 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Seneca. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Seneca, South Carolina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Seneca hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### What are the best 4-star hotels in Seneca? > If you're looking for upscale comfort and loads of amenities during your Seneca retreat, consider [The Abernathy of Clemson](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information). This sought-after 4-star hotel offers concierge services and a rainfall shower-head. [The Shepherd Hotel Downtown Clemson](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) also gets top reviews from Expedia guests. Concierge services and free WiFi are among its conveniences. ### How much does it cost to stay in a 4-star hotel in Seneca? > We can help you quickly find the perfect 4-star hotel for your stay in Seneca. Use our handy filter tool to tailor your search by things like price, amenities and property star rating and get access to terrific deals in a few clicks. > > > > - Search for the lowest price from CA $215 ### What's the difference between 5-star and 4-star hotels in Seneca? > If you choose to vacation at a 4-star hotel in Seneca, you'll typically find plenty of conveniences to make sure you're relaxed, such as a gym, pool and restaurant. You can look forward to high-quality service and deluxe accommodations. Go for a 5-star hotel and you'll get a few more perks — think on-site spas, around-the-clock concierge and indulgent turndown services. 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