CA $355 Cheap Flights from Buffalo (BUF) to Panama City (PTY)

View CA $355 flight on Fri, Aug 21, 2026Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Tocumen Intl. Airport (PTY)

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Cheap flights from Buffalo (BUF) to Panama City (PTY)

Prices were available within the past 7 days and start at CA $355 for one-way flights and CA $775 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Sat, Sep 19 - Sun, Sep 27
BUF
Buffalo
PTY
Panama City
CA $775 Roundtrip, found 8 hours ago
CA $775
Roundtrip
found 8 hours ago
Select JetBlue Airways flight, departing Sat, Sep 19 from Buffalo to Panama City, returning Sun, Sep 27, priced at CA $775 found 8 hours ago
JetBlue Airways
Wed, May 20 - Fri, May 29
BUF
Buffalo
PTY
Panama City
CA $830 Roundtrip, found 2 days ago
CA $830
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 20 from Buffalo to Panama City, returning Fri, May 29, priced at CA $830 found 2 days ago
Delta
Tue, Aug 18 - Wed, Aug 26
BUF
Buffalo
PTY
Panama City
CA $834 Roundtrip, found 2 days ago
CA $834
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, Aug 18 from Buffalo to Panama City, returning Wed, Aug 26, priced at CA $834 found 2 days ago
JetBlue Airways
Fri, Aug 21 - Wed, Aug 26
BUF
Buffalo
PTY
Panama City
CA $868 Roundtrip, found 2 days ago
CA $868
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Fri, Aug 21 from Buffalo to Panama City, returning Wed, Aug 26, priced at CA $868 found 2 days ago
Delta
Fri, Aug 21 - Wed, Aug 26
BUF
Buffalo
PTY
Panama City
CA $875 Roundtrip, found 2 days ago
CA $875
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Aug 21 from Buffalo to Panama City, returning Wed, Aug 26, priced at CA $875 found 2 days ago
American Airlines
Fri, Aug 21 - Wed, Aug 26
BUF
Buffalo
PTY
Panama City
CA $875 Roundtrip, found 2 days ago
CA $875
Roundtrip
found 2 days ago
Select American Airlines flight, departing Fri, Aug 21 from Buffalo to Panama City, returning Wed, Aug 26, priced at CA $875 found 2 days ago
American Airlines
Wed, Dec 2 - Sun, Dec 6
BUF
Buffalo
PTY
Panama City
CA $883 Roundtrip, found 23 hours ago
CA $883
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Dec 2 from Buffalo to Panama City, returning Sun, Dec 6, priced at CA $883 found 23 hours ago
JetBlue Airways
Sun, Jun 7 - Thu, Jun 11
BUF
Buffalo
PTY
Panama City
CA $885 Roundtrip, found 2 days ago
CA $885
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Sun, Jun 7 from Buffalo to Panama City, returning Thu, Jun 11, priced at CA $885 found 2 days ago
United
Wed, Dec 2 - Sun, Dec 6
BUF
Buffalo
PTY
Panama City
CA $950 Roundtrip, found 23 hours ago
CA $950
Roundtrip
found 23 hours ago
Select United flight, departing Wed, Dec 2 from Buffalo to Panama City, returning Sun, Dec 6, priced at CA $950 found 23 hours ago
avianca
Tue, Jun 23 - Fri, Jun 26
BUF
Buffalo
PTY
Panama City
CA $5,322 Roundtrip, found 1 day ago
CA $5,322
Roundtrip
found 1 day ago
Select avianca flight, departing Tue, Jun 23 from Buffalo to Panama City, returning Fri, Jun 26, priced at CA $5,322 found 1 day ago

Frequently asked questions

How much does a flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) cost?
One-way flights typically cost between $1,477 and $5,701 and return flights often range between $1,477 and $5,701. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Anaa (AAA) to Toronto, ON (YYZ-Pearson Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
How do I find cheap flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
There are approximately 34 connecting flights per day from Buffalo Niagara Intl. (BUF) to Tocumen Intl. (PTY). Some common connection points include John F. Kennedy Intl. (JFK), Washington Dulles Intl. (IAD), and O'Hare Intl. (ORD).
What is the earliest flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Buffalo Niagara Intl. (BUF) to Tocumen Intl. (PTY) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in December. An early departure like this can help you maximize your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll typically find the most flights from Buffalo Niagara Intl. (BUF) to Tocumen Intl. (PTY) on a Thursday, with around 27 flights available. This gives you a good selection for your travel plans. Major airlines on this route include United Airlines, American Airlines, and Delta Air Lines. Flight schedules are consistent throughout the week.
What are the most popular departure times for flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) are in the early morning, from 6am to 9am. About 48% of passengers prefer this time. Many major carriers, including Delta, American Airlines and United, offer flights during this window. This timing works well because it allows you to get an early start on your journey and arrive in Panama City with plenty of time to settle in.
How long does it take to fly from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
Flights from BUF to PTY with one stop typically take around 10 hours 50 minutes, covering approximately 2,340 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
Select the "Business class" and "First class" filters when looking for BUF to PTY flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Buffalo Niagara Intl. (BUF)?
When traveling from Buffalo Niagara Intl. (BUF) to Panama City, you can fly into Tocumen Intl. (PTY) and Northwest Florida Beaches Intl. (ECP). Some flights may connect through major hubs like Charlotte-Douglas Intl. (CLT), John F. Kennedy Intl. (JFK), Washington Dulles Intl. (IAD) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Buffalo, NY (BUF-Buffalo Niagara Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
CA $774
Distance
3744 km

Book with confidence

Buffalo to Tocumen Flights

The easy way to book your flights from Buffalo to Panama City 

With Expedia, it’s simple to find and book flights to Panama City from Buffalo whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Tocumen Intl., too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Buffalo to Panama City today, tomorrow, or this week.  

 

Save dollars with cheap flights from Buffalo Niagara Intl., BUF to Tocumen Intl., PTY 

Sort your search results by price to find great deals on your flight from Buffalo to Panama City—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Panama City from Buffalo currently is just CA $775 rising to CA $5,322.  

Here are more money-saving tips: 

  • Fly in September when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Panama City  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Panama City from Buffalo 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Panama City with Expedia today.

Buffalo to Tocumen Flights

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*Available to Expedia members.