CA $257 Cheap Flights from Medellín (MDE) to Cusco (CUZ)

View CA $257 flight on Thu, May 28, 2026Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Alejandro Velasco Astete Intl. Airport (CUZ)

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Cheap flights from Medellín (MDE) to Cusco (CUZ)

Prices were available within the past 7 days and start at CA $257 for one-way flights and CA $402 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $402 Roundtrip, found 6 days ago
CA $402
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $402 found 6 days ago
Jetsmart SPA
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $407 Roundtrip, found 6 days ago
CA $407
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $407 found 6 days ago
Jetsmart SPA
Mon, Jun 8 - Wed, Jun 17
MDE
Medellín
CUZ
Cusco
CA $432 Roundtrip, found 6 days ago
CA $432
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Mon, Jun 8 from Medellín to Cusco, returning Wed, Jun 17, priced at CA $432 found 6 days ago
Jetsmart SPA
Mon, Jun 8 - Wed, Jun 17
MDE
Medellín
CUZ
Cusco
CA $440 Roundtrip, found 6 days ago
CA $440
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Mon, Jun 8 from Medellín to Cusco, returning Wed, Jun 17, priced at CA $440 found 6 days ago
Jetsmart SPA
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $455 Roundtrip, found 6 days ago
CA $455
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $455 found 6 days ago
Jetsmart SPA
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $460 Roundtrip, found 6 days ago
CA $460
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $460 found 6 days ago
Jetsmart SPA
Mon, Jun 8 - Wed, Jun 17
MDE
Medellín
CUZ
Cusco
CA $460 Roundtrip, found 6 days ago
CA $460
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Mon, Jun 8 from Medellín to Cusco, returning Wed, Jun 17, priced at CA $460 found 6 days ago
Jetsmart SPA
Mon, Jun 8 - Wed, Jun 17
MDE
Medellín
CUZ
Cusco
CA $468 Roundtrip, found 6 days ago
CA $468
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Mon, Jun 8 from Medellín to Cusco, returning Wed, Jun 17, priced at CA $468 found 6 days ago
LATAM Airlines Group
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $637 Roundtrip, found 6 days ago
CA $637
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $637 found 6 days ago
avianca
Thu, May 28 - Thu, Jun 4
MDE
Medellín
CUZ
Cusco
CA $649 Roundtrip, found 6 days ago
CA $649
Roundtrip
found 6 days ago
Select avianca flight, departing Thu, May 28 from Medellín to Cusco, returning Thu, Jun 4, priced at CA $649 found 6 days ago

Frequently asked questions

How much does a flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) cost?
One-way flights typically cost between $436 and $1,034 and return flights often range between $436 and $1,034. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.
How do I find cheap flights from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
To find a cheap flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
There are approximately 38 connecting flights per day from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.). Some common connection points include El Dorado Intl. (BOG), Jorge Chavez Intl. (LIM), and Rafael Nunez Intl. (CTG).
What is the earliest flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The earliest flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) typically departs at approximately 12:10 AM local time. This is a seasonal service active in May, operated by AV. An early departure like this can help you maximize your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
You'll typically find the most flights from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) on a Wednesday, with around 30 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include Avianca, LATAM Airlines, and Viva Air Colombia.
What are the most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
The most popular departure times for flights from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) are in the early morning, from 3am to 6am. About 28% of passengers prefer this time. LATAM Airlines and Avianca offer flights during this window. Many travelers prefer these early flights as they allow for an early arrival at your destination, giving you more time to explore Cusco.
How long does it take to fly from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
Flying from MDE to CUZ with a connection usually takes about 14 hours 20 minutes, traveling roughly 1,383 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
Select the "Business class" and "First class" filters when looking for MDE to CUZ flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight with Expedia?
It's easy to earn miles on a Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Cusco from Jose Maria Cordova Intl. (MDE)?
From Jose Maria Cordova Intl. (MDE), you can fly directly into Alejandro Velasco Astete Intl. (CUZ) to reach Cusco. Some flights may connect through major hubs like El Dorado Intl. (BOG), Jorge Chavez Intl. (LIM), Rafael Nunez Intl. (CTG) before reaching Cusco. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) at the last minute?
Typically, booking a last minute flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight and hotel package?
Securing a Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.)?
If you booked your Medellín (MDE-José María Córdova Intl.) to Cusco (CUZ-Alejandro Velasco Astete Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
José María Córdova Intl.
Destination airport
Alejandro Velasco Astete Intl.
Roundtrip price
CA $401
Distance
2212 km

Book with confidence

Rionegro to Cusco Flights

The easy way to book your flights from Medellín to Cusco 

With Expedia, it’s simple to find and book flights to Cusco from Medellín whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Alejandro Velasco Astete Intl., too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Medellín to Cusco today, tomorrow, or this week.  

 

Save dollars with cheap flights from José María Córdova Intl., MDE to Alejandro Velasco Astete Intl., CUZ 

Sort your search results by price to find great deals on your flight from Medellín to Cusco—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Cusco from Medellín currently is just CA $402 rising to CA $649.  

Here are more money-saving tips: 

  • Fly in May when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Cusco  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Cusco from Medellín 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Cusco with Expedia today.

Rionegro to Cusco Flights

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*Available to Expedia members.