Title: 4 Stars Hotels in Seneca, South Carolina from CA $254 - Find Cheap Seneca Hotels With 4 Stars | Expedia.ca [Seneca Travel Guide](https://expedia.ca/Seneca.dx6548)[Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Seneca, South Carolina from CA $254 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca 4 Star Hotels Tonight [Dec 12 - Dec 13](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Seneca 4-star hotels ![Lobby](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/db1c155b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0de8634b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0a5500d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Shepherd Hotel Downtown Clemson [](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) Clemson 9.8/10 Exceptional (742) "Staff was amazing and our room was clean and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda R CA $228 CA $254 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/a5d6b89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/8963c3c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) Clemson 9.6/10 Exceptional (557) "location is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) colleen [](https://www.expedia.ca/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7ccc39b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Double Room](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/bd9ed0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7b9d65c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/679dc208.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Liberty Hall Bed and Breakfast [](https://www.expedia.ca/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) Pendleton 10/10 Exceptional (78) "The owners are amazing. Comfy rooms, stellar breakfast and good people. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee CA $172 CA $260 total includes taxes & fees Dec 20 - Dec 21 [](https://www.expedia.ca/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat) | Interior](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/0dab2c45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat) | Living area](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/dd7667b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/a2d472c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House, Multiple Beds, Patio, Garden View (Southern Sunshine Retreat) | Private kitchen](https://images.trvl-media.com/lodging/112000000/111650000/111649000/111648957/cd2b74b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Southern Sunshine Retreat [](https://www.expedia.ca/Easley-Hotels-Southern-Sunshine-Retreat.h111648957.Hotel-Information) Easley [](https://www.expedia.ca/Easley-Hotels-Southern-Sunshine-Retreat.h111648957.Hotel-Information) ![Signature House, 4 Bedrooms, Patio | In-room dining](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/157c00b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | Private kitchen](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/f8ba8fcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 4 Bedrooms, Patio | Living room](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/877220d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/90000000/89480000/89473800/89473761/9a24528f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Hartwell Frank Howard Home Clemson [](https://www.expedia.ca/Anderson-Hotels-Lake-Hartwell-Frank-Howard-Home-Clemson.h89473761.Hotel-Information) Anderson CA $160 CA $407 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Anderson-Hotels-Lake-Hartwell-Frank-Howard-Home-Clemson.h89473761.Hotel-Information) ![Family House, 4 Bedrooms, Patio, Courtyard View | Private kitchen](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/f91516fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Patio, Courtyard View](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/1bcec3cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family House, 4 Bedrooms, Patio, Courtyard View | View from room](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/769a03d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/106000000/105560000/105550100/105550047/c252d911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Belvedere [](https://www.expedia.ca/Anderson-Hotels-Belvedere.h105550047.Hotel-Information) Anderson 8.0/10 Very good (1) "Bring everything. Including hangers for your clothes, salt and pepper, etc. it is like staying at a place that has one purpose, to rent out. Beds are uncomfortable. Nice big closets with one wire hanger. Why??? " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) CANDACE [](https://www.expedia.ca/Anderson-Hotels-Belvedere.h105550047.Hotel-Information) ![Dock](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/ed9aaf39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 3 Bedrooms, Kitchen, Lake View | In-room dining](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/895db893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 3 Bedrooms, Kitchen, Lake View | Private kitchen](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/e9f9aeba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Signature House, 3 Bedrooms, Kitchen, Lake View | Living room](https://images.trvl-media.com/lodging/112000000/111440000/111438900/111438806/454aaffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 228 Lakeland [](https://www.expedia.ca/Anderson-Hotels-228-Lakeland.h111438806.Hotel-Information) Anderson [](https://www.expedia.ca/Anderson-Hotels-228-Lakeland.h111438806.Hotel-Information) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Living room](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/16c3a46b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/94645e85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/d0882306.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort House, 3 Bedrooms, Non Smoking, Fireplace | Private kitchen](https://images.trvl-media.com/lodging/106000000/105580000/105574100/105574095/e2eac5f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pendleton [](https://www.expedia.ca/Pendleton-Hotels-Pendleton.h105574095.Hotel-Information) Pendleton [](https://www.expedia.ca/Pendleton-Hotels-Pendleton.h105574095.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/52000000/51670000/51663200/51663188/b97e0a63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/52000000/51670000/51663200/51663188/9b426252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/52000000/51670000/51663200/51663188/827a2ca9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/52000000/51670000/51663200/51663188/e9df570e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Historic Miller's Bungalow [](https://www.expedia.ca/Central-Hotels-Historic-Millers-Bungalow.h51663188.Hotel-Information) Central [](https://www.expedia.ca/Central-Hotels-Historic-Millers-Bungalow.h51663188.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Seneca-Hotels.s40-0-d6548.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Seneca-Hotels.s40-0-d6548.Travel-Guide-Filter-Hotels) ## Learn more about Seneca Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons. [See all hotels in Seneca](https://www.expedia.ca/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27&adults=2®ionId=6548) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=899&h=314&p=1&q=high) ## Top Seneca Hotel Reviews ## Find out more about Seneca If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Seneca are calling your name. Known for providing first-rate service in amazing locations, each of the Seneca 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Seneca. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Seneca, South Carolina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Seneca hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### What are the best 4-star hotels in Seneca? ### How much does it cost to stay in a 4-star hotel in Seneca? > - Search for the lowest price from CA $254 ### What's the difference between 5-star and 4-star hotels in Seneca? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [3 Star Hotels in Belvedere ](https://www.expedia.ca/3Star-Belvedere-Hotels.s30-0-d553248634999443381.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Blacksburg ](https://www.expedia.ca/3Star-Blacksburg-Hotels.s30-0-d183936.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Greenville ](https://www.expedia.ca/3Star-Greenville-Hotels.s30-0-d1388.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Highland ](https://www.expedia.ca/3Star-Highland-Hotels.s30-0-d553248635975852355.Travel-Guide-Filter-Hotels) - 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