A historic building with ornate architecture and a modern skyscraper in the background.

CA $134 Cheap Flights from Cusco (CUZ) to Santiago (SCL)

View CA $134 flight on Tue, Sep 8, 2026Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Santiago Intl. Airport (SCL)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards
    Sign in

Cheap flights from Cusco (CUZ) to Santiago (SCL)

Prices were available within the past 7 days and start at CA $134 for one-way flights and CA $320 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Tue, Sep 15 - Sat, Sep 19
CUZ
Cusco
SCL
Santiago
CA $320 Roundtrip, found 4 days ago
CA $320
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Tue, Sep 15 from Cusco to Santiago, returning Sat, Sep 19, priced at CA $320 found 4 days ago
SKY AIRLINE
Thu, Oct 22 - Thu, Oct 29
CUZ
Cusco
SCL
Santiago
CA $354 Roundtrip, found 6 days ago
CA $354
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Thu, Oct 22 from Cusco to Santiago, returning Thu, Oct 29, priced at CA $354 found 6 days ago
Jetsmart SPA
Tue, Sep 15 - Sat, Sep 19
CUZ
Cusco
SCL
Santiago
CA $366 Roundtrip, found 4 days ago
CA $366
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Tue, Sep 15 from Cusco to Santiago, returning Sat, Sep 19, priced at CA $366 found 4 days ago
Jetsmart SPA
Fri, Oct 23 - Sun, Oct 25
CUZ
Cusco
SCL
Santiago
CA $370 Roundtrip, found 6 days ago
CA $370
Roundtrip
found 6 days ago
Select Jetsmart SPA flight, departing Fri, Oct 23 from Cusco to Santiago, returning Sun, Oct 25, priced at CA $370 found 6 days ago
SKY AIRLINE
Tue, Oct 20 - Thu, Oct 29
CUZ
Cusco
SCL
Santiago
CA $379 Roundtrip, found 6 days ago
CA $379
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Tue, Oct 20 from Cusco to Santiago, returning Thu, Oct 29, priced at CA $379 found 6 days ago
SKY AIRLINE
Thu, Oct 22 - Sun, Nov 1
CUZ
Cusco
SCL
Santiago
CA $381 Roundtrip, found 6 days ago
CA $381
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Thu, Oct 22 from Cusco to Santiago, returning Sun, Nov 1, priced at CA $381 found 6 days ago
Jetsmart SPA
Tue, Sep 15 - Sat, Sep 19
CUZ
Cusco
SCL
Santiago
CA $388 Roundtrip, found 4 days ago
CA $388
Roundtrip
found 4 days ago
Select Jetsmart SPA flight, departing Tue, Sep 15 from Cusco to Santiago, returning Sat, Sep 19, priced at CA $388 found 4 days ago
SKY AIRLINE
Tue, Oct 20 - Mon, Nov 2
CUZ
Cusco
SCL
Santiago
CA $403 Roundtrip, found 6 days ago
CA $403
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Tue, Oct 20 from Cusco to Santiago, returning Mon, Nov 2, priced at CA $403 found 6 days ago
SKY AIRLINE
Tue, Oct 20 - Sun, Nov 1
CUZ
Cusco
SCL
Santiago
CA $406 Roundtrip, found 6 days ago
CA $406
Roundtrip
found 6 days ago
Select SKY AIRLINE flight, departing Tue, Oct 20 from Cusco to Santiago, returning Sun, Nov 1, priced at CA $406 found 6 days ago
LATAM Airlines Group
Fri, Aug 14 - Tue, Aug 18
CUZ
Cusco
SCL
Santiago
CA $412 Roundtrip, found 1 hour ago
CA $412
Roundtrip
found 1 hour ago
Select LATAM Airlines Group flight, departing Fri, Aug 14 from Cusco to Santiago, returning Tue, Aug 18, priced at CA $412 found 1 hour ago

Find the cheapest month to fly from Cusco (CUZ) to Santiago (SCL)

April is typically the cheapest month to fly

From CA $306 - CA $504 per traveller.

Frequently asked questions

How much does a flight from Cusco (CUZ) to Santiago (SCL) cost?
You can find cheap one-way flights from CA $134 and cheap return flights from CA $320 CUZ to SCL with Expedia. One-way flights typically cost between CA$286 and CA$600. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when CUZ to SCL ticket fares go up or down.
What is the cheapest month to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The cheapest months to fly from CUZ to SCL are typically during off-peak season when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you are able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
Only one airline offers direct flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez). LATAM Airlines Group operates 9 direct flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) every week.
How do I find cheap flights from Cusco (CUZ) to Santiago (SCL)?
To find a cheap flight from Cusco (CUZ) to Santiago (SCL), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best airline to fly with from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) will differ from traveler to traveler. If you like to fly early, LATAM Airlines Group offers early morning flights. If price is the most important factor, LATAM Airlines Group typically offers the lowest fares. LATAM Airlines Group offers the most daily flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You'll find around 1 nonstop flight per day from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez). For even more choices, look at flights that include layovers, as there are approximately 37 connecting flights per day. Some common connection points include Jorge Chavez Intl. (LIM), Rodriguez Ballon Intl. (AQP), and El Dorado Intl. (BOG).
What is the earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) typically departs around 12:05 AM local time. This service is operated by LATAM Airlines Group. This is a seasonal service, active in April, May, June, August, and September. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You'll typically find the most flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) on a Monday, with around 22 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include LATAM Airlines Group, Sky Airlines, and Avianca. Monday offers notably more flight options compared to other days of the week, making it a good day to consider for your journey.
What are the most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
The most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) are in the late evening, from 9pm to midnight. Many major carriers, including LATAM Airlines Group, Sky Airlines and Skyways, offer flights during this window. Many travellers prefer this time because it allows you to make the most of your day in Cusco before your flight, and you'll arrive in Santiago ready to start your day.
How long does it take to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
A non-stop flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez) typically takes around 3 hours 18 minutes. This route covers a distance of approximately 2,211 kilometres. If you opt for a one-stop flight, your travel time will be longer, usually around 15 hours. Flights with two or more stops will take even longer, typically around 18 hours 30 minutes. Keep in mind that actual flight times can vary due to factors like wind patterns and air traffic, so it's always a good idea to allow for some extra time when planning your journey.
Can you fly business or first class from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Santiago (SCL-Arturo Merino Benitez)?
You can fly business class between CUZ and SCL. Airlines that offer business class service on this route include:
  • Avianca
How do I earn miles on a Cusco (CUZ) to Santiago (SCL) flight with Expedia?
It's easy to earn miles on a Cusco (CUZ) to Santiago (SCL) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Santiago (SCL) from Cusco (CUZ)?
If you're planning to travel to Santiago from Alejandro Velasco Astete Intl. (CUZ), you can fly directly into Arturo Merino Benitez (SCL). Some flights may connect through major hubs like Jorge Chavez Intl. (LIM), Rodriguez Ballon Intl. (AQP), or Padre Aldamiz Intl. (PEM) before reaching Santiago. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Cusco (CUZ) to Santiago (SCL) at the last minute?
Typically, booking a last minute flight from Cusco (CUZ) to Santiago (SCL) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Cusco (CUZ) to Santiago (SCL) flight and hotel package?
Securing a Cusco (CUZ) to Santiago (SCL) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cusco (CUZ) to Santiago (SCL)?
If you booked your Cusco (CUZ) to Santiago (SCL) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Jetsmart SPA, LATAM Airlines Group, SKY AIRLINE
Roundtrip price
CA $319
Distance
2198 km
Average flight time
4 hours 20 mins

Book with confidence

Cusco to Santiago Flights

The easy way to book your flights from Cusco to Santiago 

With Expedia, it’s simple to find and book flights to Santiago from Cusco whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Arturo Merino Benitez, too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Cusco to Santiago today, tomorrow, or this week.  

 

Save dollars with cheap flights from Alejandro Velasco Astete Intl., CUZ to Arturo Merino Benitez, SCL 

Sort your search results by price to find great deals on your flight from Cusco to Santiago—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Santiago from Cusco currently is just CA $320 rising to CA $412.  

Here are more money-saving tips: 

  • Fly in September when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Santiago  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Santiago from Cusco 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Santiago with Expedia today.

Cusco to Santiago Flights

Explore a world of travel with Expedia

*Available to Expedia members.